---
title: "FGF21 reduces sepsis-associated myocardial injury by activating AMPK-driven mitochondrial biogenes"
id: "pubmed-42570491"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42570491"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42570491/"
doi: "10.1016/j.bbrc.2026.154403"
published_at: "2026-09-24T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# FGF21 reduces sepsis-associated myocardial injury by activating AMPK-driven mitochondrial biogenes
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42570491
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42570491/)
- **DOI:** [10.1016/j.bbrc.2026.154403](https://doi.org/10.1016%2Fj.bbrc.2026.154403)
- **Published At:** 2026-09-24T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Sepsis commonly causes myocardial injury; this study used a cecal ligation and puncture (CLP) mouse model to investigate the role of **FGF21** in sepsis-associated cardiac damage. - Serum FGF21 was increased in CLP mice (sham ≈ 300 pg/mL; CLP ≈ 420 pg/mL). - CLP induced myocardial injury characterized by histological damage, inflammation, and increased apoptosis. - Cardiac-specific overexpression of **FGF21** was achieved using AAV9-cTnT; overexpression improved the 5-day survival rate from ≈20% (CLP) to ≈60% (CLP + OE-FGF21). - FGF21 overexpression reduced histological cardiac damage and suppressed cardiomyocyte apoptosis in CLP mice. - Molecularly, FGF21 overexpression increased the p-AMPK/AMPK ratio and upregulated **PGC-1α**, consistent with activation of the **AMPK**/PGC-1α pathway. - In LPS-treated H9C2 cardiomyoblasts, FGF21 overexpression reversed LPS-induced declines in **mitochondrial function**. - Pharmacologic modulation of AMPK showed pathway relevance: the AMPK agonist AICAR reproduced FGF21’s protective effects, while the AMPK antagonist Compound C partially reversed them. - Overall conclusion: FGF21 alleviates sepsis-associated myocardial injury by restoring mitochondrial function through an **AMPK/PGC-1α**–mediated increase in mitochondrial biogenesis. - Details on experimental protocols, sample sizes beyond reported values, and broader translational steps were not reported in the abstract and would require the full text for clarification.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42570491/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42570491%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42570491/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42570491/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42570491/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/c24ab723-7c80-48cd-9c68-022ded852586/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42570491/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42570491/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42570491%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42570491%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42570491/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42570491/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42570491/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42570491/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Elsevier Science full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif) Elsevier Science ](https://linkinghub.elsevier.com/retrieve/pii/S0006-291X\(26\)01167-8 "See full text options at Elsevier Science") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42570491/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42570491/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42570491/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42570491/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42570491/#conflict-of-interest) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42570491/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42570491/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42570491/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42570491/#related-links) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42570491/#linkout) Title & authors Abstract Conflict of interest statement Similar articles MeSH terms Substances Related information LinkOut - more resources Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) . 2026 Sep 24:832:154403. doi: 10.1016/j.bbrc.2026.154403. Epub 2026 Aug 6. # FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis [Liping Mao](https://pubmed.ncbi.nlm.nih.gov/?term=Mao+L&cauthor_id=42570491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42570491/#full-view-affiliation-1 "Department of Pediatrics, Xi'an People's Hospital \(Xi'an Fourth Hospital\), Xi'an, 710004, China."), [Dan Dang](https://pubmed.ncbi.nlm.nih.gov/?term=Dang+D&cauthor_id=42570491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42570491/#full-view-affiliation-2 "Department of Critical Care Medicine, Xi'an People's Hospital \(Xi'an Fourth Hospital\), Xi'an, 710004, China."), [Wenjing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+W&cauthor_id=42570491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42570491/#full-view-affiliation-3 "Department of Pediatrics, Xi'an People's Hospital \(Xi'an Fourth Hospital\), Xi'an, 710004, China. Electronic address: aei619@163.com.") Affiliations Expand ### Affiliations * 1 Department of Pediatrics, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, 710004, China. * 2 Department of Critical Care Medicine, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, 710004, China. * 3 Department of Pediatrics, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, 710004, China. Electronic address: aei619@163.com. * PMID: **42570491** * DOI: [ 10.1016/j.bbrc.2026.154403 ](https://doi.org/10.1016/j.bbrc.2026.154403) Item in Clipboard # FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis Liping Mao et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) . 2026 Sep 24:832:154403. doi: 10.1016/j.bbrc.2026.154403. Epub 2026 Aug 6. ### Authors [Liping Mao](https://pubmed.ncbi.nlm.nih.gov/?term=Mao+L&cauthor_id=42570491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42570491/#short-view-affiliation-1 "Department of Pediatrics, Xi'an People's Hospital \(Xi'an Fourth Hospital\), Xi'an, 710004, China."), [Dan Dang](https://pubmed.ncbi.nlm.nih.gov/?term=Dang+D&cauthor_id=42570491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42570491/#short-view-affiliation-2 "Department of Critical Care Medicine, Xi'an People's Hospital \(Xi'an Fourth Hospital\), Xi'an, 710004, China."), [Wenjing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+W&cauthor_id=42570491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42570491/#short-view-affiliation-3 "Department of Pediatrics, Xi'an People's Hospital \(Xi'an Fourth Hospital\), Xi'an, 710004, China. Electronic address: aei619@163.com.") ### Affiliations * 1 Department of Pediatrics, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, 710004, China. * 2 Department of Critical Care Medicine, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, 710004, China. * 3 Department of Pediatrics, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, 710004, China. Electronic address: aei619@163.com. * PMID: **42570491** * DOI: [ 10.1016/j.bbrc.2026.154403 ](https://doi.org/10.1016/j.bbrc.2026.154403) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Sepsis is a life-threatening infection that often leads to myocardial injury. Here we explored the role of fibroblast growth factor 21 (FGF21) in sepsis-induced myocardial injury and its underlying mechanism. A mouse model of sepsis-associated myocardial injury was established by cecal ligation and puncture (CLP). Serum FGF21 levels were upregulated in CLP mice (sham: ∼300 pg/mL; CLP: ∼420 pg/mL). CLP led to myocardial injury, inflammation, and apoptosis. Cardiac-specific overexpression of FGF21 via AAV9-cTnT improved 5-day survival rate from ∼20% (CLP) to ∼60% (CLP + OE-FGF21), reduced histological damage, suppressed apoptosis, and upregulated p-AMPK/AMPK and PGC-1α. In LPS-treated H9C2 cells, FGF21 overexpression reversed the LPS-induced decline in mitochondrial function. The AMPK agonist AICAR mimicked, while the AMPK antagonist Compound C partially reversed, the protective effects of FGF21. In conclusion, FGF21 overexpression alleviates sepsis-associated myocardial injury by restoring mitochondrial function via AMPK/PGC-1α pathway. **Keywords:** AMPK signaling; Apoptosis; FGF21; Mitochondrial biogenesis; Oxidative stress; Sepsis-associated myocardial injury. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Astragaloside II-preconditioned bone marrow mesenchymal stem cells attenuate sepsis-induced acute lung injury by restoring mitochondrial function via NRF2/PGC-1α pathway activation. ](https://pubmed.ncbi.nlm.nih.gov/42349124/) Zhang H, Sun Y, Tang Y, Yao L, Abulimiti X, Wu Q.Zhang H, et al.Biochem Biophys Res Commun. 2026 Sep 3;829:154148. doi: 10.1016/j.bbrc.2026.154148. Epub 2026 Jun 15.Biochem Biophys Res Commun. 2026.PMID: 42349124 * [ CTRP6-mediated cardiac protection in heart failure via the AMPK/SIRT1/PGC-1α signalling pathway. ](https://pubmed.ncbi.nlm.nih.gov/39325807/) Fan T, Zhu N, Li M, Wang Z, Lin X.Fan T, et al.Exp Physiol. 2024 Dec;109(12):2031-2045. doi: 10.1113/EP092036. Epub 2024 Sep 26.Exp Physiol. 2024.PMID: 39325807Free PMC article. * [ Semaglutide Pretreatment Induces Cardiac Autophagy to Reduce Myocardial Injury in Septic Mice. ](https://pubmed.ncbi.nlm.nih.gov/37811623/) Zhang W, Zhang J.Zhang W, et al.Discov Med. 2023 Oct;35(178):853-860. doi: 10.24976/Discov.Med.202335178.80.Discov Med. 2023.PMID: 37811623 * [ MECHANISM OF MICRORNA-218-5P IN MITOCHONDRIAL BIOGENESIS OF SEPSIS-INDUCED ACUTE KIDNEY INJURY BY THE REGULATION OF PGC-1Α. ](https://pubmed.ncbi.nlm.nih.gov/38888503/) Kuang J, Fang J, Hu S, Yang X, Fan X.Kuang J, et al.Shock. 2024 Sep 1;62(3):426-436. doi: 10.1097/SHK.0000000000002410. Epub 2024 May 30.Shock. 2024.PMID: 38888503 * [ The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling. ](https://pubmed.ncbi.nlm.nih.gov/25560828/) Jiang X, Chen J, Zhang C, Zhang Z, Tan Y, Feng W, Skibba M, Xin Y, Cai L.Jiang X, et al.Endocrinology. 2015 Mar;156(3):1156-70. doi: 10.1210/en.2014-1619. Epub 2015 Jan 5.Endocrinology. 