---
title: "Commentary on Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive"
id: "pubmed-42638555"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42638555"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42638555/"
doi: "10.1111/nicc.70661"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Commentary on Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42638555
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42638555/)
- **DOI:** [10.1111/nicc.70661](https://doi.org/10.1111%2Fnicc.70661)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed entry is a published comment titled “Comment on 'Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial'.” - Article metadata: Nurs Crit Care. 2026 Sep;31(5):e70661. DOI 10.1111/nicc.70661. PMID 42638555. PMCID PMC13504400. - Authors: Sachin Kumar, Nirupma Gupta, Sujeet Kumar Singh, Hariharan Srinivasan, Varshini Vadhithala, Sushma Narsing Katkuri, Brajgopal Kushwaha (affiliations span multiple Indian universities and medical centres). - No abstract is provided on the PubMed entry; the record explicitly states “No abstract available.” - Keywords listed in the record: **catheter‐related bloodstream infection**, **central venous catheter**, **chlorhexidine gluconate**, **dermatological safety**, **paediatric intensive care**. - Conflict of interest: the authors declare no conflicts of interest as reported in the PubMed record. - Full text links: free full text available via PubMed Central and a Wiley link is provided (DOI link present). - The PubMed record cites the primary randomized clinical trial by Portero‑Prados et al. (Nursing in Critical Care 2026) and other references related to chlorhexidine safety and methodological considerations; specific content of the authors’ comment is not summarized in the PubMed entry. - Details of the comment’s content, results, or specific critique are not reported in this PubMed abstract entry; readers must consult the full text (PMC link or Wiley DOI) for the authors’ arguments or analyses. - The entry includes related articles and Cochrane/systematic review references relevant to dressings and central venous catheter care, which are listed as similar articles in the record.
## Clinical Analysis & Structured Key Points
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Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth \(Deemed-to-be-University\), Pune, Maharashtra, India."), [Sushma Narsing Katkuri](https://pubmed.ncbi.nlm.nih.gov/?term=Katkuri+SN&cauthor_id=42638555)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#full-view-affiliation-7 "Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Malla Reddy Vishwavidyapeeth, Hyderabad, Telangana, India."), [Brajgopal Kushwaha](https://pubmed.ncbi.nlm.nih.gov/?term=Kushwaha+B&cauthor_id=42638555)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#full-view-affiliation-8 "IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India.") Affiliations Expand ### Affiliations * 1 Faculty of Pharmaceutical Sciences, Graphic Era Hill University, Dehradun, India. * 2 Centre for Promotion of Research, Graphic Era Deemed University, Dehradun, India. * 3 Department of Anatomy, School of Medical Sciences and Research, Sharda University, Greater Noida, India. * 4 Department of Biotechnology, Noida Institute of Engineering & Technology (Pharmacy Institute), Greater Noida, India. * 5 Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. * 6 Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pune, Maharashtra, India. * 7 Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Malla Reddy Vishwavidyapeeth, Hyderabad, Telangana, India. * 8 IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India. * PMID: **42638555** * PMCID: [ PMC13504400 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13504400/) * DOI: [ 10.1111/nicc.70661 ](https://doi.org/10.1111/nicc.70661) Item in Clipboard # Comment on 'Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial' Sachin Kumar et al. Nurs Crit Care. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID Nurs Crit Care Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Nurs+Crit+Care%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Nurs+Crit+Care%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42638555/) . 