---
title: "Incidence and Risk Stratification of Hepatitis B Reactivation With Anti-CD38 Therapy"
id: "journal-of-hepatology-58-incidence-and-risk-stratification-of-hepatitis-b-reactivation-in-patients-receiving-anti-cd38-monoclonal-antibody-therapy"
canonical_url: "https://medichelpline.com/clinical-feed/journal-of-hepatology-58-incidence-and-risk-stratification-of-hepatitis-b-reactivation-in-patients-receiving-anti-cd38-monoclonal-antibody-therapy"
content_type: "clinical_feed_article"
specialty: "Gastroenterology"
source_name: "Journal of Hepatology"
source_url: "https://www.journal-of-hepatology.eu/article/S0168-8278(26)00067-X/fulltext?rss=yes"
published_at: "2026-02-13T12:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Incidence and Risk Stratification of Hepatitis B Reactivation With Anti-CD38 Therapy
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/journal-of-hepatology-58-incidence-and-risk-stratification-of-hepatitis-b-reactivation-in-patients-receiving-anti-cd38-monoclonal-antibody-therapy
- **Specialty:** [Gastroenterology](https://medichelpline.com/clinical-feed/gastroenterology.md)
- **Primary Source:** Journal of Hepatology
- **Source URL:** [Original Journal Publication](https://www.journal-of-hepatology.eu/article/S0168-8278(26)00067-X/fulltext?rss=yes)
- **Published At:** 2026-02-13T12:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
Recently updated European Association for the Study of the Liver (EASL) clinical practice guidelines highlight the importance of nucleos(t)ide analogue (NA) prophylaxis in patients with risk of reactivation.[1] Risk factors include B-cell–depleting agents such as rituximab,[2] T-cell–modulating treatments, several cytokine-targeting regimens, and combination immune-modifying therapies. These recommendations highlight the broad vulnerability of patients exposed to intensive or prolonged immunosuppression.
## Clinical Analysis & Structured Key Points
Journal of Hepatology published a clinical update in Research Highlights on 13 Feb 2026. The item focuses on Incidence and Risk Stratification of Hepatitis B Reactivation in Patients Receiving Anti-CD38 Monoclonal Antibody Therapy. Review the original article for the full source wording and details.
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