---
title: "β‑Caryophyllene (CB2 agonist) reduces lung inflammation after 5/6 nephrectomy in mice"
id: "pubmed-42732653"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42732653"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42732653/"
doi: "10.1016/j.bbrc.2026.154579"
published_at: "2026-10-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# β‑Caryophyllene (CB2 agonist) reduces lung inflammation after 5/6 nephrectomy in mice
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42732653
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42732653/)
- **DOI:** [10.1016/j.bbrc.2026.154579](https://doi.org/10.1016%2Fj.bbrc.2026.154579)
- **Published At:** 2026-10-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study used a 5/6 partial nephrectomy (PNx) mouse model to simulate **chronic kidney disease** and its pulmonary consequences; investigators compared sham, PNx+vehicle, and PNx+β‑caryophyllene (βC) groups. - Treatment with **β‑caryophyllene** was given at 10 mg/kg/day from postoperative day 7 through day 14; assessments occurred on day 15 and included bronchoalveolar lavage, blood sampling, organ collection, and lung histology. - PNx animals developed pulmonary inflammation marked by increased leukocyte infiltration, elevated MPO activity, greater protein content in bronchoalveolar lavage, histologic lung injury, and increased superoxide generation, investigators reported. - Western blotting showed higher pulmonary **ICAM‑1** expression in PNx mice; the study team observed that **β‑caryophyllene** treatment reduced inflammatory cell infiltration, decreased protein extravasation, and lowered ICAM‑1 levels in the lungs. - The authors reported that **β‑caryophyllene** improved renal function parameters in PNx mice, which the team suggested may have contributed to reduced lung inflammation but did not specify which renal biomarkers changed in the abstract. - Expression of **CB2** receptors in lung tissue did not differ across experimental groups, according to the data presented in the abstract. - The report did not include clinical human data, details on specific renal function measurements in the abstract, nor safety/tolerability endpoints for β‑caryophyllene in this model beyond the described findings. - Funding disclosures: several authors reported financial support from the National Council for Scientific and Technological Development and the Foundation for Research and Innovation of the Santa Catarina State; other authors declared no known competing interests.
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Epub 2026 Sep 10. # Beta-caryophyllene reduces lung inflammation secondary to chronic kidney disease [Bruna Barcelos de Simas](https://pubmed.ncbi.nlm.nih.gov/?term=Barcelos+de+Simas+B&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Maria Eduarda Sandin Milani Schütz](https://pubmed.ncbi.nlm.nih.gov/?term=Sandin+Milani+Sch%C3%BCtz+ME&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Gustavo Ferreira-Alves](https://pubmed.ncbi.nlm.nih.gov/?term=Ferreira-Alves+G&cauthor_id=42732653)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-2 "Department of Neurosciences "Rita Levi Montalcini" University of Turin, Turin, Italy."), [Filipe Rodolfo Moreira Borges Oliveira](https://pubmed.ncbi.nlm.nih.gov/?term=Moreira+Borges+Oliveira+FR&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Gustavo Jorge Dos Santos](https://pubmed.ncbi.nlm.nih.gov/?term=Dos+Santos+GJ&cauthor_id=42732653)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-3 "Department of Physiology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Evelise Nazari](https://pubmed.ncbi.nlm.nih.gov/?term=Nazari+E&cauthor_id=42732653)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-4 "Department of Cellular Biology, Embryology, and Genetics, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Daniel Fernandes](https://pubmed.ncbi.nlm.nih.gov/?term=Fernandes+D&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Regina Sordi](https://pubmed.ncbi.nlm.nih.gov/?term=Sordi+R&cauthor_id=42732653)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#full-view-affiliation-5 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil. Electronic address: r.sordi@ufsc.br.") Affiliations Expand ### Affiliations * 1 Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. * 2 Department of Neurosciences "Rita Levi Montalcini" University of Turin, Turin, Italy. * 3 Department of Physiology, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. * 4 Department of Cellular Biology, Embryology, and Genetics, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. * 5 Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. Electronic address: r.sordi@ufsc.br. * PMID: **42732653** * DOI: [ 10.1016/j.bbrc.2026.154579 ](https://doi.org/10.1016/j.bbrc.2026.154579) Free article Item in Clipboard # Beta-caryophyllene reduces lung inflammation secondary to chronic kidney disease Bruna Barcelos de Simas et al. Biochem Biophys Res Commun. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42732653/) . 