---
title: "Remdesivir Impairs Endometrial Receptivity in Pregnant Mice: Effects on Estradiol, IL-6, and Pinop"
id: "pubmed-42710901"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42710901"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42710901/"
doi: "10.5653/cerm.2026.09138"
published_at: "2026-09-09T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Remdesivir Impairs Endometrial Receptivity in Pregnant Mice: Effects on Estradiol, IL-6, and Pinop
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42710901
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42710901/)
- **DOI:** [10.5653/cerm.2026.09138](https://doi.org/10.5653%2Fcerm.2026.09138)
- **Published At:** 2026-09-09T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Study evaluated effects of intravenous **remdesivir** on endometrial tissue and markers of receptivity in pregnant female NMRI mice. Treatment lasted 10 days and mice were mated; gestational day 1 was defined by presence of a vaginal plug and analyses occurred on gestational day 4.5. - Thirty mice were allocated to five groups: untreated control, sham (dimethyl sulfoxide solvent), and remdesivir at **2 mg**, **4 mg**, and **8 mg**. - Primary endpoints included uterine histology, number/status of uterine **pinopodes** (surface structures linked to implantation), serum **estradiol** concentration, and endometrial tissue expression of **interleukin-6 (IL-6)** and interleukin-1β. - After remdesivir exposure, serum estradiol levels decreased in a **dose-dependent** fashion. - Endometrial **IL-6** expression also decreased dose-dependently following remdesivir treatment; interleukin-1β findings were not detailed in the abstract. - Remdesivir-treated groups showed fewer uterine pinopodes and histological evidence of endometrial injury compared with controls (statistically significant, p<0.05). - Authors conclude remdesivir may adversely affect the endometrium and potentially impair implantation in this mouse model, but they note that direct functional validation (for example, implantation or pregnancy outcome measures) is required. - The study context is antiviral treatment during **COVID-19** in pregnant patients, where remdesivir use is considered in severe disease; potential tissue-specific toxicity was a motivating concern. - Details such as full quantitative data, exact histologic features, interleukin-1β results, and functional reproductive outcomes were not reported in the abstract and would require consulting the full article for complete data.
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Online ahead of print. # The effect of intravenous remdesivir on endometrial receptivity in female mice [Jamileh Sadat Mirsanei](https://pubmed.ncbi.nlm.nih.gov/?term=Mirsanei+JS&cauthor_id=42710901)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-1 "Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-2 "Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran."), [Azam Govahi](https://pubmed.ncbi.nlm.nih.gov/?term=Govahi+A&cauthor_id=42710901)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-3 "Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran."), [Zahra Abroodi](https://pubmed.ncbi.nlm.nih.gov/?term=Abroodi+Z&cauthor_id=42710901)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-1 "Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-2 "Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran."), [Rana Mehdizadeh](https://pubmed.ncbi.nlm.nih.gov/?term=Mehdizadeh+R&cauthor_id=42710901)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-4 "Islamic Azad University Central Tehran Branch, School of Dentistry Tehran Iran School of Dentistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran."), [Ronak Shabani](https://pubmed.ncbi.nlm.nih.gov/?term=Shabani+R&cauthor_id=42710901)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-5 "Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran."), [Mehdi Mehdiadeh](https://pubmed.ncbi.nlm.nih.gov/?term=Mehdiadeh+M&cauthor_id=42710901)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-6 "Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. mehdizadeh.m@iums.ac.ir."), [Marziyeh Ajdary](https://pubmed.ncbi.nlm.nih.gov/?term=Ajdary+M&cauthor_id=42710901)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#full-view-affiliation-7 "Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. ajdari.m@iums.ac.ir.") Affiliations Expand ### Affiliations * 1 Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. * 2 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. * 3 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. * 4 Islamic Azad University Central Tehran Branch, School of Dentistry Tehran Iran School of Dentistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran. * 5 Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. * 6 Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. mehdizadeh.m@iums.ac.ir. * 7 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. ajdari.m@iums.ac.ir. * PMID: **42710901** * DOI: [ 10.5653/cerm.2026.09138 ](https://doi.org/10.5653/cerm.2026.09138) Item in Clipboard # The effect of intravenous remdesivir on endometrial receptivity in female mice Jamileh Sadat Mirsanei et al. Clin Exp Reprod Med. 2026. Show details Display options Display options Format Abstract PubMed PMID Clin Exp Reprod Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Exp+Reprod+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Exp+Reprod+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42710901/) . 