---
title: "Accuracy of Dexcom G7 Continuous Glucose Monitoring in Critically Ill Patients"
id: "pubmed-42765166"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42765166"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42765166/"
doi: "10.1177/19322968261486451"
published_at: "2026-09-21T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Accuracy of Dexcom G7 Continuous Glucose Monitoring in Critically Ill Patients
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42765166
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42765166/)
- **DOI:** [10.1177/19322968261486451](https://doi.org/10.1177%2F19322968261486451)
- **Published At:** 2026-09-21T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This prospective ancillary study evaluated the accuracy of the **Dexcom G7** interstitial continuous glucose monitoring (**CGM**) system in 20 critically ill adult patients with stress hyperglycemia and no prior diabetes, expected to remain in the ICU ≥5 days. - CGM values were compared with arterial blood glucose over the first 10 ICU days using paired measurements, mean bias, mean absolute relative difference (**MARD**), linear regression (R2), and Clarke error grid analysis. - Outside intravenous glucose tolerance tests (**IVGTT**), 716 paired values demonstrated moderate agreement: R2 = 0.58, mean bias +11 mg/dL, and MARD 17%; 98.9% of values fell in Clarke error grid zones A or B. - During IVGTT (rapid glucose excursions), accuracy worsened markedly across 1,018 paired values: R2 = 0.028, mean bias −34 mg/dL, and MARD 24%; only 80.3% of values were in zones A/B while 18.6% were in zone D. - A post hoc 20-minute temporal shift analysis to account for CGM delay improved metrics during IVGTT: R2 = 0.34, MARD 19%, and 94.7% of values in zones A/B. - No sensor-related adverse events were reported in the study population. - Authors conclude that **Dexcom G7** provides acceptable accuracy during relatively stable ICU conditions but performs poorly during rapid glycemic excursions; thus, a hybrid monitoring approach pairing **CGM** with intermittent blood glucose confirmation may be preferable in critically ill patients. - Study design, population size (n=20), and exact patient characteristics beyond inclusion criteria were reported; additional methodological details and longer-term outcomes were not provided in the abstract.
## Clinical Analysis & Structured Key Points
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Online ahead of print. # Accuracy of an Interstitial Continuous Glucose Management System in Critically Ill Patients: A Prospective Observational Study [Marie Seret](https://pubmed.ncbi.nlm.nih.gov/?term=Seret+M&cauthor_id=42765166)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-1 "Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium."), [Claire Dupuis](https://pubmed.ncbi.nlm.nih.gov/?term=Dupuis+C&cauthor_id=42765166)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-2 "Médecine Intensive et Réanimation, Clermont-Ferrand University Hospital, France.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium."), [Vanessa Alves de Araújo](https://pubmed.ncbi.nlm.nih.gov/?term=Alves+de+Ara%C3%BAjo+V&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-4 "Faculty of Nutrition \(FANUT\), Federal University of Goiás, Goiânia, Brazil.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-5 "Hospital das Clínicas \(HC-UFG/EBSERH\), Federal University of Goiás, Goiânia, Brazil."), [Claudio Annicchiarico](https://pubmed.ncbi.nlm.nih.gov/?term=Annicchiarico+C&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium."), [Gabriela Macedo](https://pubmed.ncbi.nlm.nih.gov/?term=Macedo+G&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-6 "Faculty of Medicine, Universidade da Região de Joinville \(UNIVILLE\), Brazil.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-7 "Pontifícia Universidade Católica do Paraná \(PUCPR\), Rua Imaculada Conceição, Curitiba, Brazil."), [Caio Pinto Teixeira Araujo](https://pubmed.ncbi.nlm.nih.gov/?term=Pinto+Teixeira+Araujo+C&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-8 "University of Campinas \(UNICAMP\), Brazil.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-9 "Hospital de Clínicas \(HC-UNICAMP\), University of Campinas \(UNICAMP\), Brazil."), [Fabio Taccone](https://pubmed.ncbi.nlm.nih.gov/?term=Taccone+F&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium."), [Miriam Cnop](https://pubmed.ncbi.nlm.nih.gov/?term=Cnop+M&cauthor_id=42765166)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-10 "Division of Endocrinology, ULB Erasmus Hospital, Brussels University Hospital, Université Libre de Bruxelles, Belgium.