---
title: "Antenatal Interventions to Improve Newborn Survival: LiST Model Updates"
id: "pubmed-42825345"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42825345"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42825345/"
doi: "10.7189/jogh.16.04303"
published_at: "2026-10-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Antenatal Interventions to Improve Newborn Survival: LiST Model Updates
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42825345
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42825345/)
- **DOI:** [10.7189/jogh.16.04303](https://doi.org/10.7189%2Fjogh.16.04303)
- **Published At:** 2026-10-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This review summarizes recent effect estimates for antenatal and intrapartum interventions relevant to **newborn survival** and their incorporation into the Lives Saved Tool (LiST). - Researchers searched PubMed and CENTRAL (2022–2023) and consulted a technical advisory group to determine which meta-analysed effect estimates to update or retain for LiST. - Key antenatal interventions reviewed include **maternal immunization**, screening and management of infections, treatment of chronic conditions (hypertension, diabetes), nutritional supplementation, psychosocial smoking-cessation interventions, and management of preterm pre-labour rupture of membranes (PPROM). - The review reports that **tetanus toxoid vaccination** during pregnancy was associated with a meaningful reduction in neonatal mortality. - For PPROM, **antibiotics** reduced neonatal mortality related to sepsis; **corticosteroids** for fetal lung maturation reduced mortality attributed to prematurity. - Nutritional interventions — balanced protein-energy supplementation and **multiple micronutrient supplementation** — lowered risks of small-for-gestational-age (SGA) births. - Interventions reducing stillbirth risk included **insecticide-treated bed nets** for malaria, antibiotic treatment for maternal syphilis, and **post-term induction of labour**. - Evidence on interventions affecting preterm birth outcomes informed LiST inputs for treatment of asymptomatic bacteriuria, **omega-3 fatty acids**, **calcium supplementation**, and **low-dose aspirin** for pre-eclampsia, projecting reductions in SGA risk. - Authors conclude that these updated estimates can be used as LiST inputs to model the impact of context-specific antenatal healthcare packages on neonatal survival. - The review emphasizes implementation of high-yield, context-appropriate antenatal packages to improve neonatal outcomes and survival.
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Affiliations Expand ### Affiliations * 1 Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan. * 2 Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. * 3 Center for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada. * 4 Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan. * PMID: **42825345** * DOI: [ 10.7189/jogh.16.04303 ](https://doi.org/10.7189/jogh.16.04303) Item in Clipboard Review # Antenatal interventions to support newborn survival: updates for the Lives Saved Tool Rahima Yasin et al. J Glob Health. 2026. Show details Display options Display options Format Abstract PubMed PMID J Glob Health Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Glob+Health%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Glob+Health%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42825345/) . 2026 Oct 2:16:04303. doi: 10.7189/jogh.16.04303. ### Authors [Rahima Yasin](https://pubmed.ncbi.nlm.nih.gov/?term=Yasin+R&cauthor_id=42825345)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-1 "Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan."), [Yvonne Tam](https://pubmed.ncbi.nlm.nih.gov/?term=Tam+Y&cauthor_id=42825345)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-2 "Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA."), [Arjumand Rizvi](https://pubmed.ncbi.nlm.nih.gov/?term=Rizvi+A&cauthor_id=42825345)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-1 "Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan."), [Tyler Vaivada](https://pubmed.ncbi.nlm.nih.gov/?term=Vaivada+T&cauthor_id=42825345)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-3 "Center for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada."), [Ayesha Arshad Ali](https://pubmed.ncbi.nlm.nih.gov/?term=Ali+AA&cauthor_id=42825345)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-1 "Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan."), [Robert E Black](https://pubmed.ncbi.nlm.nih.gov/?term=Black+RE&cauthor_id=42825345)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-2 "Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA."), [Jai K Das](https://pubmed.ncbi.nlm.nih.gov/?term=Das+JK&cauthor_id=42825345)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-1 "Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-4 "Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan."), [Zulfiqar A Bhutta](https://pubmed.ncbi.nlm.nih.gov/?term=Bhutta+ZA&cauthor_id=42825345)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-1 "Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42825345/#short-view-affiliation-3 "Center for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.") ### Affiliations * 1 Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan. * 2 Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. * 3 Center for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada. * 4 Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan. * PMID: **42825345** * DOI: [ 10.7189/jogh.16.04303 ](https://doi.org/10.7189/jogh.16.04303) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Background:** Antenatal care strategies encompass a series of interventions delivered to expectant mothers to optimise both their health outcomes and those of their neonate. We summarise the most recent effect estimates for maternal immunisation, screening and management of infections, pre-existing chronic diseases such as hypertension and diabetes, nutrition, psychosocial interventions for smoking cessation, pre-term pre-labour rupture of membranes, administration of corticosteroids for foetal lung maturation, and induction of post-term labour. **Methods:** We synthesised effect estimates for antenatal and intrapartum interventions using PubMed and CENTRAL searches (2022-2023) and in consultation with a technical advisory group to determine whether and how new meta-analysed effect estimates could be incorporated into the Lives Saved Tool (LiST) model, as well as which of these estimates should be updated and which should be retained. **Results:** Tetanus toxoid vaccination during the antenatal period lead to a significant reduction in neonatal mortality. Antibiotics for pre-term pre-labour rupture of membranes and administration of corticosteroids for foetal lung maturation lead to significant reductions in neonatal mortality due to sepsis and prematurity, respectively. Nutritional interventions including balanced protein and energy supplementation and multiple micronutrient supplementation reduced the risks of small-for-gestational-age babies. Insecticide-treated bed-nets for malaria, antibiotic treatment of syphilis, and post-term induction of labour demonstrated significant reductions in the risks of stillbirth. The effect estimates for preterm births contributed to the LiST model for interventions including treatment of asymptomatic bacteriuria, omega-3 fatty acid supplementation, calcium supplementation, and provision of low-dose aspirin for pre-eclampsia, which projected significant reductions in the risks of small-for-gestational-age babies. **Conclusions:** The evidence described here highlights the potential impact of implementing high-yield healthcare packages in context-specific settings to effectively improve neonatal survival. These estimates can be used as inputs to model the impact of antenatal care interventions using the LiST. **Keywords:** Lives Saved Tool; antenatal care; infectious disease; neonatal health; nutrition; vaccination. © 2026 The Authors. 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