---
title: "Durability of response to icotrokinra in adults with moderate-to-severe plaque psoriasis — 1-year"
id: "pubmed-42397072"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42397072"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42397072/"
doi: "10.1093/bjd/ljag264"
published_at: "2026-09-18T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Durability of response to icotrokinra in adults with moderate-to-severe plaque psoriasis — 1-year
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42397072
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42397072/)
- **DOI:** [10.1093/bjd/ljag264](https://doi.org/10.1093%2Fbjd%2Fljag264)
- **Published At:** 2026-09-18T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The publication reports 1-year results from two phase III, placebo- and active comparator–controlled trials, ICONIC-ADVANCE 1 and ICONIC-ADVANCE 2, evaluating **icotrokinra** in adults with moderate-to-severe plaque psoriasis. - Trials are described as phase III and controlled versus both **placebo** and an active comparator; the report focuses on the durability of treatment response over one year. - The article appears in the British Journal of Dermatology (Br J Dermatol) and is indexed in PubMed (PMID 42397072; DOI 10.1093/bjd/ljag264), published 18 September 2026. - The author list is extensive and multi-institutional, including academic dermatologists and investigators from clinical research centers; several authors are affiliated with Johnson & Johnson, indicating industry involvement. - The source entry on PubMed identifies the trials, population (adults with moderate-to-severe plaque psoriasis), and study design (phase III, placebo- and active comparator-controlled) but does not provide numerical efficacy outcomes, responder rates, safety data, or detailed methodology in the accessible abstract text shown here. - Full-text access is indicated (free article link available), and the PubMed record lists affiliations and trial designation but the accessible excerpt lacks trial endpoints, statistical analyses, and specific durability metrics. - Where the PubMed record is silent, the summary below explicitly notes that specific efficacy results, adverse event rates, comparator identities, dosing regimens, and statistical outcomes were not reported in the visible source text and must be obtained from the full article. - This record is useful to clinicians as a pointer to primary phase III data on **icotrokinra** durability in plaque psoriasis but requires consultation of the full published article for actionable clinical details such as magnitude and maintenance of response, safety profile, and comparator performance.
## Clinical Analysis & Structured Key Points
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resources ](https://pubmed.ncbi.nlm.nih.gov/42397072/#linkout) Title & authors Abstract Plain language summary Similar articles Publication types MeSH terms Substances Related information Grants and funding LinkOut - more resources Clinical Trial Br J Dermatol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Br+J+Dermatol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Br+J+Dermatol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42397072/) . 2026 Sep 18;195(4):600. doi: 10.1093/bjd/ljag264. # Durability of response to icotrokinra in adults with moderate-to-severe plaque psoriasis: 1-year results from the phase III, placebo- and active comparator-controlled ICONIC-ADVANCE 1 and ICONIC-ADVANCE 2 trials [Linda Stein Gold](https://pubmed.ncbi.nlm.nih.gov/?term=Stein+Gold+L&cauthor_id=42397072)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-1 "Henry Ford Health System, West Bloomfield, MI, USA."), [April W Armstrong](https://pubmed.ncbi.nlm.nih.gov/?term=Armstrong+AW&cauthor_id=42397072)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-2 "Department of Dermatology, University of California Los Angeles, Los Angeles, CA, USA."), [Jennifer Soung](https://pubmed.ncbi.nlm.nih.gov/?term=Soung+J&cauthor_id=42397072)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-3 "Southern California Clinical Research, Santa Ana and Harbor University of California Los Angeles, CA, USA."), [Ronald B Vender](https://pubmed.ncbi.nlm.nih.gov/?term=Vender+RB&cauthor_id=42397072)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-4 "Venderm Consulting Inc., Hamilton, ON, Canada."), [Álvaro González Cantero](https://pubmed.ncbi.nlm.nih.gov/?term=Gonz%C3%A1lez+Cantero+%C3%81&cauthor_id=42397072)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-5 "Department of Dermatology, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-6 "Facultad de Medicina, Universidad Francisco de Vitoria, Madrid, Spain."), [Matthias Hoffmann](https://pubmed.ncbi.nlm.nih.gov/?term=Hoffmann+M&cauthor_id=42397072)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-7 "Dermatology Practice Dr. Matthias Hoffmann, Witten, Germany."), [Scott T Guenthner](https://pubmed.ncbi.nlm.nih.gov/?term=Guenthner+ST&cauthor_id=42397072)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-8 "The Indiana Clinical Trials Center, PC, Plainfield, IN, USA.