---
title: "Sirtuins in Lung Disease: Mechanisms, Clinical Implications, and Translational Advances"
id: "pubmed-42663289"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42663289"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42663289/"
doi: "10.3892/ijmm.2026.5967"
published_at: "2026-08-28T12:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Sirtuins in Lung Disease: Mechanisms, Clinical Implications, and Translational Advances
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42663289
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42663289/)
- **DOI:** [10.3892/ijmm.2026.5967](https://doi.org/10.3892%2Fijmm.2026.5967)
- **Published At:** 2026-08-28T12:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Sirtuins are a family of **NAD+‑dependent deacetylases** implicated in regulation of oxidative stress, metabolic homeostasis and inflammation in the lung. - By deacetylating proteins, sirtuins influence mitochondrial function, cell survival and death pathways, which can affect progression of multiple pulmonary disorders. - Dysregulated sirtuin expression and activity have been observed across lung pathologies and are linked to disease mechanisms in chronic obstructive pulmonary disease (**COPD**), pulmonary fibrosis and **lung cancer**. - Sirtuins present dual roles as potential **diagnostic biomarkers** and as therapeutic targets due to their pleiotropic effects on cellular metabolism and stress responses. - The reviewed literature was identified through searches of PubMed and Web of Science up to May 2025 using terms including 'sirtuin', 'SIRTs', 'lung disease', and 'pulmonary disease'. - The review synthesizes molecular mechanisms and translational applications reported in recent studies to support development of prevention and treatment strategies for lung diseases. - The article is a narrative synthesis and focuses on mechanistic connections between sirtuin biology and lung disease pathology rather than presenting new experimental data. - Key thematic areas covered include sirtuin regulation of oxidative stress, mitochondrial integrity, inflammatory signaling, cell survival/death, and implications for diagnosis and therapy.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 28. # Advances in sirtuin research in lung diseases (Review) [Shuangyun Xi](https://pubmed.ncbi.nlm.nih.gov/?term=Xi+S&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#full-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Weijun Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+W&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#full-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Xiuli Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+X&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#full-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Yudan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#full-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Yong Ke](https://pubmed.ncbi.nlm.nih.gov/?term=Ke+Y&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#full-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China.") Affiliations Expand ### Affiliation * 1 Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China. * PMID: **42663289** * DOI: [ 10.3892/ijmm.2026.5967 ](https://doi.org/10.3892/ijmm.2026.5967) Item in Clipboard Review # Advances in sirtuin research in lung diseases (Review) Shuangyun Xi et al. Int J Mol Med. 2026 Nov. Show details Display options Display options Format Abstract PubMed PMID Int J Mol Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Int+J+Mol+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Int+J+Mol+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42663289/) . 2026 Nov;58(5):296. doi: 10.3892/ijmm.2026.5967. Epub 2026 Aug 28. ### Authors [Shuangyun Xi](https://pubmed.ncbi.nlm.nih.gov/?term=Xi+S&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#short-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Weijun Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+W&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#short-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Xiuli Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+X&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#short-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Yudan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#short-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China."), [Yong Ke](https://pubmed.ncbi.nlm.nih.gov/?term=Ke+Y&cauthor_id=42663289)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663289/#short-view-affiliation-1 "Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China.") ### Affiliation * 1 Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China. * PMID: **42663289** * DOI: [ 10.3892/ijmm.2026.5967 ](https://doi.org/10.3892/ijmm.2026.5967) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Sirtuins, which comprise a family of NAD+-dependent deacetylases, have emerged as critical regulators in the pathogenesis of pulmonary diseases because of their pleiotropic roles in oxidative stress, metabolic homeostasis and inflammation. Growing evidence indicates that sirtuins modulate key cellular processes, including mitochondrial function, cell survival and death pathways, via protein deacetylation, thereby influencing disease progression in chronic obstructive pulmonary disease, pulmonary fibrosis and lung cancer. Notably, dysregulated sirtuin expression and activity are implicated in various lung pathologies, highlighting their dual potential as diagnostic biomarkers and therapeutic targets. The present review synthesized recent advances in sirtuin research, focusing on molecular mechanisms and translational applications, to provide a foundation for developing novel strategies for lung disease prevention and treatment. A comprehensive literature review of the relationship between sirtuins and lung‑related diseases was conducted. Literature published in PubMed and Web of Science up to May 2025 was searched using the keywords 'sirtuin,' 'SIRTs,' 'lung disease,' and 'pulmonary disease.' **Keywords:** SIRTs; lung disease; pulmonary disease; sirtuin. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Sirtuins as Endogenous Regulators of Cardiac Fibrosis: A Current Perspective. ](https://pubmed.ncbi.nlm.nih.gov/40789811/) Farhadi Z, Esmailidehaj M, Masoumi S, Azizian H.Farhadi Z, et al.Cardiovasc Toxicol. 2025 Oct;25(10):1634-1649. doi: 10.1007/s12012-025-10052-0. Epub 2025 Aug 11.Cardiovasc Toxicol. 2025.PMID: 40789811Review. * [ Sirtuins as endogenous regulators of lung fibrosis: A current perspective. ](https://pubmed.ncbi.nlm.nih.gov/32781070/) Mazumder S, Barman M, Bandyopadhyay U, Bindu S.Mazumder S, et al.Life Sci. 2020 Oct 1;258:118201. doi: 10.1016/j.lfs.2020.118201. Epub 2020 Aug 8.Life Sci. 2020.PMID: 32781070Review. * [ Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. ](https://pubmed.ncbi.nlm.nih.gov/29447380/) Tatone C, Di Emidio G, Barbonetti A, Carta G, Luciano AM, Falone S, Amicarelli F.Tatone C, et al.Hum Reprod Update. 2018 May 1;24(3):267-289. doi: 10.1093/humupd/dmy003.Hum Reprod Update. 2018.PMID: 29447380Review. * [ The crosstalk between MicroRNAs and sirtuins: a bit unexpected therapeutic target for cardiovascular diseases. ](https://pubmed.ncbi.nlm.nih.gov/41088315/) Kamvar R, Barjasteh AH, Omouri-Kharashtomi M, Roumiani PH, Beheshtirooy A, Adib-Hajbagheri P, Rezaei P, Shokraei R, Pourhanifeh MH.Kamvar R, et al.Eur J Med Res. 2025 Oct 14;30(1):969. doi: 10.1186/s40001-025-03235-6.Eur J Med Res. 2025.PMID: 41088315Free PMC article.Review. * [ Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer. ](https://pubmed.ncbi.nlm.nih.gov/35328633/) Colloca A, Balestrieri A, Anastasio C, Balestrieri ML, D'Onofrio N.Colloca A, et al.Int J Mol Sci. 2022 Mar 16;23(6):3212. doi: 10.3390/ijms23063212.Int J Mol Sci. 2022.PMID: 35328633Free PMC article.Review. 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