---
title: "Mental Disorders in Caregivers of ICU Sepsis Survivors and Links to Patient PICS — Prospective Coh"
id: "pubmed-42872916"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42872916"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42872916/"
doi: "10.1097/CCM.0000000000007378"
published_at: "2026-10-14T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Mental Disorders in Caregivers of ICU Sepsis Survivors and Links to Patient PICS — Prospective Coh
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42872916
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42872916/)
- **DOI:** [10.1097/CCM.0000000000007378](https://doi.org/10.1097%2FCCM.0000000000007378)
- **Published At:** 2026-10-14T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Investigators conducted a prospective, multicenter cohort study examining long-term mental disorders in **caregivers** of ICU survivors of **sepsis** and associations with patients' **post-intensive care syndrome** (PICS). - The report lists many coauthors and broad institutional participation across Japanese and international centers, indicating a large collaborative network but the PubMed entry did not list sample sizes or enrollment dates. - The source entry confirms the study was published online ahead of print in Crit Care Med with DOI 10.1097/CCM.0000000000007378; it did not provide the abstract text or primary endpoints in the PubMed summary shown. - The PubMed record identifies the study group as the Investigating Long-term Outcomes of ICU patients with Sepsis or Septic shock (ILOSS) Study Group; the affiliations cover emergency, critical care, rehabilitation, nursing research and data science units. - Data indicating specific mental-health outcomes (for example, rates of depression, anxiety, PTSD in caregivers), temporal follow-up intervals, diagnostic instruments, statistical analyses, or patient-level PICS measures were not available in the captured source text. - Because the source record on PubMed lacks the abstract and methods text in the provided content, readers cannot confirm key methodological details (inclusion/exclusion criteria, sample size, baseline characteristics, outcome definitions) from this excerpt. - The PubMed entry documents publication metadata (authors, journal, DOI, PMID) that enable retrieval of the full text; those seeking detailed results must consult the journal article itself for full methods, results, and limitations.
## Clinical Analysis & Structured Key Points
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Online ahead of print. # Long-Lasting Mental Disorders in Caregivers of ICU Sepsis Survivors and Their Association With Patients' Post-Intensive Care Syndrome: A Prospective Multicenter Cohort Study [Kasumi Shirasaki](https://pubmed.ncbi.nlm.nih.gov/?term=Shirasaki+K&cauthor_id=42872916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-1 "Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, Tokyo, Japan.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-2 "Department of Emergency and Disaster Medicine, Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University, Kanazawa, Japan."), [Keibun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+K&cauthor_id=42872916)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-3 "Non-Profit Organization ICU Collaboration Network \(ICON\), Tokyo, Japan."), [Akira Kawauchi](https://pubmed.ncbi.nlm.nih.gov/?term=Kawauchi+A&cauthor_id=42872916)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-4 "Department of Critical Care, Aso Iizuka Hospital, Fukuoka, Japan."), [Shutaro Isokawa](https://pubmed.ncbi.nlm.nih.gov/?term=Isokawa+S&cauthor_id=42872916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-1 "Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, Tokyo, Japan."), [Kensuke Nakamura](https://pubmed.ncbi.nlm.nih.gov/?term=Nakamura+K&cauthor_id=42872916)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-5 "Division of Disaster and Emergency Medicine, Department of Surgery Related, Kobe University Graduate School of Medicine, Hyogo, Japan."), [Hidehiko Nakano](https://pubmed.ncbi.nlm.nih.gov/?term=Nakano+H&cauthor_id=42872916)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-6 "Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Ibaraki, Japan."), [Maiko Motoki](https://pubmed.ncbi.nlm.nih.gov/?term=Motoki+M&cauthor_id=42872916)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-6 "Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Ibaraki, Japan."), [Hiroshi Kamijo](https://pubmed.ncbi.nlm.nih.gov/?term=Kamijo+H&cauthor_id=42872916)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-7 "Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, Nagano, Japan."), [Ayaka Matsuoka](https://pubmed.ncbi.nlm.nih.gov/?term=Matsuoka+A&cauthor_id=42872916)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-8 "Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University Hospital, Saga, Japan."), [Kenzo Ishii](https://pubmed.ncbi.nlm.nih.gov/?term=Ishii+K&cauthor_id=42872916)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-9 "Department of Anesthesiology, Intensive Care Unit, Fukuyama City Hospital, Hiroshima, Japan."), [Yasunari Morita](https://pubmed.ncbi.nlm.nih.gov/?term=Morita+Y&cauthor_id=42872916)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-10 "Department of Emergency and Intensive Care Medicine, National Hospital Organization Nagoya Medical Center, Aichi, Japan."), [Takashi Hongo](https://pubmed.ncbi.nlm.nih.gov/?term=Hongo+T&cauthor_id=42872916)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-11 "Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-12 "Department of Emergency, Okayama Saiseikai General Hospital, Okayama, Japan."), [Nobutake Shimojo](https://pubmed.ncbi.nlm.nih.gov/?term=Shimojo+N&cauthor_id=42872916)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-13 "Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan."), [Yukiko Tanaka](https://pubmed.ncbi.nlm.nih.gov/?term=Tanaka+Y&cauthor_id=42872916)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-14 "Department of Emergency, Tsukuba Medical Center Hospital, Ibaraki, Japan."), [Manabu Hanazawa](https://pubmed.ncbi.nlm.nih.gov/?term=Hanazawa+M&cauthor_id=42872916)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-15 "Department of Rehabilitation, Japan Red Cross Narita Hospital, Chiba, Japan."), [Tomohiro Hamagami](https://pubmed.ncbi.nlm.nih.gov/?term=Hamagami+T&cauthor_id=42872916)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-16 "Tajima Emergency and Critical Care Medical Center, Toyooka Public Hospital, Hyogo, Japan."), [Kenji Oike](https://pubmed.ncbi.nlm.nih.gov/?term=Oike+K&cauthor_id=42872916)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-17 "Department of Rehabilitation, Tsuchiura Kyodo General Hospital, Ibaraki, Japan."), [Daisuke Kasugai](https://pubmed.ncbi.nlm.nih.gov/?term=Kasugai+D&cauthor_id=42872916)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-18 "Department of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan."), [Yutaka Sakuda](https://pubmed.ncbi.nlm.nih.gov/?term=Sakuda+Y&cauthor_id=42872916)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-19 "Department of Intensive Care Medicine, Okinawa Kyodo Hospital, Okinawa, Japan."), [Yuhei Irie](https://pubmed.ncbi.nlm.nih.gov/?term=Irie+Y&cauthor_id=42872916)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-20 "Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Fukuoka, Japan."), [Masakazu Nitta](https://pubmed.ncbi.nlm.nih.gov/?term=Nitta+M&cauthor_id=42872916)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-21 "Department of Intensive Care Unit, Niigata University Medical and Dental Hospital, Niigata, Japan."), [Kazuki Akieda](https://pubmed.ncbi.nlm.nih.gov/?term=Akieda+K&cauthor_id=42872916)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-22 "Department of Emergency Medicine, SUBARU Health Insurance Society Ota Memorial Hospital, Gunma, Japan."), [Daigo Shimakura](https://pubmed.ncbi.nlm.nih.gov/?term=Shimakura+D&cauthor_id=42872916)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-23 "Graduate School of Data Science, Shiga University, Shiga, Japan."), [Hajime Katsukawa](https://pubmed.ncbi.nlm.nih.gov/?term=Katsukawa+H&cauthor_id=42872916)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-24 "Japanese Society for Early Mobilization, Tokyo, Japan."), [Toru Kotani](https://pubmed.ncbi.nlm.nih.gov/?term=Kotani+T&cauthor_id=42872916)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-25 "Department of Intensive Care Medicine, Showa Medical University, Tokyo, Japan."), [David McWilliams](https://pubmed.ncbi.nlm.nih.gov/?term=McWilliams+D&cauthor_id=42872916)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-26 "Centre for Care Excellence, Coventry University, Coventry, United Kingdom.")[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-27 "Critical Care, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom."), [Peter Nydahl](https://pubmed.ncbi.nlm.nih.gov/?term=Nydahl+P&cauthor_id=42872916)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-28 "Nursing Research, University Hospital Schleswig-Holstein, Kiel, Germany.")[ 29 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-29 "Institute of Nursing Science and Development, Paracelsus Medical University, Salzburg, Austria."), [Stefan J Schaller](https://pubmed.ncbi.nlm.nih.gov/?term=Schaller+SJ&cauthor_id=42872916)[ 30 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-30 "Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Clinical Division of General Anaesthesia and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria.")