---
title: "Precision Medicine in Pediatric Sepsis-Associated Acute Kidney Injury — Editorial Summary and Sour"
id: "pubmed-42752807"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42752807"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42752807/"
doi: "10.1007/s12519-026-01096-5"
published_at: "2026-09-17T00:00:00.000Z"
evidence_level: "Editorial"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Precision Medicine in Pediatric Sepsis-Associated Acute Kidney Injury — Editorial Summary and Sour
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42752807
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42752807/)
- **DOI:** [10.1007/s12519-026-01096-5](https://doi.org/10.1007%2Fs12519-026-01096-5)
- **Published At:** 2026-09-17T00:00:00.000Z
- **Evidence Rating:** Editorial
## Executive GIST (TL;DR)
- This PubMed entry is an editorial titled **Precision medicine in pediatric sepsis-associated acute kidney injury: when systemic heterogeneity meets organ-level heterogeneity**, published online ahead of print in World Journal of Pediatrics (2026 Sep 17). - Authors are Meng-Yuan Wu, Yu Zhao, Xiao-He Chen, and Xu-Hua Ge, all affiliated with the Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China. - The article is indexed with PMID 42752807 and DOI 10.1007/s12519-026-01096-5. - No abstract is available in the PubMed record; the source provides bibliographic and administrative metadata but not the editorial text or summary. - A conflict of interest statement declares no financial or non-financial benefits related to the subject; Xu-Hua Ge is an editorial board member of the journal but was not involved in review or decisions for this manuscript. - The authors declare use of a generative AI tool (Gemini) to improve language readability and grammar; they state they reviewed and edited the content and take full responsibility for the final publication. - Grants listed in the record include National Natural Science Foundation of China (82170733) and a Jiangsu Province postgraduate education reform project (JX12214459). - The PubMed entry shows a references list (56 total references available from the record). The visible references include epidemiology and risk factor studies on acute kidney injury and sepsis (for example Kaddourah et al., Hoste et al., Meena et al., Ouyang et al., and the Sepsis-3 consensus by Singer et al.). - The PubMed page supplies full bibliographic and navigation metadata (title, authors, affiliations, publication types, grants, DOI, PMID) but does not report the editorial’s internal content or specific recommendations; those details were not reported in the PubMed source.
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Online ahead of print. # Precision medicine in pediatric sepsis-associated acute kidney injury: when systemic heterogeneity meets organ-level heterogeneity [Meng-Yuan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+MY&cauthor_id=42752807)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#full-view-affiliation-1 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China."), [Yu Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+Y&cauthor_id=42752807)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#full-view-affiliation-1 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China."), [Xiao-He Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+XH&cauthor_id=42752807)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#full-view-affiliation-1 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China."), [Xu-Hua Ge](https://pubmed.ncbi.nlm.nih.gov/?term=Ge+XH&cauthor_id=42752807)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#full-view-affiliation-2 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China. gexuhua@njmu.edu.cn.") Affiliations Expand ### Affiliations * 1 Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China. * 2 Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China. gexuhua@njmu.edu.cn. * PMID: **42752807** * DOI: [ 10.1007/s12519-026-01096-5 ](https://doi.org/10.1007/s12519-026-01096-5) Item in Clipboard Editorial # Precision medicine in pediatric sepsis-associated acute kidney injury: when systemic heterogeneity meets organ-level heterogeneity Meng-Yuan Wu et al. World J Pediatr. 2026. Show details Display options Display options Format Abstract PubMed PMID World J Pediatr Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22World+J+Pediatr%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22World+J+Pediatr%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42752807/) . 2026 Sep 17. doi: 10.1007/s12519-026-01096-5. Online ahead of print. ### Authors [Meng-Yuan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+MY&cauthor_id=42752807)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#short-view-affiliation-1 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China."), [Yu Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+Y&cauthor_id=42752807)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#short-view-affiliation-1 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China."), [Xiao-He Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+XH&cauthor_id=42752807)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#short-view-affiliation-1 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China."), [Xu-Hua Ge](https://pubmed.ncbi.nlm.nih.gov/?term=Ge+XH&cauthor_id=42752807)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42752807/#short-view-affiliation-2 "Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China. gexuhua@njmu.edu.cn.") ### Affiliations * 1 Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China. * 2 Department of Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210018, China. gexuhua@njmu.edu.cn. * PMID: **42752807** * DOI: [ 10.1007/s12519-026-01096-5 ](https://doi.org/10.1007/s12519-026-01096-5) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID _No abstract available_ [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Author Xu-Hua Ge is a member of the Editorial Board for World Journal of Pediatrics. The paper was handled independently and has undergone rigorous peer review. Author Xu-Hua Ge was not involved in the journal's review of, or decisions related to, this manuscript. Ethical approval: Not applicable. Declaration of generative AI and AI-assisted technologies in the writing process: During the preparation of this work, we used Gemini to improve language readability and grammar. After using this tool, we reviewed and edited the content as needed and take full responsibility for the final content of the publication. ## References 1. 1. Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL. Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med. 2017;376:11–20. . - [DOI](https://doi.org/10.1056/nejmoa1611391) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/27959707/) 2. 1. Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015;41:1411–23. . - [DOI](https://doi.org/10.1007/s00134-015-3934-7) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/26162677/) 3. 1. Meena J, Kumar J, Kocharlakota JP, Gupta H, Mittal P, Kumar A, et al. Acute kidney injury in neonates: a meta-analysis. Pediatrics. 2024;154:e2023065182. . - [DOI](https://doi.org/10.1542/peds.2023-065182) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/38872621/) 4. 1. Ouyang X, Fu M, Li J, Gao J, Xu L, Pei Y, et al. Risk factors for occurrence and death of sepsis-associated acute kidney injury in children with sepsis. Int Immunopharmacol. 2024;143:113551. . - [DOI](https://doi.org/10.1016/j.intimp.2024.113551) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/39488919/) 5. 1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315:801–10. . - [DOI](https://doi.org/10.1001/jama.2016.0287) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/26903338/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/4968574/) Show all 56 references ## Publication types * Editorial Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Editorial%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Editorial) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42752807/) ## Grants and funding * [ 82170733/National Natural Science Foundation of China ](https://pubmed.ncbi.nlm.nih.gov/?term=82170733%2FNational+Natural+Science+Foundation+of+China%5BGrants+and+Funding%5D&sort=date&sort_order=desc "All articles for grant 82170733/National Natural Science Foundation of China") * [ JX12214459/Postgraduate Education Reform Project of Jiangsu Province ](https://pubmed.ncbi.nlm.nih.gov/?term=JX12214459%2FPostgraduate+Education+Reform+Project+of+Jiangsu+Province%5BGrants+and+Funding%5D&sort=date&sort_order=desc "All articles for grant JX12214459/Postgraduate Education Reform Project of Jiangsu Province") [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42752807/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42752807%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.gov/42752807/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42752807%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42752807%2F%23open-collections-panel) * [Citation Manager](https://pubmed.ncbi.nlm.nih.gov/42752807/) [x] NCBI Literature Resources [MeSH](https://www.ncbi.nlm.nih.gov/mesh/) [PMC](https://www.ncbi.nlm.nih.gov/pmc/) [Bookshelf](https://www.ncbi.nlm.nih.gov/books) [Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 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