---
title: "Safety of low lipoprotein(a) levels in the FOURIER trial"
id: "pubmed-42234492"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42234492"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42234492/"
doi: "10.1093/eurheartj/ehag398"
published_at: "2026-10-26T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Safety of low lipoprotein(a) levels in the FOURIER trial
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42234492
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42234492/)
- **DOI:** [10.1093/eurheartj/ehag398](https://doi.org/10.1093%2Feurheartj%2Fehag398)
- **Published At:** 2026-10-26T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The PubMed record describes a randomized controlled analysis titled “Safety of low **lipoprotein(a)** levels: the **FOURIER** trial” authored by Baris Gencer and colleagues and published in the European Heart Journal. - The abstract begins by framing **Lp(a)** as a causal risk factor for atherogenesis and notes prior reports of higher prevalence of selected adverse events, including diabetes mellitus, among patients with low **Lp(a)**. - The study’s stated aim in the available text was to examine safety signals associated with low **Lp(a)** levels; therapeutics that lower **Lp(a)** are mentioned but the sentence is truncated in the source. - The PubMed entry lists full author names and multi-center affiliations spanning TIMI/Brigham and Women’s, several European cardiology centers, and other collaborating institutions. - The record provides citation metadata (Eur Heart J. 2026 Oct 26;47(40):6039-6047; DOI: 10.1093/eurheartj/ehag398; PMID: 42234492). - Critical trial details (design specifics beyond RCT label, sample size, inclusion criteria, defined safety endpoints, statistical results, event rates, follow-up duration, and conclusions) are not present in the truncated PubMed abstract. - The PubMed page includes links to full-text sources (Silverchair/academic.oup.com) but the extract available here does not include outcome data or the authors’ conclusions. - Key unanswered clinical questions from the record: what safety endpoints were assessed; how low **Lp(a)** was defined; whether diabetes incidence differed by **Lp(a)** strata; and whether lowering **Lp(a)** with therapies produced adverse metabolic or other safety signals. - Readers are directed to the full-text article (DOI link) for complete methods, results, and interpretation because the PubMed abstract supplied here is incomplete.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42234492/#article-details) ### NIH Websites Are Changing * [Get the Latest Updates and FAQs on the transition](https://www.nih.gov/web-modernization) * Per [Executive Order 14434](https://www.whitehouse.gov/presidential-actions/2026/09/inaugurating-the-era-of-super-intelligence/), federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition. ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42234492%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42234492/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42234492/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42234492/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/a447896c-976f-490b-b86b-2668b65114a8/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42234492/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42234492/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42234492/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42234492%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42234492%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42234492/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42234492/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42234492/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42234492/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Silverchair Information Systems full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--academic.oup.com-images-oup_pubmed.png) Silverchair Information Systems ](https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehag398 "See full text options at Silverchair Information Systems") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42234492/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42234492/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Experimental Resource Linked Discoveries ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42234492/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42234492/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42234492/#similar) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42234492/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42234492/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42234492/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42234492/#related-links) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42234492/#grants) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42234492/#linkout) Title & authors Abstract Similar articles Publication types MeSH terms Substances Related information Grants and funding LinkOut - more resources Randomized Controlled Trial Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42234492/) . 2026 Oct 26;47(40):6039-6047. doi: 10.1093/eurheartj/ehag398. # Safety of low lipoprotein(a) levels: the FOURIER trial [Baris Gencer](https://pubmed.ncbi.nlm.nih.gov/?term=Gencer+B&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-2 "Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-3 "Institute of Primary Health Care \(BIHAM\), University of Bern, Bern, Switzerland.