2026 Sep;31(5):e70661. doi: 10.1111/nicc.70661. ### Authors [Sachin Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+S&cauthor_id=42638555)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-1 "Faculty of Pharmaceutical Sciences, Graphic Era Hill University, Dehradun, India.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-2 "Centre for Promotion of Research, Graphic Era Deemed University, Dehradun, India."), [Nirupma Gupta](https://pubmed.ncbi.nlm.nih.gov/?term=Gupta+N&cauthor_id=42638555)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-3 "Department of Anatomy, School of Medical Sciences and Research, Sharda University, Greater Noida, India."), [Sujeet Kumar Singh](https://pubmed.ncbi.nlm.nih.gov/?term=Singh+SK&cauthor_id=42638555)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-4 "Department of Biotechnology, Noida Institute of Engineering & Technology \(Pharmacy Institute\), Greater Noida, India."), [Hariharan Srinivasan](https://pubmed.ncbi.nlm.nih.gov/?term=Srinivasan+H&cauthor_id=42638555)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-5 "Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India."), [Varshini Vadhithala](https://pubmed.ncbi.nlm.nih.gov/?term=Vadhithala+V&cauthor_id=42638555)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-6 "Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth \(Deemed-to-be-University\), Pune, Maharashtra, India."), [Sushma Narsing Katkuri](https://pubmed.ncbi.nlm.nih.gov/?term=Katkuri+SN&cauthor_id=42638555)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-7 "Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Malla Reddy Vishwavidyapeeth, Hyderabad, Telangana, India."), [Brajgopal Kushwaha](https://pubmed.ncbi.nlm.nih.gov/?term=Kushwaha+B&cauthor_id=42638555)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42638555/#short-view-affiliation-8 "IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India.") ### Affiliations * 1 Faculty of Pharmaceutical Sciences, Graphic Era Hill University, Dehradun, India. * 2 Centre for Promotion of Research, Graphic Era Deemed University, Dehradun, India. * 3 Department of Anatomy, School of Medical Sciences and Research, Sharda University, Greater Noida, India. * 4 Department of Biotechnology, Noida Institute of Engineering & Technology (Pharmacy Institute), Greater Noida, India. * 5 Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. * 6 Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pune, Maharashtra, India. * 7 Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Malla Reddy Vishwavidyapeeth, Hyderabad, Telangana, India. * 8 IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India. * PMID: **42638555** * PMCID: [ PMC13504400 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13504400/) * DOI: [ 10.1111/nicc.70661 ](https://doi.org/10.1111/nicc.70661) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID _No abstract available_ **Keywords:** catheter‐related bloodstream infection; central venous catheter; chlorhexidine gluconate; dermatological safety; paediatric intensive care. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement The authors declare no conflicts of interest. ## Similar articles * [ Effectiveness of chlorhexidine gluconate-impregnated dressings in preventing central line-associated bloodstream infection in a paediatric intensive care unit: A randomised controlled trial. ](https://pubmed.ncbi.nlm.nih.gov/42102647/) Portero-Prados FJ, Pabón-Carrasco M, Ponce-Blandón JA.Portero-Prados FJ, et al.Intensive Crit Care Nurs. 2026 Oct;96:104441. doi: 10.1016/j.iccn.2026.104441. Epub 2026 May 7.Intensive Crit Care Nurs. 2026.PMID: 42102647Clinical Trial. * [ Dressing and securement for central venous access devices (CVADs): A Cochrane systematic review. ](https://pubmed.ncbi.nlm.nih.gov/27222463/) Ullman AJ, Cooke ML, Mitchell M, Lin F, New K, Long DA, Mihala G, Rickard CM.Ullman AJ, et al.Int J Nurs Stud. 2016 Jul;59:177-96. doi: 10.1016/j.ijnurstu.2016.04.003. Epub 2016 Apr 24.Int J Nurs Stud. 2016.PMID: 27222463 * [ Polyhexamethylene biguanide discs versus unmedicated dressings for prevention of central venous catheter-associated infection in the intensive care unit: A pilot