---
title: "CFT+ Versus Interdisciplinary Pain Management Program for Severe Chronic Low Back Pain: Pragmatic"
id: "pubmed-42676088"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42676088"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42676088/"
doi: "10.2519/jospt.2026.14238"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# CFT+ Versus Interdisciplinary Pain Management Program for Severe Chronic Low Back Pain: Pragmatic
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42676088
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42676088/)
- **DOI:** [10.2519/jospt.2026.14238](https://doi.org/10.2519%2Fjospt.2026.14238)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This pragmatic, patient-blinded randomized controlled trial compared initial **cognitive functional therapy with psychologist support (CFT+)** followed by optional interdisciplinary pain management program (IPMP) if needed, versus **IPMP alone** in adults with severely disabling chronic low back pain (cLBP). - 133 adults referred to an interdisciplinary pain center were randomized; primary outcome was the proportion achieving a ≥8-point improvement on the **Oswestry Disability Index (ODI)** at 12 months. - Trial had concealed allocation, patient blinding, and intention-to-treat analysis. ODI data at 12 months were available for 46 (70%) in the CFT+ group and 45 (67%) in the IPMP group. - A ≥8-point ODI improvement occurred in 22% with CFT+ versus 18% with IPMP (difference 3.9%; 95% CI: -12.4% to 20.3%; P = .64). Mean ODI change between groups did not differ (difference 0.2; 95% CI: -3.8 to 4.2; P = .92). - No significant between-group differences were observed for secondary outcomes including pain intensity, pain catastrophizing, patient enablement, and global impression of change. - Economic analysis estimated an incremental cost-effectiveness ratio of €53,075 per **QALY** for CFT+ versus IPMP, based on QALYs derived from EQ-5D-3L and health care contacts. - The authors conclude that **CFT+ was not superior to IPMP** for people with severely disabling cLBP at 12 months. - Trial registry: NCT04399772. Key measures, sample sizes, effect estimates, and the cost-effectiveness result are reported in the abstract.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42676088/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42676088%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42676088/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42676088/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42676088/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42676088/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42676088/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42676088%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42676088%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42676088/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42676088/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42676088/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42676088/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42676088/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42676088/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42676088/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42676088/#similar) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42676088/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42676088/#mesh-terms) Title & authors Abstract Similar articles Publication types MeSH terms Randomized Controlled Trial J Orthop Sports Phys Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Orthop+Sports+Phys+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Orthop+Sports+Phys+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) . 2026 Sep;56(9):596-610. doi: 10.2519/jospt.2026.14238. # CFT+ With a Subsequent Interdisciplinary Pain Management Program (IPMP) If Needed Versus IPMP Alone for Patients With Severe Disabling Chronic LBP: Pragmatic Patient-Blinded RCT With Economic Analysis [Henrik Bjarke Vaegter](https://pubmed.ncbi.nlm.nih.gov/?term=Vaegter+HB&cauthor_id=42676088), [Anne Smith](https://pubmed.ncbi.nlm.nih.gov/?term=Smith+A&cauthor_id=42676088), [Jannick Vaaben Johansen](https://pubmed.ncbi.nlm.nih.gov/?term=Johansen+JV&cauthor_id=42676088), [Irene Stegemejer](https://pubmed.ncbi.nlm.nih.gov/?term=Stegemejer+I&cauthor_id=42676088), [Kira Søndberg Fuglsang](https://pubmed.ncbi.nlm.nih.gov/?term=Fuglsang+KS&cauthor_id=42676088), [Jesper Fredslund Pedersen](https://pubmed.ncbi.nlm.nih.gov/?term=Pedersen+JF&cauthor_id=42676088), [Liza Sopina](https://pubmed.ncbi.nlm.nih.gov/?term=Sopina+L&cauthor_id=42676088), [Rob Schutze](https://pubmed.ncbi.nlm.nih.gov/?term=Schutze+R&cauthor_id=42676088), [Peter O'Sullivan](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Sullivan+P&cauthor_id=42676088), [Peter Kent](https://pubmed.ncbi.nlm.nih.gov/?term=Kent+P&cauthor_id=42676088), [Gitte Handberg](https://pubmed.ncbi.nlm.nih.gov/?term=Handberg+G&cauthor_id=42676088), [Francis Fatoye](https://pubmed.ncbi.nlm.nih.gov/?term=Fatoye+F&cauthor_id=42676088), [Kasper Ussing](https://pubmed.ncbi.nlm.nih.gov/?term=Ussing+K&cauthor_id=42676088), [Jonas Bloch Thorlund](https://pubmed.ncbi.nlm.nih.gov/?term=Thorlund+JB&cauthor_id=42676088) * PMID: **42676088** * DOI: [ 10.2519/jospt.2026.14238 ](https://doi.org/10.2519/jospt.2026.14238) Item in Clipboard Randomized Controlled Trial # CFT+ With a Subsequent Interdisciplinary Pain Management Program (IPMP) If Needed Versus IPMP Alone for Patients With Severe Disabling Chronic LBP: Pragmatic Patient-Blinded RCT With Economic Analysis Henrik Bjarke Vaegter et al. J Orthop Sports Phys Ther. