---
title: "Reach and engagement in the ECAIL trial: implementation study across COVID-19 and cost-of-living c"
id: "pubmed-42848780"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42848780"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42848780/"
doi: "10.1371/journal.pone.0350372"
published_at: "2026-10-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Reach and engagement in the ECAIL trial: implementation study across COVID-19 and cost-of-living c
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42848780
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42848780/)
- **DOI:** [10.1371/journal.pone.0350372](https://doi.org/10.1371%2Fjournal.pone.0350372)
- **Published At:** 2026-10-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The ECAIL trial, launched in 2017, evaluated a **multicomponent intervention** aimed at **childhood obesity prevention** among socially disadvantaged, hard-to-reach families. - Recruitment efforts occurred at a maternity hospital in Lille, France, where healthcare providers screened pregnant women; the trial focused on enrolling families considered socially disadvantaged. - The published study is a **mixed-methods implementation study** that examined **reach** and **engagement** of the target population during two major contextual shocks: the **COVID-19 pandemic** and the **cost-of-living crisis**. - Authors are affiliated with multiple French institutions including Université Paris Cité, Université Lille, Inserm, CHU Lille, and associative partners; the article appears in PLoS One (2026) with PMID 42848780 and DOI 10.1371/journal.pone.0350372. - The PubMed record provides the trial rationale and study framing but the abstract text in the source is truncated; specific details on methods, participant numbers, recruitment metrics, engagement measures, quantitative results, and precise conclusions were not reported in the source provided. - Because the available source content is incomplete, the implementation methods (for example, components of the intervention, evaluation instruments, timelines), statistical findings, and thematic qualitative results cannot be summarized from this record and are explicitly noted as not reported here. - The study’s stated aim—assessing reach and engagement during pandemic and economic stressors—indicates attention to real-world external factors that may alter implementation outcomes for interventions targeting disadvantaged families. - The PubMed entry lists extensive author and affiliation information and bibliographic metadata but does not include the full abstract or outcome data in the provided content.
## Clinical Analysis & Structured Key Points
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Institute for Translational Research in Inflammation, Lille, France."), [Dominique Deplanque](https://pubmed.ncbi.nlm.nih.gov/?term=Deplanque+D&cauthor_id=42848780)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-2 "Université Lille, Inserm, CHU Lille, Clinical Investigation Center, CIC 1403, Lille, France."), [Damien Subtil](https://pubmed.ncbi.nlm.nih.gov/?term=Subtil+D&cauthor_id=42848780)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-4 "Université Lille, Women and Newborn Mother Unit, CHU Lille, EA 2694, METRICS, Evaluation of Health Technologies and Medical Practices, Lille, France."), [Oriane Sion](https://pubmed.ncbi.nlm.nih.gov/?term=Sion+O&cauthor_id=42848780)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-5 "Research and Content Department, Association Programme Malin, Paris, France."), [Benjamin Cavalli](https://pubmed.ncbi.nlm.nih.gov/?term=Cavalli+B&cauthor_id=42848780)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-5 "Research and Content Department, Association Programme Malin, Paris, France."), [Lucie Vanhoutte](https://pubmed.ncbi.nlm.nih.gov/?term=Vanhoutte+L&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Victoria Jacobsen](https://pubmed.ncbi.nlm.nih.gov/?term=Jacobsen+V&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Ketevan Marr](https://pubmed.ncbi.nlm.nih.gov/?term=Marr+K&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Ioannis Sakellaris](https://pubmed.ncbi.nlm.nih.gov/?term=Sakellaris+I&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Blandine de Lauzon Guillain](https://pubmed.ncbi.nlm.nih.gov/?term=de+Lauzon+Guillain+B&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Marie-Aline Charles](https://pubmed.ncbi.nlm.nih.gov/?term=Charles+MA&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Delphine Ley](https://pubmed.ncbi.nlm.nih.gov/?term=Ley+D&cauthor_id=42848780)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-3 "Université Lille, Inserm, CHU Lille, INFINITE - Institute for Translational Research in Inflammation, Lille, France.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-6 "Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, CHU Lille, Lille, France."), [Priscille Sauvegrain](https://pubmed.ncbi.nlm.nih.gov/?term=Sauvegrain+P&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-7 "Universitary Department of Midwifery, Sorbonne Université, Paris, France."), [Sandrine Lioret](https://pubmed.ncbi.nlm.nih.gov/?term=Lioret+S&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#full-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France.") Affiliations Expand ### Affiliations * 1 Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France. * 2 Université Lille, Inserm, CHU Lille, Clinical Investigation Center, CIC 1403, Lille, France. * 3 Université Lille, Inserm, CHU Lille, INFINITE - Institute for Translational Research in Inflammation, Lille, France. * 4 Université Lille, Women and Newborn Mother Unit, CHU