---
title: "DNMT3A and CHIP-associated Germline and Somatic Variants Linked to Pulmonary Arterial Hypertension"
id: "pubmed-40878867"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-40878867"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/40878867/"
doi: "10.1093/eurheartj/ehaf611"
published_at: "2026-09-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# DNMT3A and CHIP-associated Germline and Somatic Variants Linked to Pulmonary Arterial Hypertension
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-40878867
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/40878867/)
- **DOI:** [10.1093/eurheartj/ehaf611](https://doi.org/10.1093%2Feurheartj%2Fehaf611)
- **Published At:** 2026-09-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The cited Eur Heart J article reports that both **germline and somatic variants** in **DNMT3A** and other genes associated with **clonal haematopoiesis of indeterminate potential (CHIP)** are implicated in pulmonary arterial hypertension (PAH). - The study is authored by Ruaa Al-Qazazi et al. and appears in European Heart Journal (2026 Sep 2;47(33):4658-4675) with DOI 10.1093/eurheartj/ehaf611 and PubMed ID 40878867. - Authors are affiliated with multiple institutions including Queen's University, Laval University, Johns Hopkins, Columbia University, Vanderbilt, Cincinnati Children’s, and Boston Children’s Hospital. - The paper is available as a free article; full-text links are provided via the journal platform. - The PubMed record provides bibliographic metadata (title, authors, affiliations, citation, DOI, PMID) but the provided source extract did not include the abstract, study methods, numerical results, or specific variant frequencies; those details were not reported in the supplied source text. - Because the source content here is a PubMed record without the article abstract or body, specific findings, methods, cohort characteristics, statistical results, and conclusions beyond the title-level claim are not available in this source excerpt. - Clinicians and researchers interested in the association between **DNMT3A**, CHIP genes, and PAH should consult the full article (Eur Heart J) for study design, variant classification (germline vs somatic), cohort details, and clinical implications. - The record establishes the primary message: variants in **DNMT3A** and other CHIP genes contribute to PAH risk or pathobiology, supporting investigation of clonal haematopoiesis in pulmonary vascular disease. - The PubMed entry confirms multi-institutional collaboration and that the article is indexed and citable; further details require access to the complete manuscript.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/40878867/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F40878867%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/40878867/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/40878867/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/40878867/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/40878867/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/40878867/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/40878867/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F40878867%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F40878867%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/40878867/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/40878867/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/40878867/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/40878867/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Silverchair Information Systems full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--academic.oup.com-images-oup_pubmed_free.png) Silverchair Information Systems ](https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehaf611 "See full text options at Silverchair Information Systems") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/40878867/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/40878867/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/40878867/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/40878867/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/40878867/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/40878867/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/40878867/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/40878867/#related-links) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/40878867/#grants) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/40878867/#linkout) Title & authors Abstract Similar articles MeSH terms Substances Related information Grants and funding LinkOut - more resources Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40878867/) . 2026 Sep 2;47(33):4658-4675. doi: 10.1093/eurheartj/ehaf611. # Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension [Ruaa Al-Qazazi](https://pubmed.ncbi.nlm.nih.gov/?term=Al-Qazazi+R&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Isaac M Emon](https://pubmed.ncbi.nlm.nih.gov/?term=Emon+IM&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [François Potus](https://pubmed.ncbi.nlm.nih.gov/?term=Potus+F&cauthor_id=40878867)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-2 "Pulmonary Hypertension Research Group, Instituted Universitaire de Cardiologie et de Pneumology de Québec Research Center, Laval University, Quebec City, Canada G1V 4G5."), [Ashley Y Martin](https://pubmed.ncbi.nlm.nih.gov/?term=Martin+AY&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Patricia D A Lima](https://pubmed.ncbi.nlm.nih.gov/?term=Lima+PDA&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopulmonary Unit \(QCPU\), Queen's University, Kingston, Ontario, Canada K7L 3N6."), [Caitlyn Vlasschaert](https://pubmed.ncbi.nlm.nih.gov/?term=Vlasschaert+C&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Benjamin P Ott](https://pubmed.ncbi.nlm.nih.gov/?term=Ott+BP&cauthor_id=40878867)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopulmonary Unit \(QCPU\), Queen's University, Kingston, Ontario, Canada K7L 3N6."), [Kuang-Hueih Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+KH&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Danchen Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+D&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Asish Dasgupta](https://pubmed.ncbi.nlm.nih.gov/?term=Dasgupta+A&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Curtis Noordhof](https://pubmed.ncbi.nlm.nih.gov/?term=Noordhof+C&cauthor_id=40878867)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopulmonary Unit \(QCPU\), Queen's University, Kingston, Ontario, Canada K7L 3N6."), [Lindsay Jefferson](https://pubmed.ncbi.nlm.nih.gov/?term=Jefferson+L&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Marco M Buttigieg](https://pubmed.ncbi.nlm.nih.gov/?term=Buttigieg+MM&cauthor_id=40878867)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-4 "Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada K7L 2V7."), [Amy J M McNaughton](https://pubmed.ncbi.nlm.nih.gov/?term=McNaughton+AJM&cauthor_id=40878867)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-4 "Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada K7L 2V7."), [Charles C T Hindmarch](https://pubmed.ncbi.nlm.nih.gov/?term=Hindmarch+CCT&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopulmonary Unit \(QCPU\), Queen's University, Kingston, Ontario, Canada K7L 3N6.