---
title: "Septic shock: early vasopressors with restricted fluids did not improve 90-day outcomes vs liberal"
id: "pubmed-42673586"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42673586"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42673586/"
doi: "10.7326/ANNALS-26-03036-JC"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Septic shock: early vasopressors with restricted fluids did not improve 90-day outcomes vs liberal
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42673586
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42673586/)
- **DOI:** [10.7326/ANNALS-26-03036-JC](https://doi.org/10.7326%2FANNALS-26-03036-JC)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- A recent report in Annals of Internal Medicine summarized a trial comparing two initial resuscitation strategies for **septic shock**: early initiation of **vasopressors** with restricted intravenous fluids versus a liberal-fluid strategy with vasopressors started later as needed. - The headline result: the early-vasopressors plus restricted-fluids approach did not improve **90-day outcomes** compared with liberal fluids with later vasopressors. - The citation provided: Shahriar Zehtabchi et al., Ann Intern Med. 2026 Sep 1; PubMed PMID 42673586; DOI 10.7326/ANNALS-26-03036-JC. - The PubMed entry is an editorial-style summary on the PubMed site; the authorship listed includes Shahriar Zehtabchi and the ACP Journal Club Editorial Team at McMaster University. - The PubMed record notes the article is online ahead of print and that a disclosure form is available with the article online. - The PubMed summary does not include trial design details, sample size, patient characteristics, effect estimates, statistical significance, secondary outcomes, or safety/adverse-event data; those details were not reported in the PubMed source text provided. - Because the abstract and full trial data are not included in the PubMed summary shown here, readers must consult the full article (Ann Intern Med) or the linked DOI for complete methods and results. - The record confirms standard bibliographic metadata (PMID and DOI) that can be used to locate the full report for clinical appraisal and application of the findings. - No additional numerical results, subgroup analyses, or guideline implications were reported in the PubMed summary; those items are not available in this source.
## Clinical Analysis & Structured Key Points
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Online ahead of print. # In septic shock, early vasopressors with restricted fluids vs. liberal fluids with later vasopressors as needed did not improve 90-d outcomes [Shahriar Zehtabchi](https://pubmed.ncbi.nlm.nih.gov/?term=Zehtabchi+S&cauthor_id=42673586)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42673586/#full-view-affiliation-1 "Kings County Hospital, Brooklyn, New York, USA \(S.Z.\)."); [ACP Journal Club Editorial Team at McMaster University](https://pubmed.ncbi.nlm.nih.gov/?term=ACP+Journal+Club+Editorial+Team+at+McMaster+University%5BCorporate+Author%5D) Affiliations Expand ### Affiliation * 1 Kings County Hospital, Brooklyn, New York, USA (S.Z.). * PMID: **42673586** * DOI: [ 10.7326/ANNALS-26-03036-JC ](https://doi.org/10.7326/annals-26-03036-jc) Item in Clipboard # In septic shock, early vasopressors with restricted fluids vs. liberal fluids with later vasopressors as needed did not improve 90-d outcomes Shahriar Zehtabchi et al. Ann Intern Med. 2026. 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