---
title: "DELLA control of root transcriptional responses to water limitation in Arabidopsis and rice"
id: "biorxiv-0-della-proteins-modulate-responsive-and-buffered-transcriptional-programs-in"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-0-della-proteins-modulate-responsive-and-buffered-transcriptional-programs-in"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.22.760938v1?rss=1"
published_at: "2026-10-25T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# DELLA control of root transcriptional responses to water limitation in Arabidopsis and rice
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-0-della-proteins-modulate-responsive-and-buffered-transcriptional-programs-in
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.22.760938v1?rss=1)
- **Published At:** 2026-10-25T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The authors used polyethylene glycol (PEG) to simulate reduced water availability and examined root growth and gene expression in Arabidopsis thaliana and Oryza sativa. - Loss of **DELLA** function reduced root growth sensitivity to water limitation: primary root elongation in Arabidopsis and crown root formation in rice were affected. - Transcriptomic profiling identified two DELLA-dependent response modes: genes that require DELLAs for appropriate water-stress responses, labeled 'WT-responsive', and genes that become responsive mainly when DELLAs are absent, labeled 'buffered'. - The term 'buffered' is operational in this study; the authors did not claim a mechanistic explanation for buffering. - Data indicated that DELLA proteins both enable specific transcriptional responses to osmotic stress and limit broader transcriptional responsiveness, suggesting a dual regulatory role. - Although DELLA dependence of response patterns is conserved between species, the developmental outcomes (primary root elongation vs crown root formation) and downstream transcriptional programs showed substantial species specificity. - The preprint reports these observations but does not provide peer review certification; methodological or quantitative details such as sample sizes and statistical parameters are not included in the abstract and were not reported there.
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Cynthia Wong Instituto de Biologia Celular y Molecular de Plantas (UPV-CSIC) * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Cynthia%2BWong%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Wong%20C&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ACynthia%2BWong%2B) David Alabadi Instituto de Biologia Celular y Molecular de Plantas (UPV-CSIC) * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=David%2BAlabadi%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Alabadi%20D&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ADavid%2BAlabadi%2B) * [ORCID record for David Alabadi](http://orcid.org/0000-0001-8492-6713 "Open in new tab") Miguel A Blazquez Instituto de Biologia Celular y Molecular de Plantas (UPV-CSIC) * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Miguel%2BA%2BBlazquez%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Blazquez%20MA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMiguel%2BA%2BBlazquez%2B) * [ORCID record for Miguel A Blazquez](http://orcid.org/0000-0001-5743-0448 "Open in new tab") Bruno Catarino Instituto de Biologia Celular y Molecular de Plantas (UPV-CSIC) * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Bruno%2BCatarino%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Catarino%20B&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ABruno%2BCatarino%2B) * [ORCID record for Bruno Catarino](http://orcid.org/0000-0002-9546-6932 "Open in new tab") * For correspondence: bcatari@ibmcp.upv.es * [Abstract](https://www.biorxiv.org/content/10.64898/2026.10.22.760938v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5901325/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.10.22.760938v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5901325/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.10.22.760938v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5901325/1) * [Supplementary material](https://www.biorxiv.org/content/10.64898/2026.10.22.760938v1.supplementary-material)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_data/node:5901325/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.10.22.760938v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5901325/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Water limitation constrains plant growth and productivity, yet the molecular mechanisms regulating root responses remain incompletely understood. The DELLA repressors of gibberellin signaling are key growth regulators under stress, but their role in shaping transcriptional responses to water limitation, and its conservation, remain unclear. Here, we investigated DELLA function in roots of Arabidopsis thaliana and Oryza sativa under reduced water availability simulated by polyethylene glycol (PEG). Loss of DELLA function reduced the sensitivity of root growth to water limitation, affecting primary root elongation in A. thaliana and crown root formation in O. sativa. Transcriptomic profiling revealed extensive DELLA-dependent regulation, partitioned into two modes: (i) genes requiring DELLAs for appropriate responses to water limitation ('WT-responsive'), and (ii) genes whose responsiveness is detected predominantly in the absence of DELLAs ('buffered', an operational label for an expression pattern, not a demonstrated mechanism). These patterns suggest that DELLAs both enable specific responses and apparently constrain broader transcriptional responsiveness under osmotic stress. Although the requirement for DELLA function is conserved, the developmental outputs and downstream transcriptional programs are largely species-specific. Together, our results identify DELLAs as key modulators of root responses to water limitation, with a proposed dual role in shaping and limiting transcriptional dynamics. ### Competing Interest Statement The authors have declared no competing interest. ## Funder Information Declared Generalitat Valenciana, GRISOLIAP/2021/021 Agencia Estatal de Investigación, FJC2018-035750-I Agencia Estatal de Investigación, PID2019-109925GB-I00 Agencia Estatal de Investigación, PID2019-110717-GB Agencia Estatal de Investigación, PID2022-141770NB-I00 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC-ND 4.0 International license](http://creativecommons.org/licenses/by-nc-nd/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. 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