---
title: "Intratumoral Mycobacterium abscessus and cytidine deaminase mutagenesis in non-small cell lung can"
id: "pubmed-42675040"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42675040"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42675040/"
doi: "10.1038/s41392-026-02878-z"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Intratumoral Mycobacterium abscessus and cytidine deaminase mutagenesis in non-small cell lung can
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42675040
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42675040/)
- **DOI:** [10.1038/s41392-026-02878-z](https://doi.org/10.1038%2Fs41392-026-02878-z)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Citation: article titled "Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer" published in Signal Transduct Target Ther (2026 Sep 1;11(1):355), DOI 10.1038/s41392-026-02878-z, PMID 42675040. - Authors: First authors Xun Li, Mei-Ting Li, Ke-Peng Ou, and Pan-Qi Gao contributed equally; full author list includes An-Hua Xiao, Ji Yang, Jia-Ning Li, Wan-Yan Deng, Meng-Jun Bie, Ai-Long Huang, Xiao-Feng Shi, and Quan-Xin Long. - Affiliations: Multiple groups in Chongqing, China, including the Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University; College of Pharmacy, Chongqing University of Arts and Sciences; and Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University. - Equal contribution: Several authors are noted as contributing equally (indicated in the PubMed record). - Primary topic keywords reported in the title: **Mycobacterium abscessus**, **cytidine deaminase mutagenesis**, **non-small cell lung cancer**; these are the main focus per the article title. - Article metadata available on PubMed: journal name, volume/issue/page, DOI, PMID, publication date; however, the PubMed page excerpt provided does not include the abstract text, results, methods, sample size, or conclusions. - Missing details: The record excerpt does not report study design, experimental methods, patient or specimen numbers, key results, statistical findings, mechanistic data, therapeutic implications, or conflict of interest statements; those details require access to the full article. - Access: Full text is available through the journal Signal Transduct Target Ther and via DOI link; PubMed entry lists identifiers for locating the complete publication. - Practical note: Clinical interpretation or application cannot be inferred from the PubMed metadata alone; consult the full published article for evidence, methodology, and validated conclusions.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42675040/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42675040/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42675040/#references) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42675040/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42675040/#substances) Title & authors Abstract Conflict of interest statement References MeSH terms Substances Signal Transduct Target Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Signal+Transduct+Target+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Signal+Transduct+Target+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42675040/) . 2026 Sep 1;11(1):355. doi: 10.1038/s41392-026-02878-z. # Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer [Xun Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+X&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Mei-Ting Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+MT&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Ke-Peng Ou](https://pubmed.ncbi.nlm.nih.gov/?term=Ou+KP&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-equal-contrib-explanation "Contributed equally")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-2 "College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, China."), [Pan-Qi Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+PQ&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [An-Hua Xiao](https://pubmed.ncbi.nlm.nih.gov/?term=Xiao+AH&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Ji Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+J&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Jia-Ning Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+JN&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Wan-Yan Deng](https://pubmed.ncbi.nlm.nih.gov/?term=Deng+WY&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Meng-Jun Bie](https://pubmed.ncbi.nlm.nih.gov/?term=Bie+MJ&cauthor_id=42675040)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-3 "Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. biemengjun@hospital.cqmu.edu.cn."), [Ai-Long Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+AL&cauthor_id=42675040)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-4 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn."), [Xiao-Feng Shi](https://pubmed.ncbi.nlm.nih.gov/?term=Shi+XF&cauthor_id=42675040)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-5 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. sxf7776@163.com."), [Quan-Xin Long](https://pubmed.ncbi.nlm.nih.gov/?term=Long+QX&cauthor_id=42675040)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#full-view-affiliation-6 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. longqx@cqmu.edu.cn.") Affiliations Expand ### Affiliations * 1 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. * 2 College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, China. * 3 Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. biemengjun@hospital.cqmu.edu.cn. * 4 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn. * 5 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. sxf7776@163.com. * 6 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. longqx@cqmu.edu.cn. # Contributed equally. * PMID: **42675040** * DOI: [ 10.1038/s41392-026-02878-z ](https://doi.org/10.1038/s41392-026-02878-z) Item in Clipboard # Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer Xun Li et al. Signal Transduct Target Ther. 2026. Show details Display options Display options Format Abstract PubMed PMID Signal Transduct Target Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Signal+Transduct+Target+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Signal+Transduct+Target+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42675040/) . 2026 Sep 1;11(1):355. doi: 10.1038/s41392-026-02878-z. ### Authors [Xun Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+X&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Mei-Ting Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+MT&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Ke-Peng Ou](https://pubmed.ncbi.nlm.nih.gov/?term=Ou+KP&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-equal-contrib-explanation "Contributed equally")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-2 "College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, China."), [Pan-Qi Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+PQ&cauthor_id=42675040)[#](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [An-Hua Xiao](https://pubmed.ncbi.nlm.nih.gov/?term=Xiao+AH&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Ji Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+J&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Jia-Ning Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+JN&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Wan-Yan Deng](https://pubmed.ncbi.nlm.nih.gov/?term=Deng+WY&cauthor_id=42675040)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-1 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China."), [Meng-Jun Bie](https://pubmed.ncbi.nlm.nih.gov/?term=Bie+MJ&cauthor_id=42675040)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-3 "Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. biemengjun@hospital.cqmu.edu.cn."), [Ai-Long Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+AL&cauthor_id=42675040)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-4 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn."), [Xiao-Feng Shi](https://pubmed.ncbi.nlm.nih.gov/?term=Shi+XF&cauthor_id=42675040)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-5 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. sxf7776@163.com."), [Quan-Xin Long](https://pubmed.ncbi.nlm.nih.gov/?term=Long+QX&cauthor_id=42675040)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42675040/#short-view-affiliation-6 "Key Laboratory of Molecular Biology for Infectious Diseases \(Ministry of Education\), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. longqx@cqmu.edu.cn.") ### Affiliations * 1 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. * 2 College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, China. * 3 Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. biemengjun@hospital.cqmu.edu.cn. * 4 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn. * 5 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. sxf7776@163.com. * 6 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. longqx@cqmu.edu.cn. # Contributed equally. * PMID: **42675040** * DOI: [ 10.1038/s41392-026-02878-z ](https://doi.org/10.1038/s41392-026-02878-z) Item in Clipboard Cite Display options Display options
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