---
title: "Integrated cell death networks and diet‑related small molecule modulation in sepsis‑associated AKI"
id: "pubmed-42695405"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42695405"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42695405/"
doi: "10.3892/ijmm.2026.5974"
published_at: "2026-09-04T12:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Integrated cell death networks and diet‑related small molecule modulation in sepsis‑associated AKI
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42695405
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42695405/)
- **DOI:** [10.3892/ijmm.2026.5974](https://doi.org/10.3892%2Fijmm.2026.5974)
- **Published At:** 2026-09-04T12:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Sepsis‑associated acute kidney injury (SA‑AKI) arises from multiple interacting disturbances — inflammation, metabolic derangement, microcirculatory failure, mitochondrial dysfunction and programmed cell death — rather than a single dominant pathway. - Multiple programmed death modalities (including **apoptosis**, **pyroptosis**, **ferroptosis**, **necroptosis** and **autophagy**‑related responses) act as an integrated, heterogeneous network with extensive crosstalk, compensatory signaling and regulation that varies by disease stage. - The review reframes SA‑AKI through an integrated cell death network model, organizing evidence around shared regulatory nodes classified as upstream drivers, amplifiers/permissive states, context‑dependent modifiers and terminal execution mechanisms. - Key shared injury conditions highlighted include **mitochondrial dysfunction**, **redox‑iron imbalance**, **NF‑κB‑dependent inflammatory activation**, **inflammasome priming**, failures in **autophagy/mitophagy**, and **immunometabolic stress**. - Diet‑related small molecules are grouped into food‑derived phytochemicals, nutritional compounds, microbiota‑derived metabolites and ICU antioxidant/vitamin regimens; their potential benefit may stem from reshaping common upstream environments rather than selectively blocking single death pathways. - Major translational barriers are emphasized: limited bioavailability, unclear active metabolites, sepsis‑altered pharmacokinetics, disease‑stage specificity, renal target exposure and inter‑patient heterogeneity. - The authors propose an exposure‑aware and endotype‑guided framework to evaluate diet‑related small molecules in SA‑AKI, stressing the need to account for pharmacology, timing and patient subgroups rather than relying on single‑target strategies.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42695405/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42695405%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42695405/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42695405/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42695405/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/c24ab723-7c80-48cd-9c68-022ded852586/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42695405/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42695405/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42695405%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42695405%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42695405/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42695405/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42695405/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42695405/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42695405/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42695405/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42695405/#abstract) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42695405/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42695405/#mesh-terms) Title & authors Abstract Publication types MeSH terms Review Int J Mol Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Int+J+Mol+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Int+J+Mol+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) . 2026 Nov;58(5):303. doi: 10.3892/ijmm.2026.5974. Epub 2026 Sep 4. # Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review) [Lin Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+L&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Aifeng He](https://pubmed.ncbi.nlm.nih.gov/?term=He+A&cauthor_id=42695405)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-2 "Department of Emergency Medicine, Binhai County People's Hospital/Binhai Clinical College of Yangzhou University Medical College, Binhai, Jiangsu 224500, P.R. China."), [Wei Jiang](https://pubmed.ncbi.nlm.nih.gov/?term=Jiang+W&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Keran Shi](https://pubmed.ncbi.nlm.nih.gov/?term=Shi+K&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Jing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Lu Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+L&cauthor_id=42695405)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-3 "Department of Critical Care Medicine, The Yangzhou Clinical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, P.R. China."), [Jiangquan Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+J&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Ruiqiang Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+R&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#full-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.") Affiliations Expand ### Affiliations * 1 Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China. * 2 Department of Emergency Medicine, Binhai County People's Hospital/Binhai Clinical College of Yangzhou University Medical College, Binhai, Jiangsu 224500, P.R. China. * 3 Department of Critical Care Medicine, The Yangzhou Clinical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, P.R. China. * PMID: **42695405** * DOI: [ 10.3892/ijmm.2026.5974 ](https://doi.org/10.3892/ijmm.2026.5974) Item in Clipboard Review # Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review) Lin Song et al. Int J Mol Med. 2026 Nov. Show details Display options Display options Format Abstract PubMed PMID Int J Mol Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Int+J+Mol+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Int+J+Mol+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) . 