---
title: "TCM non-pharmacological therapies for cancer-related fatigue in lung cancer: network meta-analysis"
id: "pubmed-42758224"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42758224"
content_type: "clinical_feed_article"
specialty: "Critical Care"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42758224/"
doi: "10.1007/s00520-026-11208-6"
published_at: "2026-09-18T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# TCM non-pharmacological therapies for cancer-related fatigue in lung cancer: network meta-analysis
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42758224
- **Specialty:** [Critical Care](https://medichelpline.com/clinical-feed/critical-care.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42758224/)
- **DOI:** [10.1007/s00520-026-11208-6](https://doi.org/10.1007%2Fs00520-026-11208-6)
- **Published At:** 2026-09-18T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Cancer-related fatigue (CRF) is common in lung cancer and impairs health and quality of life. - This systematic review and network meta-analysis compared **Traditional Chinese Medicine (TCM)**-based non-pharmacological therapies for CRF in lung cancer. - Eight databases were searched through 24 November 2025; randomized controlled trials (RCTs) were assessed with the Cochrane Risk of Bias 2.0 tool. - Thirty-two RCTs evaluating eight TCM-based non-pharmacological therapies were included. - Statistical analyses were performed using **STATA 18.0** and a network meta-analysis approach to compare therapies indirectly and directly. - **Moxibustion** showed the largest benefit versus usual care (SMD = -2.56, 95% CI -3.60 to -1.51). - **Auricular acupressure** also significantly improved CRF versus usual care (SMD = -1.82, 95% CI -3.61 to -0.03). - Moxibustion was significantly better than **qigong** (SMD = -2.12, 95% CI -3.58 to -0.65). - Qigong appeared less effective in this analysis. - The authors caution that many included trials had a considerable risk of bias; results require confirmation in higher-quality, rigorously designed RCTs. - Keywords emphasized: **cancer-related fatigue**, **lung neoplasms**, **network meta-analysis**, **non-pharmacological therapies**, **Traditional Chinese Medicine**.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. * 2 Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 380560679@qq.com. * 3 Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. gengshuangsky@126.com. # Contributed equally. * PMID: **42758224** * DOI: [ 10.1007/s00520-026-11208-6 ](https://doi.org/10.1007/s00520-026-11208-6) Item in Clipboard Review # Comparative efficacy of traditional Chinese medicine-based non-pharmacological therapies for managing cancer-related fatigue in lung cancer patients: a systematic review and network meta-analysis Yu Song et al. Support Care Cancer. 2026. Show details Display options Display options Format Abstract PubMed PMID Support Care Cancer Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Support+Care+Cancer%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Support+Care+Cancer%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) . 2026 Sep 18;34(10):984. doi: 10.1007/s00520-026-11208-6. ### Authors [Yu Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+Y&cauthor_id=42758224)[#](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-affiliation-1 "Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."), [Xinyu Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+X&cauthor_id=42758224)[#](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-affiliation-1 "Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."), [Yao Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+Y&cauthor_id=42758224)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-affiliation-1 "Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."), [Hongying Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+H&cauthor_id=42758224)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-affiliation-1 "Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."), [Ying Xia](https://pubmed.ncbi.nlm.nih.gov/?term=Xia+Y&cauthor_id=42758224)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-affiliation-1 "Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."), [Fang Ni](https://pubmed.ncbi.nlm.nih.gov/?term=Ni+F&cauthor_id=42758224)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-affiliation-2 "Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 380560679@qq.com."), [Shuang Geng](https://pubmed.ncbi.nlm.nih.gov/?term=Geng+S&cauthor_id=42758224)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42758224/#short-view-affiliation-3 "Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. gengshuangsky@126.com.") ### Affiliations * 1 Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. * 2 Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 380560679@qq.com. * 3 Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. gengshuangsky@126.com. # Contributed equally. * PMID: **42758224** * DOI: [ 10.1007/s00520-026-11208-6 ](https://doi.org/10.1007/s00520-026-11208-6) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Fatigue is a prevalent symptom in lung cancer patients and adversely affects their health and quality of life. While some evidence