---
title: "Definium Therapeutics reports Phase 3 LSD pill DT120 reduced anxiety in generalized anxiety disord"
id: "stat-news-1-stat-definium-therapeutics-says-its-lsd-therapy-eased-anxiety-in-late-stage"
canonical_url: "https://medichelpline.com/clinical-feed/stat-news-1-stat-definium-therapeutics-says-its-lsd-therapy-eased-anxiety-in-late-stage"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "STAT News"
source_url: "https://www.statnews.com/2026/08/12/definium-lsd-treatment-anxiety-study/?utm_campaign=rss"
published_at: "2026-08-12T12:01:16.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Definium Therapeutics reports Phase 3 LSD pill DT120 reduced anxiety in generalized anxiety disord
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/stat-news-1-stat-definium-therapeutics-says-its-lsd-therapy-eased-anxiety-in-late-stage
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** STAT News
- **Source URL:** [Original Journal Publication](https://www.statnews.com/2026/08/12/definium-lsd-treatment-anxiety-study/?utm_campaign=rss)
- **Published At:** 2026-08-12T12:01:16.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Definium Therapeutics announced that its single-dose **LSD**-based pill, **DT120**, produced a statistically significant benefit for patients with **generalized anxiety disorder** in the first of two large Phase 3 trials, according to the source article. - The randomized Phase 3 anxiety study enrolled 214 participants who were assigned to receive either a single dose of DT120 or placebo. - This result follows a recent Phase 3 success for the company in **major depression**, making this the second major positive outcome reported by Definium within about two months. - The STAT News report states that DT120 is a proprietary, pharmaceutically optimized formulation of LSD developed by Definium. - Key trial details and full efficacy and safety data (magnitude of effect, statistical values, secondary endpoints, adverse events, follow-up duration, and subgroup analyses) were not reported in the source article because the remainder of the story is behind a STAT+ paywall. - The announcement represents a clinical and corporate milestone for Definium, but independent verification, regulatory context, and complete trial data were not available in the source text. - The STAT article is an exclusive STAT+ story; readers must subscribe or log in to access the full report, and the available public details are limited to enrollment, randomization, and the company’s summary claim of a positive outcome. - No information about trial sites, inclusion/exclusion criteria, sponsor-controlled analyses, or plans for regulatory submission were provided in the accessible portion of the article. - Given the limited publicly reported information, clinicians and researchers should seek the full trial report or peer-reviewed data to assess clinical relevance, safety profile, durability of effect, and generalizability.
## Clinical Analysis & Structured Key Points
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Test your knowledge with our new weekday mini crossword [ Start solving ](https://www.statnews.com/stat-mini-crossword/) [STAT Plus](https://www.statnews.com/stat-plus/)[Biotech](https://www.statnews.com/category/biotech/) # Definium Therapeutics says its LSD therapy eased anxiety in late-stage trial ## Results mark second major win for company in the past two months * [Manage alerts for this article](https://www.statnews.com/my-account/edit/#emails) * Email this article * [Share this article](https://www.statnews.com/2026/08/12/definium-lsd-treatment-anxiety-study/?utm_campaign=rss) ![Nasdaq](https://www.statnews.com/wp-content/uploads/2016/06/Nasdaq_GettyImages-76051122-645x645.jpg) Mario Tama/Getty Images ![](https://www.statnews.com/wp-content/uploads/2022/05/jason-mast-avatar-round-80x80.png) By [Jason Mast](https://www.statnews.com/staff/jason-mast/) Aug. 12, 2026 General Assignment Reporter ![](https://www.statnews.com/wp-content/uploads/2022/05/jason-mast-avatar-round-80x80.png) [Jason Mast](https://www.statnews.com/staff/jason-mast/) 1. [](https://x.com/JasonMMast "X") jason.mast@statnews.com Jason is a general assignment reporter, with particular focus on genetic medicine and rare disease. Confidential tips can be sent on Signal at JasonMast.77. Definium Therapeutics said Wednesday that its LSD therapy significantly helped patients with generalized anxiety disorder in the first of two large trials. It’s the second major win for Definium in the past two months, following a [Phase 3 success](https://www.statnews.com/2026/06/22/definium-lsd-dt120-major-depression-phase-3-data/) in major depression. Advertisement In the Phase 3 anxiety study, 214 patients were randomly assigned to receive a single dose of DT120 — Definium “proprietary, pharmaceutically optimized” LSD pill — or a placebo. [![STAT+](https://www.statnews.com/wp-content/themes/stat/images/stat-plus-logo.svg)](https://www.statnews.com/stat-plus/) To read the rest of this story subscribe to STAT+. 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