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-4 "Service of Cardiology, Lausanne University Hospital \(CHUV\), Lausanne, Switzerland."), [Robert P Giugliano](https://pubmed.ncbi.nlm.nih.gov/?term=Giugliano+RP&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [Xinhui Ran](https://pubmed.ncbi.nlm.nih.gov/?term=Ran+X&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [François Mach](https://pubmed.ncbi.nlm.nih.gov/?term=Mach+F&cauthor_id=42234492)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-3 "Institute of Primary Health Care \(BIHAM\), University of Bern, Bern, Switzerland."), [Erik S G Stroes](https://pubmed.ncbi.nlm.nih.gov/?term=Stroes+ESG&cauthor_id=42234492)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-5 "Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands."), [Ioanna Gouni-Berthold](https://pubmed.ncbi.nlm.nih.gov/?term=Gouni-Berthold+I&cauthor_id=42234492)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-6 "Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University of Cologne, Cologne, Germany."), [Richard Češka](https://pubmed.ncbi.nlm.nih.gov/?term=%C4%8Ce%C5%A1ka+R&cauthor_id=42234492)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-7 "Center for Preventive Cardiology, 3rd Internal Medicine Clinic, University General Hospital and Charles University 1st Medical Faculty, Prague, Czech Republic."), [Marat V Ezhov](https://pubmed.ncbi.nlm.nih.gov/?term=Ezhov+MV&cauthor_id=42234492)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-8 "National Cardiology Research Center, Moscow, Ministry of Health of the Russian Federation, Moscow, Russia."), [J Wouter Jukema](https://pubmed.ncbi.nlm.nih.gov/?term=Jukema+JW&cauthor_id=42234492)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-9 "Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands."), [Henrik K Jensen](https://pubmed.ncbi.nlm.nih.gov/?term=Jensen+HK&cauthor_id=42234492)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-10 "Department of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark."), [S Lale Tokgözoğlu](https://pubmed.ncbi.nlm.nih.gov/?term=Tokg%C3%B6zo%C4%9Flu+SL&cauthor_id=42234492)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-11 "Cardiovascular Division, Hacettepe University, Ankara, Turkey."), [Kurt Huber](https://pubmed.ncbi.nlm.nih.gov/?term=Huber+K&cauthor_id=42234492)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-12 "Austrian Heart Foundation, Vienna, Austria.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-13 "Medical Private University Burgenland \(GmbH\), Pinkafeld, Austria."), [KyungAh Im](https://pubmed.ncbi.nlm.nih.gov/?term=Im+K&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [Marc S Sabatine](https://pubmed.ncbi.nlm.nih.gov/?term=Sabatine+MS&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [Michelle L O'Donoghue](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Donoghue+ML&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#full-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.") Affiliations Expand ### Affiliations * 1 TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA. * 2 Cardiology Division, Geneva University Hospitals, Geneva, Switzerland. * 3 Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland. * 4 Service of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland. * 5 Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. * 6 Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University of Cologne, Cologne, Germany. * 7 Center for Preventive Cardiology, 3rd Internal Medicine Clinic, University General Hospital and Charles University 1st Medical Faculty, Prague, Czech Republic. * 8 National Cardiology Research Center, Moscow, Ministry of Health of the Russian Federation, Moscow, Russia. * 9 Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. * 10 Department of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. * 11 Cardiovascular Division, Hacettepe University, Ankara, Turkey. * 12 Austrian Heart Foundation, Vienna, Austria. * 13 Medical Private University Burgenland (GmbH), Pinkafeld, Austria. * PMID: **42234492** * DOI: [ 10.1093/eurheartj/ehag398 ](https://doi.org/10.1093/eurheartj/ehag398) Item in Clipboard Randomized Controlled Trial # Safety of low lipoprotein(a) levels: the FOURIER trial Baris Gencer et al. Eur Heart J. 2026. Show details Display options Display options Format Abstract PubMed PMID Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42234492/) . 2026 Oct 26;47(40):6039-6047. doi: 10.1093/eurheartj/ehag398. ### Authors [Baris Gencer](https://pubmed.ncbi.nlm.nih.gov/?term=Gencer+B&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-2 "Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-3 "Institute of Primary Health Care \(BIHAM\), University of Bern, Bern, Switzerland.