---
title: "Clopidogrel vs Aspirin Monotherapy After PCI: Sex-Stratified SMART-CHOICE 3 Analysis"
id: "pubmed-42765401"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42765401"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42765401/"
doi: "10.4244/EIJ-D-26-00332"
published_at: "2026-09-21T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Clopidogrel vs Aspirin Monotherapy After PCI: Sex-Stratified SMART-CHOICE 3 Analysis
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42765401
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42765401/)
- **DOI:** [10.4244/EIJ-D-26-00332](https://doi.org/10.4244%2FEIJ-D-26-00332)
- **Published At:** 2026-09-21T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The publication reports a sex-stratified analysis from the **SMART-CHOICE 3** trial comparing **clopidogrel monotherapy** with **aspirin monotherapy** after **percutaneous coronary intervention (PCI)**. - The article is a randomized controlled trial published in EuroIntervention on 21 September 2026 and indexed in PubMed (PMID 42765401, DOI 10.4244/EIJ-D-26-00332). - The analysis explicitly stratifies outcomes by **sex** (females and males) to evaluate any differential effects of antiplatelet monotherapy after PCI. - The report lists a large multi-center Korean author group led by Woochan Kwon and collaborators from numerous South Korean hospitals and academic centers; the work is presented on behalf of the Smart-Choice Investigators. - The PubMed entry identifies the article type as a Randomized Controlled Trial but the PubMed page excerpt provided does not include abstract-level details such as patient numbers, inclusion/exclusion criteria, primary and secondary endpoints, statistical methods, or outcome results. - Key bibliographic details available: EuroIntervention. 2026 Sep 21;22(18):e990-e1000; PMID 42765401; DOI 10.4244/EIJ-D-26-00332. - Because the source excerpt contains bibliographic and author/affiliation information but lacks study methods and results, any efficacy, safety, or subgroup findings are not reported in the provided source and therefore cannot be summarized here. - For clinicians and researchers seeking data to inform practice or guideline interpretation, the full article (EuroIntervention) should be consulted to review methodology, endpoint definitions, numerical outcomes, and authors’ conclusions.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42765401/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42765401/#similar) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42765401/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42765401/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42765401/#substances) Title & authors Abstract Similar articles Publication types MeSH terms Substances Randomized Controlled Trial EuroIntervention Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22EuroIntervention%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22EuroIntervention%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42765401/) . 2026 Sep 21;22(18):e990-e1000. doi: 10.4244/EIJ-D-26-00332. # Clopidogrel monotherapy versus aspirin monotherapy in females and males after percutaneous coronary intervention: a sex-stratified analysis of the SMART-CHOICE 3 trial [Woochan Kwon](https://pubmed.ncbi.nlm.nih.gov/?term=Kwon+W&cauthor_id=42765401)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-1 "Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Ki Hong Choi](https://pubmed.ncbi.nlm.nih.gov/?term=Choi+KH&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Yong Hwan Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+YH&cauthor_id=42765401)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-3 "Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea."), [Jin-Ok Jeong](https://pubmed.ncbi.nlm.nih.gov/?term=Jeong+JO&cauthor_id=42765401)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-4 "Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, South Korea."), [Chan Joon Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+CJ&cauthor_id=42765401)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-5 "Uijeongbu St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea."), [Kyeong Ho Yun](https://pubmed.ncbi.nlm.nih.gov/?term=Yun+KH&cauthor_id=42765401)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-6 "Wonkwang University Hospital, Iksan, South Korea."), [Han Cheol Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+HC&cauthor_id=42765401)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-7 "Pusan National University Hospital, Busan, South Korea."), [Kiyuk Chang](https://pubmed.ncbi.nlm.nih.gov/?term=Chang+K&cauthor_id=42765401)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-8 "Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea."), [Mahn-Won Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+MW&cauthor_id=42765401)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-9 "Daejeon St Mary's Hospital, The Catholic University of Korea, Daejeon, South Korea."), [Jang-Whan Bae](https://pubmed.ncbi.nlm.nih.gov/?term=Bae+JW&cauthor_id=42765401)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-10 "Chungbuk National University Hospital, Cheongju, South Korea."), [Joon-Hyung Doh](https://pubmed.ncbi.nlm.nih.gov/?term=Doh+JH&cauthor_id=42765401)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-11 "Inje University Ilsan Paik Hospital, Goyang, South Korea."), [Byung Ryul Cho](https://pubmed.ncbi.nlm.nih.gov/?term=Cho+BR&cauthor_id=42765401)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-12 "Kangwon National University Hospital, Chuncheon, South Korea."), [Hee-Yeol Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+HY&cauthor_id=42765401)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-13 "Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, South Korea."), [Weon Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+W&cauthor_id=42765401)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-14 "Kyung Hee University Hospital, Seoul, South Korea."), [Ung Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+U&cauthor_id=42765401)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-15 "Yeungnam University Medical Center, Daegu, South Korea."), [Seung-Woon Rha](https://pubmed.ncbi.nlm.nih.gov/?term=Rha+SW&cauthor_id=42765401)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-16 "Korea University Guro Hospital, Seoul, South Korea."), [Young Joon Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+YJ&cauthor_id=42765401)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-17 "Chonnam National University Medical School, Gwangju, South Korea."), [Hyun-Jong Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+HJ&cauthor_id=42765401)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-18 "Sejong General Hospital, Bucheon, South Korea."), [Sung Gyun Ahn](https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+SG&cauthor_id=42765401)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-19 "Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea."), [Doo-Il Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+DI&cauthor_id=42765401)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-20 "Inje University Haeundae Paik Hospital, Busan, South Korea."), [Jang Hyun Cho](https://pubmed.ncbi.nlm.nih.gov/?term=Cho+JH&cauthor_id=42765401)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-21 "St Carollo Hospital, Suncheon, South Korea."), [Sung Ho Her](https://pubmed.ncbi.nlm.nih.gov/?term=Her+SH&cauthor_id=42765401)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-22 "St Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea."), [Doo Soo Jeon](https://pubmed.ncbi.nlm.nih.gov/?term=Jeon+DS&cauthor_id=42765401)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-23 "Incheon St Mary's Hospital, The Catholic University of Korea, Incheon, South Korea."), [Seung Hwan Han](https://pubmed.ncbi.nlm.nih.gov/?term=Han+SH&cauthor_id=42765401)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-24 "Gachon University Gil Hospital, Incheon, South Korea."), [Jin-Bae Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+JB&cauthor_id=42765401)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-25 "Daegu Catholic University Medical Center, Daegu, South Korea."), [Cheol Whan Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+CW&cauthor_id=42765401)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-26 "Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea."), [Danbee Kang](https://pubmed.ncbi.nlm.nih.gov/?term=Kang+D&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Joo Myung Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+JM&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Taek Kyu Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+TK&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Jeong Hoon Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+JH&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Soo-Youn Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+SY&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Seung-Hyuk Choi](https://pubmed.ncbi.nlm.nih.gov/?term=Choi+SH&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Hyeon-Cheol Gwon](https://pubmed.ncbi.nlm.nih.gov/?term=Gwon+HC&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Young Bin Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+YB&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Jong-Young Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+JY&cauthor_id=42765401)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-27 "Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea."), [Joo-Yong Hahn](https://pubmed.ncbi.nlm.nih.gov/?term=Hahn+JY&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [On Behalf Of The Smart-Choice Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=Smart-Choice+Investigators+OBOT&cauthor_id=42765401)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#full-view-affiliation-3 "Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.") Affiliations Expand ### Affiliations * 1 Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. * 2 Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. * 3 Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea. * 4 Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, South Korea. * 5 Uijeongbu St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea. * 6 Wonkwang University Hospital, Iksan, South Korea. * 7 Pusan National University Hospital, Busan, South Korea. * 8 Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea. * 9 Daejeon St Mary's Hospital, The Catholic University of Korea, Daejeon, South Korea. * 10 Chungbuk National University Hospital, Cheongju, South Korea. * 11 Inje University Ilsan Paik Hospital, Goyang, South Korea. * 12 Kangwon National University Hospital, Chuncheon, South Korea. * 13 Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, South Korea. * 14 Kyung Hee University Hospital, Seoul, South Korea. * 15 Yeungnam University Medical Center, Daegu, South Korea. * 16 Korea University Guro Hospital, Seoul, South Korea. * 17 Chonnam National University Medical School, Gwangju, South Korea. * 18 Sejong General Hospital, Bucheon, South Korea. * 19 Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea. * 20 Inje University Haeundae Paik Hospital, Busan, South Korea. * 21 St Carollo Hospital, Suncheon, South Korea. * 22 St Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea. * 23 Incheon St Mary's Hospital, The Catholic University of Korea, Incheon, South Korea. * 24 Gachon University Gil Hospital, Incheon, South Korea. * 25 Daegu Catholic University Medical Center, Daegu, South Korea. * 26 Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. * 27 Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea. * PMID: **42765401** * DOI: [ 10.4244/EIJ-D-26-00332 ](https://doi.org/10.4244/eij-d-26-00332) Item in Clipboard Randomized Controlled Trial # Clopidogrel monotherapy versus aspirin monotherapy in females and males after percutaneous coronary intervention: a sex-stratified analysis of the SMART-CHOICE 3 trial Woochan Kwon et al. EuroIntervention. 2026. Show details Display options Display options Format Abstract PubMed PMID EuroIntervention Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22EuroIntervention%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22EuroIntervention%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42765401/) . 2026 Sep 21;22(18):e990-e1000. doi: 10.4244/EIJ-D-26-00332. ### Authors [Woochan Kwon](https://pubmed.ncbi.nlm.nih.gov/?term=Kwon+W&cauthor_id=42765401)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-1 "Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Ki Hong Choi](https://pubmed.ncbi.nlm.nih.gov/?term=Choi+KH&cauthor_id=42765401)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-2 "Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea."), [Yong Hwan Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+YH&cauthor_id=42765401)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-3 "Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea."), [Jin-Ok Jeong](https://pubmed.ncbi.nlm.nih.gov/?term=Jeong+JO&cauthor_id=42765401)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-4 "Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, South Korea."), [Chan Joon Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+CJ&cauthor_id=42765401)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-5 "Uijeongbu St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea."), [Kyeong Ho Yun](https://pubmed.ncbi.nlm.nih.gov/?term=Yun+KH&cauthor_id=42765401)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-6 "Wonkwang University Hospital, Iksan, South Korea."), [Han Cheol Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+HC&cauthor_id=42765401)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-7 "Pusan National University Hospital, Busan, South Korea."), [Kiyuk Chang](https://pubmed.ncbi.nlm.nih.gov/?term=Chang+K&cauthor_id=42765401)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-8 "Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea."), [Mahn-Won Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+MW&cauthor_id=42765401)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42765401/#short-view-affiliation-9 "Daejeon St Mary's Hospital, The Catholic Uni
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