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID J Orthop Sports Phys Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Orthop+Sports+Phys+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Orthop+Sports+Phys+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) . 2026 Sep;56(9):596-610. doi: 10.2519/jospt.2026.14238. ### Authors [Henrik Bjarke Vaegter](https://pubmed.ncbi.nlm.nih.gov/?term=Vaegter+HB&cauthor_id=42676088), [Anne Smith](https://pubmed.ncbi.nlm.nih.gov/?term=Smith+A&cauthor_id=42676088), [Jannick Vaaben Johansen](https://pubmed.ncbi.nlm.nih.gov/?term=Johansen+JV&cauthor_id=42676088), [Irene Stegemejer](https://pubmed.ncbi.nlm.nih.gov/?term=Stegemejer+I&cauthor_id=42676088), [Kira Søndberg Fuglsang](https://pubmed.ncbi.nlm.nih.gov/?term=Fuglsang+KS&cauthor_id=42676088), [Jesper Fredslund Pedersen](https://pubmed.ncbi.nlm.nih.gov/?term=Pedersen+JF&cauthor_id=42676088), [Liza Sopina](https://pubmed.ncbi.nlm.nih.gov/?term=Sopina+L&cauthor_id=42676088), [Rob Schutze](https://pubmed.ncbi.nlm.nih.gov/?term=Schutze+R&cauthor_id=42676088), [Peter O'Sullivan](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Sullivan+P&cauthor_id=42676088), [Peter Kent](https://pubmed.ncbi.nlm.nih.gov/?term=Kent+P&cauthor_id=42676088), [Gitte Handberg](https://pubmed.ncbi.nlm.nih.gov/?term=Handberg+G&cauthor_id=42676088), [Francis Fatoye](https://pubmed.ncbi.nlm.nih.gov/?term=Fatoye+F&cauthor_id=42676088), [Kasper Ussing](https://pubmed.ncbi.nlm.nih.gov/?term=Ussing+K&cauthor_id=42676088), [Jonas Bloch Thorlund](https://pubmed.ncbi.nlm.nih.gov/?term=Thorlund+JB&cauthor_id=42676088) * PMID: **42676088** * DOI: [ 10.2519/jospt.2026.14238 ](https://doi.org/10.2519/jospt.2026.14238) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **OBJECTIVES:** We aimed to determine whether, for patients with severely disabling chronic low back pain (cLBP), initiating care with cognitive functional therapy combined with psychologist support (CFT+) improved disability and pain, and was cost-effective compared with an interdisciplinary pain management program (IPMP) at 12 months. **METHODS:** We conducted a randomized controlled trial ([NCT04399772](http://clinicaltrials.gov/show/NCT04399772 "See in ClinicalTrials.gov")) with concealed allocation, blinded patients, and intention-to-treat analysis. One hundred thirty-three adults with severely disabling cLBP, who were referred to an interdisciplinary pain center, were randomized to CFT+ for 3 months, with optional access to IPMP thereafter, or to IPMP alone. The primary outcome was the proportion of patients who achieved a ≥8-point improvement on the Oswestry Disability Index (ODI) at 12 months. Secondary outcomes were pain intensity, pain catastrophizing, patient enablement, global impression of change, and cost-effectiveness assessed using quality-adjusted life years (QALYs) derived from the EQ-5D-3L (EuroQol 5-Dimension 3-Level Questionnaire) and health care contacts. **RESULTS:** At 12 months, ODI data were available for 46 (70%) patients in the CFT+ group and 45 (67%) in the IPMP group. A ≥8-point ODI improvement was achieved by 22% of patients who received CFT+ and 18% who received IPMP (difference, 3.9%; 95% CI: -12.4%, 20.3%; _P_ = .64). Mean ODI change did not differ between groups (difference, 0.2; 95% CI: -3.8, 4.2; _P_ = .92). There were no significant between-group differences for the secondary outcomes. Economic analysis estimated an incremental cost-effectiveness ratio of €53 075 per QALY for CFT+ versus IPMP. **CONCLUSION:** CFT+ was not superior to IPMP for people with severely disabling cLBP. _J Orthop Sports Phys Ther 2026;56(9):596-610. Epub 25 June 2026. doi:10.2519/jospt.2026.14238_. **Keywords:** chronic pain; cognitive functional therapy; economic analysis; pain management; randomized controlled trial. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ A multicentred randomised controlled trial of a primary care-based cognitive behavioural programme for low back pain. The Back Skills Training (BeST) trial. ](https://pubmed.ncbi.nlm.nih.gov/20807469/) Lamb SE, Lall R, Hansen Z, Castelnuovo E, Withers EJ, Nichols V, Griffiths F, Potter R, Szczepura A, Underwood M; BeST trial group.Lamb SE, et al.Health Technol Assess. 2010 Aug;14(41):1-253, iii-iv. doi: 10.3310/hta14410.Health Technol Assess. 2010.PMID: 20807469Clinical Trial. * [ Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2). ](https://pubmed.ncbi.nlm.nih.gov/40230183/) Geraghty AWA, Becque T, Roberts LC, Hill J, Foster NE, Yardley L, Stuart B, Turner DA, Griffiths G, Webley F, Durcan L, Morgan A, Hughes S, Bathers S, Butler-Walley S, Wathall S, Mansell G, White M, Davies F, Little P.Geraghty AWA, et al.Health Technol Assess. 2025 Apr;29(7):1-90. doi: 10.3310/GDPS2418.Health Technol Assess. 2025.PMID: 40230183Free PMC article.Clinical Trial. * [ Group cognitive-behavioural programme to reduce the impact of rheumatoid arthritis fatigue: the RAFT RCT with economic and qualitative evaluations. ](https://pubmed.ncbi.nlm.nih.gov/31601357/) Hewlett S, Almeida C, Ambler N, Blair PS, Choy E, Dures E, Hammond A, Hollingworth W, Kadir B, Kirwan J, Plummer Z, Rooke C, Thorn J, Turner N, Pollock J.Hewlett S, et al.Health Technol Assess. 