---
title: "Sympathetic Overdrive, Vascular Dysfunction, and Exercise Intolerance in Long-Term Breast Cancer"
id: "journal-of-the-american-heart-association-65-sympathetic-neural-overactivation-vascular-dysfunction-and-exercise-intolerance-in-long-term-survivors-of-breast-cancer-treated-with-doxorubicin-and-trastuzumab-based-chemotherapy"
canonical_url: "https://medichelpline.com/clinical-feed/journal-of-the-american-heart-association-65-sympathetic-neural-overactivation-vascular-dysfunction-and-exercise-intolerance-in-long-term-survivors-of-breast-cancer-treated-with-doxorubicin-and-trastuzumab-based-chemotherapy"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "Journal of the American Heart Association"
source_url: "https://www.ahajournals.org/doi/abs/10.1161/JAHA.125.048047?ai=sg&mi=3&af=R"
published_at: "2026-03-13T11:32:58.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Sympathetic Overdrive, Vascular Dysfunction, and Exercise Intolerance in Long-Term Breast Cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/journal-of-the-american-heart-association-65-sympathetic-neural-overactivation-vascular-dysfunction-and-exercise-intolerance-in-long-term-survivors-of-breast-cancer-treated-with-doxorubicin-and-trastuzumab-based-chemotherapy
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** Journal of the American Heart Association
- **Source URL:** [Original Journal Publication](https://www.ahajournals.org/doi/abs/10.1161/JAHA.125.048047?ai=sg&mi=3&af=R)
- **Published At:** 2026-03-13T11:32:58.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
Journal of the American Heart Association, Volume 15, Issue 6 , March 17, 2026. BackgroundLong‐term survivors of breast cancer (BC) treated with doxorubicin and trastuzumab‐based chemotherapy are at increased risk of developing cardiovascular disease. However, the physiological mechanisms associated with increased cardiovascular disease risk are completely unknown. We hypothesized that long‐term survivors of BC, compared with controls, exhibit sympathetic neural hyperactivity, vascular dysfunction, cardiac morphofunctional changes, exercise intolerance, and alterations in the circulating milieu.MethodsTwenty‐three survivors of BC (age: 48.9±1.3 years; body mass index: 25.2±0.8 kg/m2) and 18 (age: 46.4±1.3 years; body mass index: 26.8±0.8 kg/m2) well‐matched controls were studied. Muscle sympathetic nerve activity (microneurography), brachial artery flow‐mediated dilation (ultrasound‐Doppler), carotid‐femoral pulse wave velocity (tonometry), left ventricular ejection fraction and global longitudinal strain (echocardiography), peak oxygen uptake (cardiopulmonary exercise testing), endothelial cell‐derived extracellular vesicles (flow cytometry), and plasma metabolome (mass spectrometry) were assessed. Complementary experiments were conducted on human umbilical vein endothelial cells cultured with plasma samples from subjects.ResultsSurvivors of breast cancer were tested ⁓8 years after cancer treatment completion.
## Clinical Analysis & Structured Key Points
Journal of the American Heart Association published a clinical update in Cardiology on 13 Mar 2026. The item focuses on Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long‐Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab‐Based Chemotherapy. Review the original article for the full source wording and details.
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