Lille, EA 2694, METRICS, Evaluation of Health Technologies and Medical Practices, Lille, France. * 5 Research and Content Department, Association Programme Malin, Paris, France. * 6 Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, CHU Lille, Lille, France. * 7 Universitary Department of Midwifery, Sorbonne Université, Paris, France. * PMID: **42848780** * DOI: [ 10.1371/journal.pone.0350372 ](https://doi.org/10.1371/journal.pone.0350372) Item in Clipboard # Reach and engagement in the ECAIL trial targeting socially disadvantaged families across the COVID-19 pandemic and cost-of-living crisis: A mixed-methods implementation study Delphine Poquet et al. PLoS One. 2026. Show details Display options Display options Format Abstract PubMed PMID PLoS One Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PLoS+One%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22PLoS+One%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42848780/) . 2026 Oct 8;21(10):e0350372. doi: 10.1371/journal.pone.0350372. eCollection 2026. ### Authors [Delphine Poquet](https://pubmed.ncbi.nlm.nih.gov/?term=Poquet+D&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Camille Le Gal](https://pubmed.ncbi.nlm.nih.gov/?term=Le+Gal+C&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Pascale Hincker](https://pubmed.ncbi.nlm.nih.gov/?term=Hincker+P&cauthor_id=42848780)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-2 "Université Lille, Inserm, CHU Lille, Clinical Investigation Center, CIC 1403, Lille, France."), [Laurent Béghin](https://pubmed.ncbi.nlm.nih.gov/?term=B%C3%A9ghin+L&cauthor_id=42848780)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-2 "Université Lille, Inserm, CHU Lille, Clinical Investigation Center, CIC 1403, Lille, France.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-3 "Université Lille, Inserm, CHU Lille, INFINITE - Institute for Translational Research in Inflammation, Lille, France."), [Dominique Deplanque](https://pubmed.ncbi.nlm.nih.gov/?term=Deplanque+D&cauthor_id=42848780)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-2 "Université Lille, Inserm, CHU Lille, Clinical Investigation Center, CIC 1403, Lille, France."), [Damien Subtil](https://pubmed.ncbi.nlm.nih.gov/?term=Subtil+D&cauthor_id=42848780)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-4 "Université Lille, Women and Newborn Mother Unit, CHU Lille, EA 2694, METRICS, Evaluation of Health Technologies and Medical Practices, Lille, France."), [Oriane Sion](https://pubmed.ncbi.nlm.nih.gov/?term=Sion+O&cauthor_id=42848780)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-5 "Research and Content Department, Association Programme Malin, Paris, France."), [Benjamin Cavalli](https://pubmed.ncbi.nlm.nih.gov/?term=Cavalli+B&cauthor_id=42848780)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-5 "Research and Content Department, Association Programme Malin, Paris, France."), [Lucie Vanhoutte](https://pubmed.ncbi.nlm.nih.gov/?term=Vanhoutte+L&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Victoria Jacobsen](https://pubmed.ncbi.nlm.nih.gov/?term=Jacobsen+V&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Ketevan Marr](https://pubmed.ncbi.nlm.nih.gov/?term=Marr+K&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Ioannis Sakellaris](https://pubmed.ncbi.nlm.nih.gov/?term=Sakellaris+I&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Blandine de Lauzon Guillain](https://pubmed.ncbi.nlm.nih.gov/?term=de+Lauzon+Guillain+B&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Marie-Aline Charles](https://pubmed.ncbi.nlm.nih.gov/?term=Charles+MA&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France."), [Delphine Ley](https://pubmed.ncbi.nlm.nih.gov/?term=Ley+D&cauthor_id=42848780)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-3 "Université Lille, Inserm, CHU Lille, INFINITE - Institute for Translational Research in Inflammation, Lille, France.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-6 "Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, CHU Lille, Lille, France."), [Priscille Sauvegrain](https://pubmed.ncbi.nlm.nih.gov/?term=Sauvegrain+P&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-7 "Universitary Department of Midwifery, Sorbonne Université, Paris, France."), [Sandrine Lioret](https://pubmed.ncbi.nlm.nih.gov/?term=Lioret+S&cauthor_id=42848780)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42848780/#short-view-affiliation-1 "Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France.") ### Affiliations * 1 Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics, Paris, France. * 2 Université Lille, Inserm, CHU Lille, Clinical Investigation Center, CIC 1403, Lille, France. * 3 Université Lille, Inserm, CHU Lille, INFINITE - Institute for Translational Research in Inflammation, Lille, France. * 4 Université Lille, Women and Newborn Mother Unit, CHU Lille, EA 2694, METRICS, Evaluation of Health Technologies and Medical Practices, Lille, France. * 5 Research and Content Department, Association Programme Malin, Paris, France. * 6 Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, CHU Lille, Lille, France. * 7 Universitary Department of Midwifery, Sorbonne Université, Paris, France. * PMID: **42848780** * DOI: [ 10.1371/journal.pone.0350372 ](https://doi.org/10.1371/journal.pone.0350372) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Background:** The ECAIL trial, launched in 2017, was designed to evaluate a multicomponent intervention for childhood obesity prevention among hard-to-reach families. At a maternity hospital in Lille, France, healthcare providers screened pregnant women exper
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