---
title: "Interleukin‑6 and C‑reactive Protein as Prognostic Markers After Acute Coronary Syndrome"
id: "pubmed-42185072"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42185072"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42185072/"
doi: "10.1093/eurheartj/ehag317"
published_at: "2026-10-26T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Interleukin‑6 and C‑reactive Protein as Prognostic Markers After Acute Coronary Syndrome
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42185072
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42185072/)
- **DOI:** [10.1093/eurheartj/ehag317](https://doi.org/10.1093%2Feurheartj%2Fehag317)
- **Published At:** 2026-10-26T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article is a randomized controlled trial report listed in the European Heart Journal examining the prognostic value of **Interleukin‑6** and **C‑reactive protein** after **acute coronary syndrome**. - The publication is authored by Johan Wouter Jukema and the ODYSSEY OUTCOMES Investigators; affiliations span European and North American cardiovascular research centers. - The PubMed entry includes bibliographic details: Eur Heart J, 2026 Oct 26;47(40):6008-6017; DOI 10.1093/eurheartj/ehag317; PMID 42185072. - The record identifies the work as a Randomized Controlled Trial and names the ODYSSEY OUTCOMES Investigators as corporate author. - The PubMed landing page lists full-text links but the included source text provided here does not contain the abstract, patient numbers, outcomes, statistical results, biomarker assay methods, sampling times, or endpoint definitions. - Because the provided source excerpt lacks outcomes and methods, no conclusions about the prognostic performance, hazard ratios, sensitivity/specificity, or clinical thresholds for IL‑6 or CRP can be extracted from this text. - The document does provide complete author and affiliation metadata and confirms the trial is available as a free article via the journal site; the full manuscript should be consulted for endpoints, methodology, and results. - Key unanswered questions from the available record include: precise trial design specifics, biomarker assay platforms, timing of sampling after index event, adjudicated endpoints, and whether biomarkers influenced treatment or risk stratification in the trial.
## Clinical Analysis & Structured Key Points
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Ltd, Rotkreuz, Switzerland."), [Deepak L Bhatt](https://pubmed.ncbi.nlm.nih.gov/?term=Bhatt+DL&cauthor_id=42185072)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-4 "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA."), [Sergio Fazio](https://pubmed.ncbi.nlm.nih.gov/?term=Fazio+S&cauthor_id=42185072)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-9 "Scientific Council, Cardiovascular and Metabolic Diseases, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA."), [Shaun G Goodman](https://pubmed.ncbi.nlm.nih.gov/?term=Goodman+SG&cauthor_id=42185072)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-10 "Division of Cardiology, Department of Medicine, Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-11 "Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada."), [Robert A Harrington](https://pubmed.ncbi.nlm.nih.gov/?term=Harrington+RA&cauthor_id=42185072)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-12 "Dean, Weill Cornell Medicine, New York, NY, USA."), [Irena Stevanovic](https://pubmed.ncbi.nlm.nih.gov/?term=Stevanovic+I&cauthor_id=42185072)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-13 "Dyslipidemia Medical Affairs, Sanofi, Paris, France."), [Harvey D White](https://pubmed.ncbi.nlm.nih.gov/?term=White+HD&cauthor_id=42185072)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-14 "Green Lane Cardiovascular Research Unit, Te Whatu Ora-Health New Zealand, Te Toka Tumai, and University of Auckland, Auckland, New Zealand."), [Philippe Gabriel Steg](https://pubmed.ncbi.nlm.nih.gov/?term=Steg+PG&cauthor_id=42185072)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-15 "Université Paris-Cité, UMR 1148/LVTS, FACT/F-CRIN \(French Alliance for Cardiovascular Trials\), AP-HP, Paris, France."), [Gregory G Schwartz](https://pubmed.ncbi.nlm.nih.gov/?term=Schwartz+GG&cauthor_id=42185072)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#full-view-affiliation-5 "Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA."); [ODYSSEY OUTCOMES Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=ODYSSEY+OUTCOMES+Investigators%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Department of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands. * 2 Netherlands Heart Institute, Postbus 19258, 3501 DG Utrecht, The Netherlands. * 3 School of Public Health, Suny Downstate Medical Center, Brooklyn, USA. * 4 Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA. * 5 Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA. * 6 CPC (Colorado Prevention Center) Clinical Research, Aurora, CO, USA. * 7 Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA. * 8 Medical Affairs, Roche Diagnostics Int. Ltd, Rotkreuz, Switzerland. * 9 Scientific Council, Cardiovascular and Metabolic Diseases, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. * 10 Division of Cardiology, Department of Medicine, Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada. * 11 Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. * 12 Dean, Weill Cornell Medicine, New York, NY, USA. * 13 Dyslipidemia Medical Affairs, Sanofi, Paris, France. * 14 Green Lane Cardiovascular Research Unit, Te Whatu Ora-Health New Zealand, Te Toka Tumai, and University of Auckland, Auckland, New Zealand. * 15 Université Paris-Cité, UMR 1148/LVTS, FACT/F-CRIN (French Alliance for Cardiovascular Trials), AP-HP, Paris, France. * PMID: **42185072** * DOI: [ 10.1093/eurheartj/ehag317 ](https://doi.org/10.1093/eurheartj/ehag317) Free article Item in Clipboard Randomized Controlled Trial # Interleukin-6 and C-reactive protein prognostic value following acute coronary syndrome Johan Wouter Jukema et al. Eur Heart J. