---
title: "Menopausal Hormone Therapy Linked to 69% Lower Risk of Low Bone Mineral Density"
id: "endocrine-news-0-video-menopausal-hormone-therapy-reduces-risk-of-low-bone-mineral-density-by-69"
canonical_url: "https://medichelpline.com/clinical-feed/endocrine-news-0-video-menopausal-hormone-therapy-reduces-risk-of-low-bone-mineral-density-by-69"
content_type: "clinical_feed_article"
specialty: "Endocrinology"
source_name: "Endocrine News"
source_url: "https://endocrinenews.endocrine.org/menopausal-hormone-therapy-reduces-risk-of-low-bone-mineral-density-by-69/"
published_at: "2026-08-26T12:55:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Menopausal Hormone Therapy Linked to 69% Lower Risk of Low Bone Mineral Density
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/endocrine-news-0-video-menopausal-hormone-therapy-reduces-risk-of-low-bone-mineral-density-by-69
- **Specialty:** [Endocrinology](https://medichelpline.com/clinical-feed/endocrinology.md)
- **Primary Source:** Endocrine News
- **Source URL:** [Original Journal Publication](https://endocrinenews.endocrine.org/menopausal-hormone-therapy-reduces-risk-of-low-bone-mineral-density-by-69/)
- **Published At:** 2026-08-26T12:55:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- A retrospective cohort study presented at **ENDO 2026** found that postmenopausal women using **menopausal hormone therapy** had a substantially lower risk of developing **low bone mineral density** compared with non-users. - The analysis included 387 postmenopausal women who underwent **DXA** scans between 2021 and 2025; 33% were classified as hormone therapy users and 67% as non-users. - Low bone mineral density was defined in the study as either **osteopenia** or **osteoporosis**. - Users of menopausal hormone therapy had about a **69% lower risk** of low bone mineral density in the spine and hip versus non-users, a result that persisted after adjustment for age, time since menopause, vitamin D levels, smoking, and other health conditions. - Diego Espinoza-Peralta, M.D., M.Sc., the study’s principal investigator, emphasized that the finding suggests hormone therapy may independently protect bone health rather than merely being associated by chance. - The authors and speakers suggest this evidence could shift clinical conversations from “avoid if possible” to “reconsider in the right patient,” particularly for women early after menopause seeking symptom relief and bone protection. - The published news summary does not report additional study details such as specific hormone formulations, doses, duration of therapy, exact statistical measures, fracture outcomes, or study limitations; those details were not reported in the source. - The report frames the finding as potentially relevant to clinicians weighing benefits and risks of menopausal hormone therapy for symptom management and long-term bone health preservation.
## Clinical Analysis & Structured Key Points
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[Login](https://endocrinenews.endocrine.org/auth/login/?redirect=https://endocrinenews.endocrine.org/menopausal-hormone-therapy-reduces-risk-of-low-bone-mineral-density-by-69/) ![](https://endocrinenews.endocrine.org/wp-content/themes/mg-starter/assets/images/Endocrine_News_standard_logo.svg) * * * # VIDEO: Menopausal Hormone Therapy Reduces Risk of Low Bone Mineral Density by 69% August 26, 2026 Print this article Share this article ![](https://endocrinenews.endocrine.org/wp-content/uploads/YouTube_Peralta.jpg)[Women taking menopausal hormone therapy faced a lower risk of developing low bone mineral density, according to research presented at ENDO 2026. Diego Espinoza-Peralta, MD, MSc, shares the findings in our video series.](https://www.youtube.com/shorts/tnASgXAIbEk) [VIDEO]: Women on menopausal hormone therapy face less risk of developing low bone mineral density, according to research presented at **ENDO 2026**. Diego Espinoza-Peralta, MD, MSc, describes the research findings. Women who do not use menopausal hormone therapy have a greater risk of developing osteopenia and osteoporosis, which can lead to fractures, disability, and loss of independence. “For years, many women have avoided menopausal hormone therapy because of safety concerns and warning labels. This study revisits that narrative and shows that menopausal hormone therapy may have an important added benefit: protecting bone health. That shifts the conversation from ‘avoid if possible’ to ‘reconsider in the right patient,’” said Diego Espinoza-Peralta, M.D., M.Sc., Vice President of the Mexican Society of Nutrition and Endocrinology (SMNE) and principal investigator at Investigación Médica Sonora (INMEDS). The retrospective cohort study included 387 postmenopausal women who underwent DXA scans (between 2021 and 2025). They were designated as menopausal hormone therapy users (33%) or non-users (67%). Low bone mineral density was defined as osteopenia or osteoporosis. Those taking menopausal hormone therapy has about 69% less risk of low bone mineral density in the spine and hip compared to those not using it. This finding remained even after the researchers accounted for age, time since menopause, vitamin D levels, smoking, and other health conditions. “In simple terms: menopausal hormone therapy appears to independently protect bones, not just by coincidence,” Espinoza-Peralta said. This suggests that hormone therapy could be a way to help people find relief from menopausal symptoms and prevent bone loss or lower fracture risks. “Clinicians may begin to weigh its benefits more carefully, especially in women early after menopause, potentially improving long-term health and quality of life,” Espinoza-Peralta said. * * * ## TOPICS IN THIS ARTICLE: [Bone and Mineral](https://endocrinenews.endocrine.org/category/health-topic/bone-and-mineral/)[Hormone Therapies](https://endocrinenews.endocrine.org/category/hormone-therapies/) ←[Star Power 2026: Q&A with Konstantinos Stefanakis, MD](https://endocrinenews.endocrine.org/star-power-2026-qa-with-konstantinos-stefanakis-md/) ## RELATED ARTICLES * ### [ CPAP Therapy Reverses Low Testosterone in Men with Severe Obesity, Independent of Weight Loss ](https://endocrinenews.endocrine.org/cpap-therapy-reverses-low-testosterone-in-men-with-severe-obesity-independent-of-weight-loss/) July 8, 2026 * ![Growth Therapies Fall Short for Girls with Classical CAH](https://endocrinenews.endocrine.org/wp-content/uploads/jcem_110_1cover-1-e1786367244743-1024x576.jpeg) ### [ Growth Therapies Fall Short for Girls with Classical CAH ](https://endocrinenews.endocrine.org/growth-therapies-fall-short-for-girls-with-classical-cah/) July 7, 2026 * ![Denosumab Triggers Paradoxical Hungry Bone Syndrome-Like State in Multiple Myeloma Patient](https://endocrinenews.endocrine.org/wp-content/uploads/jcemcr_2_5cover-765x1024.jpeg) ### [ Denosumab Triggers Paradoxical Hungry Bone Syndrome-Like State in Multiple Myeloma Patient ](https://endocrinenews.endocrine.org/denosumab-triggers-paradoxical-hungry-bone-syndrome-like-state-in-multiple-myeloma-patient/) July 6, 2026 * * * ADVERTISEMENT ![August 2026](https://endocrinenews.endocrine.org/wp-content/uploads/08.26_coverPROOF001-749x1024.jpg) [View Archives](https://endocrinenews.endocrine.org/magazine-issues/) ADVERTISEMENT ADVERTISEMENT ![](https://endocrinenews.endocrine.org/wp-content/themes/mg-starter/assets/images/scientists_optim-1024x569.jpg) ## Join the Global Movement Advancing Endocrine Science and Medicine Become a part of a community of 18,000-plus endocrine investigators and clinicians who conduct research and provide quality patient care in more than 100 countries. 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