---
title: "CD19 CAR T-cell therapy GLPG5101 for relapsed/refractory B-cell NHL: ATALANTA-1 phase 1 report"
id: "pubmed-42660131"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42660131"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42660131/"
doi: "10.1016/S2352-3026(26)00192-4"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# CD19 CAR T-cell therapy GLPG5101 for relapsed/refractory B-cell NHL: ATALANTA-1 phase 1 report
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42660131
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42660131/)
- **DOI:** [10.1016/S2352-3026(26)00192-4](https://doi.org/10.1016%2FS2352-3026(26)00192-4)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This record reports phase 1 results of the ATALANTA-1 study evaluating **CD19 CAR T-cell therapy** (GLPG5101) in adults with relapsed or refractory **B‑cell non‑Hodgkin lymphoma**. The study is a single‑arm, multicentre, phase 1/2 clinical trial. - The report is published in Lancet Haematology (Sep 2026;13[9]:e648–e659) with PMID 42660131 and DOI 10.1016/S2352-3026(26)00192-4. - Lead and contributing authors include Marie José Kersten, Maria T Kuipers, Pim G N J Mutsaers, Evelyne Willems, Kirsten Saevels, Martin Dreyling, Caron Jacobson, Michael R Bishop, and multiple industry and academic collaborators across centres in the Netherlands, Belgium, Germany, the USA, Switzerland, Italy, and industry sites (Galapagos/CellPoint/Valos). - Participating academic sites spanned Amsterdam University Medical Center, Erasmus MC Cancer Institute, Centre Hospitalier Universitaire de Liège, Antwerp University Hospital, LMU Hospital Munich, Dana‑Farber Cancer Institute, University of Chicago, and others; industry contributors included Galapagos and affiliated units. - Study identifiers and metadata are provided, but the abstract text and numerical results (safety, efficacy, response rates, adverse events, dosing cohorts, manufacturing success, follow‑up duration) are not included in the source record presented here. - Because the source excerpt contains bibliographic and authorship details but not outcome data, specifics on patient eligibility criteria, cohort sizes, response outcomes, toxicity profiles (including cytokine release syndrome or neurotoxicity), dose escalation schema, or correlative biomarker findings were not reported in the provided source text. - Readers should consult the full text (Lancet Haematol) or the linked full‑text options for complete methods, results, and interpretation; the PubMed entry supplies journal citation, DOI, PMID, authors, and affiliations only.
## Clinical Analysis & Structured Key Points
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Electronic address: m.j.kersten@amsterdamumc.nl."), [Maria T Kuipers](https://pubmed.ncbi.nlm.nih.gov/?term=Kuipers+MT&cauthor_id=42660131)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-2 "Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands."), [Pim G N J Mutsaers](https://pubmed.ncbi.nlm.nih.gov/?term=Mutsaers+PGNJ&cauthor_id=42660131)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-3 "Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands."), [Evelyne Willems](https://pubmed.ncbi.nlm.nih.gov/?term=Willems+E&cauthor_id=42660131)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-4 "Department of Hematology, Centre Hospitalier Universitaire de Liège, Liège, Belgium."), [Kirsten Saevels](https://pubmed.ncbi.nlm.nih.gov/?term=Saevels+K&cauthor_id=42660131)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-5 "Division of Hematology and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp, Belgium."), [Martin Dreyling](https://pubmed.ncbi.nlm.nih.gov/?term=Dreyling+M&cauthor_id=42660131)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-6 "Department of Medicine III, LMU Hospital Munich, Munich, Germany."), [Caron Jacobson](https://pubmed.ncbi.nlm.nih.gov/?term=Jacobson+C&cauthor_id=42660131)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-7 "Division of Lymphoma, Department of Medicine, Dana-Farber Cancer Institute, Boston, MA, USA."), [Michael R Bishop](https://pubmed.ncbi.nlm.nih.gov/?term=Bishop+MR&cauthor_id=42660131)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-8 "The David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL, USA."), [Maarten Zandvliet](https://pubmed.ncbi.nlm.nih.gov/?term=Zandvliet+M&cauthor_id=42660131)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-9 "Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands."), [Stavros