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42185072/) . 2026 Oct 26;47(40):6008-6017. doi: 10.1093/eurheartj/ehag317. ### Authors [Johan Wouter Jukema](https://pubmed.ncbi.nlm.nih.gov/?term=Jukema+JW&cauthor_id=42185072)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-1 "Department of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-2 "Netherlands Heart Institute, Postbus 19258, 3501 DG Utrecht, The Netherlands."), [Nicolaas J Van Neer](https://pubmed.ncbi.nlm.nih.gov/?term=Van+Neer+NJ&cauthor_id=42185072)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-1 "Department of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands."), [Michael Szarek](https://pubmed.ncbi.nlm.nih.gov/?term=Szarek+M&cauthor_id=42185072)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-3 "School of Public Health, Suny Downstate Medical Center, Brooklyn, USA.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-4 "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-5 "Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-6 "CPC \(Colorado Prevention Center\) Clinical Research, Aurora, CO, USA."), [Christa Cobbaert](https://pubmed.ncbi.nlm.nih.gov/?term=Cobbaert+C&cauthor_id=42185072)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-1 "Department of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands."), [Vera A Bittner](https://pubmed.ncbi.nlm.nih.gov/?term=Bittner+VA&cauthor_id=42185072)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-7 "Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA."), [Markus Schwertfeger](https://pubmed.ncbi.nlm.nih.gov/?term=Schwertfeger+M&cauthor_id=42185072)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-8 "Medical Affairs, Roche Diagnostics Int. Ltd, Rotkreuz, Switzerland."), [Deepak L Bhatt](https://pubmed.ncbi.nlm.nih.gov/?term=Bhatt+DL&cauthor_id=42185072)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-4 "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA."), [Sergio Fazio](https://pubmed.ncbi.nlm.nih.gov/?term=Fazio+S&cauthor_id=42185072)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-9 "Scientific Council, Cardiovascular and Metabolic Diseases, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA."), [Shaun G Goodman](https://pubmed.ncbi.nlm.nih.gov/?term=Goodman+SG&cauthor_id=42185072)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-10 "Division of Cardiology, Department of Medicine, Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-11 "Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada."), [Robert A Harrington](https://pubmed.ncbi.nlm.nih.gov/?term=Harrington+RA&cauthor_id=42185072)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-12 "Dean, Weill Cornell Medicine, New York, NY, USA."), [Irena Stevanovic](https://pubmed.ncbi.nlm.nih.gov/?term=Stevanovic+I&cauthor_id=42185072)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-13 "Dyslipidemia Medical Affairs, Sanofi, Paris, France."), [Harvey D White](https://pubmed.ncbi.nlm.nih.gov/?term=White+HD&cauthor_id=42185072)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-14 "Green Lane Cardiovascular Research Unit, Te Whatu Ora-Health New Zealand, Te Toka Tumai, and University of Auckland, Auckland, New Zealand."), [Philippe Gabriel Steg](https://pubmed.ncbi.nlm.nih.gov/?term=Steg+PG&cauthor_id=42185072)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-15 "Université Paris-Cité, UMR 1148/LVTS, FACT/F-CRIN \(French Alliance for Cardiovascular Trials\), AP-HP, Paris, France."), [Gregory G Schwartz](https://pubmed.ncbi.nlm.nih.gov/?term=Schwartz+GG&cauthor_id=42185072)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42185072/#short-view-affiliation-5 "Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA."); [ODYSSEY OUTCOMES Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=ODYSSEY+OUTCOMES+Investigators%5BCorporate+Author%5D) ### Affiliations * 1 Department of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands. * 2 Netherlands Heart Institute, Postbus 19258, 3501 DG Utrecht, The Netherlands. * 3 School of Public Health, Suny Downstate Medical Center, Brooklyn, USA. * 4 Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA. * 5 Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA. * 6 CPC (Colorado Prevention Center) Clinical Research, Aurora, CO, USA. * 7 Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA. * 8 Medical Affairs, Roche Diagnostics Int. Ltd, Rotkreuz, Switzerland. * 9 Scientific Council, Cardiovascular and Metabolic Diseases, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. * 10 Division of Cardiology, Department of Medicine, Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada. * 11 Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. * 12 Dean, Weill Cornell Medicine, New York, NY, USA. * 13 Dyslipidemia Medical Affairs, Sanofi, P
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