---
title: "Innovation, development, and licensure of improved influenza vaccines"
id: "pubmed-42759246"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42759246"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42759246/"
doi: "10.1016/j.vaccine.2026.129135"
published_at: "2026-10-24T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Innovation, development, and licensure of improved influenza vaccines
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42759246
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42759246/)
- **DOI:** [10.1016/j.vaccine.2026.129135](https://doi.org/10.1016%2Fj.vaccine.2026.129135)
- **Published At:** 2026-10-24T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The source is a peer-reviewed review article titled “Innovation, development, and licensure of improved **influenza vaccines**” published in the journal **Vaccine**. - Publication details provided: Volume 92, article 129135; electronic publication date 2026 Sep 18; citation lists PMID 42759246 and DOI 10.1016/j.vaccine.2026.129135. - The manuscript is authored by a large, multidisciplinary group of investigators (Julia T Ostrowsky et al.) representing academic, regulatory, and public-health institutions across North America, Europe, Asia, and Africa. - Affiliations listed include the Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota, Georgetown University School of Medicine, the European Medicines Agency, St. Jude Children’s Research Hospital, University of Bergen, and multiple independent consultants and public-health institutes. - The PubMed entry labels the piece as a Review and provides full author and affiliation metadata; a free full-text link and Elsevier hosting are indicated. - The PubMed record included metadata only in the provided source; the abstract and the body text of the review were not present in the pasted content, and therefore the source did not report specific trial data, endpoints, methodologies, or regulatory recommendations from the review. - Because the supplied source content lacks the article abstract or main text, no clinical outcomes, quantitative results, or detailed recommendations from the review can be summarized here. - Users seeking the full clinical and regulatory details will need to consult the article at the publisher link or PubMed full-text link referenced in the record.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 18. # Innovation, development, and licensure of improved influenza vaccines: the way forward [Julia T Ostrowsky](https://pubmed.ncbi.nlm.nih.gov/?term=Ostrowsky+JT&cauthor_id=42759246)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-1 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: jto@umn.edu."), [Bruce G Gellin](https://pubmed.ncbi.nlm.nih.gov/?term=Gellin+BG&cauthor_id=42759246)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-2 "Georgetown University School of Medicine, Washington, DC, USA."), [Marco Cavaleri](https://pubmed.ncbi.nlm.nih.gov/?term=Cavaleri+M&cauthor_id=42759246)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-3 "European Medicines Agency, Amsterdam, the Netherlands."), [Joseph S Bresee](https://pubmed.ncbi.nlm.nih.gov/?term=Bresee+JS&cauthor_id=42759246)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-4 "Task Force for Global Health, Decatur, Georgia, USA."), [Rajeev Venkayya](https://pubmed.ncbi.nlm.nih.gov/?term=Venkayya+R&cauthor_id=42759246)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-5 "Independent Consultant, Cambridge, Massachusetts, USA."), [Rebecca Jane Cox](https://pubmed.ncbi.nlm.nih.gov/?term=Cox+RJ&cauthor_id=42759246)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-6 "Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Microbiology, Haukeland University Hospital, Bergen, Norway."), [Stacey Schultz-Cherry](https://pubmed.ncbi.nlm.nih.gov/?term=Schultz-Cherry+S&cauthor_id=42759246)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-7 "St. Jude Children's Research Hospital, Memphis, Tennessee, USA."), [Rosalind Hollingsworth](https://pubmed.ncbi.nlm.nih.gov/?term=Hollingsworth+R&cauthor_id=42759246)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-8 "Independent Consultant, Swiftwater, Pennsylvania, USA."), [Kanta Subbarao](https://pubmed.ncbi.nlm.nih.gov/?term=Subbarao+K&cauthor_id=42759246)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-9 "Université Laval, Quebec City, Quebec, Canada; University of Melbourne, Melbourne, Australia."), [Cheryl Cohen](https://pubmed.ncbi.nlm.nih.gov/?term=Cohen+C&cauthor_id=42759246)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-10 "School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Centre for Respiratory Disease and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa."), [Ethan C Settembre](https://pubmed.ncbi.nlm.nih.gov/?term=Settembre+EC&cauthor_id=42759246)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-11 "Independent Consultant, Boston, Massachusetts, USA."), [Edward Belongia](https://pubmed.ncbi.nlm.nih.gov/?term=Belongia+E&cauthor_id=42759246)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-12 "Independent Consultant, Madison, Wisconsin, USA."), [John W McCauley](https://pubmed.ncbi.nlm.nih.gov/?term=McCauley+JW&cauthor_id=42759246)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-13 "Francis Crick Institute, London, UK."), [Rino Rappuoli](https://pubmed.ncbi.nlm.nih.gov/?term=Rappuoli+R&cauthor_id=42759246)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-14 "Biotecnopolo Foundation, Siena, Italy."), [Benjamin J Cowling](https://pubmed.ncbi.nlm.nih.gov/?term=Cowling+BJ&cauthor_id=42759246)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-15 "The University of Hong Kong, Hong Kong SAR, China."), [Jessica Taaffe](https://pubmed.ncbi.nlm.nih.gov/?term=Taaffe+J&cauthor_id=42759246)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-16 "Independent Consultant, Washington, DC, USA."), [Natalie C Vestin](https://pubmed.ncbi.nlm.nih.gov/?term=Vestin+NC&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Angela J Mehr](https://pubmed.ncbi.nlm.nih.gov/?term=Mehr+AJ&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Angela K Ulrich](https://pubmed.ncbi.nlm.nih.gov/?term=Ulrich+AK&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Michael T Osterholm](https://pubmed.ncbi.nlm.nih.gov/?term=Osterholm+MT&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Kristine A Moore](https://pubmed.ncbi.nlm.nih.gov/?term=Moore+KA&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#full-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA.") Affiliations Expand ### Affiliations * 1 Center for Infectious Disease Research and Policy (CIDRAP), University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: jto@umn.edu. * 2 Georgetown University School of Medicine, Washington, DC, USA. * 3 European Medicines Agency, Amsterdam, the Netherlands. * 4 Task Force for Global Health, Decatur, Georgia, USA. * 5 Independent Consultant, Cambridge, Massachusetts, USA. * 6 Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Microbiology, Haukeland University Hospital, Bergen, Norway. * 7 St. Jude Children's Research Hospital, Memphis, Tennessee, USA. * 8 Independent Consultant, Swiftwater, Pennsylvania, USA. * 9 Université Laval, Quebec City, Quebec, Canada; University of Melbourne, Melbourne, Australia. * 10 School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Centre for Respiratory Disease and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa. * 11 Independent Consultant, Boston, Massachusetts, USA. * 12 Independent Consultant, Madison, Wisconsin, USA. * 13 Francis Crick Institute, London, UK. * 14 Biotecnopolo Foundation, Siena, Italy. * 15 The University of Hong Kong, Hong Kong SAR, China. * 16 Independent Consultant, Washington, DC, USA. * 17 Center for Infectious Disease Research and Policy (CIDRAP), University of Minnesota, Minneapolis, Minnesota, USA. * PMID: **42759246** * DOI: [ 10.1016/j.vaccine.2026.129135 ](https://doi.org/10.1016/j.vaccine.2026.129135) Free article Item in Clipboard Review # Innovation, development, and licensure of improved influenza vaccines: the way forward Julia T Ostrowsky et al. Vaccine. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Vaccine Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Vaccine%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Vaccine%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42759246/) . 