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-9 "The Dermatology Center of Indiana, PC, Plainfield, IN, USA."), [H Chih-Ho Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+HC&cauthor_id=42397072)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-10 "University of British Columbia, Department of Dermatology and Skin Science, Vancouver, BC, Canada.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-11 "Dr. Chih-Ho Hong Medical Inc., a member of Probity Medical Research, Surrey, BC, Canada."), [Dedee F Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DF&cauthor_id=42397072)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-12 "Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-13 "Department of Dermatology, St George Hospital, Sydney, NSW, Australia."), [Eingun James Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+EJ&cauthor_id=42397072)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-14 "Frontier Dermatology, Mill Creek, WA, USA."), [Leon Kircik](https://pubmed.ncbi.nlm.nih.gov/?term=Kircik+L&cauthor_id=42397072)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-15 "Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-16 "Indiana University School of Medicine, Indianapolis, IN, USA."), [Matthias Augustin](https://pubmed.ncbi.nlm.nih.gov/?term=Augustin+M&cauthor_id=42397072)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-17 "University Medical Center Hamburg-Eppendorf, Hamburg, Germany."), [Maxwell Sauder](https://pubmed.ncbi.nlm.nih.gov/?term=Sauder+M&cauthor_id=42397072)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-18 "Probity Medical Research, Waterloo, ON, Canada.")[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-19 "University of Toronto, Toronto, ON, Canada."), [Sascha Gerdes](https://pubmed.ncbi.nlm.nih.gov/?term=Gerdes+S&cauthor_id=42397072)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-20 "Center for Inflammatory Skin Diseases, Department of Dermatology, Venereology and Allergology, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany."), [Ofelia Reyes-Servin](https://pubmed.ncbi.nlm.nih.gov/?term=Reyes-Servin+O&cauthor_id=42397072)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-21 "Johnson & Johnson, Spring House/Horsham, PA, USA."), [Bassey Effiom Edem](https://pubmed.ncbi.nlm.nih.gov/?term=Edem+BE&cauthor_id=42397072)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-22 "Johnson & Johnson, Leiden, the Netherlands."), [Jennifer Campbell](https://pubmed.ncbi.nlm.nih.gov/?term=Campbell+J&cauthor_id=42397072)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-23 "Johnson & Johnson, Cambridge, MA, USA."), [Kellen Cresswell](https://pubmed.ncbi.nlm.nih.gov/?term=Cresswell+K&cauthor_id=42397072)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-21 "Johnson & Johnson, Spring House/Horsham, PA, USA."), [Lea Kephart](https://pubmed.ncbi.nlm.nih.gov/?term=Kephart+L&cauthor_id=42397072)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-21 "Johnson & Johnson, Spring House/Horsham, PA, USA."), [Shu Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+S&cauthor_id=42397072)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-21 "Johnson & Johnson, Spring House/Horsham, PA, USA."), [Ya-Wen Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+YW&cauthor_id=42397072)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-21 "Johnson & Johnson, Spring House/Horsham, PA, USA."), [Robert Bissonnette](https://pubmed.ncbi.nlm.nih.gov/?term=Bissonnette+R&cauthor_id=42397072)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#full-view-affiliation-24 "Innovaderm Research, Montreal, QC, Canada.") Affiliations Expand ### Affiliations * 1 Henry Ford Health System, West Bloomfield, MI, USA. * 2 Department of Dermatology, University of California Los Angeles, Los Angeles, CA, USA. * 3 Southern California Clinical Research, Santa Ana and Harbor University of California Los Angeles, CA, USA. * 4 Venderm Consulting Inc., Hamilton, ON, Canada. * 5 Department of Dermatology, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain. * 6 Facultad de Medicina, Universidad Francisco de Vitoria, Madrid, Spain. * 7 Dermatology Practice Dr. Matthias Hoffmann, Witten, Germany. * 8 The Indiana Clinical Trials Center, PC, Plainfield, IN, USA. * 9 The Dermatology Center of Indiana, PC, Plainfield, IN, USA. * 10 University of British Columbia, Department of Dermatology and Skin Science, Vancouver, BC, Canada. * 11 Dr. Chih-Ho Hong Medical Inc., a member of Probity Medical Research, Surrey, BC, Canada. * 12 Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. * 13 Department of Dermatology, St George Hospital, Sydney, NSW, Australia. * 14 Frontier Dermatology, Mill Creek, WA, USA. * 15 Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. * 16 Indiana University School of Medicine, Indianapolis, IN, USA. * 17 University Medical Center