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-4 "Service of Cardiology, Lausanne University Hospital \(CHUV\), Lausanne, Switzerland."), [Robert P Giugliano](https://pubmed.ncbi.nlm.nih.gov/?term=Giugliano+RP&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [Xinhui Ran](https://pubmed.ncbi.nlm.nih.gov/?term=Ran+X&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [François Mach](https://pubmed.ncbi.nlm.nih.gov/?term=Mach+F&cauthor_id=42234492)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-3 "Institute of Primary Health Care \(BIHAM\), University of Bern, Bern, Switzerland."), [Erik S G Stroes](https://pubmed.ncbi.nlm.nih.gov/?term=Stroes+ESG&cauthor_id=42234492)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-5 "Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands."), [Ioanna Gouni-Berthold](https://pubmed.ncbi.nlm.nih.gov/?term=Gouni-Berthold+I&cauthor_id=42234492)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-6 "Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University of Cologne, Cologne, Germany."), [Richard Češka](https://pubmed.ncbi.nlm.nih.gov/?term=%C4%8Ce%C5%A1ka+R&cauthor_id=42234492)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-7 "Center for Preventive Cardiology, 3rd Internal Medicine Clinic, University General Hospital and Charles University 1st Medical Faculty, Prague, Czech Republic."), [Marat V Ezhov](https://pubmed.ncbi.nlm.nih.gov/?term=Ezhov+MV&cauthor_id=42234492)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-8 "National Cardiology Research Center, Moscow, Ministry of Health of the Russian Federation, Moscow, Russia."), [J Wouter Jukema](https://pubmed.ncbi.nlm.nih.gov/?term=Jukema+JW&cauthor_id=42234492)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-9 "Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands."), [Henrik K Jensen](https://pubmed.ncbi.nlm.nih.gov/?term=Jensen+HK&cauthor_id=42234492)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-10 "Department of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark."), [S Lale Tokgözoğlu](https://pubmed.ncbi.nlm.nih.gov/?term=Tokg%C3%B6zo%C4%9Flu+SL&cauthor_id=42234492)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-11 "Cardiovascular Division, Hacettepe University, Ankara, Turkey."), [Kurt Huber](https://pubmed.ncbi.nlm.nih.gov/?term=Huber+K&cauthor_id=42234492)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-12 "Austrian Heart Foundation, Vienna, Austria.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-13 "Medical Private University Burgenland \(GmbH\), Pinkafeld, Austria."), [KyungAh Im](https://pubmed.ncbi.nlm.nih.gov/?term=Im+K&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [Marc S Sabatine](https://pubmed.ncbi.nlm.nih.gov/?term=Sabatine+MS&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA."), [Michelle L O'Donoghue](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Donoghue+ML&cauthor_id=42234492)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42234492/#short-view-affiliation-1 "TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.") ### Affiliations * 1 TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA. * 2 Cardiology Division, Geneva University Hospitals, Geneva, Switzerland. * 3 Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland. * 4 Service of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland. * 5 Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. * 6 Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University of Cologne, Cologne, Germany. * 7 Center for Preventive Cardiology, 3rd Internal Medicine Clinic, University General Hospital and Charles University 1st Medical Faculty, Prague, Czech Republic. * 8 National Cardiology Research Center, Moscow, Ministry of Health of the Russian Federation, Moscow, Russia. * 9 Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. * 10 Department of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. * 11 Cardiovascular Division, Hacettepe University, Ankara, Turkey. * 12 Austrian Heart Foundation, Vienna, Austria. * 13 Medical Private University Burgenland (GmbH), Pinkafeld, Austria. * PMID: **42234492** * DOI: [ 10.1093/eurheartj/ehag398 ](https://doi.org/10.1093/eurheartj/ehag398) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Background and aims:** Lipoprotein(a) (Lp(a)) is considered a causal risk factor for atherogenesis. A higher prevalence of certain adverse events, including diabetes mellitus (DM), has been reported for patients with low Lp(a) concentrations. Therapeutics that lower Lp(a) ar
## Related Clinical Research

- [Four-stage framework for women’s heart health links adolescence through postmenopause](https://medichelpline.com/clinical-feed/stat-news-0-the-4-stages-of-women-s-heart-health-experts-present-new-framework.md)
- [Sex Differences in the Donor Heart Offer-to-Outcome Pathway: National UNOS Linked Cohort Analysis](https://medichelpline.com/clinical-feed/medrxiv-4-sex-differences-across-the-donor-heart-offer-to-outcome-pathway-a-linked.md)
- [Lipid Panels Predict First Heart Failure: LDL-C, ApoB and Sex-Specific Signals](https://medichelpline.com/clinical-feed/medrxiv-10-cholesterol-paradox-multi-point-heart-failure-prediction-from-lipid-panels-in.md)
- [Psychosocial profile in adults with congenital heart disease by documented anxiety disorder history](https://medichelpline.com/clinical-feed/plos-one-21-psychosocial-profile-of-adults-with-congenital-heart-disease-according-to.md)
- [Moderna CEO on next steps after intismeran Phase 3 success in melanoma](https://medichelpline.com/clinical-feed/stat-news-1-stat-moderna-ceo-on-what-s-next-after-success-in-cancer-vaccine.md)

## Navigation
- [← Back to Cardiology Feed](https://medichelpline.com/clinical-feed/cardiology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.