---
title: "Corynebacterium amycolatum SB-1 Ferment Filtrate: Ellagic Acid Reduces Melanogenesis and Promotes"
id: "biorxiv-0-skin-related-effects-of-corynebacterium-amycolatum-sb-1-ferment-filtrate-and"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-0-skin-related-effects-of-corynebacterium-amycolatum-sb-1-ferment-filtrate-and"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.02.748710v1?rss=1"
published_at: "2026-09-05T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Corynebacterium amycolatum SB-1 Ferment Filtrate: Ellagic Acid Reduces Melanogenesis and Promotes
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-0-skin-related-effects-of-corynebacterium-amycolatum-sb-1-ferment-filtrate-and
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.02.748710v1?rss=1)
- **Published At:** 2026-09-05T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Researchers isolated eight Corynebacterium strains from the facial skin of a female participant to test skin-beneficial effects. - Supernatants (ferment filtrates) from each isolate were applied to three cultured skin cell lines: **Hs68**, **HaCaT**, and **B16-F10**. - Gene expression markers assessed included **ELN**, **COL1A1**, **IL-1β**, and **HAS3** to evaluate effects on extracellular matrix, inflammation, and hyaluronan synthesis. - Melanin biosynthesis inhibition was measured in the B16-F10 melanocyte line to screen anti-pigmentation activity. - **Corynebacterium amycolatum SB-1** was chosen as the lead strain based on rapid growth and high cell yield among isolates. - LC-TOF/MS analysis of SB-1 postbiotic candidates identified **ellagic acid**, a known polyphenolic antioxidant, as a major bioactive component. - Ellagic acid was tested for effects on **FLG** expression and melanin synthesis; it demonstrated inhibition of melanogenesis and promotion of collagen-related gene expression. - RNA sequencing linked ellagic acid exposure to transcriptional changes consistent with suppressed melanogenesis and enhanced collagen synthesis pathways. - Authors conclude ellagic acid from SB-1 ferment filtrate is a promising bioactive for targeting hyperpigmentation and skin aging; the report is a preprint and not yet peer reviewed. - No competing interests were declared by the authors.
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Songmi Kim 1 Dankook University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Songmi%2BKim%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kim%20S&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASongmi%2BKim%2B) * [ORCID record for Songmi Kim](http://orcid.org/0000-0002-5497-1174 "Open in new tab") Seyoung Mun 1 Dankook University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Seyoung%2BMun%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Mun%20S&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASeyoung%2BMun%2B) * [ORCID record for Seyoung Mun](http://orcid.org/0000-0002-9669-4494 "Open in new tab") Misun Kim 2 Cosmax BTI * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Misun%2BKim%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kim%20M&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMisun%2BKim%2B) Min-Ji Kim 2 Cosmax BTI * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Min-Ji%2BKim%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kim%20M&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMin-Ji%2BKim%2B) Dong-Geol Lee 2 Cosmax BTI * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Dong-Geol%2BLee%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Lee%20D&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ADong-Geol%2BLee%2B) Seunghyun Kang 2 Cosmax BTI * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Seunghyun%2BKang%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kang%20S&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASeunghyun%2BKang%2B) HyungWoo Jo 2 Cosmax BTI * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=HyungWoo%2BJo%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Jo%20H&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AHyungWoo%2BJo%2B) Kyudong Han 1 Dankook University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Kyudong%2BHan%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Han%20K&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AKyudong%2BHan%2B) * [ORCID record for Kyudong Han](http://orcid.org/0000-0001-6791-2408 "Open in new tab") * For correspondence: kyudong.han@gmail.com * [Abstract](https://www.biorxiv.org/content/10.64898/2026.09.02.748710v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5759799/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.09.02.748710v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5759799/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.09.02.748710v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5759799/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.09.02.748710v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5759799/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Previous research has established a link between the genus Corynebacterium in the skin microbiota and skin health; however, studies investigating the specific effects of Corynebacterium-derived substances on skin cells remain limited. In this study, we isolated eight strains of Corynebacterium from the facial skin of female participant. To investigate the potential skin improvement effects of these isolates, three cultured skin cell lines (Hs68, HaCaT, and B16-F10) were treated with the supernatants of each strain. We then evaluated and compared the gene expression levels (ELN, COL1A1, IL-1β, and HAS3) alongside their inhibitory effects on melanin biosynthesis. Corynebacterium amycolatum SB-1 was selected as the final candidate for subsequent analysis, primarily based on its rapid growth rate and high cell yield. Using LC-TOF/MS, we screened the postbiotic candidates from the SB-1 strain and identified ellagic acid as a known polyphenolic antioxidant with potent anti-melanogenic effects beneficial for skin improvement. To validate the effects of ellagic acid on skin cells, we assessed FLG gene expression and its inhibition of melanin biosynthesis. Additionally, RNA sequencing was performed to elucidate the underlying molecular mechanisms, revealing that ellagic acid is significantly involved in inhibiting melanogenesis and promoting collagen synthesis. Taken together, our results highlight ellagic acid derived from strain SB-1 as a highly effective bioactive compound for improving skin health, specifically targeting hyperpigmentation and skin aging. ### Competing Interest Statement The authors have declared no competing interest. Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC-ND 4.0 International license](http://creativecommons.org/licenses/by-nc-nd/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. 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[ Download PDF](https://www.biorxiv.org/content/10.64898/2026.09.02.748710v1.full.pdf) Print/Save Options [Download PDF](https://www.biorxiv.org/content/biorxiv/early/2026/09/05/2026.09.02.748710.full.pdf)Full Text & In-line FiguresXML [More Info](https://www.biorxiv.org/about/FAQ#PrintOptions "More Information on Print/Save Options") [ Email](https://www.biorxiv.org/ "Email this Article") [ Share](https://www.biorxiv.org/) Skin-Related Effects of Corynebacterium amycolatum SB-1 Ferment Filtrate and Functional Characterization of Ellagic Acid Songmi Kim, Seyoung Mun, Misun Kim, Min-Ji Kim, Dong-Geol Lee, Seunghyun Kang, HyungWoo Jo, Kyudong Han bioRxiv 2026.09.02.748710; doi: https://doi.org/10.64898/2026.09.02.748710 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. 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