---
title: "Prognostic Factors for Long-Term Stroke Risk After TIA or Minor Stroke: A Systematic Review"
id: "circulation-18-prognostic-factors-for-long-term-risk-of-stroke-after-transient-ischemic-attack-or-minor-stroke-a-systematic-review-and-meta-analysis"
canonical_url: "https://medichelpline.com/clinical-feed/circulation-18-prognostic-factors-for-long-term-risk-of-stroke-after-transient-ischemic-attack-or-minor-stroke-a-systematic-review-and-meta-analysis"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "Circulation"
source_url: "https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.078763?af=R"
published_at: "2026-03-18T09:00:01.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Prognostic Factors for Long-Term Stroke Risk After TIA or Minor Stroke: A Systematic Review
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/circulation-18-prognostic-factors-for-long-term-risk-of-stroke-after-transient-ischemic-attack-or-minor-stroke-a-systematic-review-and-meta-analysis
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** Circulation
- **Source URL:** [Original Journal Publication](https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.078763?af=R)
- **Published At:** 2026-03-18T09:00:01.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
Circulation, Ahead of Print. Background: Patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of subsequent stroke that persists for at least 10 years. We aimed to identify prognostic factors associated with long-term risk of stroke in this patient group, and estimate their population attribution fraction (PAF).Methods: A systematic review was performed of MEDLINE, Embase, and Web of Science for cohort studies including patients with TIA or minor stroke that evaluated factors for subsequent stroke over a follow-up period of ≥1 year. We pooled hazard ratios adjusted for relevant confounders using random-effect meta-analysis and determined the PAF of factors based on their pooled prevalence and adjusted hazard ratio (aHR). We assessed certainty of evidence using the Grading of Recommendations, Assessment, Development, and Evaluation approach. The study is registered in PROSPERO (CRD42023476551).Results: From 14 732 identified citations, we included 28 cohort studies comprising 86 810 patients with TIA or minor stroke (median age, 69 years [IQR, 65-71]; 52-60% male patients).
## Clinical Analysis & Structured Key Points
Circulation published a clinical update in Cardiology on 18 Mar 2026. The item focuses on Prognostic Factors for Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis. Review the original article for the full source wording and details.
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