---
title: "CAAN-AF trial: Cardiac resynchronization therapy with or without AV node ablation in atrial fibril"
id: "pubmed-41985940"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-41985940"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/41985940/"
doi: "10.1093/eurheartj/ehag206"
published_at: "2026-09-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# CAAN-AF trial: Cardiac resynchronization therapy with or without AV node ablation in atrial fibril
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-41985940
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/41985940/)
- **DOI:** [10.1093/eurheartj/ehag206](https://doi.org/10.1093%2Feurheartj%2Fehag206)
- **Published At:** 2026-09-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The CAAN-AF trial is a randomized controlled trial published in the European Heart Journal examining **cardiac resynchronization therapy (CRT)** with or without **atrioventricular (AV) node ablation** in patients with **atrial fibrillation (AF)**. - Publication metadata: Eur Heart J, 2026 Sep 22; volume 47(36):5128-5138; doi: 10.1093/eurheartj/ehag206; PubMed PMID available at the provided URL. - A large multi-author, multi-centre investigator group from Australia, New Zealand, Germany, Malaysia and other centres contributed; lead author listed as Prashanthan Sanders and many cardiology and electrophysiology specialists are coauthors. - Affiliations include the Centre for Heart Rhythm Disorders, Adelaide University, Central Adelaide Local Health Network and numerous Australian and international cardiology departments. - Trial designation, acronym and primary clinical question (CRT with versus without AV node ablation in AF) are explicit in the title; specific study design details (sample size, inclusion/exclusion, randomization method, endpoints, follow-up duration) are not provided in the PubMed page snapshot supplied. - Key outcomes, efficacy findings, safety data, statistical results and authors’ conclusions are not reported in the source content provided here. - Full-text access is linked from PubMed (European Heart Journal full-text options); consult the full article for methods, quantified results, subgroup analyses, and clinical implications. - For clinical application or guideline changes, readers should review the complete published paper and supplementary materials; details were not reported in the source excerpt supplied.
## Clinical Analysis & Structured Key Points
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Abstract Similar articles Publication types MeSH terms Associated data Related information Grants and funding LinkOut - more resources Randomized Controlled Trial Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/41985940/) . 2026 Sep 22;47(36):5128-5138. doi: 10.1093/eurheartj/ehag206. # Cardiac resynchronization therapy with or without atrioventricular node ablation in atrial fibrillation: the CAAN-AF trial [Prashanthan Sanders](https://pubmed.ncbi.nlm.nih.gov/?term=Sanders+P&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-2 "Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia."), [Jonathan P Ariyaratnam](https://pubmed.ncbi.nlm.nih.gov/?term=Ariyaratnam+JP&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-2 "Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia."), [Martin K Stiles](https://pubmed.ncbi.nlm.nih.gov/?term=Stiles+MK&cauthor_id=41985940)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-3 "Waikato Clinical School, University of Auckland, Hamilton, New Zealand."), [Alexis Puvrez](https://pubmed.ncbi.nlm.nih.gov/?term=Puvrez+A&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia."), [Stephen J Nicholls](https://pubmed.ncbi.nlm.nih.gov/?term=Nicholls+SJ&cauthor_id=41985940)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-4 "Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia."), [Walter P Abhayaratna](https://pubmed.ncbi.nlm.nih.gov/?term=Abhayaratna+WP&cauthor_id=41985940)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-5 "Department of Medicine, Canberra Hospital and the Australian National University, Canberra, Australian Capital Territory, Australia."), [Mark J Perrin](https://pubmed.ncbi.nlm.nih.gov/?term=Perrin+MJ&cauthor_id=41985940)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-6 "Department of Cardiology, University Hospital, Geelong, Victoria, Australia."), [Jeff Alison](https://pubmed.ncbi.nlm.nih.gov/?term=Alison+J&cauthor_id=41985940)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-3 "Waikato Clinical School, University of Auckland, Hamilton, New Zealand."), [Rajeev K Pathak](https://pubmed.ncbi.nlm.nih.gov/?term=Pathak+RK&cauthor_id=41985940)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-7 "Canberra Heart Rhythm, Canberra, Australian Capital Territory, Australia."), [Anand Ganesan](https://pubmed.ncbi.nlm.nih.gov/?term=Ganesan+A&cauthor_id=41985940)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-8 "Department of Cardiology, Flinders University and Flinders Medical Centre, Adelaide, South Australia, Australia."), [Vincent Paul](https://pubmed.ncbi.nlm.nih.gov/?term=Paul+V&cauthor_id=41985940)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-9 "Department of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia."), [Stuart P Thomas](https://pubmed.ncbi.nlm.nih.gov/?term=Thomas+SP&cauthor_id=41985940)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-10 "Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia."), [Gijo Thomas](https://pubmed.ncbi.nlm.nih.gov/?term=Thomas+G&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia."), [Melissa E Middeldorp](https://pubmed.ncbi.nlm.nih.gov/?term=Middeldorp+ME&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-2 "Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia."), [Elnaz Shahmohamadi](https://pubmed.ncbi.nlm.nih.gov/?term=Shahmohamadi+E&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia."), [Adrian D Elliott](https://pubmed.ncbi.nlm.nih.gov/?term=Elliott+AD&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-2 "Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia."), [Robert Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+R&cauthor_id=41985940)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-11 "Department of Cardiology, Gold Coast Hospital, Gold Coast, Queensland, Australia."), [Haris Haqqani](https://pubmed.ncbi.nlm.nih.gov/?term=Haqqani+H&cauthor_id=41985940)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-12 "Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia."), [Dean Boddington](https://pubmed.ncbi.nlm.nih.gov/?term=Boddington+D&cauthor_id=41985940)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-13 "Department of Cardiology, Tauranga Hospital, Tauranga, New Zealand."), [Peter M Kistler](https://pubmed.ncbi.nlm.nih.gov/?term=Kistler+PM&cauthor_id=41985940)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-14 "Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia."), [Paul Martin](https://pubmed.ncbi.nlm.nih.gov/?term=Martin+P&cauthor_id=41985940)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-15 "Department of Cardiology, Royal Brisbane Hospital, Brisbane, Queensland, Australia."), [Raymond W Sy](https://pubmed.ncbi.nlm.nih.gov/?term=Sy+RW&cauthor_id=41985940)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-16 "Department of Cardiology, Royal Prince Alfred Hospital & Concord Repatriation General Hospital, Sydney, New South Wales, Australia."), [Stephan Willems](https://pubmed.ncbi.nlm.nih.gov/?term=Willems+S&cauthor_id=41985940)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-17 "Department of Cardiology, Asklepios Clinic St.Georg, Hamburg, Germany."), [Paul Stobie](https://pubmed.ncbi.nlm.nih.gov/?term=Stobie+P&cauthor_id=41985940)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-18 "Department of Cardiology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia."), [Matthew Webber](https://pubmed.ncbi.nlm.nih.gov/?term=Webber+M&cauthor_id=41985940)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-19 "Department of Cardiology, Capital & Coast Wellington Hospital, Wellington, New Zealand."), [Gerald Kaye](https://pubmed.ncbi.nlm.nih.gov/?term=Kaye+G&cauthor_id=41985940)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-20 "Department of Cardiology, Princess Alexandria Hospital, Brisbane, Queensland, Australia."), [Paul MacIntyre](https://pubmed.ncbi.nlm.nih.gov/?term=MacIntyre+P&cauthor_id=41985940)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-21 "Department of Cardiology, Royal Hobart Hospital, Hobart, Tasmania, Australia."), [Bobby John](https://pubmed.ncbi.nlm.nih.gov/?term=John+B&cauthor_id=41985940)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-22 "Department of Cardiology, Townsville Hospital, Townsville, Queensland, Australia."), [Daniel Steven](https://pubmed.ncbi.nlm.nih.gov/?term=Steven+D&cauthor_id=41985940)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-23 "Department