---
title: "Dexamethasone vs Dexmedetomidine as Adjuncts to Serratus Anterior Plane Block for Post‑MRM Analges"
id: "pubmed-42664118"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42664118"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42664118/"
doi: "10.7417/CT.2026.2098"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Dexamethasone vs Dexmedetomidine as Adjuncts to Serratus Anterior Plane Block for Post‑MRM Analges
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42664118
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42664118/)
- **DOI:** [10.7417/CT.2026.2098](https://doi.org/10.7417%2FCT.2026.2098)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This randomized clinical trial compared two adjuvants—**dexamethasone** and **dexmedetomidine**—added to a **serratus anterior plane block (SAPB)** for postoperative analgesia after **modified radical mastectomy (MRM)**. - The study enrolled 126 female patients scheduled for MRM and randomized them into two equal groups: a dexamethasone group (DXA) and a dexmedetomidine group (DMX). - Primary outcomes listed in the abstract include postoperative **pain scores**, **analgesic consumption**, and **sedation** (the abstract text is truncated and the sedation outcome description is incomplete). - The publication is a free clinical trial report in Clin Ter (2026 Sep‑Oct;177[5]:1009–1016) with PMID 42664118 and DOI 10.7417/CT.2026.2098. - Multiple author affiliations span institutions in Egypt, Saudi Arabia, and the United Kingdom, including Al‑Azhar University, Ain Shams University, and several hospitals. - The abstract reports study intent and design but the remainder of the abstract (including full methods, quantitative results, statistical comparisons, adverse events, and explicit conclusions) is not available in the provided source text. - Because the source text is truncated, specific numeric outcomes, effect sizes, p values, duration of analgesia, rescue analgesic protocols, sedation scores, and safety/adverse event data were not reported in the available content. - The report identifies SAPB as a widely used regional technique for analgesia after MRM and frames the comparison of these two adjuvants as the trial objective. - The available information suffices to summarize study purpose, population size, randomization into two equal arms, and planned outcome domains, but not to characterize which adjuvant was superior or to draw evidence‑based recommendations from this source alone. - For full appraisal (methods, statistical analysis, results, and conclusions) the complete article or full abstract is required; the PubMed entry provides a full text link to the journal site for access to the complete report.
## Clinical Analysis & Structured Key Points
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Mansoura University, Egypt."), [Murad Barakat](https://pubmed.ncbi.nlm.nih.gov/?term=Barakat+M&cauthor_id=42664118)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-8 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt."), [Ahmed Ibrahim Ali Sharaf](https://pubmed.ncbi.nlm.nih.gov/?term=Sharaf+AIA&cauthor_id=42664118)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-4 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt."), [Ibrahim Hassaan](https://pubmed.ncbi.nlm.nih.gov/?term=Hassaan+I&cauthor_id=42664118)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-9 "Department of Anesthesiology, Armed Forces Hospital Southern Region \(AFHSR\), Khamis Mushait, Saudi Arabia."), [Abdallah Elzeiny](https://pubmed.ncbi.nlm.nih.gov/?term=Elzeiny+A&cauthor_id=42664118)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-10 "Department of General Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom."), [Eslam Abdelfattah](https://pubmed.ncbi.nlm.nih.gov/?term=Abdelfattah+E&cauthor_id=42664118)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-11 "General Surgery Department, Faculty of Medicine, Ain Shams university, Cairo, Egypt."), [Raafat Mady](https://pubmed.ncbi.nlm.nih.gov/?term=Mady+R&cauthor_id=42664118)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-12 "Department of Breast Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom."), [Zain Akhtar](https://pubmed.ncbi.nlm.nih.gov/?term=Akhtar+Z&cauthor_id=42664118)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-13 "Department of General surgery, East Lancashire Hospitals NHS Trust, United Kingdom."), [Ahmed Shaaban](https://pubmed.ncbi.nlm.nih.gov/?term=Shaaban+A&cauthor_id=42664118)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#full-view-affiliation-4 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.") Affiliations Expand ### Affiliations * 1 Department of Anesthesia, ICU and pain management, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt. * 2 King Abdullah Bin Abdul-Aziz University Hospital, Riyadh, Saudi Arabia. * 3 Department of Anesthesiology, Intensive Care & Pain Management, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. * 4 Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt. * 5 Department of General Surgery, Ahmad Maher Teaching Hosp., GOTHI, Cairo, Egypt. * 6 Anesthesiology and Critical Care, Department of Surgery - College of Medicine, Jazan University, Saudi Arabia. * 7 Department of Anesthesia and Surgical Intensive Care and Pain Management, Mansoura Faculty of Medicine. Mansoura University, Egypt. * 8 Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. * 9 Department of Anesthesiology, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushait, Saudi Arabia. * 10 Department of General Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom. * 11 General Surgery Department, Faculty of Medicine, Ain Shams university, Cairo, Egypt. * 12 Department of Breast Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom. * 13 Department of General surgery, East Lancashire Hospitals NHS Trust, United Kingdom. * PMID: **42664118** * DOI: [ 10.7417/CT.2026.2098 ](https://doi.org/10.7417/ct.2026.2098) Free article Item in Clipboard Clinical Trial # Dexamethasone Versus Dexmedetomidine as Adjuncts to Serratus Anterior Plane Block for Postoperative Analgesia After Modified Radical Mastectomy: A Randomized Clinical Trial Warda Demerdash Khalifa Ali et al. Clin Ter. 2026 Sep-Oct. Free article Show details Display options Display options Format Abstract PubMed PMID Clin Ter Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Ter%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Ter%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42664118/) . 