---
title: "Low‑Dose Radiotherapy in Solid Tumors: 2026 Expert Consensus on Mechanisms, Applications, and Prac"
id: "pubmed-42764216"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42764216"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42764216/"
doi: "10.3760/cma.j.cn112152-20260205-00080"
published_at: "2026-09-23T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Low‑Dose Radiotherapy in Solid Tumors: 2026 Expert Consensus on Mechanisms, Applications, and Prac
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42764216
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42764216/)
- **DOI:** [10.3760/cma.j.cn112152-20260205-00080](https://doi.org/10.3760%2Fcma.j.cn112152-20260205-00080)
- **Published At:** 2026-09-23T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The 2026 expert consensus addresses **low-dose radiotherapy (LDRT)** as an immunomodulatory strategy for solid tumors and summarizes mechanisms, clinical evidence, and application specifications. - LDRT differs from high‑dose radiotherapy by reshaping the **tumor immune microenvironment** rather than primarily causing direct tumor cell kill. - Mechanisms described include enhanced dendritic cell antigen presentation, increased **T‑cell infiltration**, reversal of immunosuppressive microenvironment, and remodeling of tumor vasculature and stroma. - Clinical studies cited in the consensus report improved objective response rates and survival when LDRT was combined with **immunotherapy**, chemotherapy, or high‑dose radiotherapy in tumor types such as **non‑small cell lung cancer**, extensive‑stage small cell lung cancer, and head and neck squamous cell carcinoma. - The consensus notes favorable safety profiles for LDRT in reported studies but emphasizes that unified standards are lacking for patient selection, combination strategies, dose fractionation, sequencing, and target volume delineation. - The document systematically elaborates mechanisms, clinical applications, and recommended regimens, aiming to standardize LDRT use and guide future clinical research and practice. - The consensus is published in Zhonghua Zhong Liu Za Zhi (2026 Sep 23;48(9):1094–1107), DOI 10.3760/cma.j.cn112152-20260205-00080, with a PMID of 42764216. - All authors declared no conflicts of interest. - The full text is available via the Chinese Medical Association Publishing House; the English and Chinese abstracts are provided on PubMed. Details on specific dose regimens and precise technical parameters are presented in the full consensus; the abstract confirms recommendations but does not report granular protocol details.
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Zhonghua Zhong Liu Za Zhi. 2026. 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Unlike traditional high-dose radiotherapy that directly kill tumors, LDRT reshapes the tumor immune microenvironment by promoting dendritic cell antigen presentation, enhancing T-cell infiltration, reversing the immunosuppressive microenvironment, and remodeling tumor vascular and stromal structures, thereby enhancing the efficacy of immunotherapy. Clinical studies have shown that LDRT combined with immune checkpoint inhibitors, chemotherapy, or high-dose radiotherapy can increase the objective response rate and improve patient survival in solid tumors such as non-small cell lung cancer, extensive-stage small cell lung cancer, and head and neck squamous cell carcinoma, with favorable safety profiles. However, unified standards