---
title: "Effectiveness of Oseltamivir in Hospitalized Children With Laboratory-Confirmed Influenza (2014–20"
id: "pubmed-42573991"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42573991"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42573991/"
doi: "10.1001/jamapediatrics.2026.3376"
published_at: "2026-08-10T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Effectiveness of Oseltamivir in Hospitalized Children With Laboratory-Confirmed Influenza (2014–20
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42573991
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42573991/)
- **DOI:** [10.1001/jamapediatrics.2026.3376](https://doi.org/10.1001%2Fjamapediatrics.2026.3376)
- **Published At:** 2026-08-10T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Citation: Article titled "Effectiveness of Oseltamivir in Hospitalized Children With Laboratory-Confirmed Influenza, 2014-2023" published online ahead of print in JAMA Pediatrics, dated 2026 Aug 10, DOI 10.1001/jamapediatrics.2026.3376, PubMed PMID 42573991. - Study focus as stated in title: evaluation of **oseltamivir** effectiveness among **hospitalized children** with laboratory-confirmed **influenza** covering seasons 2014–2023. - Multi-institutional authorship: lead author Kacie Rytlewski with numerous coauthors from academic centers, state health departments, emerging infections programs, and the US Centers for Disease Control and Prevention (CDC). - Geographic and institutional representation includes University of Colorado/Children's Hospital Colorado, CDC Influenza Division, multiple state Departments of Health (Colorado, California, Connecticut, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon), Emory/Children's Healthcare of Atlanta, Vanderbilt University Medical Center, University of Rochester, and several emerging infections programs. - Article metadata present in source: journal (JAMA Pediatr), online-ahead-of-print date, DOI, PMID, and full author list with numbered affiliations. - The PubMed entry in the provided source does not include the article abstract, study methods, numerical results, statistical analyses, safety data, or specific conclusions; those clinical details were not reported in the source document. - Because the PubMed page content supplied is primarily bibliographic, readers must consult the full-text JAMA Pediatrics article to obtain study design, sample size, patient characteristics, antiviral dosing/timing, primary and secondary outcomes, and authors' conclusions. - Keywords implicit from title and metadata: **oseltamivir**, **influenza**, **hospitalized children**, surveillance years 2014–2023, and multi-site public health collaboration. - For clinicians and researchers, the PubMed record confirms the study exists and provides identifiers for retrieval, but the source does not permit assessment of effect size, subgroups, or clinical impact. - Contact points for further information are the corresponding author affiliations and the DOI/PMID for locating the full article and supplementary materials.
## Clinical Analysis & Structured Key Points
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Online ahead of print. # Effectiveness of Oseltamivir in Hospitalized Children With Laboratory-Confirmed Influenza, 2014-2023 [Kacie Rytlewski](https://pubmed.ncbi.nlm.nih.gov/?term=Rytlewski+K&cauthor_id=42573991)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-1 "Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora."), [Angela Dunn](https://pubmed.ncbi.nlm.nih.gov/?term=Dunn+A&cauthor_id=42573991)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-2 "Adult and Child Center for Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora."), [Alissa O'Halloran](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Halloran+A&cauthor_id=42573991)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-3 "Influenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia."), [Jennifer Habeck](https://pubmed.ncbi.nlm.nih.gov/?term=Habeck+J&cauthor_id=42573991)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-3 "Influenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-4 "Goldbelt Professional Services, Chesapeake, Virginia."), [Isaac Armistead](https://pubmed.ncbi.nlm.nih.gov/?term=Armistead+I&cauthor_id=42573991)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-5 "Colorado Department of Public Health and Environment, Denver."), [Nisha B Alden](https://pubmed.ncbi.nlm.nih.gov/?term=Alden+NB&cauthor_id=42573991)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-5 "Colorado Department of Public Health and Environment, Denver."), [Darpun Sachdev](https://pubmed.ncbi.nlm.nih.gov/?term=Sachdev+D&cauthor_id=42573991)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-6 "California Department of Public Health, Richmond."), [Pam Daily Kirley](https://pubmed.ncbi.nlm.nih.gov/?term=Daily+Kirley+P&cauthor_id=42573991)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-7 "California Emerging Infections Program, Oakland."), [James Meek](https://pubmed.ncbi.nlm.nih.gov/?term=Meek+J&cauthor_id=42573991)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-8 "Connecticut Emerging Infections Program, Yale School of Public Health, New Haven."), [Kimberly Yousey-Hindes](https://pubmed.ncbi.nlm.nih.gov/?term=Yousey-Hindes+K&cauthor_id=42573991)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-8 "Connecticut Emerging Infections Program, Yale School of Public Health, New Haven."), [Satoshi Kamidani](https://pubmed.ncbi.nlm.nih.gov/?term=Kamidani+S&cauthor_id=42573991)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-9 "Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-10 "Children's Healthcare of Atlanta, Atlanta, Georgia.