---
title: "Catheter ablation for symptomatic atrial fibrillation: PVI‑SHAM‑AF randomised sham‑controlled trial"
id: "pubmed-42669307"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42669307"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42669307/"
doi: "10.1016/S0140-6736(26)01558-8"
published_at: "2026-09-12T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Catheter ablation for symptomatic atrial fibrillation: PVI‑SHAM‑AF randomised sham‑controlled trial
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42669307
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42669307/)
- **DOI:** [10.1016/S0140-6736(26)01558-8](https://doi.org/10.1016%2FS0140-6736(26)01558-8)
- **Published At:** 2026-09-12T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article reports the PVI‑SHAM‑AF trial, a multicentre, **randomised, double‑blind, sham‑controlled** study of **catheter ablation** for symptomatic **atrial fibrillation** published in Lancet (2026). - Publication details shown: Lancet, 2026 Sep 12;408(10559):999–1009. DOI 10.1016/S0140-6736(26)01558-8; Epub 2026 Aug 30. - The title and author list identify PVI‑SHAM‑AF Investigators and lead authors from multiple German and international cardiology/electrophysiology centres, with coordinating centres at University Hospital Leipzig and Heart Centre Leipzig. - The trial is described as multicentre with numerous collaborating investigators and affiliations across Germany and at least one centre in Poland. - The PubMed entry lists many individual investigators and institutional affiliations, including departments of cardiology and electrophysiology; a Clinical Trial Centre at Leipzig University is noted. - The PubMed page includes standard navigation and access links but the abstract and core trial data (methods, sample size, primary and secondary endpoints, numerical results, statistical analyses, safety outcomes, and conclusions) are not included in the provided source excerpt. - Details on randomisation procedure, inclusion/exclusion criteria, procedural protocol for pulmonary vein isolation (PVI), sham intervention specifics, follow‑up duration, outcome measures (symptom scores, AF burden, recurrence, quality of life, or hard clinical outcomes), and adverse event data were not reported in the supplied source text. - Trial registration number, funding sources, and conflict‑of‑interest statements were not available in the excerpt provided. - Because the excerpt is limited to bibliographic and author/collaborator information, any statements about efficacy, safety, or clinical recommendations cannot be drawn from this source alone.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 30. # Catheter ablation for symptomatic atrial fibrillation (PVI-SHAM-AF): a randomised, double-blind, sham-controlled, multicentre trial [Rolf Wachter](https://pubmed.ncbi.nlm.nih.gov/?term=Wachter+R&cauthor_id=42669307)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-1 "Department of Cardiology, University Hospital Leipzig, Leipzig, Germany. Electronic address: rolf.wachter@medizin.uni-leipzig.de."), [Patrick Haag](https://pubmed.ncbi.nlm.nih.gov/?term=Haag+P&cauthor_id=42669307)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-2 "Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany."), [Tobias Uhe](https://pubmed.ncbi.nlm.nih.gov/?term=Uhe+T&cauthor_id=42669307)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-3 "Department of Cardiology, University Hospital Leipzig, Leipzig, Germany."), [Miroslav Bacak](https://pubmed.ncbi.nlm.nih.gov/?term=Bacak+M&cauthor_id=42669307)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-4 "Clinical Trial Centre ZKS Leipzig, Leipzig University, Leipzig, Germany."), [David Petroff](https://pubmed.ncbi.nlm.nih.gov/?term=Petroff+D&cauthor_id=42669307)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-4 "Clinical Trial Centre ZKS Leipzig, Leipzig University, Leipzig, Germany."), [Mathias Forkmann](https://pubmed.ncbi.nlm.nih.gov/?term=Forkmann+M&cauthor_id=42669307)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-5 "Department of Electrophysiology, Sana Klinikum Coburg, Coburg, Germany."), [Lars Eckardt](https://pubmed.ncbi.nlm.nih.gov/?term=Eckardt+L&cauthor_id=42669307)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-6 "Department of Cardiology-Electrophysiology, University Hospital Munster, Muenster, Germany; Atrial Fibrillation NETwork AFNET, Münster, Germany."), [Thomas Gaspar](https://pubmed.ncbi.nlm.nih.gov/?term=Gaspar+T&cauthor_id=42669307)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-7 "Department of Cardiology, Klinikum Dresden-Friedrichstadt, Dresden, Germany."), [Borislav Dinov](https://pubmed.ncbi.nlm.nih.gov/?term=Dinov+B&cauthor_id=42669307)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-8 "Department of Cardiology, University Hospital Gießen, Gießen, Germany."), [Martin Neef](https://pubmed.ncbi.nlm.nih.gov/?term=Neef+M&cauthor_id=42669307)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-3 "Department of Cardiology, University Hospital Leipzig, Leipzig, Germany."), [Kerstin Bode](https://pubmed.ncbi.nlm.nih.gov/?term=Bode+K&cauthor_id=42669307)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-2 "Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany."), [Timm Seewöster](https://pubmed.ncbi.nlm.nih.gov/?term=Seew%C3%B6ster+T&cauthor_id=42669307)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-9 "Department of Cardiology, Klinikum Görlitz, Görlitz, Germany."), [Sotirios Nedios](https://pubmed.ncbi.nlm.nih.gov/?term=Nedios+S&cauthor_id=42669307)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-2 "Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany."), [Sebastian Hilbert](https://pubmed.ncbi.nlm.nih.gov/?term=Hilbert+S&cauthor_id=42669307)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-2 "Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany."), [Matthias Lerche](https://pubmed.ncbi.nlm.nih.gov/?term=Lerche+M&cauthor_id=42669307)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-2 "Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany."), [Frank Lindemann](https://pubmed.ncbi.nlm.nih.gov/?term=Lindemann+F&cauthor_id=42669307)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-2 "Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany."), [Christian Spies](https://pubmed.ncbi.nlm.nih.gov/?term=Spies+C&cauthor_id=42669307)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-3 "Department of Cardiology, University Hospital Leipzig, Leipzig, Germany."), [Samira Beimel](https://pubmed.ncbi.nlm.nih.gov/?term=Beimel+S&cauthor_id=42669307)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-3 "Department of Cardiology, University Hospital Leipzig, Leipzig, Germany."), [Beatriz Tose Costa Paiva](https://pubmed.ncbi.nlm.nih.gov/?term=Paiva+BTC&cauthor_id=42669307)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-5 "Department of Electrophysiology, Sana Klinikum Coburg, Coburg, Germany."), [Felix Hohendanner](https://pubmed.ncbi.nlm.nih.gov/?term=Hohendanner+F&cauthor_id=42669307)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-10 "Department of Cardiology, Angiology and Intensive Care Medicine, Campus Charité Mitte, German Heart Centre at Charité-University Medical Centre Berlin, Berlin, Germany."), [Verena Tscholl](https://pubmed.ncbi.nlm.nih.gov/?term=Tscholl+V&cauthor_id=42669307)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-10 "Department of Cardiology, Angiology and Intensive Care Medicine, Campus Charité Mitte, German Heart Centre at Charité-University Medical Centre Berlin, Berlin, Germany."), [Radosław