Milatos](https://pubmed.ncbi.nlm.nih.gov/?term=Milatos+S&cauthor_id=42660131)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-10 "Galapagos, Basel, Switzerland."), [Chiara Lobetti-Bodoni](https://pubmed.ncbi.nlm.nih.gov/?term=Lobetti-Bodoni+C&cauthor_id=42660131)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-10 "Galapagos, Basel, Switzerland."), [Sandra Blum](https://pubmed.ncbi.nlm.nih.gov/?term=Blum+S&cauthor_id=42660131)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-10 "Galapagos, Basel, Switzerland."), [Kirsten Van Hoorde](https://pubmed.ncbi.nlm.nih.gov/?term=Van+Hoorde+K&cauthor_id=42660131)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-11 "Open Analytics, Antwerp, Belgium."), [Jigar Desai](https://pubmed.ncbi.nlm.nih.gov/?term=Desai+J&cauthor_id=42660131)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-12 "Galapagos, Princeton, NJ, USA."), [Lorenzo Acciarri](https://pubmed.ncbi.nlm.nih.gov/?term=Acciarri+L&cauthor_id=42660131)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-13 "Valos, Genoa, Italy."), [Margot J Pont](https://pubmed.ncbi.nlm.nih.gov/?term=Pont+MJ&cauthor_id=42660131)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-9 "Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands."), [Anna van Muyden](https://pubmed.ncbi.nlm.nih.gov/?term=van+Muyden+A&cauthor_id=42660131)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-9 "Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands."), [Omotayo Fasan](https://pubmed.ncbi.nlm.nih.gov/?term=Fasan+O&cauthor_id=42660131)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-12 "Galapagos, Princeton, NJ, USA."), [Joost S P Vermaat](https://pubmed.ncbi.nlm.nih.gov/?term=Vermaat+JSP&cauthor_id=42660131)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-14 "Department of Hematology, Leiden University Medical Center, Leiden, Netherlands."), [Sébastien Anguille](https://pubmed.ncbi.nlm.nih.gov/?term=Anguille+S&cauthor_id=42660131)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#full-view-affiliation-5 "Division of Hematology and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp, Belgium.") Affiliations Expand ### Affiliations * 1 Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. Electronic address: m.j.kersten@amsterdamumc.nl. * 2 Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. * 3 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands. * 4 Department of Hematology, Centre Hospitalier Universitaire de Liège, Liège, Belgium. * 5 Division of Hematology and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp, Belgium. * 6 Department of Medicine III, LMU Hospital Munich, Munich, Germany. * 7 Division of Lymphoma, Department of Medicine, Dana-Farber Cancer Institute, Boston, MA, USA. * 8 The David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL, USA. * 9 Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands. * 10 Galapagos, Basel, Switzerland. * 11 Open Analytics, Antwerp, Belgium. * 12 Galapagos, Princeton, NJ, USA. * 13 Valos, Genoa, Italy. * 14 Department of Hematology, Leiden University Medical Center, Leiden, Netherlands. * PMID: **42660131** * DOI: [ 10.1016/S2352-3026(26)00192-4 ](https://doi.org/10.1016/s2352-3026\(26\)00192-4) Item in Clipboard Clinical Trial # CD19 CAR T-cell therapy (GLPG5101) for relapsed or refractory B-cell non-Hodgkin lymphoma (ATALANTA-1): phase 1 results from a single-arm, multicentre, phase 1/2 study Marie José Kersten et al. Lancet Haematol. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID Lancet Haematol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lancet+Haematol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Lancet+Haematol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660131/) . 2026 Sep;13(9):e648-e659. doi: 10.1016/S2352-3026(26)00192-4. ### Authors [Marie José Kersten](https://pubmed.ncbi.nlm.nih.gov/?term=Kersten+MJ&cauthor_id=42660131)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-1 "Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. Electronic address: m.j.kersten@amsterdamumc.nl."), [Maria T Kuipers](https://pubmed.ncbi.nlm.nih.gov/?term=Kuipers+MT&cauthor_id=42660131)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-2 "Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands."), [Pim G N J Mutsaers](https://pubmed.ncbi.nlm.nih.gov/?term=Mutsaers+PGNJ&cauthor_id=42660131)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-3 "Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands."), [Evelyne