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-11 "ULB Center for Diabetes Research, Université Libre de Bruxelles, Belgium.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-12 "WEL Research Institute, Wavre, Belgium."), [Thomas Desaive](https://pubmed.ncbi.nlm.nih.gov/?term=Desaive+T&cauthor_id=42765166)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-1 "Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium."), [Vincent Uyttendaele](https://pubmed.ncbi.nlm.nih.gov/?term=Uyttendaele+V&cauthor_id=42765166)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-1 "Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium."), [Jean-Charles Preiser](https://pubmed.ncbi.nlm.nih.gov/?term=Preiser+JC&cauthor_id=42765166)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#full-view-affiliation-13 "Department of Internal Medicine, Erasme University Hospital, Free University of Brussels, Belgium.") Affiliations Expand ### Affiliations * 1 Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium. * 2 Médecine Intensive et Réanimation, Clermont-Ferrand University Hospital, France. * 3 Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Belgium. * 4 Faculty of Nutrition (FANUT), Federal University of Goiás, Goiânia, Brazil. * 5 Hospital das Clínicas (HC-UFG/EBSERH), Federal University of Goiás, Goiânia, Brazil. * 6 Faculty of Medicine, Universidade da Região de Joinville (UNIVILLE), Brazil. * 7 Pontifícia Universidade Católica do Paraná (PUCPR), Rua Imaculada Conceição, Curitiba, Brazil. * 8 University of Campinas (UNICAMP), Brazil. * 9 Hospital de Clínicas (HC-UNICAMP), University of Campinas (UNICAMP), Brazil. * 10 Division of Endocrinology, ULB Erasmus Hospital, Brussels University Hospital, Université Libre de Bruxelles, Belgium. * 11 ULB Center for Diabetes Research, Université Libre de Bruxelles, Belgium. * 12 WEL Research Institute, Wavre, Belgium. * 13 Department of Internal Medicine, Erasme University Hospital, Free University of Brussels, Belgium. * PMID: **42765166** * DOI: [ 10.1177/19322968261486451 ](https://doi.org/10.1177/19322968261486451) Item in Clipboard # Accuracy of an Interstitial Continuous Glucose Management System in Critically Ill Patients: A Prospective Observational Study Marie Seret et al. J Diabetes Sci Technol. 2026. Show details Display options Display options Format Abstract PubMed PMID J Diabetes Sci Technol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Diabetes+Sci+Technol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Diabetes+Sci+Technol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42765166/) . 2026 Sep 21:19322968261486451. doi: 10.1177/19322968261486451. Online ahead of print. ### Authors [Marie Seret](https://pubmed.ncbi.nlm.nih.gov/?term=Seret+M&cauthor_id=42765166)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-1 "Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium."), [Claire Dupuis](https://pubmed.ncbi.nlm.nih.gov/?term=Dupuis+C&cauthor_id=42765166)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-2 "Médecine Intensive et Réanimation, Clermont-Ferrand University Hospital, France.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium."), [Vanessa Alves de Araújo](https://pubmed.ncbi.nlm.nih.gov/?term=Alves+de+Ara%C3%BAjo+V&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-4 "Faculty of Nutrition \(FANUT\), Federal University of Goiás, Goiânia, Brazil.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-5 "Hospital das Clínicas \(HC-UFG/EBSERH\), Federal University of Goiás, Goiânia, Brazil."), [Claudio Annicchiarico](https://pubmed.ncbi.nlm.nih.gov/?term=Annicchiarico+C&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium."), [Gabriela Macedo](https://pubmed.ncbi.nlm.nih.gov/?term=Macedo+G&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-6 "Faculty of Medicine, Universidade da Região de Joinville \(UNIVILLE\), Brazil.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-7 "Pontifícia Universidade Católica do Paraná \(PUCPR\), Rua Imaculada Conceição, Curitiba, Brazil."), [Caio Pinto Teixeira Araujo](https://pubmed.ncbi.nlm.nih.gov/?term=Pinto+Teixeira+Araujo+C&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-8 "University of Campinas \(UNICAMP\), Brazil.