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-5 "Biomedical and Molecular Sciences \(DBMS\), Queen's University, Kingston, Ontario, Canada K7L 3N6."), [Alexander G Bick](https://pubmed.ncbi.nlm.nih.gov/?term=Bick+AG&cauthor_id=40878867)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-6 "Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA."), [William C Nichols](https://pubmed.ncbi.nlm.nih.gov/?term=Nichols+WC&cauthor_id=40878867)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-7 "Division of Human Genetics, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA."), [Wendy K Chung](https://pubmed.ncbi.nlm.nih.gov/?term=Chung+WK&cauthor_id=40878867)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-8 "Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA."), [Paul M Hassoun](https://pubmed.ncbi.nlm.nih.gov/?term=Hassoun+PM&cauthor_id=40878867)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-9 "Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21218, USA."), [Rachel L Damico](https://pubmed.ncbi.nlm.nih.gov/?term=Damico+RL&cauthor_id=40878867)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-9 "Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21218, USA."), [Na Zhu](https://pubmed.ncbi.nlm.nih.gov/?term=Zhu+N&cauthor_id=40878867)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-10 "Department of Systems Biology, Columbia University Medical Center, New York, NY 10027, USA."), [Yufeng Shen](https://pubmed.ncbi.nlm.nih.gov/?term=Shen+Y&cauthor_id=40878867)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-10 "Department of Systems Biology, Columbia University Medical Center, New York, NY 10027, USA."), [Michael J Rauh](https://pubmed.ncbi.nlm.nih.gov/?term=Rauh+MJ&cauthor_id=40878867)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-4 "Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada K7L 2V7."), [Stephen L Archer](https://pubmed.ncbi.nlm.nih.gov/?term=Archer+SL&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#full-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopulmonary Unit \(QCPU\), Queen's University, Kingston, Ontario, Canada K7L 3N6.") Affiliations Expand ### Affiliations * 1 Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6. * 2 Pulmonary Hypertension Research Group, Instituted Universitaire de Cardiologie et de Pneumology de Québec Research Center, Laval University, Quebec City, Canada G1V 4G5. * 3 Translational Institute of Medicine (TIME) and Queen's Cardiopulmonary Unit (QCPU), Queen's University, Kingston, Ontario, Canada K7L 3N6. * 4 Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada K7L 2V7. * 5 Biomedical and Molecular Sciences (DBMS), Queen's University, Kingston, Ontario, Canada K7L 3N6. * 6 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA. * 7 Division of Human Genetics, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. * 8 Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. * 9 Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. * 10 Department of Systems Biology, Columbia University Medical Center, New York, NY 10027, USA. * PMID: **40878867** * DOI: [ 10.1093/eurheartj/ehaf611 ](https://doi.org/10.1093/eurheartj/ehaf611) Free article Item in Clipboard # Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension Ruaa Al-Qazazi et al. Eur Heart J. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40878867/) . 2026 Sep 2;47(33):4658-4675. doi: 10.1093/eurheartj/ehaf611. ### Authors [Ruaa Al-Qazazi](https://pubmed.ncbi.nlm.nih.gov/?term=Al-Qazazi+R&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Isaac M Emon](https://pubmed.ncbi.nlm.nih.gov/?term=Emon+IM&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [François Potus](https://pubmed.ncbi.nlm.nih.gov/?term=Potus+F&cauthor_id=40878867)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-2 "Pulmonary Hypertension Research Group, Instituted Universitaire de Cardiologie et de Pneumology de Québec Research Center, Laval University, Quebec City, Canada G1V 4G5."), [Ashley Y Martin](https://pubmed.ncbi.nlm.nih.gov/?term=Martin+AY&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Patricia D A Lima](https://pubmed.ncbi.nlm.nih.gov/?term=Lima+PDA&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopulmonary Unit \(QCPU\), Queen's University, Kingston, Ontario, Canada K7L 3N6."), [Caitlyn Vlasschaert](https://pubmed.ncbi.nlm.nih.gov/?term=Vlasschaert+C&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Benjamin P Ott](https://pubmed.ncbi.nlm.nih.gov/?term=Ott+BP&cauthor_id=40878867)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopulmonary Unit \(QCPU\), Queen's University, Kingston, Ontario, Canada K7L 3N6."), [Kuang-Hueih Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+KH&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Danchen Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+D&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Asish Dasgupta](https://pubmed.ncbi.nlm.nih.gov/?term=Dasgupta+A&cauthor_id=40878867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-1 "Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6."), [Curtis Noordhof](https://pubmed.ncbi.nlm.nih.gov/?term=Noordhof+C&cauthor_id=40878867)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40878867/#short-view-affiliation-3 "Translational Institute of Medicine \(TIME\) and Queen's Cardiopu
## Related Clinical Research

- [ATS Core Curriculum 2026: Pulmonary Hypertension Diagnosis and Management](https://medichelpline.com/clinical-feed/pubmed-42765479.md) (DOI: 10.1093/atsscholar/aapag062)
- [Right atrial function in OSAHS assessed by two-dimensional speckle tracking echocardiography](https://medichelpline.com/clinical-feed/pubmed-42722633.md) (DOI: 10.1080/14017431.2026.2709195)
- [Composite Patient Profiling Predicts Blood Pressure Response in the VALUE Trial](https://medichelpline.com/clinical-feed/medrxiv-15-patient-profiling-and-outcome-of-antihypertensive-treatment-an-exploratory.md)
- [Bidirectional association between sleep disturbance and atrial fibrillation in SPRINT participants](https://medichelpline.com/clinical-feed/medrxiv-16-bidirectional-relationship-between-sleep-disturbance-and-atrial-fibrillation-a.md)
- [Machine learning and deep learning prediction of hypertension and key risk factors in Bangladesh](https://medichelpline.com/clinical-feed/plos-one-12-machine-learning-and-deep-learning-based-prediction-of-hypertension-and.md)

## Navigation
- [← Back to Critical Care Feed](https://medichelpline.com/clinical-feed/critical-care.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.