---
title: "Tricuspid-Valve Intervention in Heart Failure — Randomized Controlled Trial Overview"
id: "pubmed-42670975"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42670975"
content_type: "clinical_feed_article"
specialty: "Cardiology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42670975/"
doi: "10.1056/NEJMoa2606934"
published_at: "2026-10-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Tricuspid-Valve Intervention in Heart Failure — Randomized Controlled Trial Overview
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42670975
- **Specialty:** [Cardiology](https://medichelpline.com/clinical-feed/cardiology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42670975/)
- **DOI:** [10.1056/NEJMoa2606934](https://doi.org/10.1056%2FNEJMoa2606934)
- **Published At:** 2026-10-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This record reports a randomized controlled trial titled **Tricuspid-Valve Intervention in Heart Failure** published in the New England Journal of Medicine (NEJM). - Publication metadata: NEJM, 2026 Oct 8; volume 395(14):1363–1373; doi: 10.1056/NEJMoa2606934; Epub 2026 Aug 30. The full text is linked through NEJM/Atypon. - The work lists numerous cardiology investigators and institutions across Germany and collaborators under the corporate author **TRIC-I-HF-DZHK24 Investigators**. Lead authors include Jörg Hausleiter and Thomas J. Stocker, among many others. - Affiliations include Ludwig-Maximilians-Universität München, Technical University of Munich Heart Center, and multiple university heart centers and DZHK partner sites in Germany; international collaborator affiliations include Royal College of Surgeons in Ireland and Dublin cardiovascular institutes. - The PubMed entry classifies the article as a **Randomized Controlled Trial**. - The abstract and detailed trial methods, patient population, intervention specifics, outcomes, safety results, statistical analyses, and numeric findings are not included in the provided PubMed page content excerpt. Details of trial endpoints, inclusion/exclusion criteria, device or procedural descriptions, and results were not reported in the source excerpt. - The PubMed entry provides navigation to Title & authors, Abstract, Similar articles, and Related information; however, the excerpt contained only the bibliographic and author metadata. - Readers are referred to the NEJM full text link (doi: 10.1056/NEJMoa2606934) for complete trial design, results, and clinical interpretation, as those elements were not available in the supplied source content.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 30. # Tricuspid-Valve Intervention in Heart Failure [Jörg Hausleiter](https://pubmed.ncbi.nlm.nih.gov/?term=Hausleiter+J&cauthor_id=42670975)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-1 "Department of Medicine I, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-2 "German Center for Cardiovascular Research \(DZHK\) Partner Site Munich Heart Alliance, Munich."), [Thomas J Stocker](https://pubmed.ncbi.nlm.nih.gov/?term=Stocker+TJ&cauthor_id=42670975)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-1 "Department of Medicine I, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-2 "German Center for Cardiovascular Research \(DZHK\) Partner Site Munich Heart Alliance, Munich."), [Tobias Geisler](https://pubmed.ncbi.nlm.nih.gov/?term=Geisler+T&cauthor_id=42670975)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-3 "Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany."), [Philipp Lurz](https://pubmed.ncbi.nlm.nih.gov/?term=Lurz+P&cauthor_id=42670975)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-4 "Department of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-5 "DZHK Partner Site Rhine-Main, Germany \[several locations\]."), [Wolfgang Rottbauer](https://pubmed.ncbi.nlm.nih.gov/?term=Rottbauer+W&cauthor_id=42670975)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-6 "Department of Cardiology, University Heart Center, Ulm, Germany."), [Edith Lubos](https://pubmed.ncbi.nlm.nih.gov/?term=Lubos+E&cauthor_id=42670975)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-7 "Department of Cardiology, Asklepios Klinik Barmbek, Hamburg, Germany."), [Niklas Schofer](https://pubmed.ncbi.nlm.nih.gov/?term=Schofer+N&cauthor_id=42670975)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-8 "Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-9 "Department of Cardiology, Electrophysiology, Pulmonology, and General Internal Medicine, Friedrich-Ebert-Krankenhaus Neumünster, Neumünster, Germany.