2019 Oct;23(57):1-130. doi: 10.3310/hta23570.Health Technol Assess. 2019.PMID: 31601357Free PMC article.Clinical Trial. * [ Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas. ](https://pubmed.ncbi.nlm.nih.gov/36321557/) Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P.Crider K, et al.Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.Cochrane Database Syst Rev. 2022.Update in: [Cochrane Database Syst Rev. 2026 Feb 18;2:CD014217. doi: 10.1002/14651858.CD014217.pub2.](https://pubmed.ncbi.nlm.nih.gov/41705996/)PMID: 36321557Free PMC article.Updated. * [ Behavioural modification interventions for medically unexplained symptoms in primary care: systematic reviews and economic evaluation. ](https://pubmed.ncbi.nlm.nih.gov/32975190/) Leaviss J, Davis S, Ren S, Hamilton J, Scope A, Booth A, Sutton A, Parry G, Buszewicz M, Moss-Morris R, White P.Leaviss J, et al.Health Technol Assess. 2020 Sep;24(46):1-490. doi: 10.3310/hta24460.Health Technol Assess. 2020.PMID: 32975190Free PMC article. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42676088) ## Publication types * Randomized Controlled Trial Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Randomized+Controlled+Trial%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Randomized+Controlled+Trial) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Pragmatic Clinical Trial Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pragmatic+Clinical+Trial%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Pragmatic+Clinical+Trial) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) ## MeSH terms * Adult Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Adult%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Adult) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Chronic Pain* / psychology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chronic+Pain%2Fpsychology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Chronic+Pain) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Chronic Pain* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chronic+Pain%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Chronic+Pain) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Cognitive Behavioral Therapy* / economics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cognitive+Behavioral+Therapy%2Feconomics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cognitive+Behavioral+Therapy) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Cost-Benefit Analysis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cost-Benefit+Analysis%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cost-Benefit+Analysis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Cost-Effectiveness Analysis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cost-Effectiveness+Analysis%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cost-Effectiveness+Analysis) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Disability Evaluation Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Disability+Evaluation%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Disability+Evaluation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Female) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Low Back Pain* / psychology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Low+Back+Pain%2Fpsychology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Low+Back+Pain) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Low Back Pain* / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Low+Back+Pain%2Ftherapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Low+Back+Pain) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Male Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Male) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Middle Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Pain Management* / economics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pain+Management%2Feconomics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Pain+Management) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676088/) * Pain Management* / methods Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pain+Management%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Pain+Management) * [
## Related Clinical Research

- [Brief-COPE Questionnaire Shows Five-Factor Structure in Seropositive Rheumatoid Arthritis](https://medichelpline.com/clinical-feed/medrxiv-1-validation-of-the-brief-cope-questionnaire-in-a-seropositive-rheumatoid.md)
- [Yoga vs Combined Exercise for Women with Rheumatoid Arthritis: RCT Showing Superior Pain and Psych](https://medichelpline.com/clinical-feed/pubmed-42661382.md) (DOI: 10.1002/msc.70261)
- [Lineage-specific XCI escape and skew drive sex-biased immune gene dosage and X-linked variant expo](https://medichelpline.com/clinical-feed/biorxiv-11-lineage-specific-x-chromosome-inactivation-escape-and-skew-underlie-sex-biased.md)
- [Emergency diagnosis frequency and outcomes across 13 non-cancer conditions in England: analysis of](https://medichelpline.com/clinical-feed/plos-medicine-2-frequency-and-prognostic-outcomes-of-emergency-diagnosis-in-13-non-neoplastic.md)
- [Climate change worsens health for people with chronic illness](https://medichelpline.com/clinical-feed/stat-news-1-opinion-climate-change-is-making-people-with-chronic-illness-even-sicker.md)

## Navigation
- [← Back to General Feed](https://medichelpline.com/clinical-feed/general.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.