---
title: "Mathematical model reveals how stress and circadian disruption drive adipogenic commitment via PPA"
id: "biorxiv-22-deciphering-the-dynamical-origin-of-the-adipogenic-commitment-during-stress"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-22-deciphering-the-dynamical-origin-of-the-adipogenic-commitment-during-stress"
content_type: "clinical_feed_article"
specialty: "Endocrinology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.18.752812v1?rss=1"
published_at: "2026-09-22T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Mathematical model reveals how stress and circadian disruption drive adipogenic commitment via PPA
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-22-deciphering-the-dynamical-origin-of-the-adipogenic-commitment-during-stress
- **Specialty:** [Endocrinology](https://medichelpline.com/clinical-feed/endocrinology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.18.752812v1?rss=1)
- **Published At:** 2026-09-22T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Obesity results from excessive fat accumulation driven by **adipogenesis**; recent work links increased adipogenic commitment to excessive stress and circadian rhythm disruption. - Adipogenic commitment shows time-of-day dependence, indicating a coupling between differentiation and the **circadian** phase. - The authors developed a mathematical model focused on the transcription factor **PPARγ**, a central regulator of adipogenic differentiation. - The model characterizes adipogenic commitment as a **bistable**, irreversible differentiation process; a slow positive-feedback loop in PPARγ dynamics primarily sets the commitment threshold. - Simulations reproduce reported experimental patterns for adipogenesis triggered by both constant and pulsatile stress inputs and explain the observed relationship between differentiation timing and circadian phase. - The model generates testable predictions about how adipogenic commitment might be controlled under stressful conditions. - The work provides a dynamical systems explanation for how stress signaling gates adipogenesis but is presented as a preprint and has not been peer reviewed. - Details such as specific parameter values, experimental datasets used for calibration, and mechanistic molecular interactions beyond PPARγ feedback were not reported in the summary available.
## Clinical Analysis & Structured Key Points
Deciphering the dynamical origin of the Adipogenic commitment during stress-induced disruption of the circadian rhythm | bioRxiv Skip to main content New Results Deciphering the dynamical origin of the Adipogenic commitment during stress-induced disruption of the circadian rhythm Debjit Das , View ORCID Profile Kajal Charan , Sandip Kar doi: https://doi.org/10.64898/2026.09.18.752812 Debjit Das Indian Institute of Technology Bombay Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kajal Charan Indian Institute of Technology Bombay Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Kajal Charan Sandip Kar Indian Institute of Technology Bombay Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: sandipkar{at}iitb.ac.in Abstract Info/History Metrics Supplementary material Preview PDF Abstract Obesity is a major health concern worldwide and is caused by an excessive fat accumulation in the body due to adipogenesis. Recent studies suggest that excessive stress or disruption of circadian rhythms can enhance adipogenic commitment and lead to obesity. Moreover, this adipogenic commitment occurs at a specific time of day, highlighting a correlation with the circadian rhythm. However, the dynamical nature of this kind of stress-induced adipogenic differentiation remains an unresolved puzzle. Herein, we proposed a mathematical model centred on the key transcription factor PPARγ, associated with adipogenic differentiation, and demonstrated that adipogenic commitment is a bistable, irreversible differentiation process in which slow positive feedback regulation of PPARγ primarily controls the differentiation commitment threshold. The model reproduced the experimental observations regarding the extent of adipogenesis induced by constant and pulsatile stress input signals and explained the correlation between adipogenic differentiation time and circadian phase. It further predicts how to control the adipogenic commitment even under stressful conditions. Overall, our study elucidates how stress signalling dynamically governs adipogenesis. Competing Interest Statement The authors have declared no competing interest. Funder Information Declared UGC-CSIR-JRF , NTA Ref. No: 191620004555 ANRF (erstwhile SERB) , CRG/2023/002165 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Back to top Previous Next Posted September 22, 2026. Download PDF Supplementary Material Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Deciphering the dynamical origin of the Adipogenic commitment during stress-induced disruption of the circadian rhythm Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Share Deciphering the dynamical origin of the Adipogenic commitment during stress-induced disruption of the circadian rhythm Debjit Das , Kajal Charan , Sandip Kar bioRxiv 2026.09.18.752812; doi: https://doi.org/10.64898/2026.09.18.752812 Share This Article: Copy Citation Tools Deciphering the dynamical origin of the Adipogenic commitment during stress-induced disruption of the circadian rhythm Debjit Das , Kajal Charan , Sandip Kar bioRxiv 2026.09.18.752812; doi: https://doi.org/10.64898/2026.09.18.752812 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Areas All Articles Animal Behavior and Cognition (8019) Biochemistry (18746) Bioengineering (14899) Bioinformatics (44471) Biophysics (22615) Cancer Biology (19731) Cell Biology (26911) Clinical Trials (138) Developmental Biology (13973) Ecology (21012) Epidemiology (2067) Evolutionary Biology (25466) Genetics (16177) Genomics (23526) Immunology (18720) Microbiology (42540) Molecular Biology (18072) Neuroscience (93552) Paleontology (701) Pathology (2984) Pharmacology and Toxicology (5102) Physiology (8123) Plant Biology (16003) Scientific Communication and Education (2095) Synthetic Biology (4562) Systems Biology (10239) Zoology (2392)
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