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-9 "Hospital de Clínicas \(HC-UNICAMP\), University of Campinas \(UNICAMP\), Brazil."), [Fabio Taccone](https://pubmed.ncbi.nlm.nih.gov/?term=Taccone+F&cauthor_id=42765166)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-3 "Department of Intensive Care, Hôpital Universitaire de Bruxelles \(HUB\), Université Libre de Bruxelles \(ULB\), Belgium."), [Miriam Cnop](https://pubmed.ncbi.nlm.nih.gov/?term=Cnop+M&cauthor_id=42765166)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-10 "Division of Endocrinology, ULB Erasmus Hospital, Brussels University Hospital, Université Libre de Bruxelles, Belgium.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-11 "ULB Center for Diabetes Research, Université Libre de Bruxelles, Belgium.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-12 "WEL Research Institute, Wavre, Belgium."), [Thomas Desaive](https://pubmed.ncbi.nlm.nih.gov/?term=Desaive+T&cauthor_id=42765166)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-1 "Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium."), [Vincent Uyttendaele](https://pubmed.ncbi.nlm.nih.gov/?term=Uyttendaele+V&cauthor_id=42765166)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-1 "Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium."), [Jean-Charles Preiser](https://pubmed.ncbi.nlm.nih.gov/?term=Preiser+JC&cauthor_id=42765166)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42765166/#short-view-affiliation-13 "Department of Internal Medicine, Erasme University Hospital, Free University of Brussels, Belgium.") ### Affiliations * 1 Model-Based Therapeutics, GIGA Institute, University of Liège, Belgium. * 2 Médecine Intensive et Réanimation, Clermont-Ferrand University Hospital, France. * 3 Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Belgium. * 4 Faculty of Nutrition (FANUT), Federal University of Goiás, Goiânia, Brazil. * 5 Hospital das Clínicas (HC-UFG/EBSERH), Federal University of Goiás, Goiânia, Brazil. * 6 Faculty of Medicine, Universidade da Região de Joinville (UNIVILLE), Brazil. * 7 Pontifícia Universidade Católica do Paraná (PUCPR), Rua Imaculada Conceição, Curitiba, Brazil. * 8 University of Campinas (UNICAMP), Brazil. * 9 Hospital de Clínicas (HC-UNICAMP), University of Campinas (UNICAMP), Brazil. * 10 Division of Endocrinology, ULB Erasmus Hospital, Brussels University Hospital, Université Libre de Bruxelles, Belgium. * 11 ULB Center for Diabetes Research, Université Libre de Bruxelles, Belgium. * 12 WEL Research Institute, Wavre, Belgium. * 13 Department of Internal Medicine, Erasme University Hospital, Free University of Brussels, Belgium. * PMID: **42765166** * DOI: [ 10.1177/19322968261486451 ](https://doi.org/10.1177/19322968261486451) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Introduction:** Glycemic management in the intensive care unit (ICU) remains challenging because glucose levels fluctuate rapidly and monitoring is intermittent. Interstitial continuous glucose monitoring (CGM) could improve surveillance, but its performance during rapid glucose excursions remains uncertain. We assessed the accuracy of the Dexcom G7 CGM in critically ill patients under stable conditions and during intravenous glucose tolerance tests (IVGTT). **Methods:** We conducted a prospective ancillary study of the Determination of Insulin Resistance in ICU (DIRICU) study. Twenty critically ill adults with stress hyperglycemia, no prior diabetes, and expected ICU stay ≥5 days were included. A Dexcom G7 sensor was compared with arterial blood glucose measurements. Accuracy was assessed over the first 10 ICU days using paired measurements, mean bias, mean absolute relative difference (MARD), linear regression (_R_ 2), and Clarke error grid analysis, both outside and during IVGTT. A post hoc 20-minute temporal shift analysis was performed to account for delayed CGM peaks. **Results:** Outside IVGTT, 716 paired values showed moderate agreement with reference glucose (_R_ 2 = .58, mean bias +11 mg/dL, MARD 17%), with 98.9% of values in Clarke zones A/B. During IVGTT, accuracy deteriorated markedly (1018 paired values): _R_ 2 = .028, mean bias -34 mg/dL, MARD 24%, and only 80.3% of values in zones A/B, with 18.6% in zone D. After temporal shifting, performance improved (_R_ 2 = .34, MARD 19%, 94.7% in zones A/B). No sensor-related adverse events occurred. **Conclusions:** Dexcom G7 showed acceptable accuracy during stable ICU conditions, but performance deteriorated during rapid glucose excursions. Hybrid monitoring strategies combining CGM with intermittent blood glucose confirmation may therefore be preferable in critically ill patients. **Keywords:** Dexcom G7; accuracy; continuous glucose monitoring; intensive care. 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