---
title: "Nanotherapeutic macrophage reprogramming for sepsis via immunometabolic and microbial modulation"
id: "pubmed-42901916"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42901916"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42901916/"
doi: "10.1038/s41392-026-02947-3"
published_at: "2026-10-21T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Nanotherapeutic macrophage reprogramming for sepsis via immunometabolic and microbial modulation
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42901916
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42901916/)
- **DOI:** [10.1038/s41392-026-02947-3](https://doi.org/10.1038%2Fs41392-026-02947-3)
- **Published At:** 2026-10-21T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article titled “Nanotherapeutic macrophage reprogramming through immunometabolic and microbial modulation for sepsis treatment” was published in Signal Transduct Target Ther (2026) and is indexed under PMID 42901916 and DOI 10.1038/s41392-026-02947-3. - The manuscript focus, as stated in the title, is on **nanotherapeutic** approaches to reprogram **macrophage** function by targeting immunometabolism and microbial factors to treat **sepsis**. - The source metadata lists multiple contributing authors and institutional affiliations across pharmaceutical engineering and cellular metabolism research groups in China. - The provided PubMed page text did not include the article abstract, methods, experimental models, dosing regimens, primary endpoints, outcome data, or statistical results; those specifics were not available in the supplied source content. - Because the abstract and results are not present in the source text provided, investigators’ reported efficacy signals, safety findings, mechanistic assays, and translational steps cannot be summarized here without accessing the full article. - Key unanswered items in the supplied record include preclinical versus clinical status, animal models or human cohorts used, nanomaterial composition and dosing, measured immunometabolic readouts, microbial modulation strategy, primary endpoints, and adverse-event profiles. - The manuscript metadata confirms peer-reviewed publication and provides bibliographic identifiers for clinicians or researchers who wish to retrieve full methods and data from the publisher or PubMed Central where available.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42901916/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42901916/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42901916/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42901916/#references) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42901916/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42901916/#substances) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42901916/#grants) Title & authors Abstract Conflict of interest statement References MeSH terms Substances Grants and funding Signal Transduct Target Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Signal+Transduct+Target+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Signal+Transduct+Target+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42901916/) . 2026 Oct 21;11(1):467. doi: 10.1038/s41392-026-02947-3. # Nanotherapeutic macrophage reprogramming through immunometabolic and microbial modulation for sepsis treatment [Xintong Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+X&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China."), [Wenhui Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+W&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-equal-contrib-explanation "Contributed equally")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Bingjie Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+B&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-equal-contrib-explanation "Contributed equally")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Qian Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Q&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-equal-contrib-explanation "Contributed equally")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-4 "Department of Anesthesiology, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China."), [Ye Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y&cauthor_id=42901916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China."), [Yongrui Hai](https://pubmed.ncbi.nlm.nih.gov/?term=Hai+Y&cauthor_id=42901916)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Renming Fan](https://pubmed.ncbi.nlm.nih.gov/?term=Fan+R&cauthor_id=42901916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China."), [Shuo Fu](https://pubmed.ncbi.nlm.nih.gov/?term=Fu+S&cauthor_id=42901916)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-5 "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Jiaxin Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+J&cauthor_id=42901916)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Guiquan Ding](https://pubmed.ncbi.nlm.nih.gov/?term=Ding+G&cauthor_id=42901916)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-5 "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Zhuang Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+Z&cauthor_id=42901916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China."), [Junke Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+J&cauthor_id=42901916)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-6 "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. smilejunke@imm.ac.cn."), [Maosheng Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+M&cauthor_id=42901916)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-7 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China. mscheng@syphu.edu.cn."), [Gaofei Wei](https://pubmed.ncbi.nlm.nih.gov/?term=Wei+G&cauthor_id=42901916)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-8 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China. weigf0605@163.com.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#full-view-affiliation-9 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China. weigf0605@163.com.") Affiliations Expand ### Affiliations * 1 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China. * 2 Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China. * 3 Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China. * 4 Department of Anesthesiology, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. * 5 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. * 6 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. smilejunke@imm.ac.cn. * 7 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China. mscheng@syphu.edu.cn. * 8 Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China. weigf0605@163.com. * 9 Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China. weigf0605@163.com. # Contributed equally. * PMID: **42901916** * DOI: [ 10.1038/s41392-026-02947-3 ](https://doi.org/10.1038/s41392-026-02947-3) Item in Clipboard # Nanotherapeutic macrophage reprogramming through immunometabolic and microbial modulation for sepsis treatment Xintong Lu et al. Signal Transduct Target Ther. 2026. Show details Display options Display options Format Abstract PubMed PMID Signal Transduct Target Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Signal+Transduct+Target+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Signal+Transduct+Target+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42901916/) . 2026 Oct 21;11(1):467. doi: 10.1038/s41392-026-02947-3. ### Authors [Xintong Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+X&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China."), [Wenhui Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+W&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-equal-contrib-explanation "Contributed equally")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Bingjie Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+B&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-equal-contrib-explanation "Contributed equally")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Qian Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Q&cauthor_id=42901916)[#](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-equal-contrib-explanation "Contributed equally")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-4 "Department of Anesthesiology, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China."), [Ye Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y&cauthor_id=42901916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China."), [Yongrui Hai](https://pubmed.ncbi.nlm.nih.gov/?term=Hai+Y&cauthor_id=42901916)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Renming Fan](https://pubmed.ncbi.nlm.nih.gov/?term=Fan+R&cauthor_id=42901916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China."), [Shuo Fu](https://pubmed.ncbi.nlm.nih.gov/?term=Fu+S&cauthor_id=42901916)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-5 "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Jiaxin Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+J&cauthor_id=42901916)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-2 "Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-3 "Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China."), [Guiquan Ding](https://pubmed.ncbi.nlm.nih.gov/?term=Ding+G&cauthor_id=42901916)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-5 "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Zhuang Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+Z&cauthor_id=42901916)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-1 "School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China."), [Junke Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+J&cauthor_id=42901916)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42901916/#short-view-affiliation-6 "Instit
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