---
title: "Body Roundness Index and Risk of Current Asthma in Children and Adolescents: NHANES 1999–2020"
id: "pubmed-42560486"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42560486"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42560486/"
doi: "10.1080/03014460.2026.2705281"
published_at: "2026-08-06T12:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Body Roundness Index and Risk of Current Asthma in Children and Adolescents: NHANES 1999–2020
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42560486
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42560486/)
- **DOI:** [10.1080/03014460.2026.2705281](https://doi.org/10.1080%2F03014460.2026.2705281)
- **Published At:** 2026-08-06T12:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This cross-sectional analysis used data from NHANES 1999–2020 to examine the association between **Body Roundness Index (BRI)** and current asthma in children and adolescents aged 6–20 years. - The analytic sample included 28,789 participants. Current asthma was identified from questionnaire responses. - **BRI**, calculated from waist circumference and height, was the primary exposure representing central adiposity; **BMI z-score** was included for comparative predictive analyses. - Weighted multivariable logistic regression showed higher BRI was associated with increased odds of current asthma (OR 1.233, 95% CI 1.158–1.313, p < 0.001). - Restricted cubic spline (RCS) models suggested a **nonlinear** relationship between BRI and asthma risk. - In fully adjusted models, BRI and BMI z-score had **comparable discriminative performance** by weighted ROC analyses; no significant difference in AUC was reported. - Authors conclude higher BRI is positively associated with current asthma in youth and recommend prospective studies to clarify temporality and biological mechanisms. - The abstract does not report specific covariates included in adjusted models, exact AUC values, or details of subgroup and sensitivity analyses; these details were not reported in the source abstract.
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Epub 2026 Aug 6. # Association between body roundness index and asthma in children and adolescents: findings from NHANES 1999-2020 [Tingqiaonan Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+T&cauthor_id=42560486)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42560486/#full-view-affiliation-1 "Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China."), [Shujing Cai](https://pubmed.ncbi.nlm.nih.gov/?term=Cai+S&cauthor_id=42560486)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42560486/#full-view-affiliation-1 "Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China."), [Huiqin Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+H&cauthor_id=42560486)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42560486/#full-view-affiliation-1 "Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China.") Affiliations Expand ### Affiliation * 1 Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China. * PMID: **42560486** * DOI: [ 10.1080/03014460.2026.2705281 ](https://doi.org/10.1080/03014460.2026.2705281) Item in Clipboard # Association between body roundness index and asthma in children and adolescents: findings from NHANES 1999-2020 Tingqiaonan Chen et al. Ann Hum Biol. 2026 Dec. Show details Display options Display options Format Abstract PubMed PMID Ann Hum Biol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Ann+Hum+Biol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Ann+Hum+Biol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42560486/) . 2026 Dec;53(1):2705281. doi: 10.1080/03014460.2026.2705281. Epub 2026 Aug 6. ### Authors [Tingqiaonan Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+T&cauthor_id=42560486)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42560486/#short-view-affiliation-1 "Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China."), [Shujing Cai](https://pubmed.ncbi.nlm.nih.gov/?term=Cai+S&cauthor_id=42560486)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42560486/#short-view-affiliation-1 "Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China."), [Huiqin Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+H&cauthor_id=42560486)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42560486/#short-view-affiliation-1 "Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China.") ### Affiliation * 1 Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China. * PMID: **42560486** * DOI: [ 10.1080/03014460.2026.2705281 ](https://doi.org/10.1080/03014460.2026.2705281) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Childhood and adolescent asthma remains a major public health concern, and obesity may contribute through mechanical and inflammatory pathways. The Body Roundness Index (BRI), derived from waist circumference and height, may better reflect central adiposity than general body-size measures. **Aim:** To investigate the association between BRI and asthma in children and adolescents. **Subjects and methods:** A total of 28,789 National Health and Nutrition Examination Survey (NHANES) 1999-2020 participants aged 6-20 years were included. Current asthma was identified using questionnaire data. BRI, calculated from waist circumference and height, was used as the primary exposure. Weighted multivariable logistic regression models were used to examine the association between BRI and current asthma, and restricted cubic spline (RCS) models were applied to assess potential nonlinear associations. Subgroup and sensitivity analyses were performed to assess the robustness of the findings. Weighted receiver operating characteristic (ROC) analyses were used to compare the predictive abilities of BRI and Body Mass Index (BMI) z-score in fully adjusted models. **Results:** Higher BRI was associated with higher odds of current asthma (OR = 1.233, 95% CI:1.158-1.313, _p_ < 0.001). RCS analysis suggested a nonlinear association between BRI and current asthma. In fully adjusted analyses, BRI and BMI z score showed comparable discriminative performance, with no significant difference in the area under the curve. **Conclusions:** Higher BRI was positively associated with current asthma among children and adolescents. Future prospective studies are warranted to clarify the temporal relationship and underlying biological mechanisms. **Keywords:** Body Roundness Index; NHANES; asthma; children and adolescents; obesity. 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