2026 Sep-Oct;177(5):1009-1016. doi: 10.7417/CT.2026.2098. ### Authors [Warda Demerdash Khalifa Ali](https://pubmed.ncbi.nlm.nih.gov/?term=Ali+WDK&cauthor_id=42664118)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-1 "Department of Anesthesia, ICU and pain management, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-2 "King Abdullah Bin Abdul-Aziz University Hospital, Riyadh, Saudi Arabia."), [Elsayed M Elkarta](https://pubmed.ncbi.nlm.nih.gov/?term=Elkarta+EM&cauthor_id=42664118)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-3 "Department of Anesthesiology, Intensive Care & Pain Management, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt."), [Mohammed El Sayed Abdel Hameed](https://pubmed.ncbi.nlm.nih.gov/?term=Abdel+Hameed+MES&cauthor_id=42664118)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-4 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt."), [Khaled Asem Allam](https://pubmed.ncbi.nlm.nih.gov/?term=Allam+KA&cauthor_id=42664118)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-5 "Department of General Surgery, Ahmad Maher Teaching Hosp., GOTHI, Cairo, Egypt."), [Gamal Eldin Adel Abdelhameed](https://pubmed.ncbi.nlm.nih.gov/?term=Abdelhameed+GEA&cauthor_id=42664118)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-4 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt."), [Mohammed Abdulgadir Ageel](https://pubmed.ncbi.nlm.nih.gov/?term=Ageel+MA&cauthor_id=42664118)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-6 "Anesthesiology and Critical Care, Department of Surgery - College of Medicine, Jazan University, Saudi Arabia."), [Mohamed Mahmoud Abdelfattah Abdelrahman](https://pubmed.ncbi.nlm.nih.gov/?term=Abdelrahman+MMA&cauthor_id=42664118)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-7 "Department of Anesthesia and Surgical Intensive Care and Pain Management, Mansoura Faculty of Medicine. Mansoura University, Egypt."), [Murad Barakat](https://pubmed.ncbi.nlm.nih.gov/?term=Barakat+M&cauthor_id=42664118)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-8 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt."), [Ahmed Ibrahim Ali Sharaf](https://pubmed.ncbi.nlm.nih.gov/?term=Sharaf+AIA&cauthor_id=42664118)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-4 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt."), [Ibrahim Hassaan](https://pubmed.ncbi.nlm.nih.gov/?term=Hassaan+I&cauthor_id=42664118)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-9 "Department of Anesthesiology, Armed Forces Hospital Southern Region \(AFHSR\), Khamis Mushait, Saudi Arabia."), [Abdallah Elzeiny](https://pubmed.ncbi.nlm.nih.gov/?term=Elzeiny+A&cauthor_id=42664118)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-10 "Department of General Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom."), [Eslam Abdelfattah](https://pubmed.ncbi.nlm.nih.gov/?term=Abdelfattah+E&cauthor_id=42664118)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-11 "General Surgery Department, Faculty of Medicine, Ain Shams university, Cairo, Egypt."), [Raafat Mady](https://pubmed.ncbi.nlm.nih.gov/?term=Mady+R&cauthor_id=42664118)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-12 "Department of Breast Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom."), [Zain Akhtar](https://pubmed.ncbi.nlm.nih.gov/?term=Akhtar+Z&cauthor_id=42664118)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-13 "Department of General surgery, East Lancashire Hospitals NHS Trust, United Kingdom."), [Ahmed Shaaban](https://pubmed.ncbi.nlm.nih.gov/?term=Shaaban+A&cauthor_id=42664118)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664118/#short-view-affiliation-4 "Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.") ### Affiliations * 1 Department of Anesthesia, ICU and pain management, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt. * 2 King Abdullah Bin Abdul-Aziz University Hospital, Riyadh, Saudi Arabia. * 3 Department of Anesthesiology, Intensive Care & Pain Management, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. * 4 Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt. * 5 Department of General Surgery, Ahmad Maher Teaching Hosp., GOTHI, Cairo, Egypt. * 6 Anesthesiology and Critical Care, Department of Surgery - College of Medicine, Jazan University, Saudi Arabia. * 7 Department of Anesthesia and Surgical Intensive Care and Pain Management, Mansoura Faculty of Medicine. Mansoura University, Egypt. * 8 Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. * 9 Department of Anesthesiology, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushait, Saudi Arabia. * 10 Department of General Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom. * 11 General Surgery Department, Faculty of Medicine, Ain Shams university, Cairo, Egypt. * 12 Department of Breast Surgery, Kettering General Hospital NHS Foundation Trust, Kettering, United Kingdom. * 13 Department of General surgery, East Lancashire Hospitals NHS Trust, United Kingdom. * PMID: **42664118** * DOI: [ 10.7417/CT.2026.2098 ](https://doi.org/10.7417/ct.2026.2098) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Serratus anterior plane block (SAPB) is widely used for postoperative analgesia following modified radical mastectomy (MRM). Adjuvant drugs such as dexamethasone and dexmedetomidine may enhance its efficacy. **Objective:** To compare the analgesic efficacy of dexamethasone versus dexmedetomidine as adjuncts to SAPB in patients undergoing MRM. **Methods:** This randomized clinical study included 126 female patients undergoing MRM, allocated into two equal groups: dexamethasone (DXA) and dexmedetomidine (DMX). Outcomes included postoperative pain scores, analgesic consumption, sedation leve
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