suggests that Traditional Chinese Medicine (TCM)-based non-pharmacological therapies can effectively alleviate cancer-related fatigue (CRF), it remains unclear which therapy is most effective for managing CRF in this population. **Objective:** To compare the effects of different TCM-based non-pharmacological therapies on reducing CRF in lung cancer patients. **Methods:** We searched eight databases from their inception to 24 November 2025. Following literature screening, the quality of the included randomized controlled trials (RCTs) was assessed using the Cochrane Risk of Bias 2.0 tool. A network meta-analysis was conducted to evaluate the relative efficacy of the TCM-based non-pharmacological therapies. Statistical analyses were performed using STATA 18.0 software. **Results:** A total of 32 RCTs involving eight TCM-based non-pharmacological therapies were included. The network meta-analysis results indicated that moxibustion (SMD = -2.56, 95% CI = -3.60 to -1.51) and auricular acupressure (SMD = -1.82, 95% CI = -3.61 to -0.03) were significantly more effective than usual care in improving CRF. Furthermore, moxibustion showed a significant advantage over qigong (SMD = -2.12, 95% CI = -3.58 to -0.65). **Conclusion:** Current evidence shows that moxibustion and auricular acupressure may be the most promising TCM-based non-pharmacological therapies for alleviating CRF in lung cancer patients, whereas qigong appears less effective. However, given the considerable risk of bias across the included studies, these conclusions require further validation through more rigorously designed, high-quality clinical trials. **Keywords:** Cancer-related fatigue; Lung neoplasms; Network meta-analysis; Non-pharmacological therapies; Traditional Chinese Medicine. © 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declarations. Competing interests: The authors declare no competing interests. ## References 1. 1. Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263 - [PubMed](https://pubmed.ncbi.nlm.nih.gov/38572751/) 2. 1. Berger AM, Mooney K, Alvarez-Perez A et al (2015) Cancer-related fatigue, version 2.2015. J Natl Compr Canc Netw 13(8):1012–1039 - [PubMed](https://pubmed.ncbi.nlm.nih.gov/26285247/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/5499710/) - [DOI](https://doi.org/10.6004/jnccn.2015.0122) 3. 1. Zeilinger EL, Zrnic-Novakovic I, Oppenauer C et al (2024) Prevalence and biopsychosocial indicators of fatigue in cancer patients. Cancer Med 13(11):e7293 - [PubMed](https://pubmed.ncbi.nlm.nih.gov/38819432/) - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/11141333/) - [DOI](https://doi.org/10.1002/cam4.7293) 4. 1. Jung JY, Lee JM, Kim MS et al (2018) Comparison of fatigue, depression, and anxiety as factors affecting posttreatment health-related quality of life in lung cancer survivors. Psychooncology 27(2):465–470 - [PubMed](https://pubmed.ncbi.nlm.nih.gov/28755492/) - [DOI](https://doi.org/10.1002/pon.4513) 5. 1. Shin JW, Lee BJ, Chung S et al (2024) Understanding experiences of cancer-related fatigue in patients with lung cancer after their cancer treatment: a qualitative content analysis. Qual Life Res 33(4):975–987 - [DOI](https://doi.org/10.1007/s11136-023-03578-9) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/38085453/) Show all 58 references ## Publication types * Systematic Review Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Systematic+Review%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Systematic+Review) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Network Meta-Analysis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Network+Meta-Analysis%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Network+Meta-Analysis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Comparative Study Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Comparative+Study%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Comparative+Study) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Review Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Review%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Review) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) ## MeSH terms * Acupressure / methods Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acupressure%2Fmethods%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Acupressure) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Fatigue* / etiology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fatigue%2Fetiology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Fatigue) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Fatigue* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fatigue%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Fatigue) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Lung Neoplasms* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lung+Neoplasms%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Lung+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42758224/) * Medicine, Chinese Traditional* / methods Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Medicine%2C+Chinese+Traditional%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Medicine%2C+Chinese+Tradition
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