---
title: "Diagnostics and the 100-day Mission: Building Preparedness for Rapid Outbreak Response"
id: "pubmed-42065140"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42065140"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42065140/"
doi: "10.1093/trstmh/trag052"
published_at: "2026-08-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Diagnostics and the 100-day Mission: Building Preparedness for Rapid Outbreak Response
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42065140
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42065140/)
- **DOI:** [10.1093/trstmh/trag052](https://doi.org/10.1093%2Ftrstmh%2Ftrag052)
- **Published At:** 2026-08-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The 2025 International Panel for Pandemic Surveillance Report and the G7 **100-day mission** call for very rapid deployment of diagnostics during emerging outbreaks. - Achieving a 100-day diagnostic response requires preparatory infrastructure and pre-established diagnostic components rather than rapid development from scratch. - Key diagnostic building blocks include ready access to **monoclonal antibodies**, well-characterised antigens, biological reference materials and clear **regulatory pathways**. - The authors draw on development of **lateral flow tests** and haemorrhagic fever case studies to illustrate that upstream preparedness matters; specific case details were not reported in the abstract. - Persistent funding imbalances and unequal global investment jeopardise timely outbreak responses and the feasibility of the 100-day target. - The article highlights the need for sustained preparedness investment, strengthened **biobanking**, and equitable access frameworks to ensure diagnostics can be delivered within meaningful response timelines. - Core themes link **diagnostics**, **pandemic preparedness**, global health equity and public health infrastructure as essential to rapid response capability.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK. * 2 Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford, Oxford OX3 7Q, UK. * 3 Global Access Diagnostics, Thurleigh MK44 2YA, UK. * PMID: **42065140** * DOI: [ 10.1093/trstmh/trag052 ](https://doi.org/10.1093/trstmh/trag052) Free article Item in Clipboard Review # Diagnostics and the 100-day mission: why preparedness cannot wait Caitlin R Thompson et al. Trans R Soc Trop Med Hyg. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Trans R Soc Trop Med Hyg Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Trans+R+Soc+Trop+Med+Hyg%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Trans+R+Soc+Trop+Med+Hyg%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42065140/) . 2026 Aug 5;120(8):898-900. doi: 10.1093/trstmh/trag052. ### Authors [Caitlin R Thompson](https://pubmed.ncbi.nlm.nih.gov/?term=Thompson+CR&cauthor_id=42065140)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42065140/#short-view-affiliation-1 "Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK."), [Emily R Adams](https://pubmed.ncbi.nlm.nih.gov/?term=Adams+ER&cauthor_id=42065140)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42065140/#short-view-affiliation-2 "Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford, Oxford OX3 7Q, UK.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42065140/#short-view-affiliation-3 "Global Access Diagnostics, Thurleigh MK44 2YA, UK."), [Tom E Fletcher](https://pubmed.ncbi.nlm.nih.gov/?term=Fletcher+TE&cauthor_id=42065140)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42065140/#short-view-affiliation-1 "Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.") ### Affiliations * 1 Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK. * 2 Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford, Oxford OX3 7Q, UK. * 3 Global Access Diagnostics, Thurleigh MK44 2YA, UK. * PMID: **42065140** * DOI: [ 10.1093/trstmh/trag052 ](https://doi.org/10.1093/trstmh/trag052) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract The 2025 International Panel for Pandemic Surveillance Report and the G7 100-day mission emphasise rapid deployment of diagnostics, but preparatory infrastructure is vital to achieve this goal. Drawing on lateral flow development and haemorrhagic fever case studies, we highlight the requirement for pre-established diagnostic building blocks, including monoclonal antibodies, antigens, biological reference materials and regulatory pathways. Persistent funding imbalances and inequitable global investment threaten timely outbreak response. Sustained preparedness investment, strengthened biobanking and equitable access frameworks will ensure that diagnostics can be delivered within meaningful response timelines. **Keywords:** diagnostics; global health equity; lateral flow tests; pandemic preparedness. © The Author(s) 2026. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. 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