---
title: "Semaglutide and High-Sensitivity CRP in SELECT: Prespecified Secondary Analysis in Patients With C"
id: "pubmed-42610271"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42610271"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42610271/"
doi: "10.1161/CIRCULATIONAHA.125.074482"
published_at: "2026-09-15T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Semaglutide and High-Sensitivity CRP in SELECT: Prespecified Secondary Analysis in Patients With C
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42610271
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42610271/)
- **DOI:** [10.1161/CIRCULATIONAHA.125.074482](https://doi.org/10.1161%2FCIRCULATIONAHA.125.074482)
- **Published At:** 2026-09-15T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This record reports a prespecified secondary analysis from the SELECT trial examining the effect of **Semaglutide** on the inflammatory biomarker **high-sensitivity CRP** (hs-CRP) in people with established **cardiovascular disease** and overweight or obesity. - The article is a randomized controlled trial published in Circulation (2026 Sep 15;154[11]:976-991) and is indexed with PMID 42610271 and DOI 10.1161/CIRCULATIONAHA.125.074482. - The analysis is titled “Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis.” - Multi-author, multi-center collaboration includes academic investigators and contributors affiliated with Novo Nordisk A/S; lead and senior authors include Jorge Plutzky and Paul M Ridker among others. - The PubMed entry identifies the article as a free article and labels it a Randomized Controlled Trial; full text links are available via the publisher (Circulation / Atypon). - Important trial details such as sample size, dosing regimen, statistical methods, numerical results for hs-CRP, effect sizes, p values, safety outcomes, and authors’ conclusions are not reported in the provided PubMed page content excerpt. - Where numeric or outcome data, subgroup analyses, and interpretations are absent from the source excerpt, those details cannot be inferred or supplied and are noted as not reported here. - Readers are directed to the full text link (Circulation DOI) for complete methods, results, and conclusions because the PubMed summary page excerpt provided does not include the abstract or specific findings of this prespecified secondary analysis.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 18. # Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis [Jorge Plutzky](https://pubmed.ncbi.nlm.nih.gov/?term=Plutzky+J&cauthor_id=42610271)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-1 "Division of Cardiovascular Medicine \(J.P.\), Brigham and Women's Hospital, Harvard Medical School, Boston, MA."), [Paweł Bogdański](https://pubmed.ncbi.nlm.nih.gov/?term=Bogda%C5%84ski+P&cauthor_id=42610271)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-2 "Department of Treatment of Obesity, Metabolic Disorders, and Clinical Dietetics, Poznan University of Medical Sciences, Poland \(P.B.\)."), [Helen M Colhoun](https://pubmed.ncbi.nlm.nih.gov/?term=Colhoun+HM&cauthor_id=42610271)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-3 "Institute of Genetics and Cancer, University of Edinburgh, Scotland \(H.M.C.\)."), [Selçuk Dağdelen](https://pubmed.ncbi.nlm.nih.gov/?term=Da%C4%9Fdelen+S&cauthor_id=42610271)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-4 "Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara, Turkey \(S.D.\)."), [John E Deanfield](https://pubmed.ncbi.nlm.nih.gov/?term=Deanfield+JE&cauthor_id=42610271)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-5 "Institute of Cardiovascular Science, University College London, UK \(J.E.D.\)."), [Scott S Emerson](https://pubmed.ncbi.nlm.nih.gov/?term=Emerson+SS&cauthor_id=42610271)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-6 "Department of Biostatistics, University of Washington, Seattle \(S.S.E.\)."), [G Kees Hovingh](https://pubmed.ncbi.nlm.nih.gov/?term=Hovingh+GK&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\).")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-8 "Department of Vascular Medicine, Amsterdam University Medical Center, the Netherlands \(G.K.H.\)."), [Steven E Kahn](https://pubmed.ncbi.nlm.nih.gov/?term=Kahn+SE&cauthor_id=42610271)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-9 "Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle \(S.E.K.