of Electrophysiology, University Hospital Cologne, Cologne, Germany."), [Azlan Hussin](https://pubmed.ncbi.nlm.nih.gov/?term=Hussin+A&cauthor_id=41985940)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-24 "Department of Cardiology, National Heart Institute, Kuala Lumpur, Malaysia."), [Suresh Singarayar](https://pubmed.ncbi.nlm.nih.gov/?term=Singarayar+S&cauthor_id=41985940)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-25 "Department of Cardiology, Prince of Wales Hospital, Sydney, New South Wales, Australia."), [David Whalley](https://pubmed.ncbi.nlm.nih.gov/?term=Whalley+D&cauthor_id=41985940)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-26 "RDepartment of Cardiology, oyal North Shore Hospital, Sydney, New South Wales, Australia."), [David O'Donnell](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Donnell+D&cauthor_id=41985940)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-27 "Department of Cardiology, Austin Health, Melbourne, Victoria, Australia."), [Nigel Lever](https://pubmed.ncbi.nlm.nih.gov/?term=Lever+N&cauthor_id=41985940)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-28 "Department of Cardiology, Auckland City Hospital, Auckland, New Zealand."), [Rajiv Mahajan](https://pubmed.ncbi.nlm.nih.gov/?term=Mahajan+R&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia.")[ 29 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-29 "Department of Cardiology, Lyell McEwin Hospital, Adelaide, South Australia, Australia."), [Daniel Ninio](https://pubmed.ncbi.nlm.nih.gov/?term=Ninio+D&cauthor_id=41985940)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-2 "Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia."), [John Amerena](https://pubmed.ncbi.nlm.nih.gov/?term=Amerena+J&cauthor_id=41985940)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-6 "Department of Cardiology, University Hospital, Geelong, Victoria, Australia."), [Adrian Esterman](https://pubmed.ncbi.nlm.nih.gov/?term=Esterman+A&cauthor_id=41985940)[ 30 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-30 "College of Health, Adelaide University, Adelaide, South Australia, Australia."), [Derek P Chew](https://pubmed.ncbi.nlm.nih.gov/?term=Chew+DP&cauthor_id=41985940)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-4 "Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-8 "Department of Cardiology, Flinders University and Flinders Medical Centre, Adelaide, South Australia, Australia."), [Matthew Worthley](https://pubmed.ncbi.nlm.nih.gov/?term=Worthley+M&cauthor_id=41985940)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-1 "Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-2 "Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia."), [Andrew Tonkin](https://pubmed.ncbi.nlm.nih.gov/?term=Tonkin+A&cauthor_id=41985940)[ 31 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-31 "Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia."), [Carmine G De Pasquale](https://pubmed.ncbi.nlm.nih.gov/?term=De+Pasquale+CG&cauthor_id=41985940)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-8 "Department of Cardiology, Flinders University and Flinders Medical Centre, Adelaide, South Australia, Australia."), [Jonathan M Kalman](https://pubmed.ncbi.nlm.nih.gov/?term=Kalman+JM&cauthor_id=41985940)[ 32 ](https://pubmed.ncbi.nlm.nih.gov/41985940/#full-view-affiliation-32 "Department of Cardiology, Melbourne Health and University of Melbourne, Melbourne, Victoria, Australia.") Affiliations Expand ### Affiliations * 1 Centre for Heart Rhythm Disorders, Adelaide University, Adelaide, South Australia, Australia. * 2 Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia. * 3 Waikato Clinical School, University of Auckland, Hamilton, New Zealand. * 4 Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia. * 5 Department of Medicine, Canberra Hospital and the Australian National University, Canberra, Australian Capital Territory, Australia. * 6 Department of Cardiology, University Hospital, Geelong, Victoria, Australia. * 7 Canberra Heart Rhythm, Canberra, Australian Capital Territory, Australia. * 8 Department of Cardiology, Flinders University and Flinders Medical Centre, Adelaide, South Australia, Australia. * 9 Department of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia. * 10 Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia. * 11 Department of Cardiology, Gold Coast Hospital, Gold Coast, Queensland, Australia. *
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