---
title: "Nutrition Support in Gastroenterology: Current Evidence on Enteral and Parenteral Strategies"
id: "pubmed-42681978"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42681978"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42681978/"
doi: "10.1097/MOG.0000000000001194"
published_at: "2026-09-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Nutrition Support in Gastroenterology: Current Evidence on Enteral and Parenteral Strategies
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42681978
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42681978/)
- **DOI:** [10.1097/MOG.0000000000001194](https://doi.org/10.1097%2FMOG.0000000000001194)
- **Published At:** 2026-09-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This review examines contemporary evidence comparing **enteral nutrition** and **parenteral nutrition** across gastrointestinal oncology, inflammatory bowel disease (IBD), critical care, and gastrointestinal surgery. - Historically, enteral nutrition has been preferred for its physiologic benefits, with parenteral nutrition used when enteral feeding is contraindicated or insufficient. - Recent data prompt reassessment: in some gastric cancer settings, **parenteral nutrition** may improve nutritional status and clinical outcomes related to treatment-associated gastrointestinal dysfunction. - In IBD, **exclusive enteral nutrition** can induce remission and support mucosal healing; **parenteral nutrition** remains the choice for intestinal failure and severe complications. - In critically ill and surgical patients, early **parenteral nutrition** when enteral routes are contraindicated or inadequate has been shown to improve nutrient delivery and reduce complications in reported studies. - Ongoing areas of interest highlighted include caloric and protein dosing, use of indirect calorimetry to guide provision, and the impact of nutrition support on the **gut microbiome**. - The authors recommend a patient-centered approach: use the gastrointestinal tract when feasible (enteral), with parenteral nutrition as an important alternative or adjunct for select populations. - Future research priorities include refining supplemental parenteral nutrition practices and developing disease-specific, evidence-based nutrition strategies. - Source: Deringer R, Silva CS, Klein D. Curr Opin Gastroenterol. Online ahead of print. PMID 42681978; DOI 10.1097/MOG.0000000000001194.
## Clinical Analysis & Structured Key Points
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Online ahead of print. # Nutrition support in gastroenterology: opinion on current literature [Rianna Deringer](https://pubmed.ncbi.nlm.nih.gov/?term=Deringer+R&cauthor_id=42681978)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42681978/#full-view-affiliation-1 "Cleveland Clinic Florida, Weston, Florida, USA."), [Camila Schmeil Silva](https://pubmed.ncbi.nlm.nih.gov/?term=Silva+CS&cauthor_id=42681978), [Daniel Klein](https://pubmed.ncbi.nlm.nih.gov/?term=Klein+D&cauthor_id=42681978) Affiliations Expand ### Affiliation * 1 Cleveland Clinic Florida, Weston, Florida, USA. * PMID: **42681978** * DOI: [ 10.1097/MOG.0000000000001194 ](https://doi.org/10.1097/mog.0000000000001194) Item in Clipboard # Nutrition support in gastroenterology: opinion on current literature Rianna Deringer et al. Curr Opin Gastroenterol. 2026. Show details Display options Display options Format Abstract PubMed PMID Curr Opin Gastroenterol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Curr+Opin+Gastroenterol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Curr+Opin+Gastroenterol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681978/) . 2026 Sep 2. doi: 10.1097/MOG.0000000000001194. Online ahead of print. ### Authors [Rianna Deringer](https://pubmed.ncbi.nlm.nih.gov/?term=Deringer+R&cauthor_id=42681978)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42681978/#short-view-affiliation-1 "Cleveland Clinic Florida, Weston, Florida, USA."), [Camila Schmeil Silva](https://pubmed.ncbi.nlm.nih.gov/?term=Silva+CS&cauthor_id=42681978), [Daniel Klein](https://pubmed.ncbi.nlm.nih.gov/?term=Klein+D&cauthor_id=42681978) ### Affiliation * 1 Cleveland Clinic Florida, Weston, Florida, USA. * PMID: **42681978** * DOI: [ 10.1097/MOG.0000000000001194 ](https://doi.org/10.1097/mog.0000000000001194) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Purpose of review:** Historically, enteral nutrition has been the preferred therapy due to its physiologic benefits, with parenteral nutrition selected if enteral nutrition was contraindicated or insufficient; however, recent advances in nutrition support have prompted reevaluation of this process. This review summarizes the current evidence regarding enteral nutrition and parenteral nutrition in gastrointestinal oncology, inflammatory bowel disease (IBD), critical care, and gastrointestinal surgery. **Recent findings:** In gastric cancer, parenteral nutrition may improve the nutritional status and clinical outcomes of treatment-related gastrointestinal dysfunction. In IBD, exclusive enteral nutrition may be effective for inducing remission and promoting mucosal healing, whereas parenteral nutrition is preferred in intestinal failure and severe complications. Studies have shown the value of early parenteral nutrition when enteral nutrition is contraindicated or insufficient, specifically for improving nutrient delivery and reducing complications in critically ill and surgical patients. Additional areas of interest include caloric and protein dosing, indirect calorimetry, and the effect of nutrition support on the gut microbiome. **Summary:** Current evidence supports a patient-centered approach to nutrition support with enteral nutrition remaining as the preference when the gastrointestinal tract can be utilized and parenteral nutrition as an important alternative or adjunct in select populations. Future research should focus on the refinement of supplemental parenteral nutrition practices and the development of evidence-based approaches for specific disease states. **Keywords:** critical care; enteral nutrition; gastrointestinal surgery; inflammatory bowel disease; nutrition support; oncology; parenteral nutrition. Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## References 1. 1. Wischmeyer PE, Klek S, Berger MM, et al. Parenteral nutrition in clinical practice: international challenges and strategies. Am J Health Syst Pharm 2024; 81 (Suppl 3):S89–S101. 2. 1. Gramlich L, Guenter P. Enteral nutrition in hospitalized adults. N Engl J Med 2025; 392:1518–1530. 3. 1. Abusudah WF, Singh RB, Fedacko J, et al. Enteral nutrition in critical care: pathogenesis, complications, and the therapeutic promise of Mediterranean-style diets. Curr Gastroenterol Rep 2025; 27:69. 4. 1. Bidgood E, Huang J, Murphy E, et al. Peripheral parenteral nutrition: a retrospective observational study to evaluate utility and complications. Nutr Clin Pract 2025; 40:942–949. 5. 1. Jones D, Allsopp K, Sowerbutts AM, et al. Outcomes for patients receiving multi-chamber bags for the delivery of parenteral nutrition: a systematic review. Nutrients 2024; 16:3964. 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