---
title: "Gut microbiota alterations in flatulence point to Faecalibacterium prausnitzii as a clinical target"
id: "pubmed-42689867"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42689867"
content_type: "clinical_feed_article"
specialty: "Gastroenterology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42689867/"
doi: "10.1080/19490976.2026.2728332"
published_at: "2026-09-03T22:28:30.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Gut microbiota alterations in flatulence point to Faecalibacterium prausnitzii as a clinical target
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42689867
- **Specialty:** [Gastroenterology](https://medichelpline.com/clinical-feed/gastroenterology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42689867/)
- **DOI:** [10.1080/19490976.2026.2728332](https://doi.org/10.1080%2F19490976.2026.2728332)
- **Published At:** 2026-09-03T22:28:30.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed entry reports a 2026 Gut Microbes research article titled “Gut microbiota and metabolic alterations in participants with flatulence identify Faecalibacterium prausnitzii as a key microbial target for clinical intervention.” - Article citation: Ruimin Chen et al.; Gut Microbes. 2026;18(1):2728332. DOI 10.1080/19490976.2026.2728332. PubMed ID (PMID) 42689867. - The paper is indexed with the publication type “Randomized Controlled Trial.” - Authors are affiliated with Jiangnan University (State Key Laboratory of Food Science and Resources; School of Food Science and Technology), the Department of Gastroenterology at the Affiliated Hospital of Jiangnan University, and the National Engineering Research Center for Functional Food. - The article title identifies **Faecalibacterium prausnitzii** as a key microbial target linked to gut microbiota and metabolic changes in people reporting **flatulence**. - The PubMed record includes bibliographic metadata (authors, affiliations, PMID, DOI, journal, Epub date) but the abstract and detailed study results are not present in the provided source text. - Because the source content available here does not include study methods, participant numbers, measured outcomes, statistical findings, or specific metabolic markers, those details were not reported and cannot be summarized. - The title implies a link between microbial composition, metabolic alterations, and symptomatic flatulence, suggesting potential translational interest in targeting **F. prausnitzii** for clinical intervention, but the source does not provide interventional protocols or clinical recommendations. - Relevant clinical and research implications include the potential for microbiome-targeted therapies in patients with flatulence and the need to review the full article for methods, results, and evidence strength before applying findings clinically. - Users are advised to consult the full PubMed/Gut Microbes article (DOI provided) for complete data, methodology, and conclusions, since the current record lacks the abstract and primary data in the provided extract.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 3. # Gut microbiota and metabolic alterations in participants with flatulence identify _Faecalibacterium prausnitzii_ as a key microbial target for clinical intervention [Ruimin Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+R&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Chuan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+C&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Shikai Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+S&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-3 "Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People's Republic of China."), [Chengcheng Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+C&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Yilin Ren](https://pubmed.ncbi.nlm.nih.gov/?term=Ren+Y&cauthor_id=42689867)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-3 "Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People's Republic of China."), [Gang Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+G&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Shumao Cui](https://pubmed.ncbi.nlm.nih.gov/?term=Cui+S&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Wenwei Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+W&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-4 "National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Bo Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+B&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Xiaomei Lyu](https://pubmed.ncbi.nlm.nih.gov/?term=Lyu+X&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Peijun Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+P&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Jianxin Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+J&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Fengwei Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+F&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Yuzheng Xue](https://pubmed.ncbi.nlm.nih.gov/?term=Xue+Y&cauthor_id=42689867)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-3 "Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People's Republic of China."), [Qixiao Zhai](https://pubmed.ncbi.nlm.nih.gov/?term=Zhai+Q&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#full-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.") Affiliations Expand ### Affiliations * 1 State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China. * 2 School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China. * 3 Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People's Republic of China. * 4 National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, People's Republic of China. * PMID: **42689867** * DOI: [ 10.1080/19490976.2026.2728332 ](https://doi.org/10.1080/19490976.2026.2728332) Item in Clipboard Randomized Controlled Trial # Gut microbiota and metabolic alterations in participants with flatulence identify _Faecalibacterium prausnitzii_ as a key microbial target for clinical intervention Ruimin Chen et al. Gut Microbes. 2026. Show details Display options Display options Format Abstract PubMed PMID Gut Microbes Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Gut+Microbes%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Gut+Microbes%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42689867/) . 2026 Dec 31;18(1):2728332. doi: 10.1080/19490976.2026.2728332. Epub 2026 Sep 3. ### Authors [Ruimin Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+R&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Chuan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+C&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Shikai Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+S&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-3 "Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People's Republic of China."), [Chengcheng Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+C&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Yilin Ren](https://pubmed.ncbi.nlm.nih.gov/?term=Ren+Y&cauthor_id=42689867)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-3 "Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People's Republic of China."), [Gang Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+G&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Shumao Cui](https://pubmed.ncbi.nlm.nih.gov/?term=Cui+S&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Wenwei Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+W&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-4 "National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Bo Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+B&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Xiaomei Lyu](https://pubmed.ncbi.nlm.nih.gov/?term=Lyu+X&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Peijun Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+P&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Jianxin Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+J&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Science and resources, Jiangnan University, Wuxi, Jiangsu, People's Republic of China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-2 "School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China."), [Fengwei Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+F&cauthor_id=42689867)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42689867/#short-view-affiliation-1 "State Key Laboratory of Food Scienc
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