---
title: "Selective Extracorporeal Immunomodulation for Severe Falciparum Malaria With Multiple Organ Failure"
id: "pubmed-42644869"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42644869"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42644869/"
doi: "10.1097/CCE.0000000000001471"
published_at: "2026-08-27T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Selective Extracorporeal Immunomodulation for Severe Falciparum Malaria With Multiple Organ Failure
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42644869
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42644869/)
- **DOI:** [10.1097/CCE.0000000000001471](https://doi.org/10.1097%2FCCE.0000000000001471)
- **Published At:** 2026-08-27T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Severe malaria remains a major cause of mortality worldwide, often complicated by **acute kidney injury** (AKI) and **multiple organ failure** driven by dysregulated host hyperinflammation. Elevated cytokines such as **interleukin-6** and **tumor necrosis factor alpha** correlate with severity and mortality. - Effective adjunctive immunomodulatory therapies for severe malaria are lacking. The report describes the first clinical use of the **selective cytopheretic device (SCD)**, an extracorporeal immunomodulatory therapy, in a child with severe falciparum malaria. - Patient: a 5-year-old girl returning from the Democratic Republic of the Congo presented with fever, shock, 10.9% parasitemia, AKI, and evolving multiple organ dysfunction despite standard antimalarial treatment. - Initial malaria-directed care included intravenous artesunate and red blood cell exchange transfusion, but the patient developed refractory shock and severe lactic acidosis. - Continuous renal replacement therapy (CRRT) was initiated with adjunctive **SCD** therapy. Following initiation, inflammatory markers, vasopressor requirements, and metabolic acidosis improved and organ function progressively recovered. - The case supports that targeted extracorporeal **immunomodulation** may be a promising adjunctive strategy in severe malaria with hyperinflammation and organ failure, but this is a single-case report and broader evidence was not reported in the source. - Conflicts of interest disclosed: Drs. Humes and Humes have financial interests in SeaStar Medical; Dr. Goldstein is a consultant to SeaStar Medical; Dr. Myers received partial NIH funding; remaining authors reported no potential conflicts. - Keywords and indexed terms include cytokines, immunomodulation, inflammation, leukocytes, malaria, sepsis, AKI, and multiple organ failure.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Division of Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. * 2 Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. * 3 Division of Nephrology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI. * 4 Innovative BioTherapies, Ann Arbor, MI. * 5 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. * PMID: **42644869** * DOI: [ 10.1097/CCE.0000000000001471 ](https://doi.org/10.1097/cce.0000000000001471) Item in Clipboard Case Reports # Immunomodulation Therapy to Treat Severe Malaria With Multiple Organ Failure Saige Camara et al. Crit Care Explor. 2026. Show details Display options Display options Format Abstract PubMed PMID Crit Care Explor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Crit+Care+Explor%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Crit+Care+Explor%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) . 2026 Aug 27;8(9):e1471. doi: 10.1097/CCE.0000000000001471. eCollection 2026 Sep 1. ### Authors [Saige Camara](https://pubmed.ncbi.nlm.nih.gov/?term=Camara+S&cauthor_id=42644869)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-1 "Division of Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH."), [Amy Buck](https://pubmed.ncbi.nlm.nih.gov/?term=Buck+A&cauthor_id=42644869)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-1 "Division of Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH."), [Mikayla Burrell](https://pubmed.ncbi.nlm.nih.gov/?term=Burrell+M&cauthor_id=42644869)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-2 "Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH."), [H David Humes](https://pubmed.ncbi.nlm.nih.gov/?term=Humes+HD&cauthor_id=42644869)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-3 "Division of Nephrology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-4 "Innovative BioTherapies, Ann Arbor, MI."), [Stuart L Goldstein](https://pubmed.ncbi.nlm.nih.gov/?term=Goldstein+SL&cauthor_id=42644869)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-2 "Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-5 "Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH."), [Carlie N Myers](https://pubmed.ncbi.nlm.nih.gov/?term=Myers+CN&cauthor_id=42644869)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-1 "Division of Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-5 "Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH."), [Michael Humes](https://pubmed.ncbi.nlm.nih.gov/?term=Humes+M&cauthor_id=42644869)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42644869/#short-view-affiliation-4 "Innovative BioTherapies, Ann Arbor, MI.") ### Affiliations * 1 Division of Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. * 2 Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. * 3 Division of Nephrology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI. * 4 Innovative BioTherapies, Ann Arbor, MI. * 5 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. * PMID: **42644869** * DOI: [ 10.1097/CCE.0000000000001471 ](https://doi.org/10.1097/cce.0000000000001471) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Malaria causes more than 600,000 deaths annually. Severe malaria is frequently complicated by acute kidney injury (AKI) and multiple organ failure driven by dysregulated host hyperinflammation. Elevated cytokines, including interleukin-6 and tumor necrosis factor alpha, are associated with disease severity and mortality, yet effective adjunctive immunomodulatory therapies are lacking. We report the first clinical use of the selective cytopheretic device (SCD), an extracorporeal immunomodulatory therapy, in severe malaria. **Case summary:** A 5-year-old girl returning from the Democratic Republic of the Congo presented with fever, shock, 10.9% parasitemia, AKI, and evolving multiple organ dysfunction. Despite IV artesunate and RBC exchange, she developed refractory shock and severe lactic acidosis. Continuous renal replacement therapy with adjunctive SCD therapy was initiated, after which inflammatory markers, vasopressor requirements, and metabolic acidosis improved with progressive organ recovery. **Conclusions:** Targeted extracorporeal immunomodulation may represent a promising adjunctive strategy for severe malaria. **Keywords:** cytokines; immunomodulation; inflammation; leukocytes; malaria; sepsis. Copyright © 2026 The Authors. Published by Wolters Kluwer Health, LLC. on behalf of the Society of Critical Care Medicine. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Dr. Myers was partially funded by UM1TR005265 from the National Center for Advancing Translational Sciences of the National Institutes of Health. Drs. Humes and Humes have financial interests in SeaStar Medical. Dr. Goldstein is a consultant to SeaStar Medical. The remaining authors have disclosed that they do not have any potential conflicts of interest. ## References 1. 1. World Health Organization: World Malaria Report 2025: Addressing the Threat of Antimalarial Drug Resistance, 2025. Available at: [https://www.who.int/teams/global-malaria-programme/reports/world-malaria...](https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2025). Accessed January 10, 2026 2. 1. Snow RW: Global malaria eradication and the importance of Plasmodium falciparum epidemiology in Africa. BMC Med 2015; 13:23 3. 1. Garcia LS: Malaria. Clin Lab Med 2010; 30:93–129 4. 1. Hviid L, Jensen AT: PfEMP1—a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis. Adv Parasitol 2015; 88:51–84 5. 1. Plewes K, Leopold SJ, Kingston HWF, et al.: Malaria: What’s new in the management of malaria? Infect Dis Clin North Am 2019; 33:39–60 Show all 40 references ## Publication types * Case Reports Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Case+Reports%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Case+Reports) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) ## MeSH terms * Acute Kidney Injury / etiology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute+Kidney+Injury%2Fetiology%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Acute+Kidney+Injury) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Acute Kidney Injury / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute+Kidney+Injury%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Acute+Kidney+Injury) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Antimalarials / therapeutic use Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antimalarials%2Ftherapeutic+use%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Antimalarials) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Child, Preschool Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Child%2C+Preschool%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Child%2C+Preschool) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Female) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Immunomodulation* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunomodulation%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Immunomodulation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Malaria* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaria%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Malaria) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Malaria* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaria%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Malaria) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Malaria, Falciparum* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaria%2C+Falciparum%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Malaria%2C+Falciparum) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Malaria, Falciparum* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaria%2C+Falciparum%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Malaria%2C+Falciparum) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Multiple Organ Failure* / etiology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple+Organ+Failure%2Fetiology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Multiple+Organ+Failure) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) * Multiple Organ Failure* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple+Organ+Failure%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Multiple+Organ+Failure) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42644869/) ## Substances * Antimalarials Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antimalarials%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.
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