---
title: "Semaglutide Associated With Lower Bone Fracture Risk in Type 2 Diabetes"
id: "endocrine-news-0-video-semaglutide-linked-to-lower-bone-fracture-risk"
canonical_url: "https://medichelpline.com/clinical-feed/endocrine-news-0-video-semaglutide-linked-to-lower-bone-fracture-risk"
content_type: "clinical_feed_article"
specialty: "Endocrinology"
source_name: "Endocrine News"
source_url: "https://endocrinenews.endocrine.org/video-semaglutide-linked-to-lower-bone-fracture-risk/"
published_at: "2026-09-02T15:02:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Semaglutide Associated With Lower Bone Fracture Risk in Type 2 Diabetes
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/endocrine-news-0-video-semaglutide-linked-to-lower-bone-fracture-risk
- **Specialty:** [Endocrinology](https://medichelpline.com/clinical-feed/endocrinology.md)
- **Primary Source:** Endocrine News
- **Source URL:** [Original Journal Publication](https://endocrinenews.endocrine.org/video-semaglutide-linked-to-lower-bone-fracture-risk/)
- **Published At:** 2026-09-02T15:02:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Researchers presenting at ENDO 2026 reported that people with **type 2 diabetes** treated with **semaglutide** had fewer bone fractures than patients receiving other anti‑obesity therapies. - The analysis used the Atropos Health Eos electronic health record dataset covering roughly **161 million** U.S. patients from January 2016 to December 2023. - The retrospective cohort included adults (≥18 years) with type 2 diabetes, no prior fractures, and no use of osteoporosis medications. - The semaglutide treatment group numbered **26,324**; the control group receiving dulaglutide, phentermine/topiramate, or bupropion/naltrexone numbered **33,555**. - The semaglutide cohort experienced **794** fractures versus **1,045** fractures in the control cohort. - Semaglutide was also associated with a greater reduction in **BMI** compared with the control group. - Investigators noted prior literature showing rapid weight loss from **GLP‑1** medications can lead to bone thinning and fractures, while slower or moderate weight loss may preserve bone mass. - Study authors, including Jairo Noreña, MD, and Sun Kim, MD, MS, emphasized this work is an early step and called for prospective studies to confirm bone‑protective effects of semaglutide. - The team highlighted clinical relevance because bone fractures increase pain, cost, and reduce quality of life, especially with aging, and recommended monitoring bone health during weight‑loss programs. - The report was presented as an abstract at ENDO 2026 and summarized in a video interview; authors recommend further prospective research to confirm findings.
## Clinical Analysis & Structured Key Points
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[Login](https://endocrinenews.endocrine.org/auth/login/?redirect=https://endocrinenews.endocrine.org/video-semaglutide-linked-to-lower-bone-fracture-risk/) ![](https://endocrinenews.endocrine.org/wp-content/themes/mg-starter/assets/images/Endocrine_News_standard_logo.svg) * * * # VIDEO: Semaglutide Linked to Lower Bone Fracture Risk An ENDO 2026 abstract found people with diabetes who were taking semaglutide had fewer bone fractures than those taking other anti-obesity medications. Watch our video interview with researcher Sun Kim, MD, MS. September 2, 2026 Print this article Share this article ![](https://endocrinenews.endocrine.org/wp-content/uploads/video_kim_sept_2.jpg) **[VIDEO]: People taking semaglutide for diabetes had a lower rate of bone fractures compared to those taking other anti-obesity medications, according to research presented at ENDO 2026. Sun Kim, MD, MS, explains the significance of the findings.