Hamburg-Eppendorf, Hamburg, Germany. * 18 Probity Medical Research, Waterloo, ON, Canada. * 19 University of Toronto, Toronto, ON, Canada. * 20 Center for Inflammatory Skin Diseases, Department of Dermatology, Venereology and Allergology, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany. * 21 Johnson & Johnson, Spring House/Horsham, PA, USA. * 22 Johnson & Johnson, Leiden, the Netherlands. * 23 Johnson & Johnson, Cambridge, MA, USA. * 24 Innovaderm Research, Montreal, QC, Canada. * PMID: **42397072** * DOI: [ 10.1093/bjd/ljag264 ](https://doi.org/10.1093/bjd/ljag264) Free article Item in Clipboard Clinical Trial # Durability of response to icotrokinra in adults with moderate-to-severe plaque psoriasis: 1-year results from the phase III, placebo- and active comparator-controlled ICONIC-ADVANCE 1 and ICONIC-ADVANCE 2 trials Linda Stein Gold et al. Br J Dermatol. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Br J Dermatol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Br+J+Dermatol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Br+J+Dermatol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42397072/) . 2026 Sep 18;195(4):600. doi: 10.1093/bjd/ljag264. ### Authors [Linda Stein Gold](https://pubmed.ncbi.nlm.nih.gov/?term=Stein+Gold+L&cauthor_id=42397072)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-1 "Henry Ford Health System, West Bloomfield, MI, USA."), [April W Armstrong](https://pubmed.ncbi.nlm.nih.gov/?term=Armstrong+AW&cauthor_id=42397072)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-2 "Department of Dermatology, University of California Los Angeles, Los Angeles, CA, USA."), [Jennifer Soung](https://pubmed.ncbi.nlm.nih.gov/?term=Soung+J&cauthor_id=42397072)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-3 "Southern California Clinical Research, Santa Ana and Harbor University of California Los Angeles, CA, USA."), [Ronald B Vender](https://pubmed.ncbi.nlm.nih.gov/?term=Vender+RB&cauthor_id=42397072)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-4 "Venderm Consulting Inc., Hamilton, ON, Canada."), [Álvaro González Cantero](https://pubmed.ncbi.nlm.nih.gov/?term=Gonz%C3%A1lez+Cantero+%C3%81&cauthor_id=42397072)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-5 "Department of Dermatology, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-6 "Facultad de Medicina, Universidad Francisco de Vitoria, Madrid, Spain."), [Matthias Hoffmann](https://pubmed.ncbi.nlm.nih.gov/?term=Hoffmann+M&cauthor_id=42397072)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-7 "Dermatology Practice Dr. Matthias Hoffmann, Witten, Germany."), [Scott T Guenthner](https://pubmed.ncbi.nlm.nih.gov/?term=Guenthner+ST&cauthor_id=42397072)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-8 "The Indiana Clinical Trials Center, PC, Plainfield, IN, USA.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-9 "The Dermatology Center of Indiana, PC, Plainfield, IN, USA."), [H Chih-Ho Hong](https://pubmed.ncbi.nlm.nih.gov/?term=Hong+HC&cauthor_id=42397072)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-10 "University of British Columbia, Department of Dermatology and Skin Science, Vancouver, BC, Canada.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-11 "Dr. Chih-Ho Hong Medical Inc., a member of Probity Medical Research, Surrey, BC, Canada."), [Dedee F Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DF&cauthor_id=42397072)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-12 "Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.")[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-13 "Department of Dermatology, St George Hospital, Sydney, NSW, Australia."), [Eingun James Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+EJ&cauthor_id=42397072)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-14 "Frontier Dermatology, Mill Creek, WA, USA."), [Leon Kircik](https://pubmed.ncbi.nlm.nih.gov/?term=Kircik+L&cauthor_id=42397072)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-15 "Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-16 "Indiana University School of Medicine, Indianapolis, IN, USA."), [Matthias Augustin](https://pubmed.ncbi.nlm.nih.gov/?term=Augustin+M&cauthor_id=42397072)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-17 "University Medical Center Hamburg-Eppendorf, Hamburg, Germany."), [Maxwell Sauder](https://pubmed.ncbi.nlm.nih.gov/?term=Sauder+M&cauthor_id=42397072)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-18 "Probity Medical Research, Waterloo, ON, Canada.")[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-19 "University of Toronto, Toronto, ON, Canada."), [Sascha Gerdes](https://pubmed.ncbi.nlm.nih.gov/?term=Gerdes+S&cauthor_id=42397072)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42397072/#short-view-affiliation-20 "Center for Inflammatory Skin Diseases, Department of Dermatology, Venereology and Allergology, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany."), [Ofelia Reye
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