Lenarczyk](https://pubmed.ncbi.nlm.nih.gov/?term=Lenarczyk+R&cauthor_id=42669307)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-11 "Department of Cardiology and Electrotherapy, Medical University of Silesia, Zabrze, Poland."), [Leonard Bergau](https://pubmed.ncbi.nlm.nih.gov/?term=Bergau+L&cauthor_id=42669307)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-12 "Medical Clinic I, Klinikum Wolfsburg, Wolfsburg, Germany."), [Christian Sohns](https://pubmed.ncbi.nlm.nih.gov/?term=Sohns+C&cauthor_id=42669307)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-13 "Clinic for Electrophysiology, Heart and Diabetes Centre NRW, Ruhr University Bochum, Bad Oeynhausen, Germany."), [Christiane Prettin](https://pubmed.ncbi.nlm.nih.gov/?term=Prettin+C&cauthor_id=42669307)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-4 "Clinical Trial Centre ZKS Leipzig, Leipzig University, Leipzig, Germany."), [Ulrich Laufs](https://pubmed.ncbi.nlm.nih.gov/?term=Laufs+U&cauthor_id=42669307)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-3 "Department of Cardiology, University Hospital Leipzig, Leipzig, Germany."), [Gerhard Hindricks](https://pubmed.ncbi.nlm.nih.gov/?term=Hindricks+G&cauthor_id=42669307)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-10 "Department of Cardiology, Angiology and Intensive Care Medicine, Campus Charité Mitte, German Heart Centre at Charité-University Medical Centre Berlin, Berlin, Germany."), [Nikolaos Dagres](https://pubmed.ncbi.nlm.nih.gov/?term=Dagres+N&cauthor_id=42669307)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42669307/#full-view-affiliation-14 "Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany; Department of Cardiology, Angiology and Intensive Care Medicine, Campus Charité Mitte, German Heart Centre at Charité-University Medical Centre Berlin, Berlin, Germany."); [PVI-SHAM-AF Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=PVI-SHAM-AF+Investigators%5BCorporate+Author%5D) Collaborators, Affiliations Expand ### Collaborators * **PVI-SHAM-AF Investigators** : [Rolf Wachter](https://pubmed.ncbi.nlm.nih.gov/?term=Wachter+R), [Tobias Uhe](https://pubmed.ncbi.nlm.nih.gov/?term=Uhe+T), [Martin Neef](https://pubmed.ncbi.nlm.nih.gov/?term=Neef+M), [Christian Spies](https://pubmed.ncbi.nlm.nih.gov/?term=Spies+C), [Laura Ueberham](https://pubmed.ncbi.nlm.nih.gov/?term=Ueberham+L), [Irina Müller-Kozarez](https://pubmed.ncbi.nlm.nih.gov/?term=M%C3%BCller-Kozarez+I), [Michael Metze](https://pubmed.ncbi.nlm.nih.gov/?term=Metze+M), [Patrick Haag Née Dilk](https://pubmed.ncbi.nlm.nih.gov/?term=Haag+N%C3%A9e+Dilk+P), [Kerstin Bode](https://pubmed.ncbi.nlm.nih.gov/?term=Bode+K), [Timm Seewöster](https://pubmed.ncbi.nlm.nih.gov/?term=Seew%C3%B6ster+T), [Sotirios Nedios](https://pubmed.ncbi.nlm.nih.gov/?term=Nedios+S), [Sebastian Hilbert](https://pubmed.ncbi.nlm.nih.gov/?term=Hilbert+S), [Matthias Lerche](https://pubmed.ncbi.nlm.nih.gov/?term=Lerche+M), [Angeliki Darma](https://pubmed.ncbi.nlm.nih.gov/?term=Darma+A), [Frank Lindemann](https://pubmed.ncbi.nlm.nih.gov/?term=Lindemann+F), [Andreas Bollmann](https://pubmed.ncbi.nlm.nih.gov/?term=Bollmann+A), [Florian Fahr](https://pubmed.ncbi.nlm.nih.gov/?term=Fahr+F), [Ines Richter](https://pubmed.ncbi.nlm.nih.gov/?term=Richter+I), [Johannes Rotta Detto Loria](https://pubmed.ncbi.nlm.nih.gov/?term=Rotta+Detto+Loria+J), [Khadzhimurad Magomedov](https://pubmed.ncbi.nlm.nih.gov/?term=Magomedov+K), [Mateo Marin-Cuartes](https://pubmed.ncbi.nlm.nih.gov/?term=Marin-Cuartes+M), [Maria Buske](https://pubmed.ncbi.nlm.nih.gov/?term=Buske+M), [Niklas Lankisch](https://pubmed.ncbi.nlm.nih.gov/?term=Lankisch+N), [Anna Schulz](https://pubmed.ncbi.nlm.nih.gov/?term=Schulz+A), [Lena Hammerich](https://pubmed.ncbi.nlm.nih.gov/?term=Hammerich+L), [Arash Arya](https://pubmed.ncbi.nlm.nih.gov/?term=Arya+A), [Livio