[ 31 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-31 "Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Informatics, Berlin, Germany."), [Masaki Okajima](https://pubmed.ncbi.nlm.nih.gov/?term=Okajima+M&cauthor_id=42872916)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-2 "Department of Emergency and Disaster Medicine, Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University, Kanazawa, Japan."), [Norio Otani](https://pubmed.ncbi.nlm.nih.gov/?term=Otani+N&cauthor_id=42872916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-1 "Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, Tokyo, Japan."), [Takayuki Ogura](https://pubmed.ncbi.nlm.nih.gov/?term=Ogura+T&cauthor_id=42872916)[ 32 ](https://pubmed.ncbi.nlm.nih.gov/42872916/#full-view-affiliation-32 "Department of Emergency Medicine and Critical Care Medicine, Tochigi Prefectural Emergency and Critical Care Center, Saiseikai Utsunomiya Hospital, Tochigi, Japan."); [Investigating Long-term Outcomes of ICU patients with Sepsis or Septic shock (ILOSS) Study Group](https://pubmed.ncbi.nlm.nih.gov/?term=Investigating+Long-term+Outcomes+of+ICU+patients+with+Sepsis+or+Septic+shock+%28ILOSS%29+Study+Group%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, Tokyo, Japan. * 2 Department of Emergency and Disaster Medicine, Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University, Kanazawa, Japan. * 3 Non-Profit Organization ICU Collaboration Network (ICON), Tokyo, Japan. * 4 Department of Critical Care, Aso Iizuka Hospital, Fukuoka, Japan. * 5 Division of Disaster and Emergency Medicine, Department of Surgery Related, Kobe University Graduate School of Medicine, Hyogo, Japan. * 6 Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Ibaraki, Japan. * 7 Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, Nagano, Japan. * 8 Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University Hospital, Saga, Japan. * 9 Department of Anesthesiology, Intensive Care Unit, Fukuyama City Hospital, Hiroshima, Japan. * 10 Department of Emergency and Intensive Care Medicine, National Hospital Organization Nagoya Medical Center, Aichi, Japan. * 11 Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan. * 12 Department of Emergency, Okayama Saiseikai General Hospital, Okayama, Japan. * 13 Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. * 14 Department of Emergency, Tsukuba Medical Center Hospital, Ibaraki, Japan. * 15 Department of Rehabilitation, Japan Red Cross Narita Hospital, Chiba, Japan. * 16 Tajima Emergency and Critical Care Medical Center, Toyooka Public Hospital, Hyogo, Japan. * 17 Department of Rehabilitation, Tsuchiura Kyodo General Hospital, Ibaraki, Japan. * 18 Department of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan. * 19 Department of Intensive Care Medicine, Okinawa Kyodo Hospital, Okinawa, Japan. * 20 Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Fukuoka, Japan. * 21 Department of Intensive Care Unit, Niigata University Medical and Dental Hospital, Niigata, Japan. * 22 Department of Emergency Medicine, SUBARU Health Insurance Society Ota Memorial Hospital, Gunma, Japan. * 23 Graduate School of Data Science, Shiga University, Shiga, Japan. * 24 Japanese Society for Early Mobilization, Tokyo, Japan. * 25 Department of Intensive Care Medicine, Showa Medical University, Tokyo, Japan. * 26 Centre for Care Excellence, Coventry University, Coventry, United Kingdom. * 27 Critical Care, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom. * 28 Nursing Research, University Hospital Schleswig-Holstein, Kiel, Germany. * 29 Institute of Nursing Science and Development, Paracelsus Medical University, Salzburg, Austria. * 30 Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Clinical Division of General Anaesthesia and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria. * 31 Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Informatics, Berlin, Germany. * 32 Department of Emergency Medicine and Critical Care Medicine, Tochigi Prefectural Emergency and Critical Care Center, Saiseikai Utsunomiya Hospital, Tochigi, Japan. * PMID: **42872916** * DOI: [ 10.1097/CCM.0000000000007378 ](https://doi.org/10.1097/ccm.0000000000007378) Item in Clipboard # Long-Lasting Mental Disorders in Caregivers of ICU Sepsis Survivors and Their Association With Patients' Post-Intensive Care Syndrome: A Prospective Multicenter Cohort Study Kasumi Shirasaki et al. Crit Care Med. 2026. Show details Display options Display options Format Abstract PubMed PMID Crit Care Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Crit+Care+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Crit+Care+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42872916/) . 2026 Oct 14. doi: 10.1097/CCM.0000000000007378. Online ahead of print. ### Authors [Kasumi Shirasaki](https://pubmed.ncbi.nlm.nih.gov/?term=Shiras
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