---
title: "Dimeric mRNA RBD Vaccine Induces Broad Immunity and Protects Mice from JN.1 and XDV"
id: "pubmed-42687061"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42687061"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42687061/"
doi: "10.1186/s43556-026-00560-y"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Dimeric mRNA RBD Vaccine Induces Broad Immunity and Protects Mice from JN.1 and XDV
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42687061
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42687061/)
- **DOI:** [10.1186/s43556-026-00560-y](https://doi.org/10.1186%2Fs43556-026-00560-y)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article reports a preclinical study of a **dimeric mRNA vaccine** constructed from a combination of a key-mutant receptor-binding domain (RBD) and a KP.3 RBD variant. - According to the title, this vaccine formulation reportedly induces **broad-spectrum immunity** and confers protection in **mice** challenged with viral strains named **JN.1** and **XDV**. - The study is published in Mol Biomed (2026 Sep 3;7(1):158) with PMID 42687061 and DOI 10.1186/s43556-026-00560-y. - The research team includes multiple contributors from the Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (Kunming), Yunnan University, Guangdong Provincial CDC, and other affiliated Chinese laboratories; several authors contributed equally. - The title indicates protective efficacy in animal challenge models, but the publicly shown PubMed entry does not include the abstract or detailed methods, immunogenicity metrics, challenge doses, survival or viral load data, safety or tolerability findings, or statistical analyses. - Specific experimental details, including vaccine sequence, formulation, dosing schedule, routes of administration, sample sizes, endpoints, and quantitative results, were not reported in the provided source content. - Conflict of interest statements, full experimental methods, and referenced data (figures, tables) are not available in the clipped PubMed record shown; readers must consult the full text for complete evidence. - The available metadata (authors, affiliations, journal, DOI, PMID) are documented for retrieval and citation but do not substitute for the full article required to evaluate translational relevance or clinical implications.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42687061/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42687061/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42687061/#references) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42687061/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42687061/#substances) Title & authors Abstract Conflict of interest statement References MeSH terms Substances Mol Biomed Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mol+Biomed%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Mol+Biomed%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42687061/) . 2026 Sep 3;7(1):158. doi: 10.1186/s43556-026-00560-y. # A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges [Jiali Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+J&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-2 "Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, Yunnan University, Kunming, China."), [Rui Peng](https://pubmed.ncbi.nlm.nih.gov/?term=Peng+R&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Longhai Yuan](https://pubmed.ncbi.nlm.nih.gov/?term=Yuan+L&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Huan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+H&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-equal-contrib-explanation "Contributed equally")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-3 "Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China."), [Cong Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+C&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Yanan Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+Y&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Hao Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+H&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Yun Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Y&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Qing Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+Q&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Junbin Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Hongyu Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+H&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Wenqi Quan](https://pubmed.ncbi.nlm.nih.gov/?term=Quan+W&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Baisheng Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+B&cauthor_id=42687061)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-4 "Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. libsn@126.com."), [Qiangming Sun](https://pubmed.ncbi.nlm.nih.gov/?term=Sun+Q&cauthor_id=42687061)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-5 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. qsun@imbcams.com.cn.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-6 "State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. qsun@imbcams.com.cn.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-7 "Key Laboratory of Pathogen Infection Prevention and Control \(Peking Union Medical College\), Ministry of Education, Beijing, China. qsun@imbcams.com.cn.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-8 "Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research, Kunming, China. qsun@imbcams.com.cn."), [Shuaiyao Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+S&cauthor_id=42687061)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-9 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. lushuaiyao-km@163.com.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-10 "Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, Yunnan University, Kunming, China. lushuaiyao-km@163.com.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-11 "State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. lushuaiyao-km@163.com.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-12 "Key Laboratory of Pathogen Infection Prevention and Control \(Peking Union Medical College\), Ministry of Education, Beijing, China. lushuaiyao-km@163.com.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#full-view-affiliation-13 "Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research, Kunming, China. lushuaiyao-km@163.com.") Affiliations Expand ### Affiliations * 1 Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. * 2 Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, Yunnan University, Kunming, China. * 3 Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. * 4 Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. libsn@126.com. * 5 Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. qsun@imbcams.com.cn. * 6 State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. qsun@imbcams.com.cn. * 7 Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. qsun@imbcams.com.cn. * 8 Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research, Kunming, China. qsun@imbcams.com.cn. * 9 Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. lushuaiyao-km@163.com. * 10 Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, Yunnan University, Kunming, China. lushuaiyao-km@163.com. * 11 State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. lushuaiyao-km@163.com. * 12 Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. lushuaiyao-km@163.com. * 13 Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research, Kunming, China. lushuaiyao-km@163.com. # Contributed equally. * PMID: **42687061** * DOI: [ 10.1186/s43556-026-00560-y ](https://doi.org/10.1186/s43556-026-00560-y) Item in Clipboard # A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges Jiali Xu et al. Mol Biomed. 2026. Show details Display options Display options Format Abstract PubMed PMID Mol Biomed Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mol+Biomed%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Mol+Biomed%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42687061/) . 2026 Sep 3;7(1):158. doi: 10.1186/s43556-026-00560-y. ### Authors [Jiali Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+J&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-2 "Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, Yunnan University, Kunming, China."), [Rui Peng](https://pubmed.ncbi.nlm.nih.gov/?term=Peng+R&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Longhai Yuan](https://pubmed.ncbi.nlm.nih.gov/?term=Yuan+L&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Huan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+H&cauthor_id=42687061)[#](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-equal-contrib-explanation "Contributed equally")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-3 "Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China."), [Cong Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+C&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Yanan Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+Y&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Hao Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+H&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Yun Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Y&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Qing Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+Q&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Junbin Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Hongyu Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+H&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Wenqi Quan](https://pubmed.ncbi.nlm.nih.gov/?term=Quan+W&cauthor_id=42687061)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-1 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China."), [Baisheng Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+B&cauthor_id=42687061)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-4 "Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. libsn@126.com."), [Qiangming Sun](https://pubmed.ncbi.nlm.nih.gov/?term=Sun+Q&cauthor_id=42687061)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-5 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. qsun@imbcams.com.cn.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-6 "State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. qsun@imbcams.com.cn.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-7 "Key Laboratory of Pathogen Infection Prevention and Control \(Peking Union Medical College\), Ministry of Education, Beijing, China. qsun@imbcams.com.cn.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-8 "Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research, Kunming, China. qsun@imbcams.com.cn."), [Shuaiyao Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+S&cauthor_id=42687061)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42687061/#short-view-affiliation-9 "Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. lushuaiyao-km@
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