2026 Nov;58(5):303. doi: 10.3892/ijmm.2026.5974. Epub 2026 Sep 4. ### Authors [Lin Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+L&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Aifeng He](https://pubmed.ncbi.nlm.nih.gov/?term=He+A&cauthor_id=42695405)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-2 "Department of Emergency Medicine, Binhai County People's Hospital/Binhai Clinical College of Yangzhou University Medical College, Binhai, Jiangsu 224500, P.R. China."), [Wei Jiang](https://pubmed.ncbi.nlm.nih.gov/?term=Jiang+W&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Keran Shi](https://pubmed.ncbi.nlm.nih.gov/?term=Shi+K&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Jing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Lu Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+L&cauthor_id=42695405)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-3 "Department of Critical Care Medicine, The Yangzhou Clinical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, P.R. China."), [Jiangquan Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+J&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China."), [Ruiqiang Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+R&cauthor_id=42695405)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42695405/#short-view-affiliation-1 "Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.") ### Affiliations * 1 Department of Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China. * 2 Department of Emergency Medicine, Binhai County People's Hospital/Binhai Clinical College of Yangzhou University Medical College, Binhai, Jiangsu 224500, P.R. China. * 3 Department of Critical Care Medicine, The Yangzhou Clinical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, P.R. China. * PMID: **42695405** * DOI: [ 10.3892/ijmm.2026.5974 ](https://doi.org/10.3892/ijmm.2026.5974) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Sepsis‑associated acute kidney injury (SA‑AKI) presents a significant challenge in critical care, largely due to the multifaceted nature of renal injury stemming from interconnected disturbances in inflammation, metabolism, microcirculation, mitochondrial function and programmed cell death, rather than arising from a singular dominant pathway. Increasing evidence indicates that apoptosis, pyroptosis, ferroptosis, necroptosis and autophagy‑related responses function as an integrated yet heterogeneous cell death network, characterized by extensive crosstalk, compensatory signaling and disease stage‑dependent regulation. The present review uses an integrated cell death network framework for SA‑AKI, rather than simply summarizing individual cell death pathways or sequentially cataloguing diet‑related small molecules. Current evidence was synthesized by organizing shared regulatory nodes according to their mechanistic roles, including upstream drivers, amplifiers or permissive states, context‑dependent modifiers, and terminal execution mechanisms. Focus is placed on mitochondrial dysfunction, redox‑iron imbalance, NF‑κB‑dependent inflammatory activation, inflammasome priming, failures in autophagy/mitophagy and immunometabolic stress. Furthermore, the present review explores how diet‑related small molecules may influence these shared injury conditions, differentiating between food‑derived phytochemicals, nutritional compounds, microbiota‑derived metabolites and intensive care unit‑based antioxidant or vitamin regimens. The potential efficacy of these compounds may derive less from their ability to selectively inhibit isolated death programs and more from their capacity to reshape common upstream environments that allow multiple death pathways to manifest. Finally, major translational barriers are discussed, including limited bioavailability, uncertainty surrounding active metabolites, altered pharmacokinetics during sepsis, disease‑stage specificity, renal target exposure and inter‑patient heterogeneity. An exposure‑aware and endotype‑guided framework is proposed for the future evaluation of diet‑related small molecules in the context of SA‑AKI. **Keywords:** diet‑related small molecules; multi‑target regulation; precision medicine; programmed cell death; sepsis‑associated acute kidney injury. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Publication types * Review Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Review%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Review) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) ## MeSH terms * Acute Kidney Injury* / etiology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute+Kidney+Injury%2Fetiology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Acute+Kidney+Injury) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Acute Kidney Injury* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute+Kidney+Injury%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Acute+Kidney+Injury) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Acute Kidney Injury* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute+Kidney+Injury%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Acute+Kidney+Injury) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Cell Death* / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Death%2Fdrug+effects%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Death) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Diet* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Diet%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Diet) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Mitochondria / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitochondria%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mitochondria) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Sepsis* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sepsis%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sepsis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Sepsis* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sepsis%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sepsis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Sepsis* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sepsis%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sepsis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) * Signal Transduction Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Signal+Transduction%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Signal+Transduction) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42695405/) [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42695405/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42695405%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.gov/42695405/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42695405%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42695405%2F%23open-collections-panel) * [Citation Manager](https://pubmed.ncbi.nlm.nih.gov/42695405/) [x] NCBI Literature Resources [MeSH](https://www.ncbi.nlm.nih.gov/mesh/) [PMC](https://www.ncbi.nlm.nih.gov/pmc/) [Bookshelf
## Related Clinical Research

- [Acute Kidney Injury in Delirium Tremens: Association with Intubation, Length of Stay, and Mortality](https://medichelpline.com/clinical-feed/pubmed-42683912.md) (DOI: 10.1080/08998280.2026.2724483)
- [Thrombin‑Antithrombin Complex and Fibrinogen as Early Predictors of Trauma‑Related AKI](https://medichelpline.com/clinical-feed/pubmed-42678921.md) (DOI: 10.1182/bloodadvances.2026020806)
- [Prospective Study of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidn](https://medichelpline.com/clinical-feed/clinicaltrials-nct03720860.md) (DOI: NCT03720860)
- [Acute Sigmoid Volvulus With Abdominal Compartment Syndrome: A CT Case](https://medichelpline.com/clinical-feed/litfl-7-ct-case-102.md)
- [Incidence, trends, and in-hospital mortality of thyroid storm in Thailand (2017–2024)](https://medichelpline.com/clinical-feed/plos-one-3-epidemiology-and-mortality-rate-of-thyroid-storm-in-thailand-analysis-using-a.md)

## Navigation
- [← Back to Critical Care Feed](https://medichelpline.com/clinical-feed/critical-care.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.