for LDRT are still lacking in terms of patient selection, combination strategies, dose fractionation, sequencing, and target volume delineation. Based on current basic research and clinical evidence, this expert consensus, titled "Expert consensus on application specifications of low-dose radiotherapy in solid tumors (2026 edition)", systematically elaborates on the mechanisms, clinical applications, and recommended regimens of LDRT, aiming to promote its standardized application and providing a reference for future clinical research and practice. 低剂量放疗（LDRT）作为一种新兴的肿瘤免疫调节策略，其与免疫疗法联用所展现的协同抗肿瘤潜力已在多种实体瘤中得到证实。与以直接肿瘤杀伤作用的传统高剂量放疗不同，LDRT通过促进树突状细胞抗原提呈、增强T细胞浸润、逆转免疫抑制性微环境以及改善肿瘤血管与基质结构，重塑肿瘤免疫微环境，从而提升免疫治疗疗效。临床研究显示，LDRT联合免疫检查点抑制剂、化疗或高剂量放疗，可在非小细胞肺癌、广泛期小细胞肺癌、头颈鳞状细胞癌等实体瘤中提高客观缓解率并改善患者生存，且安全性良好。然而，目前LDRT在适应人群、联合策略、剂量分割、联合时序和靶区设计方面仍缺乏统一规范。《低剂量放疗在实体瘤治疗中的应用规范专家共识（2026版）》基于现有基础研究及临床证据，系统阐述LDRT的机制、临床应用与推荐方案，旨在推动其规范化应用，并为未来临床研究与实践提供参考。. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement 所有作者声明无利益冲突 ## Similar articles * [ Combinatorial Delivery of Low-Dose Radiotherapy and Immunotherapy to Patients with Immune-Excluded Tumors Enhances CD8+ T-cell Functionality. ](https://pubmed.ncbi.nlm.nih.gov/41995577/) Ochoa-de-Olza M, Rayroux N, Imbimbo M, Orcurto A, Fahr N, Benedetti F, Dagher J, Spagnol G, Barras D, Ghisoni E, Navarro B, Mulvey A, Berthold D, Sarivalasis A, Zaman K, Stravodimou A, Digklia A, Duran R, Dromain C, Prior JO, Schaefer N, Zimmermann S, Obeid M, Chalkidis N, Zoi T, Bisig B, Trueb L, Gulhan DC, Sempoux C, Dafni U, Tissot S, Coukos G, Herrera FG, Dangaj Laniti D.Ochoa-de-Olza M, et al.Clin Cancer Res. 2026 Jul 17;32(14):2865-2884. doi: 10.1158/1078-0432.CCR-25-2743.Clin Cancer Res. 2026.PMID: 41995577Free PMC article.Clinical Trial. * [ Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer. ](https://pubmed.ncbi.nlm.nih.gov/38964333/) Wang H, Yao Z, Kang K, Zhou L, Xiu W, Sun J, Xie C, Yu M, Li Y, Zhang Y, Zheng Y, Lin G, Pan X, Wu Y, Luo R, Wang L, Tang M, Liao S, Zhu J, Zhou X, Zhang X, Xu Y, Liu Y, Peng F, Wang J, Xiang L, Yin L, Deng L, Huang M, Gong Y, Zou B, Wang H, Wu L, Yuan Z, Bi N, Fan M, Xu Y, Tong R, Yi L, Gan L, Xue J, Mo X, Chen C, Na F, Lu Y.Wang H, et al.Med. 2024 Oct 11;5(10):1237-1254.e9. doi: 10.1016/j.medj.2024.06.002. Epub 2024 Jul 3.Med. 2024.PMID: 38964333Clinical Trial. * [ Dynamic evolution and antitumor mechanisms of CXCR6+CD8+ T cells in small cell lung cancer treated with low-dose radiotherapy and immunotherapy. ](https://pubmed.ncbi.nlm.nih.gov/40247265/) Lin G, Yao Z, Kang K, Luo R, Yi L, Lu Y.Lin G, et al.J Transl Med. 2025 Apr 17;23(1):453. doi: 10.1186/s12967-025-06450-1.J Transl Med. 2025.PMID: 40247265Free PMC article. * [ Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS-STING pathway: mechanisms, challenges, and combination therapy strategies. ](https://pubmed.ncbi.nlm.nih.gov/41803899/) He Y, Zeng X, Liu Q, Zhou L, Tang Y, Liu S, Wang X, Shen S, Ji J, Liu Z, Li J.He Y, et al.Mol Cancer. 2026 Mar 10;25(1):131. doi: 10.1186/s12943-026-02634-5.Mol Cancer. 2026.PMID: 41803899Free PMC article.Review. * [ Re-thinking the Role of Thoracic Radiotherapy in the First-Line Treatment for Extensive-Stage Small Cell Lung Cancer. ](https://pubmed.ncbi.nlm.nih.gov/40742638/) Lin G, Ge F, Yang C, Huang Y.Lin G, et al.Curr Treat Options Oncol. 2025 Aug;26(8):764-774. doi: 10.1007/s11864-025-01342-4. Epub 2025 Jul 31.Curr Treat Options Oncol. 2025.PMID: 40742638Review. 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