randomised controlled trial to assess protocol safety and feasibility. ](https://pubmed.ncbi.nlm.nih.gov/34321181/) Pearse I, Marsh N, Rickard CM, Ullman AJ, Larsen E, Pelecanos A, McGuinness N, Irvine L, Rapchuk IL, Ziegenfuss M, Corley A.Pearse I, et al.Aust Crit Care. 2022 Sep;35(5):512-519. doi: 10.1016/j.aucc.2021.05.015. Epub 2021 Jul 25.Aust Crit Care. 2022.PMID: 34321181Clinical Trial. * [ Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT. ](https://pubmed.ncbi.nlm.nih.gov/33174528/) Gilbert R, Brown M, Faria R, Fraser C, Donohue C, Rainford N, Grosso A, Sinha AK, Dorling J, Gray J, Muller-Pebody B, Harron K, Moitt T, McGuire W, Bojke L, Gamble C, Oddie SJ.Gilbert R, et al.Health Technol Assess. 2020 Nov;24(57):1-190. doi: 10.3310/hta24570.Health Technol Assess. 2020.PMID: 33174528Free PMC article.Clinical Trial. * [ Dressings and securement devices for central venous catheters (CVC). ](https://pubmed.ncbi.nlm.nih.gov/26358142/) Ullman AJ, Cooke ML, Mitchell M, Lin F, New K, Long DA, Mihala G, Rickard CM.Ullman AJ, et al.Cochrane Database Syst Rev. 2015 Sep 10;2015(9):CD010367. doi: 10.1002/14651858.CD010367.pub2.Cochrane Database Syst Rev. 2015.PMID: 26358142Free PMC article. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42638555) ## References 1. 1. Portero‐Prados F. J., Pabón‐Carrasco M., and Ponce‐Blandón J. A., “Dermatological Safety of Chlorhexidine‐Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial,” Nursing in Critical Care 31 (2026): e70554, 10.1111/nicc.70554. - [DOI](https://doi.org/10.1111/nicc.70554) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC13307245/) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/42360019/) 2. 1. Adedokun B., “P‐Value and Confidence Intervals – Facts and Farces,” Annals of Ibadan Postgraduate Medicine 6, no. 1 (2011): 33–34, 10.4314/aipm.v6i1.64041. - [DOI](https://doi.org/10.4314/aipm.v6i1.64041) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC4111020/) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/25161442/) 3. 1. Renne T., Huguet G., Dubuc A., et al., “T55. Describing the Broad Spectrum of CNVS Effect Sizes on Cognitive Ability Across Brain and Non‐Brain Tissue,” European Neuropsychopharmacology 75 (2023): S190–S191, 10.1016/j.euroneuro.2023.08.340. - [DOI](https://doi.org/10.1016/j.euroneuro.2023.08.340) 4. 1. Chapman A. K., Aucott S. W., and Milstone A. M., “Safety of Chlorhexidine Gluconate Used for Skin Antisepsis in the Preterm Infant,” Journal of Perinatology 32, no. 1 (2011): 4–9, 10.1038/jp.2011.148. - [DOI](https://doi.org/10.1038/jp.2011.148) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/22031047/) 5. 1. Pham J. P., Jepsen R., and Frew J. W., “Comment on Kridin et al.—Considering Both Relative and Absolute Risk Differences in Infection Risk Between Biologics Classes in Patients With Psoriasis,” Journal of the European Academy of Dermatology and Venereology 38, no. 4 (2023): e351–e353, 10.1111/jdv.19615. - [DOI](https://doi.org/10.1111/jdv.19615) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/37908185/) Show all 6 references ## LinkOut - more resources * ### Full Text Sources * [ PubMed Central ](https://pmc.ncbi.nlm.nih.gov/articles/pmid/42638555/) * [ Wiley ](https://doi.org/10.1111/nicc.70661) **Full text links** [x] [![Wiley full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7388-69-wiley-full-text.png) Wiley ](https://doi.org/10.1111/nicc.70661 "See full text options at Wiley")[ Free PMC article ](https://pmc.ncbi.nlm.nih.gov/articles/pmid/42638555/ "Free full text at PubMed Central") [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42638555/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42638555%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.gov/42638555/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42638555%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42638555%2F%23open-collections-panel) * [Citation Manager](https://pubmed.ncbi.nlm.nih.gov/42638555/) [x] NCBI Literature Resources [MeSH](https://www.ncbi.nlm.nih.gov/mesh/) [PMC](https://www.ncbi.nlm.nih.gov/pmc/) [Bookshelf](https://www.ncbi.nlm.nih.gov/books) [Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 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