---
title: "Resveratrol targets ITGA5 to reduce oxidative stress and NET formation in COPD: integrated bioinfo"
id: "pubmed-42251820"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42251820"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42251820/"
doi: "10.1016/j.bbrc.2026.154095"
published_at: "2026-08-27T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Resveratrol targets ITGA5 to reduce oxidative stress and NET formation in COPD: integrated bioinfo
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42251820
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42251820/)
- **DOI:** [10.1016/j.bbrc.2026.154095](https://doi.org/10.1016%2Fj.bbrc.2026.154095)
- **Published At:** 2026-08-27T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This study combined **bioinformatics** analyses and ex‑vivo human neutrophil experiments to evaluate **resveratrol** as an antioxidant modulator in chronic obstructive pulmonary disease (**COPD**). - Public transcriptomic datasets (GSE11952 and GSE232805) were analyzed to identify hub genes associated with oxidative stress and neutrophil function in COPD. - Top-ranked hub genes common across centrality algorithms were **FN1**, **CD44**, **ITGA5**, and **THBS1**, implicated in extracellular matrix–receptor interaction, AGE‑RAGE signalling, HIF‑1, cytokine signalling, and ferroptosis pathways. - Molecular docking was used to screen candidate targets; **resveratrol** showed the highest predicted binding affinity to **ITGA5** (reported binding energy -7.4 kcal/mol). - Human peripheral blood neutrophils were isolated from healthy volunteers and COPD patients, challenged ex vivo with bacteria or PMA, and exposed to cigarette smoke extract (CSE) where indicated; interventions included resveratrol treatment. - Quantitative ex‑vivo assays demonstrated that resveratrol significantly reduced bacterial‑induced **ROS** generation in healthy and CSE‑exposed neutrophils. - In neutrophils from COPD patients, resveratrol significantly decreased **ROS** production and suppressed **neutrophil extracellular trap (NET)** formation in PMA‑stimulated cells. - The integrated data support **ITGA5** as a potential mechanistic target through which resveratrol attenuates oxidant generation and NET formation in COPD. - The paper concludes that resveratrol exerts a significant antioxidant effect in modulating oxidative stress in COPD based on combined in‑silico and ex‑vivo findings. - Details such as sample sizes, exact concentrations, statistical values, and full methodological parameters were not reported in the abstract and would require consultation of the full text for complete evaluation.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 4. # Integrated bioinformatics and ex-vivo evaluation of resveratrol in modulating oxidative stress and neutrophil extracellular traps in COPD [Anshu Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+A&cauthor_id=42251820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#full-view-affiliation-1 "Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Sarvjeet Das](https://pubmed.ncbi.nlm.nih.gov/?term=Das+S&cauthor_id=42251820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#full-view-affiliation-1 "Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Nabin Koirala](https://pubmed.ncbi.nlm.nih.gov/?term=Koirala+N&cauthor_id=42251820)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#full-view-affiliation-2 "Department of Advanced Computer Science and Engineering, Vignan's Foundation for Science, Technology and Research, Guntur, A.P., 522213, India."), [Debnarayan Khatua](https://pubmed.ncbi.nlm.nih.gov/?term=Khatua+D&cauthor_id=42251820)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#full-view-affiliation-3 "Department of Applied Science and Humanities, Parul Institute of Technology, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Ravish Kshatriya](https://pubmed.ncbi.nlm.nih.gov/?term=Kshatriya+R&cauthor_id=42251820)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#full-view-affiliation-4 "Department of Respiratory Medicine, Parul Institute of Medical Sciences and Research, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Anupam Jyoti](https://pubmed.ncbi.nlm.nih.gov/?term=Jyoti+A&cauthor_id=42251820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#full-view-affiliation-5 "Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. Electronic address: anupamjyoti03@gmail.com.") Affiliations Expand ### Affiliations * 1 Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. * 2 Department of Advanced Computer Science and Engineering, Vignan's Foundation for Science, Technology and Research, Guntur, A.P., 522213, India. * 3 Department of Applied Science and Humanities, Parul Institute of Technology, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. * 4 Department of Respiratory Medicine, Parul Institute of Medical Sciences and Research, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. * 5 Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. Electronic address: anupamjyoti03@gmail.com. * PMID: **42251820** * DOI: [ 10.1016/j.bbrc.2026.154095 ](https://doi.org/10.1016/j.bbrc.2026.154095) Item in Clipboard # Integrated bioinformatics and ex-vivo evaluation of resveratrol in modulating oxidative stress and neutrophil extracellular traps in COPD Anshu Kumar et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42251820/) . 