2026 Oct 22:836:154579. doi: 10.1016/j.bbrc.2026.154579. Epub 2026 Sep 10. ### Authors [Bruna Barcelos de Simas](https://pubmed.ncbi.nlm.nih.gov/?term=Barcelos+de+Simas+B&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Maria Eduarda Sandin Milani Schütz](https://pubmed.ncbi.nlm.nih.gov/?term=Sandin+Milani+Sch%C3%BCtz+ME&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Gustavo Ferreira-Alves](https://pubmed.ncbi.nlm.nih.gov/?term=Ferreira-Alves+G&cauthor_id=42732653)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-2 "Department of Neurosciences "Rita Levi Montalcini" University of Turin, Turin, Italy."), [Filipe Rodolfo Moreira Borges Oliveira](https://pubmed.ncbi.nlm.nih.gov/?term=Moreira+Borges+Oliveira+FR&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Gustavo Jorge Dos Santos](https://pubmed.ncbi.nlm.nih.gov/?term=Dos+Santos+GJ&cauthor_id=42732653)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-3 "Department of Physiology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Evelise Nazari](https://pubmed.ncbi.nlm.nih.gov/?term=Nazari+E&cauthor_id=42732653)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-4 "Department of Cellular Biology, Embryology, and Genetics, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Daniel Fernandes](https://pubmed.ncbi.nlm.nih.gov/?term=Fernandes+D&cauthor_id=42732653)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-1 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil."), [Regina Sordi](https://pubmed.ncbi.nlm.nih.gov/?term=Sordi+R&cauthor_id=42732653)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42732653/#short-view-affiliation-5 "Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina \(UFSC\), SC, Brazil. Electronic address: r.sordi@ufsc.br.") ### Affiliations * 1 Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. * 2 Department of Neurosciences "Rita Levi Montalcini" University of Turin, Turin, Italy. * 3 Department of Physiology, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. * 4 Department of Cellular Biology, Embryology, and Genetics, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. * 5 Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina (UFSC), SC, Brazil. Electronic address: r.sordi@ufsc.br. * PMID: **42732653** * DOI: [ 10.1016/j.bbrc.2026.154579 ](https://doi.org/10.1016/j.bbrc.2026.154579) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Background:** Chronic kidney disease (CKD) causes millions of deaths and is a known risk factor for the development of other diseases. CKD has been associated with lung injury characterized by neutrophil infiltration and edema. Despite evidence that the lungs are distant organs affected in CKD, there is no treatment to impair lung injury. Cannabinoid receptors type 2 (CB2) activation has been shown to reduce renal dysfunction and organ damage in sepsis. **Objective:** Therefore, this study aimed to evaluate the effects of β-caryophyllene (βC), a CB2 agonist, on CKD-induced pulmonary alterations. **Methods:** Male Swiss mice were subjected to 5/6th partial nephrectomy (PNx) model and randomly assigned to three experimental groups: sham, PNx + vehicle and PNx+βC (10 mg/kg/day). Treatment was administered from days 7 to 14 post-surgery. On day 15, bronchoalveolar lavage, blood, and organs were obtained. **Results:** PNx animals exhibited increased pulmonary leukocyte infiltration, MPO activity, and protein content. Histological analysis of lung tissue showed signs of injury and excessive superoxide production. Increased expression of ICAM-1 was also detected by Western blotting in the lungs of PNx animals. βC treatment attenuated inflammatory cell infiltration and protein extravasation, and reduced ICAM-1 expression in lungs of CKD mice. βC improved renal function parameters, which may have contributed, at least in part, to the reduction in lung inflammation. CB2 receptors expression did not differ among the groups. **Conclusion:** In conclusion, βC attenuated PNx-induced pulmonary changes, supporting its potential as an adjuvant therapy for lung injury in CKD. **Keywords:** 5/6th partial nephrectomy; CB(2) agonist; Cannabinoid receptor; ICAM-1; Neutrophil infiltration. Copyright © 2026. Published by Elsevier Inc. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Regina Sordi reports financial support was provided by National Council for Scientific and Technological Development. Regina Sordi reports financial support was provided by Foundation for Research and Innovation of the Santa Catarina State. Daniel Fernandes reports financial support was provided by National Council for Scientific and Technological Development. Daniel Fernandes reports financial support was provided by Foundation for Research and Innovation of the Santa Catarina State. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice. ](https://pubmed.ncbi.nlm.nih.gov/28107775/) Varga ZV, Matyas C, Erdelyi K, Cinar R, Nieri D, Chicca A, Nemeth BT, Paloczi J, Lajtos T, Corey L, Hasko G, Gao B, Kunos G, Gertsch J, Pacher P.Varga ZV, et al.Br J Pharmacol. 2018 Jan;175(2):320-334. doi: 10.1111/bph.13722. Epub 2017 Feb 22.Br J Pharmacol. 2018.PMID: 28107775Free PMC article. * [ Effect of melilotus extract on lung injury by upregulating the expression of cannabinoid CB2 receptors in septic rats. ](https://pubmed.ncbi.nlm.nih.gov/24612782/) Liu MW, Su MX, Wang YH, Wei W, Qin LF, Liu X, Tian ML, Qian CY.Liu MW, et al.BMC Complement Altern Med. 2014 Mar 11;14:94. doi: 10.1186/1472-6882-14-94.BMC Complement Altern Med. 2014.PMID: 24612782Free PMC article. * [ β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. ](https://pubmed.ncbi.nlm.nih.gov/22326488/) Horváth B, Mukhopadhyay P, Kechrid M, Patel V, Tanchian G, Wink DA, Gertsch J, Pacher P.Horváth B, et al.Free Radic Biol Med. 2012 Apr 15;52(8):1325-33. doi: 10.1016/j.freeradbiomed.2012.01.014. Epub 2012 Jan 31.Free Radic Biol Med. 2012.PMID: 22326488Free PMC article. * [ Selective CB2 Receptor Agonist, HU-308, Reduces Systemic Inflammation in Endotoxin Model of Pneumonia-Induced Acute Lung Injury. ](https://pubmed.ncbi.nlm.nih.gov/36555499/) Hall S, Faridi S, Trivedi P, Sultana S, Ray B, Myers T, Euodia I, Vlatten D, Castonguay M, Zhou J, Kelly M, Lehmann C.Hall S, et al.Int J Mol Sci. 2022 Dec 13;23(24):15857. doi: 10.3390/ijms232415857.Int J Mol Sci. 2022.PMID: 36555499Free PMC article. * [ To CB2 or not CB2: Revisiting renoprotection in acute and chronic kidney injury. ](https://pubmed.ncbi.nlm.nih.gov/41469222/) de Jesus JM, Moore BM 2nd, Park F.de Jesus JM, et al.Br J Pharmacol. 2026 Mar;183(5):975-989. doi: 10.1111/bph.70314. Epub 2025 Dec 30.Br J Pharmacol. 2026.PMID: 41469222Review. 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