Bertagnolli](https://pubmed.ncbi.nlm.nih.gov/?term=Bertagnolli+L), [Danilo Obradovic](https://pubmed.ncbi.nlm.nih.gov/?term=Obradovic+D), [Julia Lurz](https://pubmed.ncbi.nlm.nih.gov/?term=Lurz+J), [Sergio Richter](https://pubmed.ncbi.nlm.nih.gov/?term=Richter+S), [Thomas Gaspar](https://pubmed.ncbi.nlm.nih.gov/?term=Gaspar+T), [Stefan Ulbrich](https://pubmed.ncbi.nlm.nih.gov/?term=Ulbrich+S), [Micaela Ebert](https://pubmed.ncbi.nlm.nih.gov/?term=Ebert+M), [Julia Mayer](https://pubmed.ncbi.nlm.nih.gov/?term=Mayer+J), [Leonhard Schleußner](https://pubmed.ncbi.nlm.nih.gov/?term=Schleu%C3%9Fner+L), [Mandy Flechsig](https://pubmed.ncbi.nlm.nih.gov/?term=Flechsig+M), [Lars Eckardt](https://pubmed.ncbi.nlm.nih.gov/?term=Eckardt+L), [Florian Doldi](https://pubmed.ncbi.nlm.nih.gov/?term=Doldi+F), [Gerrit Frommeyer](https://pubmed.ncbi.nlm.nih.gov/?term=Frommeyer+G), [Philipp Sebastian Lange](https://pubmed.ncbi.nlm.nih.gov/?term=Lange+PS), [Christian Ellermann](https://pubmed.ncbi.nlm.nih.gov/?term=Ellermann+C), [Felix Wegner](https://pubmed.ncbi.nlm.nih.gov/?term=Wegner+F), [Hauke Engelke](https://pubmed.ncbi.nlm.nih.gov/?term=Engelke+H), [Mathias Forkmann](https://pubmed.ncbi.nlm.nih.gov/?term=Forkmann+M), [Beatriz Tose Costa Paiva](https://pubmed.ncbi.nlm.nih.gov/?term=Tose+Costa+Paiva+B), [Steffi Butz](https://pubmed.ncbi.nlm.nih.gov/?term=Butz+S), [Thomas Mischke](https://pubmed.ncbi.nlm.nih.gov/?term=Mischke+T), [Sonia Busch](https://pubmed.ncbi.nlm.nih.gov/?term=Busch+S), [Borislav Dinov](https://pubmed.ncbi.nlm.nih.gov/?term=Dinov+B), [Samuel Sossalla](https://pubmed.ncbi.nlm.nih.gov/?term=Sossalla+S), [Philipp Bengel](https://pubmed.ncbi.nlm.nih.gov/?term=Bengel+P), [Jan Philip Huisel](https://pubmed.ncbi.nlm.nih.gov/?term=Huisel+JP), [Christian Fräbel](https://pubmed.ncbi.nlm.nih.gov/?term=Fr%C3%A4bel+C), [Nikita Schneider](https://pubmed.ncbi.nlm.nih.gov/?term=Schneider+N), [Vincent Größer](https://pubmed.ncbi.nlm.nih.gov/?term=Gr%C3%B6%C3%9Fer+V), [Nikolaos Dagres](https://pubmed.ncbi.nlm.nih.gov/?term=Dagres+N), [Gerhard Hindricks](https://pubmed.ncbi.nlm.nih.gov/?term=Hindricks+G), [Felix Hohendanner](https://pubmed.ncbi.nlm.nih.gov/?term=Hohendanner+F), [Verena Tscholl](https://pubmed.ncbi.nlm.nih.gov/?term=Tscholl+V), [Jin Hong Gerds-Li](https://pubmed.ncbi.nlm.nih.gov/?term=Gerds-Li+JH), [Chong-Bin Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+CB), [Emanuel Heil](https://pubmed.ncbi.nlm.nih.gov/?term=Heil+E), [Nora Henriette Wainstejn](https://pubmed.ncbi.nlm.nih.gov/?term=Wainstejn+NH), [Robert Hättasch](https://pubmed.ncbi.nlm.nih.gov/?term=H%C3%A4ttasch+R), [Thomas Kaas](https://pubmed.ncbi.nlm.nih.gov/?term=Kaas+T), [Radosław Lenarczyk](https://pubmed.ncbi.nlm.nih.gov/?term=Lenarczyk+R), [Aleksandra Mikunda-Gawel](https://pubmed.ncbi.nlm.nih.gov/?term=Mikunda-Gawel+A), [Mateusz Pajor](https://pubmed.ncbi.nlm.nih.gov/?term=Pajor+M), [Patrycja Pruszkowska-Skrzep](https://pubmed.ncbi.nlm.nih.gov/?term=Pruszkowska-Skrzep+P), [Zbigniew Kalarus](https://pubmed.ncbi.nlm.nih.gov/?term=Kalarus+Z), [Jacek Kowalczyk](https://pubmed.ncbi.nlm.nih.gov/?term=Kowalczyk+J) ### Affiliations * 1 Department of Cardiology, University Hospital Leipzig, Leipzig, Germany. Electronic address: rolf.wachter@medizin.uni-leipzig.de. * 2 Department of Electrophysiology, Heart Centre Leipzig, Leipzig University, Leipzig, Germany. * 3 Department of Cardiology, University Hospital Leipzig, Leipzig, Germany. * 4 Clinical Trial Centre ZKS Leipzig, Leipzig University, Leipzig, Germany. * 5 Department of Electrophysiology, Sana Klinikum Coburg, Coburg, Germany. * 6 Department of Cardiology-Electrophysiology, University Hospital Munster, Muenster, Germany; Atrial Fibrillation NETwork AFNET, Münster, Germany. * 7 Department of
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