Willems](https://pubmed.ncbi.nlm.nih.gov/?term=Willems+E&cauthor_id=42660131)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-4 "Department of Hematology, Centre Hospitalier Universitaire de Liège, Liège, Belgium."), [Kirsten Saevels](https://pubmed.ncbi.nlm.nih.gov/?term=Saevels+K&cauthor_id=42660131)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-5 "Division of Hematology and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp, Belgium."), [Martin Dreyling](https://pubmed.ncbi.nlm.nih.gov/?term=Dreyling+M&cauthor_id=42660131)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-6 "Department of Medicine III, LMU Hospital Munich, Munich, Germany."), [Caron Jacobson](https://pubmed.ncbi.nlm.nih.gov/?term=Jacobson+C&cauthor_id=42660131)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-7 "Division of Lymphoma, Department of Medicine, Dana-Farber Cancer Institute, Boston, MA, USA."), [Michael R Bishop](https://pubmed.ncbi.nlm.nih.gov/?term=Bishop+MR&cauthor_id=42660131)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-8 "The David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL, USA."), [Maarten Zandvliet](https://pubmed.ncbi.nlm.nih.gov/?term=Zandvliet+M&cauthor_id=42660131)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-9 "Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands."), [Stavros Milatos](https://pubmed.ncbi.nlm.nih.gov/?term=Milatos+S&cauthor_id=42660131)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-10 "Galapagos, Basel, Switzerland."), [Chiara Lobetti-Bodoni](https://pubmed.ncbi.nlm.nih.gov/?term=Lobetti-Bodoni+C&cauthor_id=42660131)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-10 "Galapagos, Basel, Switzerland."), [Sandra Blum](https://pubmed.ncbi.nlm.nih.gov/?term=Blum+S&cauthor_id=42660131)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-10 "Galapagos, Basel, Switzerland."), [Kirsten Van Hoorde](https://pubmed.ncbi.nlm.nih.gov/?term=Van+Hoorde+K&cauthor_id=42660131)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-11 "Open Analytics, Antwerp, Belgium."), [Jigar Desai](https://pubmed.ncbi.nlm.nih.gov/?term=Desai+J&cauthor_id=42660131)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-12 "Galapagos, Princeton, NJ, USA."), [Lorenzo Acciarri](https://pubmed.ncbi.nlm.nih.gov/?term=Acciarri+L&cauthor_id=42660131)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-13 "Valos, Genoa, Italy."), [Margot J Pont](https://pubmed.ncbi.nlm.nih.gov/?term=Pont+MJ&cauthor_id=42660131)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-9 "Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands."), [Anna van Muyden](https://pubmed.ncbi.nlm.nih.gov/?term=van+Muyden+A&cauthor_id=42660131)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-9 "Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands."), [Omotayo Fasan](https://pubmed.ncbi.nlm.nih.gov/?term=Fasan+O&cauthor_id=42660131)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-12 "Galapagos, Princeton, NJ, USA."), [Joost S P Vermaat](https://pubmed.ncbi.nlm.nih.gov/?term=Vermaat+JSP&cauthor_id=42660131)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-14 "Department of Hematology, Leiden University Medical Center, Leiden, Netherlands."), [Sébastien Anguille](https://pubmed.ncbi.nlm.nih.gov/?term=Anguille+S&cauthor_id=42660131)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42660131/#short-view-affiliation-5 "Division of Hematology and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp, Belgium.") ### Affiliations * 1 Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. Electronic address: m.j.kersten@amsterdamumc.nl. * 2 Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. * 3 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands. * 4 Department of Hematology, Centre Hospitalier Universitaire de Liège, Liège, Belgium. * 5 Division of Hematology and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp, Belgium. * 6 Department of Medicine III, LMU Hospital Munich, Munich, Germany. * 7 Division of Lymphoma, Department of Medicine, Dana-Farber Cancer Institute, Boston, MA, USA. * 8 The David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL, USA. * 9 Galapagos, Leiden, Netherlands; CellPoint, Leiden, Netherlands. * 10 Galapagos, Basel, Switzerland. * 11 Open Analytics, Antwerp, Belgium. * 12 Galapagos, Princeton, NJ, USA. * 13 Valos, Genoa, Italy. * 14 Department of Hematology, Leiden University Medical Center, Leiden, Netherlands. * PMID: **42660131** * DOI: [ 10.1016/S2352-3026(26)00192-4 ](https://doi.org/10.1016/s2352-3026\(26\)001
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