2026 Aug 27:828:154095. doi: 10.1016/j.bbrc.2026.154095. Epub 2026 Jun 4. ### Authors [Anshu Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+A&cauthor_id=42251820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#short-view-affiliation-1 "Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Sarvjeet Das](https://pubmed.ncbi.nlm.nih.gov/?term=Das+S&cauthor_id=42251820)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#short-view-affiliation-1 "Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Nabin Koirala](https://pubmed.ncbi.nlm.nih.gov/?term=Koirala+N&cauthor_id=42251820)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#short-view-affiliation-2 "Department of Advanced Computer Science and Engineering, Vignan's Foundation for Science, Technology and Research, Guntur, A.P., 522213, India."), [Debnarayan Khatua](https://pubmed.ncbi.nlm.nih.gov/?term=Khatua+D&cauthor_id=42251820)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#short-view-affiliation-3 "Department of Applied Science and Humanities, Parul Institute of Technology, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Ravish Kshatriya](https://pubmed.ncbi.nlm.nih.gov/?term=Kshatriya+R&cauthor_id=42251820)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#short-view-affiliation-4 "Department of Respiratory Medicine, Parul Institute of Medical Sciences and Research, Parul University, Waghodia, Vadodara, Gujarat, 391760, India."), [Anupam Jyoti](https://pubmed.ncbi.nlm.nih.gov/?term=Jyoti+A&cauthor_id=42251820)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42251820/#short-view-affiliation-5 "Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. Electronic address: anupamjyoti03@gmail.com.") ### Affiliations * 1 Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. * 2 Department of Advanced Computer Science and Engineering, Vignan's Foundation for Science, Technology and Research, Guntur, A.P., 522213, India. * 3 Department of Applied Science and Humanities, Parul Institute of Technology, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. * 4 Department of Respiratory Medicine, Parul Institute of Medical Sciences and Research, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. * 5 Department of Life Science, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. Electronic address: anupamjyoti03@gmail.com. * PMID: **42251820** * DOI: [ 10.1016/j.bbrc.2026.154095 ](https://doi.org/10.1016/j.bbrc.2026.154095) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by persistent inflammation and oxidative stress-mediated pathogenesis. Identifying patient-specific drug targeting oxidative damage is of paramount importance. Resveratrol has emerged as a promising therapeutic candidate owing to its antioxidant and anti-inflammatory properties. This study aims to identify its targets and evaluate its therapeutic efficacy in neutrophil-driven oxidative stress in COPD. **Methods:** Bioinformatic analyses were performed using the GSE11952 and GSE232805 datasets. Top-ranked hub genes were identified for candidate drug screening and validated through molecular docking. Human peripheral blood neutrophils from healthy volunteers as well as COPD patients were isolated and challenged with bacteria or PMA, with or without resveratrol, under ex-vivo cigarette smoke exposure (CSE) followed by Python-based statistical and exploratory data analyses. We further assessed the effects of resveratrol on reactive oxygen species (ROS) generation and neutrophil extracellular traps (NETs) formation. **Results:** The top-ranked identified hub genes common across the three centrality algorithms were FN1, CD44, ITGA5, and THBS1, having roles in extracellular matrix-receptor interaction, advanced glycation end-products-receptor, hypoxia-inducible factor 1, cytokine signalling, and ferroptosis pathways. Molecular docking results demonstrated the highest binding affinity between resveratrol and ITGA5 (-7.4 kcal/mol). Ex-vivo quantitative analysis revealed that resveratrol significantly attenuated bacterial-induced ROS in healthy and CSE neutrophils. Additionally, it showed significant efficacy in reducing ROS and NET formation in PMA-stimulated neutrophils of COPD patients. **Conclusion:** Resveratrol exerted a significant antioxidant effect in modulating oxidative stress in COPD. Integrated bioinformatics and ex-vivo experiments suggest that ITGA5 may be a candidate target through which Resveratrol suppressed ROS generation and NETs formation in COPD. **Keywords:** COPD; CSE; Integrin; NET; Neutrophil; ROS; Resveratrol. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare no conflict of interest. ## Similar articles * [ Unveiling the therapeutic potential of Resveratrol against neutrophil-mediated hyperinflammation in sepsis: An in-silico, molecular docking, and ex-vivo approach. ](https://pubmed.ncbi.nlm.nih.gov/41666610/) Agarwal G, Das S, Kumar A, Saxena J, Verma PK, Viramgam K, Muley A, Jyoti A.Agarwal G, et al.Biochem Biophys Res Commun. 2026 Mar 26;806:153426. doi: 10.1016/j.bbrc.2026.153426. Epub 2026 Feb 6.Biochem Biophys Res Commun. 2026.PMID: 41666610 * [ Advanced glycation end product (AGE)-modified albumin does not enhance neutrophil extracellular trap formation and minimally impacts endothelial inflammation in large vessels. ](https://pubmed.ncbi.nlm.nih.gov/42142621/) Junho CVC, Dai Y, Schieren L, Hourtz S, Rykova T, Vondenhoff S, Wessiepe M, Zou J, Jankowski J, Goettsch C, Noels H.Junho CVC, et al.Life Sci. 2026 Aug 1;398:124467. doi: 10.1016/j.lfs.2026.124467. Epub 2026 May 15.Life Sci. 2026.PMID: 42142621 * [ Neutrophil extracellular traps promote epithelial-mesenchymal transition in COPD via the RAGE/PI3K/AKT pathway. ](https://pubmed.ncbi.nlm.nih.gov/41453711/) Zou J, Chen L, Yang Y, Huo Z, Liu Y, Luo Z, Ou S, Xu C, Bai J.Zou J, et al.Exp Cell Res. 2026 Feb 15;455(2):114869. doi: 10.1016/j.yexcr.2025.114869. Epub 2025 Dec 24.Exp Cell Res. 2026.PMID: 41453711 * [ Antioxidant therapeutic targets in COPD. ](https://pubmed.ncbi.nlm.nih.gov/16787173/) Rahman I, Kilty I.Rahman I, et al.Curr Drug Targets. 2006 Jun;7(6):707-20. doi: 10.2174/138945006777435254.Curr Drug Targets. 2006.PMID: 16787173Review. * [ Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets. ](https://pubmed.ncbi.nlm.nih.gov/14561194/) Rahman I.Rahman I.Curr Drug Targets Inflamm Allergy. 2002 Sep;1(3):291-315. doi: 10.2174/1568010023344607.Curr Drug Targets Inflamm Allergy. 2002.PMID: 14561194Review. 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