2026 Sep 9. doi: 10.5653/cerm.2026.09138. Online ahead of print. ### Authors [Jamileh Sadat Mirsanei](https://pubmed.ncbi.nlm.nih.gov/?term=Mirsanei+JS&cauthor_id=42710901)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-1 "Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-2 "Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran."), [Azam Govahi](https://pubmed.ncbi.nlm.nih.gov/?term=Govahi+A&cauthor_id=42710901)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-3 "Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran."), [Zahra Abroodi](https://pubmed.ncbi.nlm.nih.gov/?term=Abroodi+Z&cauthor_id=42710901)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-1 "Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-2 "Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran."), [Rana Mehdizadeh](https://pubmed.ncbi.nlm.nih.gov/?term=Mehdizadeh+R&cauthor_id=42710901)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-4 "Islamic Azad University Central Tehran Branch, School of Dentistry Tehran Iran School of Dentistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran."), [Ronak Shabani](https://pubmed.ncbi.nlm.nih.gov/?term=Shabani+R&cauthor_id=42710901)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-5 "Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran."), [Mehdi Mehdiadeh](https://pubmed.ncbi.nlm.nih.gov/?term=Mehdiadeh+M&cauthor_id=42710901)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-6 "Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. mehdizadeh.m@iums.ac.ir."), [Marziyeh Ajdary](https://pubmed.ncbi.nlm.nih.gov/?term=Ajdary+M&cauthor_id=42710901)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42710901/#short-view-affiliation-7 "Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. ajdari.m@iums.ac.ir.") ### Affiliations * 1 Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. * 2 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. * 3 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. * 4 Islamic Azad University Central Tehran Branch, School of Dentistry Tehran Iran School of Dentistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran. * 5 Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. * 6 Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran. mehdizadeh.m@iums.ac.ir. * 7 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. ajdari.m@iums.ac.ir. * PMID: **42710901** * DOI: [ 10.5653/cerm.2026.09138 ](https://doi.org/10.5653/cerm.2026.09138) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Objective:** Pregnant women with coronavirus disease 2019 (COVID-19) are more likely than nonpregnant women to require admission to an intensive care unit, and many may require antiviral therapy. Remdesivir, an antiviral drug used to treat COVID-19, may exert toxic effects on specific tissues and organs. Therefore, this study investigated the effects of remdesivir on endometrial tissue in pregnant female mice. **Methods:** Thirty female Naval Medical Research Institute (NMRI) mice were divided into five groups. The control group received no treatment, and the sham group received the remdesivir solvent, dimethyl sulfoxide. The 2-, 4-, and 8-mg groups received the corresponding doses of remdesivir. Treatment continued for 10 days. After injection and mating, the presence of a vaginal plug was considered to indicate gestational day 1. On gestational day 4.5, uterine tissue damage, pinopode status, serum estradiol levels, and tissue expression of interleukin-6 and interleukin-1β were examined. **Results:** Serum estradiol levels and interleukin-6 expression in endometrial tissue decreased in a dose-dependent manner after remdesivir treatment. Remdesivir treatment was also associated with fewer uterine pinopodes and histological evidence of endometrial tissue injury (p<0.05). **Conclusion:** In pregnant mice, remdesivir reduced serum estradiol levels, decreased the number of endometrial pinopodes, and suppressed interleukin-6 expression. These findings suggest that remdesivir may adversely affect the endometrium and potentially compromise implantation; however, direct functional validation is required. **Keywords:** COVID-19; Endometrial injury; Remdesivir. 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