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-11 "Georgia Emerging Infections Program, Atlanta."), [Kyle P Openo](https://pubmed.ncbi.nlm.nih.gov/?term=Openo+KP&cauthor_id=42573991)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-11 "Georgia Emerging Infections Program, Atlanta.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-12 "Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia."), [Patricia A Ryan](https://pubmed.ncbi.nlm.nih.gov/?term=Ryan+PA&cauthor_id=42573991)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-13 "Maryland Department of Health, Baltimore."), [Maya Monroe](https://pubmed.ncbi.nlm.nih.gov/?term=Monroe+M&cauthor_id=42573991)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-13 "Maryland Department of Health, Baltimore."), [Sue Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+S&cauthor_id=42573991)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-14 "Michigan Department of Health and Human Services, Lansing."), [Elizabeth Urlaub](https://pubmed.ncbi.nlm.nih.gov/?term=Urlaub+E&cauthor_id=42573991)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-14 "Michigan Department of Health and Human Services, Lansing."), [Ruth Lynfield](https://pubmed.ncbi.nlm.nih.gov/?term=Lynfield+R&cauthor_id=42573991)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-15 "Minnesota Department of Health, St Paul."), [Melissa McMahon](https://pubmed.ncbi.nlm.nih.gov/?term=McMahon+M&cauthor_id=42573991)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-15 "Minnesota Department of Health, St Paul."), [Chad B Smelser](https://pubmed.ncbi.nlm.nih.gov/?term=Smelser+CB&cauthor_id=42573991)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-16 "New Mexico Department of Health, Santa Fe."), [Yomei Shaw](https://pubmed.ncbi.nlm.nih.gov/?term=Shaw+Y&cauthor_id=42573991)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-16 "New Mexico Department of Health, Santa Fe."), [Grant Barney](https://pubmed.ncbi.nlm.nih.gov/?term=Barney+G&cauthor_id=42573991)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-17 "New York State Department of Health, Albany."), [Jemma V Rowlands](https://pubmed.ncbi.nlm.nih.gov/?term=Rowlands+JV&cauthor_id=42573991)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-17 "New York State Department of Health, Albany."), [Brenda Tesini](https://pubmed.ncbi.nlm.nih.gov/?term=Tesini+B&cauthor_id=42573991)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-18 "University of Rochester Medical Center, Rochester, New York."), [Christina Felsen](https://pubmed.ncbi.nlm.nih.gov/?term=Felsen+C&cauthor_id=42573991)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-18 "University of Rochester Medical Center, Rochester, New York.")[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-19 "New York Emerging Infections Program, Albany."), [Krista Lung](https://pubmed.ncbi.nlm.nih.gov/?term=Lung+K&cauthor_id=42573991)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-20 "Ohio Department of Health, Columbus."), [Melissa Sutton](https://pubmed.ncbi.nlm.nih.gov/?term=Sutton+M&cauthor_id=42573991)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-21 "Public Health Division, Oregon Health Authority, Portland."), [Ann Thomas](https://pubmed.ncbi.nlm.nih.gov/?term=Thomas+A&cauthor_id=42573991)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-21 "Public Health Division, Oregon Health Authority, Portland."), [H Keipp Talbot](https://pubmed.ncbi.nlm.nih.gov/?term=Talbot+HK&cauthor_id=42573991)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-22 "Vanderbilt University Medical Center, Nashville, Tennessee."), [William Schaffner](https://pubmed.ncbi.nlm.nih.gov/?term=Schaffner+W&cauthor_id=42573991)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-22 "Vanderbilt University Medical Center, Nashville, Tennessee."), [Andrea George](https://pubmed.ncbi.nlm.nih.gov/?term=George+A&cauthor_id=42573991)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-23 "Salt Lake County Health Department, Salt Lake City, Utah."), [Holly Staten](https://pubmed.ncbi.nlm.nih.gov/?term=Staten+H&cauthor_id=42573991)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-23 "Salt Lake County Health Department, Salt Lake City, Utah."), [Jessica R Cataldi](https://pubmed.ncbi.nlm.nih.gov/?term=Cataldi+JR&cauthor_id=42573991)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-1 "Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora."), [Samuel R Dominguez](https://pubmed.ncbi.nlm.nih.gov/?term=Dominguez+SR&cauthor_id=42573991)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-1 "Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora."), [Catherine