2015.PMID: 25560828Free PMC article. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42570491) ## MeSH terms * AMP-Activated Protein Kinases* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22AMP-Activated+Protein+Kinases%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=AMP-Activated+Protein+Kinases) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Apoptosis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Apoptosis%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Apoptosis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Cell Line Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Fibroblast Growth Factors* / blood Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibroblast+Growth+Factors%2Fblood%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Fibroblast+Growth+Factors) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Fibroblast Growth Factors* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibroblast+Growth+Factors%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Fibroblast+Growth+Factors) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Fibroblast Growth Factors* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibroblast+Growth+Factors%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Fibroblast+Growth+Factors) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Male Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Male) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Mice Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mice) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Mice, Inbred C57BL Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mice%2C+Inbred+C57BL%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mice%2C+Inbred+C57BL) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Myocardium / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Myocardium%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Myocardium) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Myocardium / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Myocardium%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Myocardium) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Organelle Biogenesis* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Organelle+Biogenesis%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Organelle+Biogenesis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Peroxisome+Proliferator-Activated+Receptor+Gamma+Coactivator+1-alpha%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Peroxisome+Proliferator-Activated+Receptor+Gamma+Coactivator+1-alpha) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Sepsis* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sepsis%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sepsis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Sepsis* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sepsis%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sepsis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * Sepsis* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sepsis%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sepsis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) ## Substances * Fibroblast Growth Factors Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibroblast+Growth+Factors%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22Fibroblast+Growth+Factors%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * fibroblast growth factor 21 Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22fibroblast+growth+factor+21%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22fibroblast+growth+factor+21%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42570491/) * AMP-Activated Protein Kinases Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22AMP-Activated+Protein+Kinases%22%5Bnm%5D&sort=date&sort_or
## Related Clinical Research

- [Albumin-Corrected Anion Gap Predicts In-Hospital Mortality in Traumatic Lung Injury: Multicenter R](https://medichelpline.com/clinical-feed/pubmed-42626900.md) (DOI: 10.1177/10815589261483651)
- [Postcardiotomy ECMO After the Norwood Procedure: US Utilization, Outcomes, and Predictors](https://medichelpline.com/clinical-feed/pubmed-42622839.md) (DOI: 10.1177/02184923261478983)
- [Safiglipron vs dapagliflozin in type 2 diabetes: phase 3 randomized double-blind OUTSTAND-2 results](https://medichelpline.com/clinical-feed/nature-0-oral-small-molecule-glp-1ra-safiglipron-versus-dapagliflozin-in-type-2-diabetes.md)
- [Persistent critical illness in mechanically ventilated acute hypoxic respiratory failure: prevalen](https://medichelpline.com/clinical-feed/plos-one-9-persistent-critical-illness-in-acute-hypoxic-respiratory-failure-a.md)
- [Undiagnosed type 2 diabetes presenting as DKA with hypertriglyceridemia-induced acute pancreatitis](https://medichelpline.com/clinical-feed/cmaj-1-undiagnosed-type-2-diabetes-presenting-as-diabetic-ketoacidosis-with.md)

## Navigation
- [← Back to Critical Care Feed](https://medichelpline.com/clinical-feed/critical-care.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.