---
title: "SSRI/SNRI Exposure in Pregnancy and Newborn Outcomes: Increased Neonatal Support and NICU Admission"
id: "pubmed-42803544"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42803544"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42803544/"
doi: "10.17992/lbl.2026.10.911"
published_at: "2026-10-01T00:00:00.000Z"
evidence_level: "English Abstract"
license: "CC-BY-NC-4.0 / Informational Use"
---
# SSRI/SNRI Exposure in Pregnancy and Newborn Outcomes: Increased Neonatal Support and NICU Admission
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42803544
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42803544/)
- **DOI:** [10.17992/lbl.2026.10.911](https://doi.org/10.17992%2Flbl.2026.10.911)
- **Published At:** 2026-10-01T00:00:00.000Z
- **Evidence Rating:** English Abstract
## Executive GIST (TL;DR)
- This retrospective comparative study reviewed all infants born at Landspítali, Iceland, in 2023 to evaluate effects of maternal **SSRI/SNRI** treatment at delivery on newborn outcomes. - The initial cohort included 3,200 births; infants born before 35 weeks' gestation were excluded, leaving 3,069 infants for analysis. - Maternal exposure to **SSRI/SNRI** at delivery was identified in 336 infants, representing 10.9% of the study population. - The need for immediate **neonatal support** was significantly higher in the exposed group: 29.2% versus 14.6% in controls. - NICU admission or monitoring occurred more frequently among exposed neonates (19.4%) than controls (13%). - Exposed infants had higher rates of **respiratory distress**, lower **Apgar** scores at 1 and 5 minutes, and underwent sepsis work-ups more often than unexposed infants. - The authors conclude that maternal **SSRI/SNRI** treatment at delivery is associated with increased postnatal support needs, greater use of oxygen and respiratory assistance, more NICU care, and lower Apgar scores. - The study population and setting: Landspítali (Iceland), Faculty of Medicine, University of Iceland, Children's Hospital Hringur; publication in Laeknabladid (2026 Oct). - Details such as specific SSRI/SNRI agents, dosing, timing of exposure, and long-term neonatal outcomes were not reported in the abstract.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliation * 1 Faculty of Medicine, University of Iceland, Children's Hospital Hringur. * PMID: **42803544** * DOI: [ 10.17992/lbl.2026.10.911 ](https://doi.org/10.17992/lbl.2026.10.911) Free article Item in Clipboard # [SSRI/SNRI Treatment During Preganancy and It´s Effects on Newborns] [Article in Icelandic] Kolka Magnusdottir et al. Laeknabladid. 2026 Oct. Free article Show details Display options Display options Format Abstract PubMed PMID Laeknabladid Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Laeknabladid%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Laeknabladid%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42803544/) . 2026 Oct;112(10):426-431. doi: 10.17992/lbl.2026.10.911. ### Authors [Kolka Magnusdottir](https://pubmed.ncbi.nlm.nih.gov/?term=Magnusdottir+K&cauthor_id=42803544)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42803544/#short-view-affiliation-1 "Faculty of Medicine, University of Iceland, Children's Hospital Hringur."), [Sonja Baldursdottir](https://pubmed.ncbi.nlm.nih.gov/?term=Baldursdottir+S&cauthor_id=42803544)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42803544/#short-view-affiliation-1 "Faculty of Medicine, University of Iceland, Children's Hospital Hringur."), [Thordur Thorarinn Thordarson](https://pubmed.ncbi.nlm.nih.gov/?term=Thordarson+TT&cauthor_id=42803544)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42803544/#short-view-affiliation-1 "Faculty of Medicine, University of Iceland, Children's Hospital Hringur.") ### Affiliation * 1 Faculty of Medicine, University of Iceland, Children's Hospital Hringur. * PMID: **42803544** * DOI: [ 10.17992/lbl.2026.10.911 ](https://doi.org/10.17992/lbl.2026.10.911) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Introduction:** In the past decade, the use of antidepressants in Iceland has increased rapidly. Given their widespread use, it is important to assess potential effects of SSRI/SNRI exposure during pregnancy on the newborn. The aim of this study was to examine the prevalence of SSRI/SNRI use at the time of delivery, the frequency of neonatal support or resuscitation, monitoring or admissions to the neonatal intensive care unit (NICU), and which clinical signs may possibly be linked to SSRI/SNRI exposure during pregnancy. **Methods:** This was a retrospective comparative study, including all infants born at Landspítali in 2023 (n=3200). Infants born before 35 weeks of gestation were excluded. The study group consisted of infants whose mothers were on SSRI/SNRI treatment upon delivery, while the control group included all other infants in the study population. Additionally, infants admitted to the NICU were examined in more detail. **Results:** Out of 3069 infants, 336 (10.9%) were exposed to SSRI/SNRI treatment during pregnancy. The need for neonatal support was significantly higher in the SSRI/SNRI group (29.2%) compared with controls (14.6%). Similarly, NICU admission or monitoring was more common (19.4% vs. 13%). Other significant differences included higher rates of respiratory distress, lower Apgar scores at 1 and 5 minutes, and more frequent sepsis work-ups in the SSRI/SNRI group. **Conclusions:** Infants exposed to maternal SSRI/SNRI treatment are more likely to require postnatal support, including oxygen therapy and respiratory assistance, as well as NICU care. Furthermore, these infants have lower Apgar scores at birth, and increased rate of sepsis work-up. **Keywords:** Neonatal Unit; SNRI; SSRI; newborn; pregnancy. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Neonatal Morbidity After Maternal Use of Antidepressant Drugs During Pregnancy. ](https://pubmed.ncbi.nlm.nih.gov/27940758/) Nörby U, Forsberg L, Wide K, Sjörs G, Winbladh B, Källén K.Nörby U, et al.Pediatrics. 2016 Nov;138(5):e20160181. doi: 10.1542/peds.2016-0181.Pediatrics. 2016.PMID: 27940758 * [ Acute Delivery Room Resuscitation of Neonates Exposed to Selective Serotonin Reuptake Inhibitors. ](https://pubmed.ncbi.nlm.nih.gov/33453205/) Ulbrich KA, Zumpf K, Ciolino JD, Shah M, Miller ES, Wisner KL.Ulbrich KA, et al.J Pediatr. 2021 May;232:103-108.e2. doi: 10.1016/j.jpeds.2021.01.006. 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