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-10 "DZHK Partner Site North, Hamburg-Kiel-Luebeck, Germany."), [Christian Frerker](https://pubmed.ncbi.nlm.nih.gov/?term=Frerker+C&cauthor_id=42670975)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-10 "DZHK Partner Site North, Hamburg-Kiel-Luebeck, Germany.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-11 "University of Luebeck, Heart Center, Luebeck, Germany.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-12 "Department of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein, Luebeck, Germany."), [Johanne Frank](https://pubmed.ncbi.nlm.nih.gov/?term=Frank+J&cauthor_id=42670975)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-10 "DZHK Partner Site North, Hamburg-Kiel-Luebeck, Germany.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-13 "Department of Cardiology and Internal Intensive Medicine, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany."), [Holger Thiele](https://pubmed.ncbi.nlm.nih.gov/?term=Thiele+H&cauthor_id=42670975)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-10 "DZHK Partner Site North, Hamburg-Kiel-Luebeck, Germany.")[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-14 "Department of Cardiology, Heart Center Leipzig, Leipzig University, Leipzig, Germany."), [Rico Osteresch](https://pubmed.ncbi.nlm.nih.gov/?term=Osteresch+R&cauthor_id=42670975)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-15 "Bremen Institute for Heart and Circulation Research, Klinikum Links der Weser, Bremen, Germany."), [Volker Rudolph](https://pubmed.ncbi.nlm.nih.gov/?term=Rudolph+V&cauthor_id=42670975)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-16 "Heart and Diabetes Center North Rhine-Westphalia, Department of General and Interventional Cardiology/Angiology, Ruhr University Bochum, Bad Oeynhausen, Germany."), [Alexander Lauten](https://pubmed.ncbi.nlm.nih.gov/?term=Lauten+A&cauthor_id=42670975)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-17 "Department of General and Interventional Cardiology and Rhythmology, Helios Klinikum Erfurt, Health and Medical University Erfurt, Erfurt, Germany."), [Erion Xhepa](https://pubmed.ncbi.nlm.nih.gov/?term=Xhepa+E&cauthor_id=42670975)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-2 "German Center for Cardiovascular Research \(DZHK\) Partner Site Munich Heart Alliance, Munich.")[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-18 "Department of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany."), [Jürgen Rothe](https://pubmed.ncbi.nlm.nih.gov/?term=Rothe+J&cauthor_id=42670975)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-19 "Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Bad Krozingen, Germany.")[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-20 "Department of Medicine, Freiburg University, Freiburg im Breisgau, Germany."), [Tienush Rassaf](https://pubmed.ncbi.nlm.nih.gov/?term=Rassaf+T&cauthor_id=42670975)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-21 "Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Essen, Germany."), [Stephan Baldus](https://pubmed.ncbi.nlm.nih.gov/?term=Baldus+S&cauthor_id=42670975)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-22 "Department of Cardiology, University Hospital Cologne, Cologne, Germany."), [Georg Nickenig](https://pubmed.ncbi.nlm.nih.gov/?term=Nickenig+G&cauthor_id=42670975)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-23 "Heart Center University Hospital Bonn, Bonn, Germany."), [David M Leistner](https://pubmed.ncbi.nlm.nih.gov/?term=Leistner+DM&cauthor_id=42670975)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-5 "DZHK Partner Site Rhine-Main, Germany \[several locations\].")[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-24 "Department of Cardiology and Angiology, Goethe University, Frankfurt am Main, Germany."), [Eike Tigges](https://pubmed.ncbi.nlm.nih.gov/?term=Tigges+E&cauthor_id=42670975)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-25 "Department of Cardiology and Intensive Care Medicine, Asklepios Clinic St. Georg, Hamburg, Germany."), [Victoria Kehl](https://pubmed.ncbi.nlm.nih.gov/?term=Kehl+V&cauthor_id=42670975)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-26 "Münchner Studienzentrum, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.")