---
title: "Fibronectin-Tethered MAP Scaffolds Enable Shear-Thinning Annealing for Granular Hydrogels"
id: "biorxiv-7-fibronectin-tethering-as-a-shear-thinning-bio-annealing-strategy-for-granular"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-7-fibronectin-tethering-as-a-shear-thinning-bio-annealing-strategy-for-granular"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.20.760419v1?rss=1"
published_at: "2026-10-21T11:50:53.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Fibronectin-Tethered MAP Scaffolds Enable Shear-Thinning Annealing for Granular Hydrogels
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-7-fibronectin-tethering-as-a-shear-thinning-bio-annealing-strategy-for-granular
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.20.760419v1?rss=1)
- **Published At:** 2026-10-21T11:50:53.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The authors modified microporous annealed particle (MAP) building blocks by covalently tethering **fibronectin (FN)** to create **FN-MAP**, a unified strategy that combines inter-particle annealing and surface bioactivity. - FN-MAP exhibits a **shear-thinning annealing** behavior: scaffolds recover their mechanical properties after physical mixing, indicating reversible flow under shear with post-shear mechanical recovery. - Human lung fibroblasts cultured in FN-MAP adopted spread morphologies and retained high viability, showing a favorable cell–matrix interaction without separately added adhesion peptides. - The study team reported translational proof-of-principle uses: improved stability and print resolution in 3D bioprinting tests, and increased epidermal closure in a diabetic mouse wound-healing model. - FN-MAP achieves both mechanical stabilization and surface bioactivity without exogenous soluble linkers or heterogeneous particle mixtures, according to the authors. - The work builds on current granular hydrogel scaffold (GHS) and MAP approaches that typically rely on covalent photo-initiated crosslinking or reversible guest–host chemistries plus separately tethered RGD peptides. - The preprint status means this report has not been peer-reviewed; competing interest disclosed: D.R.G. is a founder and director of a company commercializing MAP technology. - The published abstract did not provide detailed quantitative metrics, protocol parameters, or full experimental methods in-line; readers should consult the full preprint PDF for methodological specifics and raw data where available.
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Ethan J Nicklow University of Virginia * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Ethan%2BJ%2BNicklow%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Nicklow%20EJ&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AEthan%2BJ%2BNicklow%2B) * [ORCID record for Ethan J Nicklow](http://orcid.org/0000-0003-1685-4919 "Open in new tab") Olivia D Ernst University of Virginia * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Olivia%2BD%2BErnst%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ernst%20OD&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AOlivia%2BD%2BErnst%2B) * [ORCID record for Olivia D Ernst](http://orcid.org/0000-0003-1828-6724 "Open in new tab") Christopher B Highley University of Virginia * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Christopher%2BB%2BHighley%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Highley%20CB&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AChristopher%2BB%2BHighley%2B) * [ORCID record for Christopher B Highley](http://orcid.org/0000-0001-9153-4013 "Open in new tab") Donald R Griffin University of Virginia * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Donald%2BR%2BGriffin%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Griffin%20DR&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ADonald%2BR%2BGriffin%2B) * [ORCID record for Donald R Griffin](http://orcid.org/0000-0002-3458-867X "Open in new tab") * For correspondence: drgriffin@virginia.edu * [Abstract](https://www.biorxiv.org/content/10.64898/2026.10.20.760419v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5886787/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.10.20.760419v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5886787/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.10.20.760419v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5886787/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.10.20.760419v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5886787/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Granular hydrogel scaffolds (GHS) are injectable, integrative biomaterials built from hydrogel microparticles that permit rapid cell infiltration independent of scaffold degradation. Microporous annealed particle (MAP) scaffolds, a sub-class of GHS, use inter-microparticle crosslinks to anneal adjacent particles, providing greater mechanical stability than purely jammed assemblies. A growing range of inter-particle crosslinking strategies, including covalent photo-initiated radical polymerization and reversible guest-host chemistries, some intended to mimic extracellular matrix (ECM) viscoelasticity, focus on mechanical stabilization, while surface bioactivity is typically added separately via orthogonally tethered cell-adhesion ligands such as RGD, a peptide derived from fibronectin (FN), a key mediator of cell-ECM and ECM-ECM interactions. Here, we present an alternative that unifies these functions: coating MAP microparticle building blocks with covalently bound fibronectin to create fibronectin-modified MAP (FN-MAP). FN-MAP exhibits shear-thinning annealing with complete recovery of scaffold mechanics after physical mixing. Human lung fibroblasts respond favorably, adopting spread morphologies with high viability. Translationally, FN-MAP shows proof-of-principle promise for 3D bioprinting (greater stability and higher print resolution) and wound healing (increased epidermal closure in a diabetic mouse model). FN-MAP thus delivers both increased scaffold strength and bioactivity without exogenous soluble linkers or mixed particle populations. ### Competing Interest Statement D.R.G. is a founder and Director of Tempo Therapeutics Inc. (San Diego, CA), a company that is currently working to commercialize MAP technology for clinical use. ## Funder Information Declared National Institute on Deafness and Other Communication Disorders, https://ror.org/04mhx6838, R01 DC020998 National Institute of Diabetes and Digestive and Kidney Diseases, https://ror.org/00adh9b73, R01 DK126020 National Institute of General Medical Sciences, https://ror.org/04q48ey07, R35 GM147410 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY 4.0 International license](http://creativecommons.org/licenses/by/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. 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