H Bozio](https://pubmed.ncbi.nlm.nih.gov/?term=Bozio+CH&cauthor_id=42573991)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-3 "Influenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia."), [Suchitra Rao](https://pubmed.ncbi.nlm.nih.gov/?term=Rao+S&cauthor_id=42573991)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#full-view-affiliation-1 "Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora.") Affiliations Expand ### Affiliations * 1 Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora. * 2 Adult and Child Center for Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora. * 3 Influenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia. * 4 Goldbelt Professional Services, Chesapeake, Virginia. * 5 Colorado Department of Public Health and Environment, Denver. * 6 California Department of Public Health, Richmond. * 7 California Emerging Infections Program, Oakland. * 8 Connecticut Emerging Infections Program, Yale School of Public Health, New Haven. * 9 Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia. * 10 Children's Healthcare of Atlanta, Atlanta, Georgia. * 11 Georgia Emerging Infections Program, Atlanta. * 12 Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia. * 13 Maryland Department of Health, Baltimore. * 14 Michigan Department of Health and Human Services, Lansing. * 15 Minnesota Department of Health, St Paul. * 16 New Mexico Department of Health, Santa Fe. * 17 New York State Department of Health, Albany. * 18 University of Rochester Medical Center, Rochester, New York. * 19 New York Emerging Infections Program, Albany. * 20 Ohio Department of Health, Columbus. * 21 Public Health Division, Oregon Health Authority, Portland. * 22 Vanderbilt University Medical Center, Nashville, Tennessee. * 23 Salt Lake County Health Department, Salt Lake City, Utah. * PMID: **42573991** * DOI: [ 10.1001/jamapediatrics.2026.3376 ](https://doi.org/10.1001/jamapediatrics.2026.3376) Item in Clipboard # Effectiveness of Oseltamivir in Hospitalized Children With Laboratory-Confirmed Influenza, 2014-2023 Kacie Rytlewski et al. JAMA Pediatr. 2026. Show details Display options Display options Format Abstract PubMed PMID JAMA Pediatr Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22JAMA+Pediatr%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22JAMA+Pediatr%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42573991/) . 2026 Aug 10. doi: 10.1001/jamapediatrics.2026.3376. Online ahead of print. ### Authors [Kacie Rytlewski](https://pubmed.ncbi.nlm.nih.gov/?term=Rytlewski+K&cauthor_id=42573991)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-1 "Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora."), [Angela Dunn](https://pubmed.ncbi.nlm.nih.gov/?term=Dunn+A&cauthor_id=42573991)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-2 "Adult and Child Center for Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora."), [Alissa O'Halloran](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Halloran+A&cauthor_id=42573991)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-3 "Influenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia."), [Jennifer Habeck](https://pubmed.ncbi.nlm.nih.gov/?term=Habeck+J&cauthor_id=42573991)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-3 "Influenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-4 "Goldbelt Professional Services, Chesapeake, Virginia."), [Isaac Armistead](https://pubmed.ncbi.nlm.nih.gov/?term=Armistead+I&cauthor_id=42573991)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-5 "Colorado Department of Public Health and Environment, Denver."), [Nisha B Alden](https://pubmed.ncbi.nlm.nih.gov/?term=Alden+NB&cauthor_id=42573991)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-5 "Colorado Department of Public Health and Environment, Denver."), [Darpun Sachdev](https://pubmed.ncbi.nlm.nih.gov/?term=Sachdev+D&cauthor_id=42573991)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-6 "California Department of Public Health, Richmond."), [Pam Daily Kirley](https://pubmed.ncbi.nlm.nih.gov/?term=Daily+Kirley+P&cauthor_id=42573991)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-7 "California Emerging Infections Program, Oakland."), [James Meek](https://pubmed.ncbi.nlm.nih.gov/?term=Meek+J&cauthor_id=42573991)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-8 "Connecticut Emerging Infections Program, Yale School of Public Health, New Haven."), [Kimberly Yousey-Hindes](https://pubmed.ncbi.nlm.nih.gov/?term=Yousey-Hindes+K&cauthor_id=42573991)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-8 "Connecticut Emerging Infections Program, Yale School of Public Health, New Haven."), [Satoshi Kamidani](https://pubmed.ncbi.nlm.nih.gov/?term=Kamidani+S&cauthor_id=42573991)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-9 "Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-10 "Children's Healthcare of Atlanta, Atlanta, Georgia.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42573991/#short-view-affiliation-11 "Georgia Emerging Infections Program, Atlanta."), [Kyle P Openo](https://pubmed.ncbi.nlm.n
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