---
title: "PICOBOO platform trial: reactogenicity of nine licensed COVID-19 vaccines in immunocompetent adults"
id: "pubmed-42700749"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42700749"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42700749/"
doi: "10.1016/j.vaccine.2026.129034"
published_at: "2026-10-24T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# PICOBOO platform trial: reactogenicity of nine licensed COVID-19 vaccines in immunocompetent adults
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42700749
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42700749/)
- **DOI:** [10.1016/j.vaccine.2026.129034](https://doi.org/10.1016%2Fj.vaccine.2026.129034)
- **Published At:** 2026-10-24T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The PICOBOO platform trial evaluated **reactogenicity** after administration of nine licensed **COVID-19 vaccines** in immunocompetent adults, according to the PubMed record. - The article title and bibliographic data (Vaccine. 2026; DOI: 10.1016/j.vaccine.2026.129034; PMID 42700749) were provided; the PubMed entry identified the trial as a randomized controlled platform study. - Authors and multi-centre Australian (and some UK) affiliations were listed; lead author affiliations include vaccine research centres and university departments. - The source entry did not include specific numeric **reactogenicity** outcomes, frequency data, severity grading, or comparative statistics across the nine vaccines. - The PubMed summary did not report exact sample sizes, age ranges, randomization schema, dosing regimens, or primary and secondary endpoints; those methodological details were not available in the displayed record. - The record links to the full text at the journal Vaccine (DOI provided) for complete methods and results; investigators reported the trial exists, but the abstract text with results was not reproduced in the source extract. - Safety and tolerability descriptors beyond the generic phrase “reactogenicity” were not supplied in the source; the entry did not list specific adverse event rates or serious adverse events. - For clinicians seeking actionable data (e.g., comparative reactogenicity profiles, subgroup analyses, or implications for booster strategies), the PubMed entry directs readers to the full article; the summary itself lacks these details. - The source therefore documents study presence, authorship, and publication metadata but does not provide the trial findings, numerical endpoints, or methodological parameters in the excerpt shown.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 5. # The platform trial in COVID-19 priming and BOOsting (PICOBOO): The reactogenicity of nine licensed COVID-19 vaccines delivered in immunocompetent adults [McLeod C](https://pubmed.ncbi.nlm.nih.gov/?term=C+M&cauthor_id=42700749)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-1 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Infectious Diseases Department, Perth Children's Hospital, Nedlands, Australia; School of Medicine, University of Western Australia, Crawley, Australia; Curtin Medical School, Curtin University, Crawley, Australia. Electronic address: charlie.mcleod@health.wa.gov.au."), [M Dymock](https://pubmed.ncbi.nlm.nih.gov/?term=Dymock+M&cauthor_id=42700749)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-2 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; School of Population and Global Health, The University of Western Australia, Nedlands, Australia."), [K L Flanagan](https://pubmed.ncbi.nlm.nih.gov/?term=Flanagan+KL&cauthor_id=42700749)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-3 "Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Tasmania, Australia; School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia."), [M Plebanski](https://pubmed.ncbi.nlm.nih.gov/?term=Plebanski+M&cauthor_id=42700749)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-4 "Accelartor for Translational Research and Clinical Trials \(ATRACT\) Centre, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University \(RMIT\), Melbourne, Australia."), [H Marshall](https://pubmed.ncbi.nlm.nih.gov/?term=Marshall+H&cauthor_id=42700749)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-5 "Women's and Children's Health Network, North Adelaide, Australia; Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Australia."), [M J Estcourt](https://pubmed.ncbi.nlm.nih.gov/?term=Estcourt+MJ&cauthor_id=42700749)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-6 "Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia."), [M C Tjiam](https://pubmed.ncbi.nlm.nih.gov/?term=Tjiam+MC&cauthor_id=42700749)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-7 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia."), [C C Blyth](https://pubmed.ncbi.nlm.nih.gov/?term=Blyth+CC&cauthor_id=42700749)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-8 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Infectious Diseases Department, Perth Children's Hospital, Nedlands, Australia; School of Medicine, University of Western Australia, Crawley, Australia; Department of Microbiology, Pathwest Laboratory Medicine WA, QEII Medical Centre, Nedlands, Australia."), [K Subbarao](https://pubmed.ncbi.nlm.nih.gov/?term=Subbarao+K&cauthor_id=42700749)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-9 "WHO Collaborating Centre for Reference and Research on Influenza, University of Melbourne, Parkville, Victoria, Australia; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia."), [S Nicholson](https://pubmed.ncbi.nlm.nih.gov/?term=Nicholson+S&cauthor_id=42700749)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-10 "Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia."), [S N Faust](https://pubmed.ncbi.nlm.nih.gov/?term=Faust+SN&cauthor_id=42700749)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-11 "National Institute of Health Research Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; Faculty of Medicine and Institute for Life Sciences, University of Southampton, United Kingdom."), [U Wadia](https://pubmed.ncbi.nlm.nih.gov/?term=Wadia+U&cauthor_id=42700749)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-12 