2026 Oct 24:92:129135. doi: 10.1016/j.vaccine.2026.129135. Epub 2026 Sep 18. ### Authors [Julia T Ostrowsky](https://pubmed.ncbi.nlm.nih.gov/?term=Ostrowsky+JT&cauthor_id=42759246)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-1 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: jto@umn.edu."), [Bruce G Gellin](https://pubmed.ncbi.nlm.nih.gov/?term=Gellin+BG&cauthor_id=42759246)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-2 "Georgetown University School of Medicine, Washington, DC, USA."), [Marco Cavaleri](https://pubmed.ncbi.nlm.nih.gov/?term=Cavaleri+M&cauthor_id=42759246)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-3 "European Medicines Agency, Amsterdam, the Netherlands."), [Joseph S Bresee](https://pubmed.ncbi.nlm.nih.gov/?term=Bresee+JS&cauthor_id=42759246)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-4 "Task Force for Global Health, Decatur, Georgia, USA."), [Rajeev Venkayya](https://pubmed.ncbi.nlm.nih.gov/?term=Venkayya+R&cauthor_id=42759246)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-5 "Independent Consultant, Cambridge, Massachusetts, USA."), [Rebecca Jane Cox](https://pubmed.ncbi.nlm.nih.gov/?term=Cox+RJ&cauthor_id=42759246)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-6 "Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Microbiology, Haukeland University Hospital, Bergen, Norway."), [Stacey Schultz-Cherry](https://pubmed.ncbi.nlm.nih.gov/?term=Schultz-Cherry+S&cauthor_id=42759246)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-7 "St. Jude Children's Research Hospital, Memphis, Tennessee, USA."), [Rosalind Hollingsworth](https://pubmed.ncbi.nlm.nih.gov/?term=Hollingsworth+R&cauthor_id=42759246)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-8 "Independent Consultant, Swiftwater, Pennsylvania, USA."), [Kanta Subbarao](https://pubmed.ncbi.nlm.nih.gov/?term=Subbarao+K&cauthor_id=42759246)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-9 "Université Laval, Quebec City, Quebec, Canada; University of Melbourne, Melbourne, Australia."), [Cheryl Cohen](https://pubmed.ncbi.nlm.nih.gov/?term=Cohen+C&cauthor_id=42759246)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-10 "School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Centre for Respiratory Disease and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa."), [Ethan C Settembre](https://pubmed.ncbi.nlm.nih.gov/?term=Settembre+EC&cauthor_id=42759246)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-11 "Independent Consultant, Boston, Massachusetts, USA."), [Edward Belongia](https://pubmed.ncbi.nlm.nih.gov/?term=Belongia+E&cauthor_id=42759246)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-12 "Independent Consultant, Madison, Wisconsin, USA."), [John W McCauley](https://pubmed.ncbi.nlm.nih.gov/?term=McCauley+JW&cauthor_id=42759246)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-13 "Francis Crick Institute, London, UK."), [Rino Rappuoli](https://pubmed.ncbi.nlm.nih.gov/?term=Rappuoli+R&cauthor_id=42759246)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-14 "Biotecnopolo Foundation, Siena, Italy."), [Benjamin J Cowling](https://pubmed.ncbi.nlm.nih.gov/?term=Cowling+BJ&cauthor_id=42759246)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-15 "The University of Hong Kong, Hong Kong SAR, China."), [Jessica Taaffe](https://pubmed.ncbi.nlm.nih.gov/?term=Taaffe+J&cauthor_id=42759246)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-16 "Independent Consultant, Washington, DC, USA."), [Natalie C Vestin](https://pubmed.ncbi.nlm.nih.gov/?term=Vestin+NC&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Angela J Mehr](https://pubmed.ncbi.nlm.nih.gov/?term=Mehr+AJ&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Angela K Ulrich](https://pubmed.ncbi.nlm.nih.gov/?term=Ulrich+AK&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Michael T Osterholm](https://pubmed.ncbi.nlm.nih.gov/?term=Osterholm+MT&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA."), [Kristine A Moore](https://pubmed.ncbi.nlm.nih.gov/?term=Moore+KA&cauthor_id=42759246)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42759246/#short-view-affiliation-17 "Center for Infectious Disease Research and Policy \(CIDRAP\), University of Minnesota, Minneapolis, Minnesota, USA.") ### Affiliations * 1 Center for Infectious Disease Research and Policy (CIDRAP), University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: jto@umn.edu. * 2 Georgetown University School of Medicine, Washington, DC, US
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