---
title: "MONUCO study: monitoring nutritional consequences of surgical and pharmacological obesity treatment"
id: "bmj-open-16-monitoring-nutritional-consequences-of-obesity-treatment-on-long-term-health-of"
canonical_url: "https://medichelpline.com/clinical-feed/bmj-open-16-monitoring-nutritional-consequences-of-obesity-treatment-on-long-term-health-of"
content_type: "clinical_feed_article"
specialty: "Endocrinology"
source_name: "BMJ Open"
source_url: "http://bmjopen.bmj.com/cgi/content/short/16/9/e119119?rss=1"
published_at: "2026-09-18T12:04:54.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# MONUCO study: monitoring nutritional consequences of surgical and pharmacological obesity treatment
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/bmj-open-16-monitoring-nutritional-consequences-of-obesity-treatment-on-long-term-health-of
- **Specialty:** [Endocrinology](https://medichelpline.com/clinical-feed/endocrinology.md)
- **Primary Source:** BMJ Open
- **Source URL:** [Original Journal Publication](http://bmjopen.bmj.com/cgi/content/short/16/9/e119119?rss=1)
- **Published At:** 2026-09-18T12:04:54.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- The MONUCO study is a multicentre prospective cohort designed to evaluate nutritional consequences of **obesity treatment** delivered surgically or pharmacologically. - At least 1,150 women with obesity, aged 18–55 years, will be enrolled and followed from pretreatment through multiple post-treatment time points up to 10 years. - The cohort focuses on women because most patients receiving these treatments are female and of reproductive age, raising concerns for maternal and offspring health. - Assessments occur pretreatment, at 3 and 6 months post-treatment, and annually thereafter, and include dietary intake, biochemical **nutrient status**, lifestyle factors, and health parameters. - Data collection uses physical measures, questionnaires and biological samples (urine, blood, faeces). - A nested pregnancy and birth cohort will follow participants who become pregnant after obesity treatment; this subcohort collects pregnancy-specific nutrient status, foetal growth, child development and human milk composition data. - Outcomes of interest include effects on musculoskeletal, reproductive, endocrine, gastrointestinal and mental health, as well as foetal growth and child development. - The observational design aims to produce comprehensive insights to inform evidence-based nutrition recommendations for long-term health after **surgical and pharmacological** obesity treatment. - Ethical approval was granted by the Medical Ethical Committee Oost-Nederland (NL86647.091.24). The study is registered: NCT06945016. - Results will be disseminated via scientific abstracts, posters, conference presentations, peer-reviewed publications and other platforms for participants and the public.
## Clinical Analysis & Structured Key Points
Introduction Over the past years, the number of people receiving surgical or pharmacological obesity treatment has been increasing globally. The majority of these patients are female and of reproductive age. Although these treatments are effective in reducing body weight and obesity-related comorbidities for most patients with obesity, they also compromise nutrient status, which may negatively impact the long-term health of women and their offspring born after obesity treatment. Hence, there is a need to investigate the nutritional consequences of obesity treatment and their long-term health effects on women and their offspring. Methods and analysis The MOnitor the NUtritional Consequences of Obesity (MONUCO) study is a multicentre prospective cohort study with an integrated pregnancy and birth cohort. At least 1150 women living with obesity, undergoing either surgical or pharmacological obesity treatment, aged 18 - 55 years, will be included. Assessments will be performed pretreatment and post-treatment at 3 months, 6 months and yearly up to 10 years. Dietary intake, nutrient status, lifestyle factors and parameters related to musculoskeletal, reproductive, endocrine, gastrointestinal and mental health will be assessed. Data will be collected using physical measurements, questionnaires or biological samples, including urine, blood and faeces. In the pregnancy and birth cohort, pregnant women with a history of obesity treatment will be followed throughout and after pregnancy. In this cohort, additional information will be collected on nutrient status during pregnancy, foetal growth, child development and human milk composition. This observational study will provide comprehensive insights into the consequences of both surgical and pharmacological obesity treatment on nutrient status and dietary intake and consequent musculoskeletal health, maternal health and foetal growth. Based on these findings, more evidence-based nutrition recommendations to optimise long-term health for individuals treated for obesity can be developed. Ethics and dissemination The MONUCO study is approved by the Medical Ethical Committee Oost-Nederland, Nijmegen, the Netherlands (NL86647.091.24). The results of this study will be disseminated in the form of scientific abstracts, posters, oral presentations at conferences and publications in peer-reviewed journals. Additionally, results may be made available to study participants and the general public via other platforms. Trial registration number NCT06945016 . Registration was perfromed in the pre-results stage.
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