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Infectious Diseases Department, Perth Children's Hospital, Nedlands, Australia; Centre for Child Health Research, University of Western Australia, Crawley, Australia."), [R B Thornton](https://pubmed.ncbi.nlm.nih.gov/?term=Thornton+RB&cauthor_id=42700749)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-13 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Centre for Child Health Research, University of Western Australia, Crawley, Australia."), [Z Ellis](https://pubmed.ncbi.nlm.nih.gov/?term=Ellis+Z&cauthor_id=42700749)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-7 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia."), [P Williams](https://pubmed.ncbi.nlm.nih.gov/?term=Williams+P&cauthor_id=42700749)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-6 "Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia."), [McKenzie A](https://pubmed.ncbi.nlm.nih.gov/?term=A+M&cauthor_id=42700749)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-7 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia."), [J A Marsh](https://pubmed.ncbi.nlm.nih.gov/?term=Marsh+JA&cauthor_id=42700749)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-13 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Centre for Child Health Research, University of Western Australia, Crawley, Australia."), [C Foulis](https://pubmed.ncbi.nlm.nih.gov/?term=Foulis+C&cauthor_id=42700749)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-7 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia."), [G Salama](https://pubmed.ncbi.nlm.nih.gov/?term=Salama+G&cauthor_id=42700749)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-7 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia."), [T L Snelling](https://pubmed.ncbi.nlm.nih.gov/?term=Snelling+TL&cauthor_id=42700749)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-6 "Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia."), [P Richmond](https://pubmed.ncbi.nlm.nih.gov/?term=Richmond+P&cauthor_id=42700749)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#full-view-affiliation-14 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; School of Medicine, University of Western Australia, Crawley, Australia; Centre for Child Health Research, University of Western Australia, Crawley, Australia; General Paediatrics and Immunology Departments, Perth Children's Hospital, Nedlands, Australia.") Affiliations Expand ### Affiliations * 1 Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Infectious Diseases Department, Perth Children's Hospital, Nedlands, Australia; School of Medicine, University of Western Australia, Crawley, Australia; Curtin Medical School, Curtin University, Crawley, Australia. Electronic address: charlie.mcleod@health.wa.gov.au. * 2 Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; School of Population and Global Health, The University of Western Australia, Nedlands, Australia. * 3 Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Tasmania, Australia; School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia. * 4 Accelartor for Translational Research and Clinical Trials (ATRACT) Centre, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University (RMIT), Melbourne, Australia. * 5 Women's and Children's Health Network, North Adelaide, Australia; Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Australia. * 6 Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia. * 7 Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia. * 8 Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Infectious Diseases Department, Perth Children's Hospital, Nedlands, Australia; School of Medicine, University of Western Australia, Crawley, Australia; Department of Microbiology, Pathwest Laboratory Medicine WA, QEII Medical Centre, Nedlands, Australia. * 9 WHO Collaborating Centre for Reference and Research on Influenza, University of Melbourne, Parkville, Victoria, Australia; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. * 10 Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. * 11 National Institute of Health Research Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; Faculty of Medicine and Institute for Life Sciences, University of Southampton, United Kingdom. * 12 Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Infectious Diseases Department, Perth Children's Hospital, Nedlands, Australia; Centre for Child Health Research, University of Western Australia, Crawley, Australia. * 13 Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Centre for Child Health Research, University of Western Australia, Crawley, Australia. * 14 Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; School of Medicine, University of Western Australia, Crawley, Australia; Centre for Child Health Research, University of Western Australia, Crawley, Australia; General Paediatrics and Immunology Departments, Perth Children's Hospital, Nedlands, Australia. * PMID: **42700749** * DOI: [ 10.1016/j.vaccine.2026.129034 ](https://doi.org/10.1016/j.vaccine.2026.129034) Item in Clipboard Randomized Controlled Trial # The platform trial in COVID-19 priming and BOOsting (PICOBOO): The reactogenicity of nine licensed COVID-19 vaccines delivered in immunocompetent adults McLeod C et al. Vaccine. 2026. Show details Display options Display options Format Abstract PubMed PMID Vaccine Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Vaccine%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Vaccine%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42700749/) . 2026 Oct 24:92:129034. doi: 10.1016/j.vaccine.2026.129034. Epub 2026 Sep 5. ### Authors [McLeod C](https://pubmed.ncbi.nlm.nih.gov/?term=C+M&cauthor_id=42700749)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42700749/#short-view-affiliation-1 "Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Nedlands, Australia; Infectious Diseases Department, Perth Children's Hospital, Nedlands, Australia; School of Medicine, University of Western Australia, Crawley, Australia; Curtin Medical School, Curtin University, Crawley, Australia. Electronic address: charlie.mcleod@health.wa.gov.au."), [M Dymock](https://pubmed.ncbi.nlm.nih.go
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