[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-27 "Biostatistics and Clinical Epidemiology, Institute for AI and Informatics in Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany."), [Mirjam Kessler](https://pubmed.ncbi.nlm.nih.gov/?term=Kessler+M&cauthor_id=42670975)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-6 "Department of Cardiology, University Heart Center, Ulm, Germany."), [Tobias Kister](https://pubmed.ncbi.nlm.nih.gov/?term=Kister+T&cauthor_id=42670975)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-14 "Department of Cardiology, Heart Center Leipzig, Leipzig University, Leipzig, Germany."), [Tobias Ruf](https://pubmed.ncbi.nlm.nih.gov/?term=Ruf+T&cauthor_id=42670975)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-4 "Department of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-5 "DZHK Partner Site Rhine-Main, Germany \[several locations\]."), [Muhammed Gerçek](https://pubmed.ncbi.nlm.nih.gov/?term=Ger%C3%A7ek+M&cauthor_id=42670975)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-16 "Heart and Diabetes Center North Rhine-Westphalia, Department of General and Interventional Cardiology/Angiology, Ruhr University Bochum, Bad Oeynhausen, Germany."), [Meinrad Gawaz](https://pubmed.ncbi.nlm.nih.gov/?term=Gawaz+M&cauthor_id=42670975)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-3 "Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany."), [Derk Frank](https://pubmed.ncbi.nlm.nih.gov/?term=Frank+D&cauthor_id=42670975)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-10 "DZHK Partner Site North, Hamburg-Kiel-Luebeck, Germany.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-13 "Department of Cardiology and Internal Intensive Medicine, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany."), [Ingo Eitel](https://pubmed.ncbi.nlm.nih.gov/?term=Eitel+I&cauthor_id=42670975)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-10 "DZHK Partner Site North, Hamburg-Kiel-Luebeck, Germany.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-11 "University of Luebeck, Heart Center, Luebeck, Germany.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-12 "Department of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein, Luebeck, Germany."), [Ralph Stephan von Bardeleben](https://pubmed.ncbi.nlm.nih.gov/?term=von+Bardeleben+RS&cauthor_id=42670975)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-4 "Department of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-5 "DZHK Partner Site Rhine-Main, Germany \[several locations\]."), [Daniel Kalbacher](https://pubmed.ncbi.nlm.nih.gov/?term=Kalbacher+D&cauthor_id=42670975)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-8 "Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-10 "DZHK Partner Site North, Hamburg-Kiel-Luebeck, Germany."), [Osama Soliman](https://pubmed.ncbi.nlm.nih.gov/?term=Soliman+O&cauthor_id=42670975)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-28 "Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin.")[ 29 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-29 "Cardiovascular Research Institute Dublin, Mater Private Network, Dublin.")[ 30 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-30 "Department of Cardiology, Mater Private Network, Dublin."), [Michael Näbauer](https://pubmed.ncbi.nlm.nih.gov/?term=N%C3%A4bauer+M&cauthor_id=42670975)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-1 "Department of Medicine I, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany."), [Steffen Massberg](https://pubmed.ncbi.nlm.nih.gov/?term=Massberg+S&cauthor_id=42670975)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-1 "Department of Medicine I, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42670975/#full-view-affiliation-2 "German Center for Cardiovascular Research \(DZHK\) Partner Site Munich Heart Alliance, Munich."); [TRIC-I-HF-DZHK24 Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=TRIC-I-HF-DZHK24+Investigators%5BCorporate+Author%5D) Collaborators, Affiliations Expand ### Collaborators * **TRIC-I-HF-DZHK24 Investigators** : [Thomas Stocker](https://pubmed.ncbi.nlm.nih.gov/?term=Stocker+T), [Jörg Hausleiter](https://pubmed.ncbi.nlm.nih.gov/?term=Hausleiter+J), [Steffen Massberg](https://pubmed.ncbi.nlm.nih.gov/?term=Massberg+S), [Michael Näbauer](https://pubmed.ncbi.nlm.nih.gov/?term=N%C3%A4bauer+M), [Lukas Stolz](https://pubmed.ncbi.nlm.nih.gov/?term=Stolz+L), [Philipp Doldi](https://pubmed.ncbi.nlm.nih.gov/?term=Doldi+P), [Julia Novotny](https://pubmed.ncbi.nlm.nih.gov/?term=Novotny+J), [Ludwig Weckbach](https://pubmed.ncbi.nlm.nih.gov/?term=Weckbach+L), [Tobias Geisler](https://pubmed.ncbi.nlm.nih.gov/?term=Geisler
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