\)."), [Kathrine Ekström](https://pubmed.ncbi.nlm.nih.gov/?term=Ekstr%C3%B6m+K&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Gustavs Latkovskis](https://pubmed.ncbi.nlm.nih.gov/?term=Latkovskis+G&cauthor_id=42610271)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-10 "Faculty of Medicine and Life Sciences, University of Latvia, Riga \(G.L.\)."), [Michael Lehrke](https://pubmed.ncbi.nlm.nih.gov/?term=Lehrke+M&cauthor_id=42610271)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-11 "Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Germany \(M.L.\)."), [Søren Hardt-Lindberg](https://pubmed.ncbi.nlm.nih.gov/?term=Hardt-Lindberg+S&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Ildiko Lingvay](https://pubmed.ncbi.nlm.nih.gov/?term=Lingvay+I&cauthor_id=42610271)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-12 "Department of Internal Medicine/Endocrinology and Peter O'Donnell Jr School of Public Health, UT Southwestern Medical Center, Dallas, TX \(I.L.\)."), [Stephen J Nicholls](https://pubmed.ncbi.nlm.nih.gov/?term=Nicholls+SJ&cauthor_id=42610271)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-13 "Victorian Heart Institute, Monash University, Clayton, Victoria, Australia \(S.J.N.\)."), [Tugce Kalayci Oral](https://pubmed.ncbi.nlm.nih.gov/?term=Kalayci+Oral+T&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Paula P Terns](https://pubmed.ncbi.nlm.nih.gov/?term=Terns+PP&cauthor_id=42610271)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-14 "Dirección Médica, Cardiología Palermo-Centro de Investigaciones Clínicas, Buenos Aires, Argentina \(P.P.T.\)."), [Søren Rasmussen](https://pubmed.ncbi.nlm.nih.gov/?term=Rasmussen+S&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Paul M Ridker](https://pubmed.ncbi.nlm.nih.gov/?term=Ridker+PM&cauthor_id=42610271)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-15 "Center for Cardiovascular Disease Prevention and Cardiovascular Division \(P.M.R.\), Brigham and Women's Hospital, Harvard Medical School, Boston, MA."), [Donna H Ryan](https://pubmed.ncbi.nlm.nih.gov/?term=Ryan+DH&cauthor_id=42610271)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-16 "Pennington Biomedical Research Center, Baton Rouge, LA \(D.H.R.\)."), [A Michael Lincoff](https://pubmed.ncbi.nlm.nih.gov/?term=Lincoff+AM&cauthor_id=42610271)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#full-view-affiliation-17 "Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH \(A.M.L.\).") Affiliations Expand ### Affiliations * 1 Division of Cardiovascular Medicine (J.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA. * 2 Department of Treatment of Obesity, Metabolic Disorders, and Clinical Dietetics, Poznan University of Medical Sciences, Poland (P.B.). * 3 Institute of Genetics and Cancer, University of Edinburgh, Scotland (H.M.C.). * 4 Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara, Turkey (S.D.). * 5 Institute of Cardiovascular Science, University College London, UK (J.E.D.). * 6 Department of Biostatistics, University of Washington, Seattle (S.S.E.). * 7 Novo Nordisk A/S, Søborg, Denmark (G.K.H., K.E., S.H.-L., T.K.O., S.R.). * 8 Department of Vascular Medicine, Amsterdam University Medical Center, the Netherlands (G.K.H.). * 9 Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle (S.E.K.). * 10 Faculty of Medicine and Life Sciences, University of Latvia, Riga (G.L.). * 11 Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Germany (M.L.). * 12 Department of Internal Medicine/Endocrinology and Peter O'Donnell Jr School of Public Health, UT Southwestern Medical Center, Dallas, TX (I.L.). * 13 Victorian Heart Institute, Monash University, Clayton, Victoria, Australia (S.J.N.). * 14 Dirección Médica, Cardiología Palermo-Centro de Investigaciones Clínicas, Buenos Aires, Argentina (P.P.T.). * 15 Center for Cardiovascular Disease Prevention and Cardiovascular Division (P.M.R.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA. * 16 Pennington Biomedical Research Center, Baton Rouge, LA (D.H.R.). * 17 Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH (A.M.L.). * PMID: **42610271** * DOI: [ 10.1161/CIRCULATIONAHA.125.074482 ](https://doi.org/10.1161/circulationaha.125.074482) Free article Item in Clipboard Randomized Controlled Trial # Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis Jorge Plutzky et al. Circulation. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Circulation Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Circulation%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Circulation%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42610271/) . 2026 Sep 15;154(11):976-991. doi: 10.1161/CIRCULATIONAHA.125.074482. Epub 2026 Aug 18. ### Authors [Jorge Plutzky](https://pubmed.ncbi.nlm.nih.gov/?term=Plutzky+J&cauthor_id=42610271)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-1 "Division of Cardiovascular Medicine \(J.P.\), Brigham and Women's Hospital, Harvard Medical School, Boston, MA."), [Paweł Bogdański](https://pubmed.ncbi.nlm.nih.gov/?term=Bogda%C5%84ski+P&cauthor_id=42610271)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-2 "Department of Treatment of Obesity, Metabolic Disorders, and Clinical Dietetics, Poznan University of Medical Sciences, Poland \(P.B.\)."), [Helen M Colhoun](https://pubmed.ncbi.nlm.nih.gov/?term=Colhoun+HM&cauthor_id=42610271)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-3 "Institute of Genetics and Cancer, University of Edinburgh, Scotland \(H.M.C.\)."), [Selçuk Dağdelen](https://pubmed.ncbi.nlm.nih.gov/?term=Da%C4%9Fdelen+S&cauthor_id=42610271)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-4 "Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara, Turkey \(S.D.\)."), [John E Deanfield](https://pubmed.ncbi.nlm.nih.gov/?term=Deanfield+JE&cauthor_id=42610271)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-5 "Institute of Cardiovascular Science, University College London, UK \(J.E.D.\)."), [Scott S Emerson](https://pubmed.ncbi.nlm.nih.gov/?term=Emerson+SS&cauthor_id=42610271)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-6 "Department of Biostatistics, University of Washington, Seattle \(S.S.E.\)."), [G Kees Hovingh](https://pubmed.ncbi.nlm.nih.gov/?term=Hovingh+GK&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\).")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-8 "Department of Vascular Medicine, Amsterdam University Medical Center, the Netherlands \(G.K.H.\)."), [Steven E Kahn](https://pubmed.ncbi.nlm.nih.gov/?term=Kahn+SE&cauthor_id=42610271)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-9 "Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle \(S.E.K.\)."), [Kathrine Ekström](https://pubmed.ncbi.nlm.nih.gov/?term=Ekstr%C3%B6m+K&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Gustavs Latkovskis](https://pubmed.ncbi.nlm.nih.gov/?term=Latkovskis+G&cauthor_id=42610271)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-10 "Faculty of Medicine and Life Sciences, University of Latvia, Riga \(G.L.\)."), [Michael Lehrke](https://pubmed.ncbi.nlm.nih.gov/?term=Lehrke+M&cauthor_id=42610271)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-11 "Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Germany \(M.L.\)."), [Søren Hardt-Lindberg](https://pubmed.ncbi.nlm.nih.gov/?term=Hardt-Lindberg+S&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Ildiko Lingvay](https://pubmed.ncbi.nlm.nih.gov/?term=Lingvay+I&cauthor_id=42610271)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-12 "Department of Internal Medicine/Endocrinology and Peter O'Donnell Jr School of Public Health, UT Southwestern Medical Center, Dallas, TX \(I.L.\)."), [Stephen J Nicholls](https://pubmed.ncbi.nlm.nih.gov/?term=Nicholls+SJ&cauthor_id=42610271)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-13 "Victorian Heart Institute, Monash University, Clayton, Victoria, Australia \(S.J.N.\)."), [Tugce Kalayci Oral](https://pubmed.ncbi.nlm.nih.gov/?term=Kalayci+Oral+T&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Paula P Terns](https://pubmed.ncbi.nlm.nih.gov/?term=Terns+PP&cauthor_id=42610271)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-14 "Dirección Médica, Cardiología Palermo-Centro de Investigaciones Clínicas, Buenos Aires, Argentina \(P.P.T.\)."), [Søren Rasmussen](https://pubmed.ncbi.nlm.nih.gov/?term=Rasmussen+S&cauthor_id=42610271)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-7 "Novo Nordisk A/S, Søborg, Denmark \(G.K.H., K.E., S.H.-L., T.K.O., S.R.\)."), [Paul M Ridker](https://pubmed.ncbi.nlm.nih.gov/?term=Ridker+PM&cauthor_id=42610271)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42610271/#short-view-affiliation-15 "Center for Cardiovascular Disease Prevention and Cardiovascular Division
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