** While these results highlight the potential bone-protective effects of semaglutide, the authors recommend that prospective studies be done to confirm the findings. ![](https://endocrinenews.endocrine.org/wp-content/uploads/Jairo-Norena-829x1024.jpg) Semaglutide is part of a group of medicines known as glucagon-like peptide-1 receptor agonists (GLP-1s), which treat type 2 diabetes and obesity. Previous studies had shown that rapid weight loss using GLP-1s can lead to thinner bones and fractures, while more moderate and slower weight loss may preserve bone mass. Scientists at Stanford University knew semaglutide helped people lose more weight than previous generations of anti-obesity medications, but they lacked evidence that compared semaglutide’s effect on bone health to other anti-obesity medications. Jairo Noreña, MD, (right) former endocrinology fellow at Stanford University Medical Center in Palo Alto, California, and his colleagues evaluated changes in body mass index (BMI) and fracture incidence in people with type 2 diabetes taking semaglutide, dulaglutide or alternative oral weight-loss therapies phentermine/topiramate and bupropion/naltrexone. “Bone fractures are painful, expensive and can seriously affect quality of life — especially as people get older,” Noreña said. “We hope this study encourages monitoring of bone health in weight-loss programs.” The team conducted a retrospective cohort analysis using the Atropos Health Eos electronic health record dataset representing 161 million patients seen in U.S. community hospitals and academic medical centers from January 2016 to December 2023. Participants were adults aged 18 years and older who were diagnosed with type 2 diabetes, with no history of prior fractures or use of osteoporosis medications. The intervention group received semaglutide (n = 26,324), while the control group received dulaglutide, phentermine/topiramate, or bupropion/naltrexone, without prior history of semaglutide use (n = 33,555). The data indicated semaglutide treatment was associated with greater reduction in BMI compared to the control group. The semaglutide group also had fewer fractures (794) compared to the control group (1045). “This work is an important early step toward understanding the impact of semaglutide-induced weight loss on bone health in patients with type 2 diabetes,” Noreña said. * * * ## TOPICS IN THIS ARTICLE: [Bone and Mineral](https://endocrinenews.endocrine.org/category/health-topic/bone-and-mineral/)[GLP-1s](https://endocrinenews.endocrine.org/category/glp-1s/) ←[Endocrine Society Advocates to Increase NIH Funding](https://endocrinenews.endocrine.org/endocrine-society-advocates-to-increase-nih-funding/) ## RELATED ARTICLES * ### [ CPAP Therapy Reverses Low Testosterone in Men with Severe Obesity, Independent of Weight Loss ](https://endocrinenews.endocrine.org/cpap-therapy-reverses-low-testosterone-in-men-with-severe-obesity-independent-of-weight-loss/) July 8, 2026 * ![Growth Therapies Fall Short for Girls with Classical CAH](https://endocrinenews.endocrine.org/wp-content/uploads/jcem_110_1cover-1-e1786367244743-1024x576.jpeg) ### [ Growth Therapies Fall Short for Girls with Classical CAH ](https://endocrinenews.endocrine.org/growth-therapies-fall-short-for-girls-with-classical-cah/) July 7, 2026 * ![Denosumab Triggers Paradoxical Hungry Bone Syndrome-Like State in Multiple Myeloma Patient](https://endocrinenews.endocrine.org/wp-content/uploads/jcemcr_2_5cover-765x1024.jpeg) ### [ Denosumab Triggers Paradoxical Hungry Bone Syndrome-Like State in Multiple Myeloma Patient ](https://endocrinenews.endocrine.org/denosumab-triggers-paradoxical-hungry-bone-syndrome-like-state-in-multiple-myeloma-patient/) July 6, 2026 * * * ADVERTISEMENT ![August 2026](https://endocrinenews.endocrine.org/wp-content/uploads/08.26_coverPROOF001-749x1024.jpg) [View Archives](https://endocrinenews.endocrine.org/magazine-issues/) ADVERTISEMENT ADVERTISEMENT ![](https://endocrinenews.endocrine.org/wp-content/themes/mg-starter/assets/images/scientists_optim-1024x569.jpg) ## Join the Global Movement Advancing Endocrine Science and Medicine Become a part of a community of 18,000-plus endocrine investigators and clinicians who conduct research and provide quality patient care in more than 100 countries. 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